PAIN

This study follows 4800 adults who use Boston Scientific neurostimulation devices for chronic pain. It aims to see how well the devices work in everyday life, including pain relief and quality of life. Participants are already scheduled to receive the device as part of their norm…

This study tests a program to help veterans manage pain and reduce risky substance use after leaving the military. About 1,800 veterans will be assigned to either standard training for case managers or extra support to adopt a new care pathway. The goal is to see if extra support…

This study is testing whether a type of scan called FDG PET/MRI can accurately locate the source of long-term pain that persists after surgery. About 128 adults with chronic pain after joint surgery and healthy volunteers will be scanned. If successful, this approach could help d…

This study tests if artificial intelligence can analyze facial expressions to recognize pain in people with fibromyalgia, a condition causing widespread body pain. Researchers will also check saliva for biological markers of pain. 61 fibromyalgia patients and 61 healthy volunteer…

This study tests whether the oral medication Venlafaxine can prevent postherpetic neuralgia, a chronic nerve pain that often follows shingles. About 832 adults with moderate to severe shingles pain will receive Venlafaxine or a placebo to see if early treatment reduces the risk o…

This study tests a special therapy called PATH-Pain for 100 older adults (60+) who have mild memory problems, chronic pain, and depression. The therapy teaches problem-solving skills to help manage pain and improve mood and thinking. Participants are compared to those receiving u…

This study tests whether wearing a virtual reality headset during a common kidney stone procedure (ESWL) can lower pain and anxiety. About 72 adults will be randomly assigned to either standard care or standard care plus VR. Researchers will measure pain levels, anxiety, and how …

This study tests whether watching a calming video before and during a thyroid biopsy can lower pain, anxiety, and boost comfort. About 68 adults will take part, with half watching the video and half getting standard care. Researchers will measure pain, anxiety, and comfort levels…

This study tests whether adding a newer pain medicine called mirogabalin to standard shingles treatment provides better pain relief than standard treatment alone. Researchers will enroll 750 adults with moderate to severe shingles pain that started within the last 30 days. Partic…

This study helps Veterans with long-term muscle or joint pain find ways to manage it without medication. Participants work with a coach to explore their values and goals and choose non-drug approaches that fit their life. The goal is to reduce how much pain interferes with daily …

This early-stage study tests an experimental pain drug called HRS-6257 in 80 healthy volunteers aged 18-55. The main goal is to check safety and how the body processes the drug, including the effect of food. Researchers will also measure pain tolerance using a cold test. This is …

This study looks at whether a numbing injection near the cheekbone before nose surgery can lower the amount of strong pain medicine needed during the operation and improve recovery. About 90 adults having septorhinoplasty will either get the nerve block plus general anesthesia or…

This study is testing a mobile app designed to help cancer survivors who have finished treatment manage their pain and other symptoms. The app provides tools and support to boost confidence in self-care. About 25 participants will use the app for a short time to see if it is easy…

This study tests whether using a virtual reality headset during interventional radiology procedures can lower pain and anxiety in children aged 8 and older. About 500 kids will either use VR or receive standard care, and researchers will compare their pain and anxiety scores alon…

This study tests whether moderate to high doses of LSD can reduce anxiety, depression, and pain in people with advanced, life-limiting illnesses. Sixty terminally ill patients will receive either two doses of LSD or a very low-dose active placebo. The goal is to improve psycholog…

This study tests whether letting children aged 4-6 play with a special toy doll before getting a shot can lower their fear, anxiety, and pain. About 80 kids will be randomly assigned to either use the doll or receive standard care. Researchers will measure fear, anxiety, and pain…

This study tests a prenatal education program designed to reduce fear of childbirth, improve beliefs about pain, and increase confidence for a normal delivery. It involves 126 first-time pregnant women between 20 and 32 weeks of pregnancy. The program is based on a learning appro…

This study tests whether using a kaleidoscope or watching cartoons can reduce pain, fear, and anxiety in children aged 7-12 when they get a numbing shot at the dentist. 126 kids will be randomly assigned to use a kaleidoscope, watch cartoons, or receive standard care during the i…

This early-phase study tests whether combining oxytocin with oxycodone can reduce the risk of opioid abuse while still relieving pain. Researchers will give 45 older adults different combinations of the drugs across six sessions and measure pain, subjective effects, and decision-…

This study tests two approaches—mindfulness training and patient-centered pain management visits—to help adults with chronic pain who have been taking opioids for at least three months. The goal is to reduce pain, improve quality of life, and lower the risk of opioid misuse. Abou…

This study compares taking pregabalin alone versus pregabalin plus toludesvenlafaxine for fibromyalgia, a condition causing widespread pain and fatigue. About 384 adults with moderate to severe pain that hasn't improved with other treatments will participate. The goal is to see i…

This study tests whether training the leg reflexes can reduce nerve pain in people with spinal cord injury. Researchers will enroll 15 adults who have had a spinal cord injury for at least a year and have nerve pain in their lower leg. Participants will attend about 50 sessions o…

This study looks at whether warm sacral massage using cherry pits or taking a shower with partner support can help reduce pain during labor and improve the overall birth experience. About 150 first-time mothers having a vaginal delivery will be split into three groups: massage, s…

This study tests a special gel and mouthwash (XCM-OM118) in 63 head and neck cancer patients getting radiation, with or without chemo. The goal is to see if it lowers the chance of severe mouth sores and improves quality of life. Patients use the product during radiation and late…

This study tests a non-drug device called NeuroCuple™ to see if it can reduce pain and the need for opioid painkillers after a cesarean delivery. About 180 women having a C-section will be randomly assigned to use the device, a sham device, or standard care. The goal is to find a…

This study is testing a new pain treatment for people having total knee replacement surgery. The goal is to see if it can help patients use fewer opioids after the operation. About 60 adults will take part. The study is currently recruiting.

This study looks at whether dronabinol, a drug similar to THC in cannabis, can reduce pain sensitivity and improve thinking and mood in people being treated for opioid use disorder. About 36 adults aged 18-70 who are stable on methadone or buprenorphine will receive either dronab…

This study looks at whether listening to music for 10 minutes while in labor can lower anxiety and pain and boost satisfaction. About 106 women in labor will either listen to music or have no music. They will rate their anxiety and pain and answer questions about how satisfied th…

This study compares two types of exercise programs—graded motor imagery (thinking about movements) and task-oriented training (practicing real tasks)—against standard physiotherapy for people with shoulder impingement syndrome. About 66 adults aged 25 to 65 with shoulder pain for…

This study looks at whether coloring nature or geometric shapes can help adults feel less pain and anxiety while waiting in the emergency department. About 168 people with moderate pain or anxiety will be asked to color and then report how they feel. The goal is to find a simple,…

This study tests whether the antidepressant desvenlafaxine can safely reduce pain in people with shingles. Researchers will enroll 750 adults who have had a shingles rash for less than 90 days and are experiencing moderate to severe pain. The goal is to see if this medication off…

This study tests a method called cryoneurolysis, which uses a small tool to freeze the nerves that cause pain from broken ribs. The goal is to see if this approach is practical and can reduce pain and complications. 24 adults with broken ribs will receive this treatment alongside…

This study tests whether using a virtual reality headset (REALICA) can lower pain and anxiety in people having common urology procedures like prostate biopsy, cystoscopy, or circumcision. About 56 adults will use the VR device during their procedure and report their anxiety and p…

This study tests whether using a stress ball can lower pain, anxiety, and changes in heart rate and blood pressure during chest tube removal after open heart surgery. About 46 adults who have one chest tube will be randomly assigned to either squeeze a stress ball or receive stan…

This study tests whether patients recovering from shoulder surgery can safely and effectively give themselves liquid acetaminophen (Tylenol) instead of receiving pills from a nurse. About 24 adults will be enrolled to see if this approach is practical and acceptable. The goal is …

This study looks at whether a traveling team of pain specialists can help children and young adults (up to age 25) with moderate to severe intellectual disabilities, autism, or multiple disabilities feel better. The team visits patients at home or in care settings to assess and m…

This study tests whether a flurbiprofen patch, applied to the skin, can safely reduce pain from shingles (herpes zoster). Shingles causes a painful rash, and current pain treatments often don't work well or have side effects. The trial will include 750 adults with moderate to sev…

This study tests whether using a virtual reality (VR) headset with a guided meditation program can reduce pain, anxiety, and distress in men during a vasectomy. About 90 adult men will be randomly assigned to either use VR during the procedure or receive standard care. Researcher…

This study looks at whether therapeutic cuddling (like kangaroo care or comfort holding) can help reduce pain, agitation, and delirium in children in the pediatric intensive care unit (PICU). About 112 children expected to stay in the PICU for more than 48 hours will be randomly …

This study tests a new pain medicine called suzetrigine in 210 adults having hip replacement surgery. Half will get the drug and half a placebo for seven days, starting before surgery. The goal is to see if it lowers the amount of opioids needed in the first 48 hours after surger…

This study looks at whether standing in the shower to urinate, instead of sitting on a toilet, can reduce pain and help women empty their bladder fully after having a urinary catheter removed following vaginal surgery. About 100 adult women will be randomly assigned to one of two…

This study tests whether a medicated patch (loxoprofen sodium) can safely reduce pain from shingles. About 750 adults with moderate to severe shingles pain will apply the patch to the painful area. The goal is to see if the patch provides better pain relief than current treatment…

This study looks at whether combining pain education with therapeutic exercise can reduce pain and improve quality of life in women with endometriosis. Researchers will track how well participants stick with the program and measure changes in pain, negative thoughts about pain, a…

This study looks at whether adding a simple breathing-based nerve stimulation technique to standard physical therapy can better reduce pain and improve jaw movement in people with temporomandibular disorders (TMD). Sixty adults with jaw muscle pain will receive four sessions of m…

This study explores whether immersive virtual reality exercise therapy can reduce pain, improve shoulder function, sleep, and thinking skills in people with mild to moderate frozen shoulder (grade 1-2). About 36 adults aged 18-64 who are new to physiotherapy will use VR headsets …

This study trains psychotherapists to give personalized talk therapy to cancer patients and their caregivers who are feeling very distressed. Therapists will learn several proven methods, like cognitive behavioral therapy and mindfulness, to help with anxiety, depression, pain, f…

This study tests whether a handheld device called Grasp can reduce pain and distress for children and teens during needle procedures like blood draws or injections. About 126 participants aged 8-15 will either use the device or receive standard care. They will rate their pain and…

This study compares a pain management plan that avoids opioids to one that includes them, for people having joint replacement or other orthopedic surgeries. About 80 adults will be randomly assigned to one of two groups and report their pain levels for 14 days after surgery. The …

This study tests if a special type of yoga, called trauma-adapted yoga, can help teenagers with ADHD or PTSD. About 180 teens will either do yoga plus their usual care or just their usual care. Researchers will check if yoga improves symptoms like stress, focus, and pain.

This study tests whether adhesive or elastic band devices are better at securing urinary catheters in critically ill patients. Researchers will track injuries, pain, and infections in 188 adults in the ICU. The goal is to find which method causes fewer complications and more comf…

This study compares a long-acting opioid (methadone) to standard short-acting opioids for pain control in 60 children aged 6 months to 4 years undergoing cleft palate repair. The goal is to see if methadone reduces the total amount of opioids needed after surgery. The study is cu…

This study compares virtual reality (VR) and music relaxation to standard care for reducing anxiety and pain in women undergoing breast biopsies. About 600 women will be randomly assigned to one of three groups: VR, music, or usual care. Researchers will measure anxiety and pain …

This study tests whether injecting a low dose of two pain medicines (flurbiprofen and ropivacaine) into the scalp before brain surgery can reduce pain and the need for stronger opioids afterward. About 216 adults having planned brain surgery will take part. The goal is to see if …

This study looks at whether the BETY exercise program, which combines physical exercises with emotional and social support, can improve pain and quality of life in people with knee osteoarthritis who have already received a joint injection. About 60 adults with moderate knee oste…

This study looks at whether a physiotherapist-led online exercise program can reduce pain and improve physical function in remote white-collar workers. About 33 adults who work from home and have low back or neck pain will take part. They will follow a guided exercise routine, an…

This study looks at whether listening to live or recorded music can help lower stress, pain, and anxiety in people about to have brain surgery. About 132 patients will take part. Researchers will check things like heart rate, blood pressure, and mood before and after the music se…

This study looks at whether adding kinesiotaping (a special tape) to prenatal stretching exercises can reduce low back pain, improve movement, and enhance quality of life in pregnant women. About 34 women between 20-34 weeks of pregnancy and aged 18-35 will take part. Participant…

This study is tracking 1,000 adults in Canada who are authorized to use medical cannabis for pain, sleep problems, anxiety, depression, or epilepsy. Researchers will use standard questionnaires to measure changes in symptoms over 24 weeks. The goal is to see how well medical cann…

This study tests whether using virtual reality (VR) during a heart device implantation procedure can make patients more comfortable. The procedure is done under local anesthesia, meaning the patient is awake. The study will measure pain and anxiety levels, and whether patients ne…

This study tests whether a single dose of methadone given during brain surgery can control pain and improve recovery better than the usual short-acting opioid remifentanil. About 40 adults having elective brain surgery will take part. The goal is to see if methadone leads to less…

This study compares two medications, pregabalin and a newer drug called crisugabalin, to see which works better for fibromyalgia pain. Fibromyalgia causes widespread pain, fatigue, and emotional distress. The trial will include 1,116 adults with moderate to severe pain who haven'…

This study tests whether a very short (7-minute) mindfulness exercise can reduce pain and anxiety in adults undergoing kyphoplasty or radiofrequency ablation. About 80 participants will be randomly assigned to receive the mindfulness intervention or standard care. The goal is to …

This study looks at whether using a standard, step-by-step method for giving blood thinner shots (low-molecular-weight heparin) can reduce bruising and pain in heart patients. About 180 people in cardiac care units who need these shots twice a day will take part. The goal is to f…

This study tests if a mouth rinse called MucoLock can safely reduce mouth pain or burning in adults with stomatitis. About 25 people will use it like a mouthwash three times a day for 28 days. The main goal is to see if pain scores improve.

This study tests whether using virtual reality (VR) can lower the amount of strong painkillers (opioids) needed after heart or chest surgery. Sixty patients aged 16 to 40 will be split into three groups: one using interactive VR games, one watching 360-degree videos, and one rece…

This study tests whether acupuncture can reduce chronic pain in people with sickle cell disease. Researchers will also use brain scans and other tests to understand how acupuncture works. The study involves 120 participants aged 14 to 80 who have had sickle cell pain in the past …

This study tests if listening to music during a first-trimester abortion procedure (manual vacuum aspiration) can help reduce pain and anxiety. About 176 women will be randomly assigned to either listen to their favorite songs through headphones or receive standard care. Research…

This study looks at whether using a stress ball during cataract surgery can lower patients' pain and fear while increasing their satisfaction. Researchers will ask 60 adults having their first cataract surgery to squeeze a stress ball during the procedure. They will then measure …

This study tests whether applying special mud (peloid) to the jaw and chewing muscles can reduce pain and improve jaw function in adults with temporomandibular joint (TMJ) disorder. Forty participants will receive 20-minute mud treatments five days a week for two weeks. Researche…

This early-stage study tests a new drug, TT5, for safety and how the body processes it. About 94 healthy adults and surgical patients will receive either TT5 or a placebo. The goal is to find a safe dose and see if it can help manage pain.

This study tests a training program that helps family caregivers assist their loved ones with mild to moderate dementia who also have chronic pain. The program teaches coping skills to reduce pain interference and improve quality of life. Researchers will enroll 60 participants (…

This study looks at whether teaching people about the science of their pain, combined with tailored exercises, can reduce fear of movement, pain intensity, and negative thoughts about pain in adults with non-specific neck pain. Researchers will compare three groups: education plu…

This study tests a numbing injection (erector spinae plane block) given before lumbar spine fusion surgery. About 32 adults will receive the injection, which includes a numbing medicine and a non-narcotic pain reliever, plus a dye to see where it spreads. Researchers will measure…

This study tests whether a small electrical device (TENS) can reduce pain during an outpatient procedure for stress urinary incontinence in women. One hundred women will be randomly assigned to receive either real TENS or a placebo device during the procedure. The goal is to see …

This study tests whether aromatherapy (lavender and orange oils) and digital anesthesia can reduce pain and anxiety in children during tooth extraction. About 132 kids aged 6-12 will receive one of these methods or standard care. The goal is to find a more comfortable, child-frie…

This study looks at whether Reiki, a non-invasive therapy where a practitioner lightly places hands near the body, can help adults with cancer who feel very tired from immunotherapy. Twelve participants will either receive six weekly Reiki sessions or wait, then switch. Researche…

This study tests two medications, pregabalin and mirogabalin, to see which one better reduces pain in people with fibromyalgia, a condition causing widespread pain and fatigue. About 674 adults with moderate to severe fibromyalgia will take one of the drugs and report their pain …

This study tests whether a single mindfulness session before endometriosis surgery can help reduce pain and the need for painkillers afterward. About 20 adults with endometriosis will either receive the mindfulness training or standard education before their operation. Researcher…

This study tests a special adhesive made with zinc oxide to secure catheters (thin tubes placed in veins) in hospitalized adults. The goal is to see if it reduces complications like the catheter moving, skin irritation, vein inflammation, and pain. About 400 participants who need…

This study looks at whether giving children a nerve block in the arm before elbow fracture surgery helps control pain afterward. About 90 children with a specific type of elbow fracture will be randomly assigned to receive either the nerve block or standard care. Researchers will…

This study looks at whether giving parents extra information about what to expect and how to manage pain after surgery helps children feel better. About 900 children ages 1 to 6 having day surgery will take part. Researchers will compare pain levels and satisfaction between famil…

This study tests whether listening to a short mindfulness audio while waiting for an orthopedic appointment can reduce pain. About 400 adults will be randomly assigned to either the mindfulness exercise or a standard injury management talk. The goal is to see if this simple, no-d…

This study tests whether playing pop or rock music during a colonoscopy can lower the pain people feel. About 1,042 adults will be randomly assigned to have music or not during their procedure. Afterward, they will rate their pain on a 0–10 scale. If music helps, it could be a si…

This study tests whether adding a new pain drug called crisugabalin to standard treatment provides better pain relief for people with shingles. About 750 adults with moderate to severe shingles pain will receive either standard care alone or standard care plus crisugabalin. The g…

This study tests whether a small electrical device (TENS) can reduce pain when an IUD is placed. About 86 women will either get real TENS or a fake device during the procedure. Researchers will compare pain scores to see if TENS helps.

This study tests whether a digital cognitive behavioral therapy (CBT) program, with or without personalized peer support, can reduce pain, opioid use, and hospital visits in 470 teens and young adults (ages 16–30) with sickle cell disease and chronic pain. Participants will be ra…

This study looks at whether wearing a lumbar brace for 4 weeks after an ER visit for low back pain can lower pain, improve spine function, and reduce the need for painkillers. About 152 adults aged 18-65 in Edmonton will be enrolled. The goal is to find a safer, non-drug option f…

This study tests whether a special, soothing way of talking called hypnotic communication can help patients feel less anxious and stressed during a heart catheterization. About 306 adults will be randomly assigned to receive either this calming talk plus usual care, or usual care…

This study compares pregabalin alone versus pregabalin plus venlafaxine for fibromyalgia, a condition causing widespread pain and fatigue. Researchers want to see if the combination provides better pain relief without more side effects. The trial will enroll 750 adults with moder…

This study tests if a small electrical device (TENS) placed inside the mouth can reduce pain after getting braces. About 150 teens and adults will have the device used on one side of their mouth and a fake device on the other side. They will rate their pain over three days to see…

This study tests whether adding nerve exercises (neural mobilization) to standard balance training can reduce pain, improve balance, and boost quality of life in people with diabetic neuropathy. About 32 adults aged 50-75 with type 2 diabetes and mild to moderate nerve pain will …

This study tests whether the muscle relaxant baclofen can safely reduce pain from shingles (herpes zoster). Researchers will enroll 750 adults with moderate to severe pain who have had a shingles rash for less than 90 days. Participants will take baclofen or a placebo, and pain l…

This study tests whether adding a non-opioid painkiller (ketorolac) to standard opioid pain medicine can reduce the amount of opioids needed after preventive thigh bone surgery. The surgery is for patients with cancer that has spread to the thigh bone but who do not have a broken…

This study compares taking pregabalin alone versus pregabalin combined with desvenlafaxine for fibromyalgia, a condition causing widespread pain and fatigue. Researchers want to see if the combination provides better pain relief without more side effects. The study will involve 3…

This study tests if dry needling—inserting thin needles into muscles—can help people with chronic low back pain feel better and improve their quality of life. Researchers will compare three different dry needling sessions in 42 adults aged 18 to 65. The goal is to see if the appr…

This study tests a device called NOVABLOC to see if it can reduce pain and the need for strong painkillers after knee replacement surgery. About 120 adults having a first knee replacement will be randomly assigned to get the real device or a sham version. The main goal is to meas…

This study tests whether using a virtual reality headset showing calming scenes (like puppies in a meadow) can reduce pain and discomfort for older adults in long-term care during wound dressing changes. About 20 residents will use VR during routine wound care for two weeks, with…

This study tests whether an oral medication called tulodsesvenlafaxine can safely reduce pain in people with shingles (herpes zoster). Shingles causes a painful rash and can lead to long-term nerve pain. The drug works by affecting brain chemicals that control pain. The trial wil…

This study is testing whether testosterone replacement therapy can improve pain, energy, sexual function, and overall quality of life in men. It focuses on men with chronic back pain who have been taking opioid painkillers for at least six months and have developed low testostero…

This study looks at whether Native American adults who smoke daily can lower their risk of chronic pain by quitting smoking for 4 weeks. Researchers will measure pain sensitivity and other health markers in 150 participants. The goal is to see if this approach is practical and to…

This study looks at how the angle of your knee bones (seen on X-rays) relates to pain, daily function, quality of life, and fear of moving in people with knee osteoarthritis. Researchers will measure these factors in 100 adults using questionnaires and X-ray readings. The goal is…

This study follows 260 adults newly diagnosed with cancer who have no prior sleep issues. Researchers will track insomnia over the first year using questionnaires to see how it develops and what factors—like treatment or emotional distress—may trigger or worsen it. The goal is to…

This study looks at whether a 3-month virtual program called Choose to Move Replacement Ready is practical for people waiting for hip or knee replacement surgery due to osteoarthritis. About 60 participants will answer surveys and interviews about their activity, pain, and well-b…

This early-stage study tests the safety of an experimental oral drug called SBS-147 in 80 healthy adults aged 18-55. Some participants get the drug, others get a placebo. The study has two parts: one group takes a single dose, another takes it daily for a week. Researchers will m…

This study looks at how metabolic markers (like insulin resistance and body measurements) relate to pain and a condition called central sensitization in women with lipedema. Researchers will measure pain levels and sensitivity in 59 women. No treatment is given—this is an observa…

This study looks at whether cannabis works differently for pain relief and carries different abuse risks in men versus women. Researchers will give cannabis to 160 people aged 21-55 who already use it 1-7 days a week. They will measure pain tolerance, drug effects, and blood leve…

This study aims to compare how much people like (abuse potential) and how well they tolerate pain after taking low-dose buprenorphine versus a common opioid, oxycodone. 120 healthy adults aged 18-65 will receive different doses of buprenorphine, oxycodone, or placebo in separate …

This study looks at how a low dose of nitrous oxide (laughing gas) affects the brain when people feel pain and form memories. Healthy volunteers will have brain scans while receiving mild pain with or without the gas. The goal is to understand which brain areas are involved, not …

This study observes 300 adults who survived a cardiac arrest outside the hospital and are now in the intensive care unit. Researchers will measure how much pain patients experience using special pain scales, even if they are unconscious or on a breathing machine. The goal is to u…

This study looks at how hormones like testosterone and estradiol influence pain sensitivity. Researchers will compare six groups of people (cisgender men, cisgender women, transgender men and women, with or without hormone therapy). Participants will undergo pain tests, provide b…

This study tests a program called PAIN-CPG-EIT, which helps nursing home staff better assess and manage pain in residents with dementia. Researchers will compare this program to standard education alone across 12 nursing homes, involving 300 residents aged 60 and older. The goal …

This study looks at how negative feelings like stress, pain, or hunger change the way healthy adults make decisions. About 900 people aged 18 to 55 will experience different emotional triggers, such as watching a stressful video or fasting, then perform computer tasks and sometim…

This study looks at how smoking high-potency cannabis changes pain perception and feelings of a 'good drug effect' in people who use cannabis nearly every day. Researchers will also measure how long THC stays in the blood. The goal is to understand these effects both during norma…

This study looks at how short-term pain, created using a capsaicin heat patch, affects the ability of older adults (ages 55-90) to learn and remember a new walking pattern on a split-belt treadmill. Researchers will measure how well participants adapt their steps and how much the…

This study follows 50 people over age 50 who had arthroscopic rotator cuff repair. Researchers will measure shoulder function, pain levels, and sleep quality during rehabilitation. The goal is to better understand recovery patterns and help create clearer rehab guidelines.

This study looks at how pain-blocking injections (called interfascial plane blocks) affect the skin's feeling and pain control in 20 adults who donate part of their liver. After surgery, researchers map the numb areas on the skin and track pain levels for 24 hours. The goal is to…

This study looks at how a pain medication called suzetrigine gets into breast milk. Twelve healthy breastfeeding women will take one dose, then pump and test their milk. The goal is to find out how much drug the baby might get and whether it is safe.

This study looks at how body composition and diet affect chronic pain and inflammation in people with spinal cord injury. Researchers will measure pain sensitivity and blood markers of inflammation after participants eat a high-fat or moderate-fat meal. The goal is to understand …

This study is working on a new way to measure pain and how well pain treatments work, especially for children and teens who may not be able to describe their pain. Researchers will use a special eye test that tracks pupil reflexes to see how pain medicines affect the body. The go…

This study looks at how age and sex change the way people react to THC, the main active ingredient in cannabis. Researchers will give smoked and oral THC to 103 adults aged 18-65 who already use cannabis weekly or monthly. They will measure pain relief, feelings of being high, an…

This study looks at how a placebo cream affects the way people feel pain on different parts of their body. Researchers will use brain scans to see if the cream changes how the brain processes pain. About 150 adults will take part, and the goal is to better understand the placebo …

This study tests whether an augmented reality (AR) system can safely help doctors guide needles during MRI scans. About 25 people aged 3 to 21 who need a needle procedure (like a biopsy or injection) will take part. The main goal is to see if the AR system works in at least 80% o…

This study watches 50 newborns who need a breathing machine to see if different machine settings cause different pain levels. Researchers place small sensors on the baby's foot to measure skin changes as a pain signal. They also test if holding the baby skin-to-skin helps reduce …

This study aims to find out how often nerve pain (neuropathic pain) occurs in people aged 80 and older, and how it relates to their overall health. Researchers will assess 450 participants using questionnaires and physical exams. The goal is to better understand pain in this age …

This study is collecting information from 5,000 adults with spinal problems to learn more about their pain, daily life, and how treatments work in the real world. Participants will fill out questionnaires about their pain, work status, and overall well-being at regular visits. Th…

This study tests whether adding oxytocin (the 'love hormone') to oxycodone can reduce pain while lowering the risk of addiction. Researchers will give 45 recreational opioid users different combinations of the drugs and measure pain relief, subjective effects, and brain activity.…

This study looks at how core stability (the strength of your midsection muscles) relates to reaction time, hand-eye coordination, pain, and daily function in people with rotator cuff tears. Researchers will compare 52 adults with shoulder injuries to healthy individuals using phy…

This study aims to learn more about how people feel pain and itch on their face. Thirty healthy adults will have their skin tested with different substances like histamine and capsaicin to see how their body reacts. The goal is to better understand these sensations, not to treat …

This study looks at how social and cultural factors affect how people express pain and how others judge that pain. Researchers will measure pain responses in healthy volunteers and then test whether observers can accurately estimate someone else's pain. The goal is to understand …

This study looks at how short walks affect pain in older adults who have muscle or joint pain. Researchers will have 40 participants do brief walking and chair-stand tests, then measure their pain levels. The goal is to understand how movement changes pain in daily life.

This study follows 8,000 adults in Denmark who are getting a screening colonoscopy for colorectal cancer. Researchers want to know how much pain or discomfort people feel during the procedure and whether that experience affects their decision to get screened again two years later…

This study looks at how two common anesthesia drugs, ketamine and propofol, change brain activity and brain waves. Researchers will give these drugs to 60 healthy adults and use MRI and EEG to measure effects on memory and pain perception. The goal is to understand how these drug…

This study aims to better understand pain by examining people with and without pain disorders. Researchers will expose participants to pleasant and unpleasant sensations, like heat, cold, or pressure, and collect health information through exams, questionnaires, and MRI scans. Th…

This study looks at how immune cells and inflammation might play a role in migraine. Researchers will compare 396 women with and without migraine, some of whom also have autoimmune diseases like multiple sclerosis or rheumatoid arthritis. The goal is to measure levels of certain …

This study looks at how cancer treatments cause nerve pain. Researchers will use simple sensory tests and small skin samples to understand the pain better. The goal is to learn more, not to treat the pain directly. Adults with advanced cancer who have pain from certain chemothera…

This study looks at how immersive virtual reality changes the way the brain processes chronic pain, compared to a placebo effect. Researchers will measure brain activity and pain tolerance in 78 adults with temporomandibular disorder (jaw pain) lasting at least 3 months. The goal…

This study aims to better understand pain in people with ADPKD, a kidney disease that causes pain in over 60% of patients. Researchers will use simple sensory tests and questionnaires to measure pain and quality of life in 150 patients and compare them to healthy volunteers. The …

This study looks at whether children aged 6-12 with a specific learning disorder that affects written expression have different fingertip touch, hand grip strength, and pain sensitivity compared to children without the disorder. Researchers will use simple tools like monofilament…

This study looks at how brain activity changes when people feel pain. Researchers will use brain scans (fMRI, EEG) and mild brain stimulation (tACS, tRNS) to measure these changes. 60 healthy adults will take part. The goal is to better understand pain, not to treat it.

This study is testing whether giving patients pain medicine without opioids after major bone surgery is possible and works well. About 100 adults who had orthopedic surgery will either get the usual opioid prescription or an opioid-free plan. The main goal is to see if a larger s…

This study is building a large collection of surveys, blood, and saliva from 300 people with pain who are eligible for military healthcare. Researchers will follow participants over time to learn more about pain and how it affects daily life. No new treatments are being tested; t…

This study looks at how a stroke can lead to long-term pain, called central poststroke pain (CPP). Researchers will use brain scans (MRI) to see if certain brain connections are linked to pain. The goal is to better understand why some stroke survivors develop this hard-to-treat …

This study looks at how a single session of exercise can temporarily reduce sensitivity to pain in both healthy adults and stroke survivors who do not currently have pain. Researchers will measure pain thresholds before and after exercise to understand the body's natural pain-blo…

This study looks at how ketamine is processed in the body after a C-section and how it affects pain and mood. It involves 50 adults who have had a C-section, plus a control group of non-pregnant women and men. The goal is to better understand ketamine's effects in the postpartum …

This study aims to see if it is possible to measure brain activity patterns related to thinking and attention in people with chronic pain or depression, compared to healthy volunteers. Participants will complete computer tasks while their brain activity is recorded, and receive m…

This study looks at how certain medicines act in the bodies of children and young adults under 21. Researchers want to find the safest and most effective doses for these age groups. Participants are already receiving these drugs as part of their normal care. No new treatments are…

This study looks at how stress, pain, and the immune system interact in people living with HIV who also have cannabis use disorder and depression. Researchers will measure stress hormones, pain levels, and heart rate during a pain stress task. The goal is to better understand the…

This study tests a new drug that blocks a specific nerve channel (NaV1.8) to see which types of pain it reduces. Healthy volunteers receive tiny, safe doses injected into the skin and undergo brief pain tests like heat, cold, and pressure. The goal is to understand pain better an…

This study looks at how CBD (a non-psychoactive cannabis compound) changes the effects of THC (the part that makes you high). Researchers will give both substances to 30 regular cannabis users (ages 21-55) who are not seeking treatment. They will measure drug effects, pain relief…

This study aims to understand how psychological factors, such as expectations and emotions, influence the way we perceive pain. Healthy volunteers aged 18-50 will undergo brain scans (MRI) and pain tests (heat or electric shocks) while their heart rate, breathing, and other respo…

This study looks at how the pain medicine remifentanil behaves in underweight intensive care patients who need a breathing machine. Researchers will measure drug levels in the blood and check vital signs like blood pressure. The goal is to find the right dose for this vulnerable …

This study will follow about 200 gender minority adults, some starting gender-affirming hormone therapy and some not, to see how chronic pain changes over a year. Participants will fill out surveys, and some will also have pain sensitivity tests, brain MRIs, and interviews. The g…

This study looks at whether giving ICU staff real-time feedback and having a dedicated nurse facilitator can increase the use of a set of proven practices (the ABCDEF bundle) for adults on breathing machines. About 8,100 patients across multiple ICUs will take part. The goal is t…

This study looks at how the body processes anesthetics and painkillers in children and teenagers up to age 18. By measuring drug levels in the blood, researchers hope to find the right doses for safer and more effective pain control. The study is currently recruiting 500 particip…

This study looks at whether swelling (edema) after knee replacement surgery affects how a TENS machine needs to be adjusted for pain relief. Researchers will test three different TENS modes on 125 patients before and after surgery, comparing the affected leg to the healthy one. T…

This study uses brain scans (fMRI) to understand how the sedative remimazolam affects memory, pain perception, and brain activity. About 60 healthy adults will receive the drug and then perform memory tasks while experiencing mild pain. The goal is to learn more about how the dru…

This study looks at how former athletes, current master's athletes, and nonathletes (ages 35-65) experience pain and how different types of moderate exercise—strength training versus aerobic exercise—affect their pain. Participants will complete three sessions: baseline tests, a …

This study looks at how keeping a consistent sleep schedule affects heart health and metabolism in healthy adults aged 18-40, and also in people with chronic pain. Over 12 weeks, researchers will track sleep patterns and measure things like blood pressure, heart rate, and blood s…