Pain

This trial is testing a new smart pump (VPIA) that delivers morphine for pain after surgery while continuously monitoring breathing. The goal is to see if this system can provide effective pain relief while reducing the risk of breathing problems. The study involves adults aged 2…

This trial tests whether proglumide, an older drug that blocks a specific receptor, can safely reduce pain and slow or reverse the scarring seen in chronic pancreatitis. The study includes adults with confirmed chronic pancreatitis and compares proglumide against a placebo over 1…

This study compares three modern dental materials used to treat deep cavities in children's permanent molars by preserving the tooth nerve. The goal is to see which material best helps the tooth root continue growing and reduces pain. About 48 healthy children aged 7 to 11 with o…

This study looks at 360 adults aged 18-75 who need a hip replacement due to arthritis or pain. It compares three different types of artificial hip parts to see which one causes less bone loss and gives better pain relief and movement over 5 years. Participants will have CT scans …

Researchers compare two ways to treat adults with at least four traumatic rib fractures and severe pain: surgery to fix the ribs or standard care with painkillers and epidural anesthesia. The trial measures pain levels, hospital stay, quality of life, and physical function to see…

Researchers in Chile are testing whether adding neural mobilization, a physical therapy technique that targets nerve movement, to standard fibromyalgia care improves daily function and reduces pain more than standard care alone. The trial enrolls 20 women aged 18 and older with a…

This study tests whether adding ketamine to a standard painkiller (bupivacaine) and rinsing the surgical area during gallbladder removal can better control pain after surgery. Sixty adults having laparoscopic gallbladder removal will be randomly assigned to receive either the sta…

This study looks at whether terpenes—natural compounds found in plants—can reduce pain when taken alone or with THC. Researchers will test 45 adults who use cannabis regularly to measure pain relief and any feelings of being high or drug liking. The goal is to find safer ways to …

This trial tests whether a specially designed drape that covers a woman's lower body during a vaginal exam can reduce pain and improve satisfaction and perceived privacy. Women aged 18 and older undergoing a vaginal exam at a gynecology clinic are randomly assigned to use the dra…

This study tests whether the steroid hydrocortisone can improve knee movement after total knee replacement. About 132 patients, some with naturally stiff knees, will receive either the drug or a placebo right after surgery. Researchers will measure how well the knee bends and str…

This trial tests whether acupressure, a technique that applies gentle pressure to specific body points, can reduce pain, fear, and anxiety in children aged 6-12 during removal of K-wires (thin metal pins used to heal elbow fractures). Children will be randomly assigned to receive…

This trial tests whether using virtual reality (VR) headsets to distract patients can reduce pain and anxiety during bone marrow examinations, which are often uncomfortable and stressful. Participants will either use VR headsets to watch or listen to calming content, or follow th…

This trial tests whether a multisensory foam, which stimulates touch, sight, hearing, and smell with a fun, cooling 'popping candy' effect, can reduce pain, anxiety, and fear in children aged 5 to 10 during a blood draw. Half the children will receive the foam during the procedur…

This pilot trial tests whether Acceptance and Commitment Therapy (ACT), a type of talking therapy, can help disease-free cancer survivors manage chronic pain and reduce long-term opioid use. Participants attend six weekly virtual sessions with a psychologist. The study focuses on…

This trial tests whether watching robotic fish or live aquarium fish can reduce pain, fear, and anxiety in children aged 5 to 10 during painful medical procedures. Children will be assigned to watch one of the two fish distractions while undergoing the procedure, and their pain, …

This study tests whether using a hand extension rubber during IV insertion can reduce pain, anxiety, and improve satisfaction. Researchers will enroll 114 adults who need an IV and randomly assign them to use the rubber or not. The goal is to see if this simple, low-cost distract…

This study tests whether a non-invasive therapy called neurofeedback can help people with chemotherapy-induced nerve pain learn to change their own brain waves to feel less pain. About 80 participants will be assigned to either receive neurofeedback training or a control conditio…

This trial tests whether listening to music for 30 minutes before and after surgery can reduce pain, anxiety, and the need for painkillers in women undergoing gynecologic surgery. Participants will choose from several music genres and report their pain, anxiety, and satisfaction …

This study tests whether two simple, drug-free techniques can ease the pain, fear, and crying that 9-month-old babies often experience during routine vaccinations. One method uses a small bee-shaped device called Buzzy, which vibrates and cools the skin near the injection site. T…

This phase II trial is testing whether an experimental lotion called ASKC200 can reduce pain in people with knee osteoarthritis. About 175 adults aged 40 to 80 with knee pain lasting at least six months will be randomly assigned to receive one of two strengths of ASKC200, a stand…

This study looks at whether acupuncture can help manage chronic pain in people with sickle cell disease. Researchers will use brain scans and other tests to understand how acupuncture affects pain signals. The study involves 60 participants aged 14 to 80 who have sickle cell dise…

This study tests if shining a special light (photobiomodulation) on the cervix before inserting a copper IUD can reduce pain. 72 women will receive either real or fake light treatment, and their pain levels will be compared. The goal is to make IUD insertion more comfortable and …

This study tests if acupuncture can reduce nerve pain caused by chemotherapy in cancer survivors. About 255 people who finished chemo at least three months ago will receive either real or sham acupuncture. The goal is to see if this drug-free approach can ease pain and improve da…

This phase 3 trial tests an experimental painkiller called YZJ-4729 for people experiencing moderate to severe pain after abdominal surgery. Participants receive either YZJ-4729, a placebo (saline), or morphine, and researchers measure pain intensity over 24 hours. The goal is to…

This study tests whether simple distraction tools—a ShotBlocker device and a finger puppet—can reduce pain and fear in children aged 5 to 10 during blood draws. About 90 children will be randomly assigned to use one of these tools or receive standard care. The goal is to see if t…

This study explores whether individualized transcranial magnetic stimulation (TMS) can improve symptoms in adults with irritable bowel syndrome (IBS). Participants receive 10 TMS sessions over two weeks, with brain scans and stool tests before and after to understand how the trea…

This study tested whether an ozone oil-based gel can reduce pain and prevent dry socket after lower wisdom tooth removal, compared to a standard CHX gel. One hundred patients received both treatments in separate sessions. Pain levels and dry socket occurrence were recorded for 48…

This study tests whether a new type of screw (Bone Bolt) reduces pain better than standard screws after surgery for a specific pelvic fracture (LC-1). About 100 adults aged 18-80 will take part. The main goal is to see if the Bone Bolt leads to lower pain scores in the days after…

This study compares two laser settings to the usual method for removing ceramic braces. Ten healthy adults who finished orthodontic treatment will have their brackets removed with a laser or the standard tool. Researchers will measure tooth temperature, enamel damage, and pain to…

This study tests whether stationary cycling (at a voluntary or assisted pace) and a type of psychotherapy called I-STOP can reduce drug cravings in adults with opioid use disorder and chronic pain. About 198 people in residential treatment will try these approaches alone or toget…

This early study tests whether vaporized cannabigerol (CBG) and THC can help with pain and appetite. Twenty occasional cannabis users will receive different doses of CBG and THC, alone or together, and report their pain tolerance, hunger, and any side effects. The goal is to see …

This study tests whether a 2-minute perineal massage before a pessary exam can reduce pain and discomfort. 68 women with prolapse or incontinence will try both massage and a gel-only method at separate visits. The goal is to find a simple, non-drug way to improve comfort during r…

This study looks at whether combining two types of exercises—Feldenkrais and active release—with standard physical therapy can help people with knee osteoarthritis feel less pain and move better. Forty adults aged 40 to 60 with mild to moderate knee OA will do these exercises thr…

This study tests whether MR-guided focused ultrasound (MR-HIFU), alone or with standard radiotherapy, can better relieve pain from bone metastases than radiotherapy alone. About 216 adults with painful bone lesions will be randomly assigned to one of three groups. The goal is to …

This small, early study is testing a new device that uses low-frequency ultrasound waves in a bath to see if it can safely help heal knee osteoarthritis and reduce pain. Ten adults aged 40 and older with chronic knee pain will try the treatment every few days. The main goal is to…

This study explores whether immersive virtual reality can help reduce chronic pain in people with temporomandibular disorder (TMD). About 259 participants will experience active VR, a sham VR, or no VR while their pain tolerance is measured. The goal is to understand how VR works…

This study looks at whether one art therapy session can improve mood and reduce symptoms like pain and anxiety in adults receiving palliative care. Twenty patients in a Canadian hospital will fill out short questionnaires before and after a 30-60 minute art session. The goal is t…

This study planned to test whether a small electrical device (TENS) could reduce pain when placing an IUD. It was designed for adults getting a new or replacement IUD. The study was withdrawn before enrolling anyone, so no results are available.

This study tests whether placing a colorful, washable walkway mat in front of children's beds can reduce pain and fear and help them start moving sooner after abdominal surgery. About 74 children aged 4–10 will be involved. The mat is designed to distract and encourage kids to wa…

This study tests whether yoga can reduce nerve pain caused by chemotherapy in cancer survivors. About 227 participants will either take yoga classes twice a week for 8 weeks, attend educational sessions, or receive standard care. Researchers will measure pain, balance, fall risk,…

This study tests whether applying cabbage leaves to the knee can reduce pain, improve physical function, and boost quality of life in people with knee osteoarthritis. Researchers will compare two different cabbage leaf preparations against standard care in 90 adults over four wee…

This study looks at two simple ways to help children feel less anxious and in less pain when getting a tooth pulled. One method uses a fun video to distract them, and the other uses gentle pressure on a specific point on the hand. The study will include 69 healthy children aged 5…

This study is testing whether laughter therapy can improve breathing and reduce pain in people aged 60 and older. 64 participants will attend weekly 45-50 minute sessions that include warm-up, breathing, and laughter exercises, plus meditation. Researchers will measure lung funct…

This study looks at two ways to manage pain after gynecological surgery: the EXORA block and epidural analgesia. Researchers will measure how well each method controls pain and how quickly patients recover their quality of life. The study involves 60 adults aged 18 to 80 who are …

This study looks at whether prescribing fewer opioid painkillers after laparoscopic hysterectomy still keeps patients comfortable. About 120 adults having the surgery for non-cancer reasons will be randomly assigned to get a smaller or standard opioid prescription. The goal is to…

This study tests whether using patterned (decorative) tape instead of plain tape to hold an IV in place can lower pain and improve vital signs in children. Forty kids aged 3-12 who get regular IV therapy for chronic conditions will try both types of tape on different days. Resear…

This study explores whether a few phone-based mindfulness sessions before spine surgery can help people who worry a lot about pain. Researchers will first adapt the therapy with a small group, then test it in 20 people scheduled for surgery. The goal is to see if it's practical a…

This Mayo Clinic study is testing an AI system that uses wearable devices to measure pain after surgery. The goal is to find physical signs of pain and create a tool that helps doctors personalize pain medication, preventing overuse. The study involves 70 patients recovering from…

This study tests whether watching calming nature videos with virtual reality glasses can lower pain and anxiety in people recovering from colorectal surgery. Sixty adults will be split into two groups: one group uses the VR glasses before and after surgery, while the other receiv…

This study tests whether listening to visualized meditation sessions for three days before an endoscopy can lower anxiety, pain, and discomfort during the procedure. About 72 first-time endoscopy patients will either listen to the meditation or receive standard care. Researchers …

This study tests whether showing finger puppets or cartoons to children aged 3-6 before a blood draw can lower their pain and fear. About 120 children will be randomly assigned to one of three groups: finger puppets, cartoons, or standard care (no extra distraction). Researchers …

This study tests a device called MILTA, which uses light and magnetic fields, to reduce pain from perineal scars after childbirth. About 110 women with moderate to severe pain will receive either MILTA or a placebo treatment in two sessions. The goal is to see if this non-drug ap…

This pilot study aimed to see if giving lorazepam, a sedative, before IUD insertion could reduce pain and anxiety. It planned to enroll 25 adults at a family medicine clinic. However, the study was withdrawn before any participants were enrolled, so no data was collected.

This study aimed to compare giving a TLIP nerve block before spine fusion surgery using ultrasound versus giving it during surgery without ultrasound. The goal was to see which method better controlled pain and reduced opioid use. However, the study was withdrawn before enrolling…

This study tests whether neurofeedback training—a non-invasive therapy that uses brain wave monitoring—can help people with chemotherapy-induced peripheral neuropathy (nerve pain, numbness, or tingling) learn to change their own brain activity to feel less pain and improve qualit…

This study compares two types of nerve blocks (PENG and FIC) to see which provides better pain relief for adults with hip fractures in the emergency department. About 80 participants will receive one of the blocks and report their pain levels. The goal is to find a safer, opioid-…

This study tests whether using a stress ball during a prostate biopsy can help reduce anxiety and pain. Researchers will enroll 66 men undergoing their first prostate biopsy. Participants will squeeze a stress ball during the procedure, and their pain and anxiety levels will be m…

This study looks at whether hearing a popping sound during spinal manipulation changes how much pain and disability people feel, and how satisfied they are with the treatment. 38 adults with non-specific neck and upper back pain will receive massage and spinal manipulation. Resea…

This study planned to compare three different medications given as nose sprays to children aged 2 to 6 years who needed stitches for a cut. The goal was to see which one worked best for pain and anxiety during the procedure. However, the trial was withdrawn before any children we…

This study tests a psychological treatment called Pain Reprocessing Therapy (PRT) for people with chronic widespread pain, including fibromyalgia. PRT teaches patients that pain can come from 'stuck' brain patterns and helps them retrain their brain to stop sending false pain ala…

This study tests a pain management toolkit for nursing home residents. The toolkit includes non-drug methods like massage, relaxation, exercise, music, and aromatherapy. Researchers will see if it helps staff manage pain better and improves residents' comfort and quality of life.…

This study tests whether showing educational videos to children aged 4-7 and their parents before a blood draw can lower the child's pain, fear, and anxiety. About 76 children will take part, and researchers will measure their distress using standard scales. The goal is to find a…

Researchers at the University of Missouri-Columbia want to understand the mental processes people use when they rate their pain. The study enrolls 44 adults who have had musculoskeletal pain in multiple locations on most days for at least three months. Participants rate their pai…

This study looks at how daily cannabis smoking changes pain sensitivity and the risk of abuse in healthy adults who already use cannabis. Researchers will measure pain tolerance and withdrawal symptoms over 16 days in a controlled hospital setting. The goal is to understand if ca…

This study aims to find out how often cancer patients treated with opioids for pain are at risk of misusing these medications. Researchers will use two screening questionnaires to assess misuse risk in 200 adult outpatients receiving opioids for cancer-related pain. The findings …

This study is testing a new physical therapy protocol for people over 50 who have had arthroscopic rotator cuff surgery. Researchers will track shoulder function, pain levels, and sleep quality over the recovery period. The goal is to gather better evidence on what helps patients…

This study explores whether artificial intelligence and video monitoring can recognize pain and delirium in intensive care unit (ICU) patients who cannot communicate verbally. Researchers will use cameras, accelerometers, and other sensors to capture facial expressions and body m…

This study looks at adults with temporomandibular disorders (TMD) — problems with the jaw joint and muscles — to measure how chronic pain, anxiety, depression, and perceived stress relate to each other. Researchers will use standard questionnaires to assess pain severity, depress…

This study looks at 50 adults with sleep bruxism (teeth grinding during sleep) to understand how it affects sleep, pain, anxiety, and overall health. Researchers will use sleep tests, blood samples, and questionnaires to find links between bruxism and other conditions. The goal i…

This study aims to understand if cannabis affects pain relief and the risk of abuse differently in men and women. Researchers will give 160 regular cannabis users either active cannabis or a placebo and measure their pain response, drug effects, and blood levels. The goal is to g…

This study tests whether a simple isometric (static) hand exercise can change how people with rheumatoid arthritis feel pain. Researchers will measure pain tolerance, pressure thresholds, and muscle oxygen levels in 66 adults. The goal is to see if this type of exercise can help …

This Phase 1 study aims to understand how the body processes ketamine after a cesarean delivery, and whether it can help with postpartum depression and pain. Fifty participants will receive a low-dose ketamine infusion, and researchers will measure drug levels and side effects. T…

This study explores how women with fibromyalgia experience pain using a smartphone app with animations and body maps. Participants will describe their pain by choosing and adjusting animations that match their sensations. The goal is to find better ways to measure pain quality an…

This study looks at why some people with early rheumatoid arthritis develop long-lasting chronic pain while others do not. Researchers will use pain sensitivity tests and brain scans to find clues. The goal is to better understand the transition from acute to chronic pain, which …

This study tests whether a Norwegian clinic (NSAC) helps people with common mental health issues or muscle pain return to work sooner. 2500 adults are split into three groups: one gets treatment quickly, one waits 10-14 weeks, and one gets a basic check-up. Researchers will track…

This study develops and tests a program called HELP Pain that trains school nurses and mental health professionals in Michigan to help students manage pain. About 68 school providers will learn cognitive behavioral therapy techniques and report on how well the program works over …

This study looks at whether a woman's insurance status affects how well her epidural works during a C-section. Researchers will review the medical records of 2,500 pregnant women at the University of Alabama at Birmingham. The goal is to uncover any unfair differences in pain man…

This study tests whether giving doctors a summary of their patient's survey answers before a consultation helps people on sick leave return to work. About 1180 adults in Norway are taking part. The goal is to see if this simple nudge improves recovery and reduces time off work.

This study looks at how well children sleep before knee surgery and whether that affects their pain and need for painkillers afterward. Researchers will ask kids about their sleep and track their pain and opioid use for two weeks after surgery. They will also use smart pill bottl…

This study tests whether a wearable skin sensor can tell the difference between mild, moderate, and severe pain in 37 adults with cancer or COPD. Participants wear the device for up to a week and report their pain levels. The goal is to create an algorithm that alerts caregivers …

This study from Stanford University aims to find biological markers that can tell doctors whether a person with chronic musculoskeletal pain is likely to recover or develop long-term disability. Researchers will follow 250 adults aged 18-80, using questionnaires and possibly imag…

This study involves 100 people with knee osteoarthritis to compare different ways of measuring knee function, including patient questionnaires and physical tests like walking and standing. The goal is to understand how subjective reports and objective performance relate to each o…

This study aims to validate a self-report questionnaire that people with Complex Regional Pain Syndrome (CRPS) can fill out at home. Researchers will compare the self-report results with in-person clinical exams to see if the questionnaire accurately measures symptom severity and…

This study planned to use high-frequency brain signals to locate important brain areas and understand conditions like epilepsy, migraine, and ADHD. It aimed to create a large database of brain activity in people aged 1 day to 69 years. However, the study was withdrawn before any …

This study follows 90 adults with implantable cardiac devices (like pacemakers) for two years. Researchers will measure shoulder pain, range of motion, posture, and how well people can do daily activities. The goal is to understand how these devices affect the shoulder and arm ov…

This study was designed to collect information about pain in people having orthopedic, chest, or gynecological surgery. Researchers planned to use questionnaires to learn about different types of pain and what factors might predict long-term pain. However, the study was withdrawn…

This study follows 275 teens aged 11–18 with chronic muscle or joint pain to find biological and behavioral markers that predict recovery versus ongoing pain. Researchers measure pain intensity and how much pain limits daily activities. The goal is to better understand why some t…

This study aimed to understand why some women develop chronic pain after breast cancer surgery. Researchers planned to track psychological and social factors in women undergoing mastectomy or lumpectomy. However, the study was withdrawn before it started, so no results are availa…