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Can we predict which teens will beat chronic pain?

NCT ID NCT04285112

Knowledge-focused Sponsor: Stanford University Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing This study
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 26, 2026 · Last updated Jun 26, 2026

Summary

This study follows 275 teens aged 11–18 with chronic muscle or joint pain to find biological and behavioral markers that predict recovery versus ongoing pain. Researchers measure pain intensity and how much pain limits daily activities. The goal is to better understand why some teens get better while others don't.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

What this could lead to
If successful, this could help doctors identify which teens are likely to recover from chronic pain and which may need extra support.
What could go wrong
This is an observational study, not a treatment trial. It may not lead to any direct changes in care, and the findings might not apply to all teens with pain.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Participants

About 275 people

The number the study aims to enrol. It can still change while the study runs.

Started

Sep 2020

Expected to finish

Dec 2025

An estimate. End dates often move.

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Who is studied

Adolescents with chronic primary musculoskeletal pain

Ages

11 to 18 years

Sex

Anyone

Healthy volunteers

Accepted

You do not need to have the condition being studied to take part.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: 1. The child has a diagnosis of Chronic widespread pain or Chronic primary musculoskeletal pain (other than orofacial) derived from ICD-11 (MG30.0; chronic primary pain is pain in 1 or more anatomic regions that persists for \> 3 months, is associated with significant distress or functional disability and cannot be better explained by another chronic pain condition (e.g., arthritis, lupus) 2. Age between 11-18 years 3. Moderate to Severe Functional Disability (FDI ≥13) 4. English proficiency (reading, speaking) 5. Moderate to severe average pain (VAS ≥30/100) Exclusion Criteria: 1. Significant cognitive impairment (e.g., severe brain injury) 2. Claustrophobia 3. Significant medical disease (e.g., systemic or central nervous system) 4. Severe psychiatric or neurological conditions (e.g., eating disorder, psychosis) 5. Pregnancy 6. MRI incompatibility (braces, pacemaker) 7. Weight \> 285 lbs. 8. History of \> 1 month opioid treatment.

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Conditions

The condition(s) this trial relates to.

Arthralgia Chronic Pain chronic pain syndrome fibromyalgia Musculoskeletal Pain Pain

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Joint pain Musculoskeletal pain Pain Pain, chronic

Contacts and locations

Locations

  • Cincinnati Children's Hospital

    Cincinnati, Ohio, 45229, United States

  • Hospital for Sick Children

    Toronto, Ontario, M5G 1X8, Canada

  • Stanford University

    Palo Alto, California, 94304, United States

  • University of Barcelona

    Barcelona, Spain

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