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Can a quick cold spray before your shot reduce pain and bruising?

NCT ID NCT07195955

Symptom relief Sponsor: Kocaeli University Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed This study
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 24, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This study tested whether applying a cold spray to the skin right before a low molecular weight heparin injection can reduce pain and bruising in patients recovering from orthopedic surgery. Researchers measured pain using a simple scale and bruise size with a clear grid. The goal is to find a practical, drug-free way to make daily injections more comfortable.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
Cold spray (topical cooling agent)
What this could lead to
If effective, cold spray could become a simple, low-cost way to reduce pain and bruising from daily blood-thinner injections after surgery.
What could go wrong
This is a small, completed study with no phase designation, so results may not apply broadly. Cold spray might not work for everyone or could cause skin irritation.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

101 people

The number who actually took part.

Started

Feb 2024

Finished

Feb 2025

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 to 70 years

Sex

Anyone

Healthy volunteers

Accepted

You do not need to have the condition being studied to take part.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: Patients who are: * 18 years of age or older * Receiving 1 x 0.4 ml anticoagulant therapy * Are on the first day of LMWH therapy * Have no infection, scar tissue, lipodystrophy, or incision at the injection site * Have not received any other parenteral therapy at the injection site * Are not allergic to cold or heparin * Volunteer to participate in the study Exclusion Criteria: * Patients were excluded from the study if they were: • Pregnant, • Had any acute or chronic coagulation disorder or hematological disease, * Had a subcutaneous injection into the same area 24 hours prior, * Wanted to withdraw from the study.

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Conditions

The condition(s) this trial relates to.

Ecchymosis Pain

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Cold application Ecchymosis Nursing care Pain

Contacts and locations

Locations

  • Kocaeli University

    Köseköy, Kocaeli, 41100, Turkey (Türkiye)

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