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Ketone drink may boost brain power – but dose matters

NCT ID NCT06032156

Knowledge-focused Sponsor: McMaster University Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed This study
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This study looked at whether a single dose of a ketone supplement can improve blood flow to the brain and thinking skills in young adults. Twenty healthy people aged 18-35 took either a low dose, high dose, or a placebo drink. Researchers measured brain blood flow and memory performance over two hours. The goal is to understand if ketone supplements can help the brain work better without needing to fast.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
ketone monoester supplement (R-3-hydroxybutyl R-3-hydroxybutyrate)
What this could lead to
If successful, this could point toward using ketone supplements to boost brain blood flow and mental performance in healthy people.
What could go wrong
This is a very small, early study in healthy young adults, so results may not apply to older or unhealthy populations. The effects on cognition are still uncertain.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

20 people

The number who actually took part.

Started

Nov 2023

Finished

Aug 2024

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 to 35 years

Sex

Anyone

Healthy volunteers

Accepted

You do not need to have the condition being studied to take part.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: \- Between the ages of 18 and 35 Exclusion Criteria: * Presence of obesity (body mass index \> 30 kg/m\^2) * Presence of known cardiovascular disease * Presence of type 2 diabetes * History of cardiovascular events requiring hospitalization (i.e., heart attack) * History of concussion(s) with persistent symptoms * Currently following a ketogenic diet and/or taking ketone body supplements

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Conditions

The condition(s) this trial relates to.

cognitive disorder

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Cerebrovascular function Cognition

Contacts and locations

Locations

  • McMaster University

    Hamilton, Ontario, L8S 4K1, Canada

More trials for these conditions

Other studies related to the condition(s) this trial covers.