Pain relief showdown: one drug vs. two for facial nerve pain
NCT ID NCT07625410
First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 1 time
Summary
This study tested whether taking gabapentin along with oxcarbazepine works better than oxcarbazepine alone for trigeminal neuralgia, a condition causing severe facial pain. 44 adults were split into two groups and had their pain measured over 2 months. The goal was to see which approach provides better pain relief.
What this could mean
Our plain-language read of the trial. This is informational only, not medical advice or a prediction.
- Active substance
- oxcarbazepine and gabapentin
- What this could lead to
- If the combination works better, it could offer a more effective way to manage trigeminal neuralgia pain with existing drugs.
- What could go wrong
- This is a small, single-center study with only 44 patients and short follow-up. Results may not apply to everyone, and side effects are possible.
This is an AI summary of the original study and may miss details. Read our disclaimer.
Study facts
What this study's own registry entry says, in plain language.
- Phase
-
Phase 2/3
Runs two stages together: whether the treatment works, then large-scale confirmation.
- Participants
-
44 people
The number who actually took part.
- Started
-
May 2023
- Finished
-
May 2024
- Lead sponsor
-
Other sponsor
The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.
Who can take part
This study's own entry requirements. Only the study team can say for certain whether you qualify.
- Ages
-
20 to 80 years
- Sex
-
Anyone
- Healthy volunteers
-
Not accepted
This study is not open to healthy volunteers. The entry requirements below say who it is open to.
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Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.
Inclusion Criteria: * Patients of either gender aged 20-80 years * Patients presenting to the Outpatient Department (OPD) * Patients fulfilling the diagnostic criteria for idiopathic trigeminal neuralgia according to the International Headache Society (IHS) Exclusion Criteria: * Patients with orofacial or odontogenic pain conditions other than trigeminal neuralgia (TN) * Patients with temporomandibular joint (TMJ) disorders * Patients with a centralized cause of TN evident on MRI * Patients unwilling to participate in the study * Patients who failed to attend follow-up visits * Pregnant or lactating females * Patients with a history of previous surgical procedures for neuralgia * Patients with known allergy to medications used for neuralgia * Patients with significant comorbid medical conditions
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
-
Rehman College of Dentistry
Peshawar, Khyber Pakhtunkhwa, 25100, Pakistan
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