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Can a laser beam replace painkillers after dental surgery?

NCT ID NCT05935306

Symptom relief Sponsor: University of Nove de Julho Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed This study
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jul 29, 2026 · Last updated Jul 30, 2026 · Updated 1 time

Summary

This trial asks whether photobiomodulation — a type of low-level laser therapy — can lessen pain and swelling after endodontic (root-end) surgery. Thirty-four adults needing surgery on an upper tooth will be randomly assigned to receive either the laser treatment or a sham procedure, alongside standard ibuprofen. Pain, swelling, and healing will be tracked over a week, with follow-up X-rays at one and three months.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
photobiomodulation (low-level laser therapy)
What this could lead to
If it works, this could offer a drug-free way to ease pain and speed healing after dental surgery.
What could go wrong
This is a small, early-stage trial with only 34 participants. The effect may be modest or no better than standard painkillers.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

34 people

The number who actually took part.

Started

Jun 2024

Finished

Dec 2025

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 to 70 years

Sex

Anyone

Healthy volunteers

Accepted

You do not need to have the condition being studied to take part.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria :• Patients with periapical lesions who have already undergone endodontic treatment (lesions smaller than 10mm in their greatest diameter - Metin et al., 2018, single and chronic lesions) * Patients with not comorbidities, * Age from 18 to 70 years, * Both genders, * Healthy permanent teeth with good hygiene. Exclusion Criteria: * Who are taking drugs that affect bone metabolism and the inflammatory process (for example: corticosteroids, bisphosphonates), * Smokers, pregnant or lactating women, * Who used anti-inflammatory drugs in the last 3 months before surgery. * Who for any reason interrupted the evolution of the treatment for not attending joint appointments. * Patients who do not follow the guidelines or have an injury in the acute phase (pain, edema, exudate)

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Conditions

The condition(s) this trial relates to.

dental pulp disorder Inflammation inflammatory disease Pain periapical periodontitis

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Endodontic disease Inflammation Pain Photobiomodulation Surgery

Contacts and locations

Locations

  • Universidade Catolica do Uruguay

    Montevideo, Uruguay

More trials for these conditions

Other studies related to the condition(s) this trial covers.