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Could your own blood help you heal faster after gum surgery?

NCT ID NCT07637838

Symptom relief Sponsor: 59th Medical Wing Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed This study
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This trial tests whether applying platelet-rich fibrin (PRF) — a wound dressing made from a patient's own blood — to the roof of the mouth after gum graft surgery improves pain, sleep, and overall quality of life compared to standard dressings. About 78 adults needing gum surgery will be randomly assigned to receive either PRF or a commercial dressing. Participants will report their pain and quality of life at several time points over two weeks and wear a sleep tracker to measure sleep quality.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
platelet-rich fibrin (PRF)
What this could lead to
If it works, this could offer a simple, natural way to reduce pain and speed healing after gum surgery, improving patients' daily comfort and sleep.
What could go wrong
This is a small, early-stage trial (78 people) testing a specific surgical setting. Results may not apply to other procedures or populations, and PRF may not outperform standard dressings.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

78 people

The number who actually took part.

Started

May 2024

Finished

Mar 2025

Lead sponsor

A government agency

The lead sponsor is a US federal agency other than the NIH.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 to 99 years

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * age \> 18 or \< 99 * required a mucogingival surgery * had not taken an antibiotic for one month * planned for a non-emergent periodontal procedure Exclusion Criteria: * pregnant or within 6 months post-partum * female subjects who are nursing * subjects who are decisionally challenged * patients who have undergone antibiotic therapy in the past month * ASA IV or higher status * patients who have undergone chronic therapy with medications that could affect periodontal status or healing * incompatible mobile phone devices.

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Conditions

The condition(s) this trial relates to.

insomnia Pain

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Analgesic consumption Pain Palatal donor site wound healing Platelet rich fibrin Sleep quality

Contacts and locations

Locations

  • Air Force Post Graduate Dental School

    San Antonio, Texas, 78236, United States

More trials for these conditions

Other studies related to the condition(s) this trial covers.