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Can ozone ease the pain of lipedema? new study tests two methods

NCT ID NCT06954870

Symptom relief Sponsor: Ankara Etlik City Hospital Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed This study
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 24, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This study tested whether ozone therapy can reduce pain and tissue thickness in women with lipedema, a painful fat disorder. 45 women received either local or systemic ozone treatments. The goal was to see if ozone's anti-inflammatory effects could improve symptoms and quality of life.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
ozone therapy
What this could lead to
If it works, this could point toward a non-drug way to ease pain and improve daily life for women with lipedema.
What could go wrong
This is a small, early-stage study with no placebo group, so results may not be reliable or apply to everyone. Ozone therapy also carries risks like infection or irritation at the injection site.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

45 people

The number who actually took part.

Started

Mar 2025

Finished

Oct 2025

Lead sponsor

A government agency

The lead sponsor is a government body.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 to 65 years

Sex

Female participants only

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * To have been diagnosed with clinical lipedema. * Pain assessed by VAS of 5 or more * Being a woman * Being between 18-65 years old Exclusion Criteria: * Presence of venous insufficiency leading to subcutaneous changes * Having diseases that may cause edema * Use of painkillers (NSAIDs/Opioids) up to 1 week before the injection * Open wound or infection at the site of infection * Bleeding disorders or use of anticoagulant, antiplatelet drugs uncontrolled systemic disease * G6PD deficiency * Cases where the pain cannot be explained by lipoedematous tissue

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Conditions

The condition(s) this trial relates to.

Lipedema Pain

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Activities of daily living Lipedema Musculoskeletal ultrasound Pain

Contacts and locations

Locations

  • Ankara Etlik City Hospital, Department of Physical Medicine and Rehabilitation

    Ankara, 06200, Turkey (Türkiye)

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