PAIN

This study tests three different dental materials used to treat deep cavities in children's permanent molars that are still growing. The goal is to see which material best helps the tooth root finish developing and reduces pain. About 48 children aged 7 to 11 with deep cavities w…

This study compares three types of hip replacement parts (the cup and stem) to see which one causes less bone damage and gives better pain relief and movement. About 360 adults with hip arthritis will be followed for 5 years after surgery. The goal is to find the safest and most …

This study aims to validate a self-report questionnaire that people with Complex Regional Pain Syndrome (CRPS) can fill out at home to measure their symptom severity. Researchers will compare the self-report results with in-person clinical exams to see if the remote tool is accur…

This study planned to see if a device called TENS could reduce pain when placing an IUD. TENS uses mild electrical pulses to block pain signals. The study was withdrawn before any participants were enrolled, so no results are available.

This study tests whether a simple visualized meditation technique can reduce anxiety, pain, and improve comfort in patients undergoing their first endoscopy. About 72 adults will be randomly assigned to receive meditation or standard care. The goal is to see if this non-drug appr…

This early-phase study looks at whether cannabigerol (CBG), a compound found in cannabis, can help with pain and appetite when taken alone or with THC. About 20 healthy adults who use cannabis occasionally will take part. Researchers will measure pain tolerance, hunger levels, an…

This study tested whether showing a video to children aged 4-7 and their parents before a blood draw can lower the child's pain, fear, and anxiety. 76 children took part. The goal is to make a common medical procedure less stressful for young kids.

This study looks at whether combining exercise (like cycling) with psychotherapy can reduce drug cravings in adults with opioid use disorder who also have chronic pain. About 198 people in residential treatment will take part. The goal is to see if these activities help with crav…

This study looks at whether one art therapy session can improve mood and reduce symptoms like pain and anxiety in adults receiving palliative care. Twenty patients in a Canadian hospital will fill out short questionnaires before and after a 30-60 minute art session. The goal is t…

This study tests whether using virtual reality (VR) goggles during the placement of a thin tube (PICC line) can reduce anxiety and pain in cancer patients. About 120 adults will be randomly assigned to either receive VR plus standard care or standard care alone. The goal is to se…

This study tests whether a new type of screw (Bone Bolt) can reduce pain better than standard screws after surgery for a specific pelvic fracture (LC-1). About 100 adults aged 18-80 who need surgery for this injury will take part. Researchers will measure pain levels using a stan…

This study looks at whether combining two types of exercises—Feldenkrais and active release—can help people with knee osteoarthritis feel less pain and move better. The study includes 40 adults aged 40-60 with mild to moderate knee pain. Researchers will measure pain levels and h…

This study tests if a non-invasive magnetic brain treatment (TMS) can improve symptoms like stomach pain in adults with Irritable Bowel Syndrome (IBS). Researchers will also use brain scans and stool samples to understand how the treatment works and who might benefit most. 160 ad…

This study explores whether a short, phone-delivered mindfulness program can help people who are very worried about pain before spine surgery. About 25 adults will take part in weekly sessions before their operation and be followed for two weeks after. The goal is to see if this …

This study looks at whether using a stress ball during a prostate biopsy can help lower anxiety and pain. About 66 men having their first prostate biopsy will be asked to squeeze a stress ball during the procedure. Researchers will measure their pain, anxiety, and vital signs to …

This study tests whether focused ultrasound (MR-HIFU), alone or with standard radiation, can better relieve bone pain caused by cancer that has spread. About 216 adults with painful bone lesions will be randomly assigned to one of three groups. The goal is to see if adding ultras…

This study tests whether a 2-minute perineal massage before a pessary check can reduce pain and improve comfort for women using a pessary for prolapse or incontinence. About 68 participants will each receive both the massage and a standard gel-only application at separate visits,…

This study aimed to compare three different nose sprays (dexmedetomidine, fentanyl, and midazolam) for reducing pain and anxiety in young children (ages 2-6) getting stitches in the emergency room. The goal was to see which spray worked best and was safest. However, the study was…

This study aimed to compare two methods of giving a TLIP nerve block to control pain after back fusion surgery. One method used ultrasound before surgery, the other did not use ultrasound during surgery. The study was withdrawn before enrolling any participants, so no results are…

This study looks at whether giving fewer opioid pain pills after laparoscopic hysterectomy still keeps pain under control. About 120 adults having this surgery for non-cancer reasons will be randomly assigned to get either a standard or a reduced opioid prescription. The goal is …

This study tests a small vibrating device held near the needle site to see if it reduces pain and anxiety during blood draws or IV placement. Researchers will compare how children and adults react with and without the device. The goal is to find a simple, drug-free way to make th…

This study is testing a new device that uses low frequency ultrasound (sound waves) to see if it can safely help heal and ease pain in people with osteoarthritis of the knee. Ten adults aged 40 and older with chronic knee pain will use the device and report any side effects or im…

This study looks at whether acupuncture can reduce pain in people with sickle cell disease. Researchers will use brain scans and other tests to understand how acupuncture works. About 60 people aged 14 to 80 with sickle cell disease and chronic pain will take part.

This study tests whether a device called MILTA, which uses light and magnetic fields, can reduce pain from perineal scars after childbirth. About 110 women who had a vaginal delivery within the past 24 hours and have significant scar pain will receive either MILTA or a placebo tr…

This study looks at whether a special light and laser device, used on the wound twice a day, can help reduce pain after a planned C-section. The goal is to find a drug-free way to manage pain, especially since strong painkillers can affect the baby. About 180 women will take part…

This study looks at two ways to manage pain after gynecological surgery: the EXORA block and epidural analgesia. Researchers want to see which method helps patients recover better and feel less pain. About 60 adults having elective gynecologic surgery will take part, and their re…

This study tests a pain management toolkit in a nursing home to help staff better manage residents' pain. About 40 residents with pain will take part. Researchers will measure how well the toolkit works by looking at staff confidence, pain treatments used, and residents' pain lev…

This study looks at whether placing cabbage leaves on the knee can help reduce pain and improve movement and quality of life in people with knee osteoarthritis. About 90 adults with knee pain will be split into three groups: two groups will use cabbage leaves (one at room tempera…

This study tests a new type of talk therapy called Pain Reprocessing Therapy (PRT) for people with chronic widespread pain, including fibromyalgia. Fifteen adults will track their pain, mood, sleep, and daily activities several times a day for up to 8 weeks. The goal is to see if…

This study looks at whether listening to music can help children aged 4 to 6 feel less pain and fear when they first get up after abdominal surgery. About 74 children will take part, with half listening to their favorite music during movement and the other half getting usual pare…

This study tested whether an ozone oil-based gel can reduce pain and prevent dry socket after lower wisdom tooth removal, compared to a standard CHX gel. One hundred patients received both treatments in separate sessions. Pain levels and dry socket occurrence were recorded for 48…

This study tests whether acupuncture can reduce nerve pain caused by chemotherapy in cancer survivors. About 255 people who have finished chemo will receive either real or sham acupuncture. The goal is to see if this drug-free approach can ease pain and improve daily life.

This study tests whether watching a calming nature video with virtual reality glasses can lower pain and anxiety in people recovering from colorectal surgery. Sixty adults will be randomly split into two groups: one group uses the VR glasses before and after surgery, while the ot…

This study tests whether using patterned (decorative) tape instead of plain tape to hold an IV in place can reduce pain and improve vital signs in children aged 3–12 who need regular IV therapy for chronic conditions. Each child will try both types of tape on different treatment …

This study looks at whether showing cartoons or using finger puppets before a blood draw can lower pain and fear in children aged 3 to 6. About 120 children will take part, and their pain and fear levels will be measured using special scales. The goal is to find simple, fun ways …

This study compares two types of nerve blocks—PENG and FIC—to see which one works better for treating hip fracture pain in the emergency department. About 80 adults with isolated hip fractures and significant pain will receive one of the two blocks, and their pain levels will be …

This study tests whether a low-cost, colorful walkway (like a mat carpet) can help children aged 4-10 feel less pain and fear when they first get up after abdominal surgery. About 74 children will use the walkway, and researchers will measure their pain, fear, and how quickly the…

This study looks at two simple methods—watching a video or having a gentle acupressure point stimulated—to help children aged 5 to 8 feel less anxious and experience less pain when getting a baby tooth pulled. Researchers will measure anxiety using a heart rate monitor and a pict…

This study tests whether yoga can reduce nerve pain caused by chemotherapy in cancer survivors. About 227 adults who finished chemo at least three months ago will either take yoga classes, attend educational sessions, or receive standard pain care. Researchers will compare pain l…

This study looks at whether hearing a popping sound during a spinal manipulation (like a chiropractic adjustment) changes how much pain relief and satisfaction people feel. About 38 adults with non-specific neck and upper back pain will be split into two groups: those who hear th…

This study tests whether neurofeedback training can help people with chemotherapy-induced peripheral neuropathy change their own brain waves to reduce pain and improve quality of life. About 91 adults with moderate to severe nerve pain will be randomly assigned to active, deactiv…

This study looks at how well a closed-loop spinal cord stimulator works for people with long-term pain. Researchers will track pain levels and quality of life in 25 adults who have had pain for at least 6 months. The device automatically adjusts stimulation to help reduce pain.

This study tests whether a non-invasive therapy called neurofeedback can help people with nerve pain caused by chemotherapy. Participants learn to change their own brain waves to reduce pain and improve quality of life. The trial involves 80 adults with moderate to severe pain, a…

This study looks at whether laughter therapy can improve lung function and reduce pain in people aged 60 and older. Researchers will measure breathing and pain levels in 64 participants before and after a 4-week laughter program. The goal is to see if a fun, non-drug activity can…

This study planned to test whether taking lorazepam, a medicine for anxiety, before getting an IUD could reduce pain and worry during the procedure. It aimed to enroll 25 adults at a family medicine clinic. However, the study was withdrawn before any participants joined, so no re…

This study looks at whether giving the steroid hydrocortisone through a vein can improve how much people can bend and straighten their new knee after total knee replacement surgery. About 132 adults with knee arthritis who are having their first knee replacement will take part. S…

This study looks at how daily cannabis smoking changes pain tolerance and the risk of addiction in healthy adults who already use cannabis. Researchers will measure pain responses and withdrawal symptoms over 16 days in a controlled hospital setting. The goal is to find out if ca…

This study tests whether a Norwegian clinic (NSAC) helps people with common mental health issues like anxiety or depression, and muscle or joint pain, return to work faster. 2,500 participants are split into three groups: one gets clinic treatment quickly, one after a wait, and o…

This study aims to create an AI system that can measure pain objectively using body signals. Researchers will collect data from 70 people recovering from outpatient plastic surgery. The goal is to help doctors personalize pain medication and reduce the risk of overuse.

This study trains school nurses and mental health professionals in Michigan to help children manage pain using cognitive behavioral therapy techniques. About 68 school staff will learn these strategies and report back on how well they work. The goal is to see if the program is pr…

This study looks at whether a person's insurance status affects how well their pain relief works during a C-section. Researchers will review records of 2,500 pregnant adults to see if there are differences in care. The goal is to understand and reduce health disparities in labor …

This study was designed to collect information about pain in people having orthopedic, chest, or gynecological surgery. Researchers planned to use questionnaires to understand pain's physical and emotional aspects and find who might be at risk for long-term pain. However, the stu…

This study looks at whether giving doctors a short summary of their patient's work-related challenges before a consultation can help people with pain, stress, or anxiety return to work faster. About 1180 adults in Norway will take part. The goal is to see if this simple nudge imp…

This study aimed to understand how psychological and social factors might affect the risk of chronic pain after breast cancer surgery. It planned to follow women undergoing mastectomy or lumpectomy and measure pain levels over time. However, the study was withdrawn before startin…

This study follows 90 adults with implantable cardiac devices (like pacemakers) for two years to track shoulder pain, movement, posture, and daily activities. Researchers will measure how these factors change over time and compare different device types. The goal is to understand…

This early-phase study looks at whether terpenes—aromatic compounds found in plants—can reduce pain and how they interact with THC. About 45 adults who use cannabis regularly will take part. The goal is to measure pain relief and any drug-like effects, helping to understand if te…

This study aimed to use high-frequency brain signals to better understand how the brain works in people with epilepsy, migraines, and other conditions. Researchers planned to create a database of these signals to improve diagnosis and treatment. However, the study was withdrawn b…

This study looks at 50 adults with sleep bruxism (teeth grinding during sleep) to understand how it affects sleep, pain, anxiety, and overall health. Researchers will use sleep tests, blood samples, and questionnaires to find links between bruxism and other conditions. The goal i…

This study tests whether a wearable skin sensor can detect different levels of pain in 37 adults with cancer or COPD who have persistent pain. Participants wear the device for up to a week and report their pain levels. The goal is to create an algorithm that alerts caregivers whe…

This study looks at how knee osteoarthritis (KOA) impacts daily activities and quality of life in 100 adults aged 45 to 75. Researchers will use both questionnaires and simple physical tests like walking and standing to better understand knee function. The goal is to improve how …

This study looks at how sleep quality before surgery affects pain and painkiller use in children and teens having knee surgery. About 166 patients aged 10-18 will answer a sleep questionnaire before surgery, then researchers will track their pain and medication use for two weeks …

This study aims to find biological markers (biomarkers) that can tell whether a person with long-term muscle or joint pain will recover or develop lasting disability. Researchers will follow 250 adults with chronic musculoskeletal pain, using questionnaires and possibly imaging t…

This study follows 275 teens aged 11–18 with chronic muscle or joint pain to learn why some get better and others don't. Researchers measure pain levels and daily function over time, looking for biological and behavioral clues. No new treatment is tested—the goal is to better und…

This study tested two different laser settings against the usual method for taking off ceramic braces. Ten healthy adults who had finished orthodontic treatment took part. The goal was to see which approach best protects the tooth surface, keeps the tooth nerve cool, and causes t…

This study looks at how immersive virtual reality changes the way people with chronic pain experience pain, compared to a placebo. Researchers will measure pain endurance and ratings in 259 adults with temporomandibular disorder (jaw pain). The goal is to understand the brain mec…