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Laser zaps pain and speeds up braces treatment, study finds

NCT ID NCT04230096

Symptom relief Sponsor: Aga Khan University Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed This study
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 2 times

Summary

This study tested whether low level laser therapy (LLLT) can reduce pain, speed up tooth movement, and improve gum health in people getting braces. 108 Pakistani patients aged 18-30 received either standard braces or braces plus laser treatment on their front teeth every three weeks for six months. Researchers measured pain, gum inflammation, and tooth movement to see if the laser helped.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
low level laser therapy (device)
What this could lead to
If it works, this could offer a non-invasive way to reduce pain and gum problems during braces treatment, and possibly shorten treatment time.
What could go wrong
This is a small, early-stage study with no blinding, so results may be biased. The laser effect may be too small to matter in practice.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

108 people

The number who actually took part.

Started

Dec 2023

Finished

Feb 2025

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 to 30 years

Sex

Anyone

Healthy volunteers

Accepted

You do not need to have the condition being studied to take part.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: 1. Selected patients will be Pakistani ethnic background. 2. Age 18 to 30 years. 3. Patients with class 1 with mild crowding (severity of malocclusion) according to little irregularity index to avoid individual variations. (Little, 1975) 4. Patient with healthy periodontium with no any sign of gingival inflamation. 5. Patients who indicated for orthodontic treatment with fixed appliances started with the conventional ligated brackets. 6. Patients who will sign consent for participation in research and use of collected specimen/data for future reference. 7. Patients who are able to read and understand English language because consent forms available only in language of English. 8. Patients with ovoid arch form to compact with laser assisted tray. Exclusion Criteria: 1. Patients on medications which alter the gingival health e.g. Phenytoin (Dilantin), Cyclosporine A (Sandimmun), Nifedipine (Adalat), Corticosteroids, contraceptive pills. 2. Patients on those medications which alter the bone metabolism or tooth movement e.g. NSAIDs, Corticosteroids, Bisphosphonates etc. 3. Patients with following disorder: Diabetes Type 1 and 2, Osteoporosis, Platelet disorders, Vitamin C deficiency, vascular conditions, Leukemia, HIV infection, crohn's disease. 4. Patients with pregnancy. 5. Patients with parafunctional habits, TMJ dysfunction, craniofacial malformation, multiple missing teeth, impacted teeth except third molars, or periodontally compromised patients will be excluded from the study. \-

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Conditions

The condition(s) this trial relates to.

gingivitis malocclusion due to protuberant upper front teeth Pain periodontitis Tooth Migration

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Gingivitis Pain Periodontitis Tooth migration

Contacts and locations

Locations

  • Aga Khan Hospital for Women Karimabad A secondary Hospital ofAga khan university Hospital

    Karachi, Sindh Pakistan, 75000, Pakistan

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