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Laughing gas may take the ouch out of Kids' needle sticks

NCT ID NCT07159425

Symptom relief Sponsor: Mother and Child Health Institute of Serbia Dr Vukan Cupic Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed This study
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 24, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This study looked at whether breathing a 50:50 mix of oxygen and nitrous oxide (laughing gas) can reduce pain and anxiety in children aged 1 to 16 during minor procedures like blood draws, stitches, or tube placements. Researchers observed 100 children and measured their pain using age-appropriate scales. The goal was to see if the gas helps kids cooperate and feel less distress without serious side effects.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
50:50 oxygen-nitrous oxide gas mixture
What this could lead to
If effective, this gas mix could become a standard option to help children stay calm and comfortable during minor medical procedures without needles or heavy sedation.
What could go wrong
This is a small, completed observational study, not a large trial. The gas may not work for all children, and side effects like low blood pressure or oxygen drops are possible.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Participants

100 people

The number who actually took part.

Started

Oct 2024

Finished

Jan 2026

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Who is studied

single tertiray center random-sample cohort of pediatric patients undergoing any in-hospital minor invasive procedure during a continuous 12 months period of recruitment.

Ages

1 year to 16 years

Sex

Anyone

Healthy volunteers

Accepted

You do not need to have the condition being studied to take part.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * 1 Age 1-16 years 2 Veinpuncture 3 Arterial line placement 4 Nasogastric tube placement 5 Urinary catheter placement 6 Removal of thoracic drain 7 Skin suture Exclusion Criteria: 1. Age \<1 year or \> 16 years 2. Pneumothorax 3. Pneumoperitoneum 4. Pneumocephalus 5. Otitis media 6. Obstructive lung disease 7. Upper airway infection 8. Methylenetetrahydrofolate reductase (MTHF) deficiency 9. Vitamin B12 deficiency 10. Megaloblastic anemia

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Conditions

The condition(s) this trial relates to.

anxiety anxiety disorder Pain

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Anxiety Pain Sedation

Contacts and locations

Locations

  • Institute for mother and child health care

    Belgrade, Serbia

More trials for these conditions

Other studies related to the condition(s) this trial covers.