Ice packs put to the test against painful antibiotic injections
NCT ID NCT07820956
First seen Sep 15, 2026 · Last updated Sep 16, 2026 · Updated 1 time
Summary
Researchers are testing whether applying ice around an intravenous catheter before an oxacillin injection can lower pain and reduce peripheral phlebitis, an inflammation of the vein. The trial enrolls 86 hospitalized adults aged 20 to 60 who receive oxacillin through a hand vein. Half receive ice before the injection and half receive a room-temperature water bag. The team compares pain scores and vein inflammation over 72 hours to see if ice offers a simple, drug-free way to improve the injection experience.
What this could mean
Our plain-language read of the trial. This is informational only, not medical advice or a prediction.
- Active substance
- Ice applied around the intravenous catheter site before oxacillin injection
- What this could lead to
- If it works, nurses could use a simple ice pack before oxacillin injections to make the shot less painful and protect the vein.
- What could go wrong
- This is a small single-center study of 86 people, so the results may not hold for other patients, other drugs, or other hospitals. Ice can also feel uncomfortable or cause brief skin numbness.
This is an AI summary of the original study and may miss details. Read our disclaimer.
Study facts
What this study's own registry entry says, in plain language.
- Phase
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Not a phased trial
Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.
- Participants
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86 people
The number who actually took part.
- Started
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Apr 2022
- Finished
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Dec 2022
- Lead sponsor
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Other sponsor
The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.
Who can take part
This study's own entry requirements. Only the study team can say for certain whether you qualify.
- Ages
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20 to 60 years
- Sex
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Anyone
- Healthy volunteers
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Not accepted
This study is not open to healthy volunteers. The entry requirements below say who it is open to.
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Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.
Inclusion Criteria: Adults aged 20 to 60 years. Conscious and able to participate in the study. Intravenous injection site located on either hand. Receiving a single antibiotic medication during the study. Eligible regardless of sex or medical diagnosis. Exclusion Criteria: Dementia. Psychiatric disorders. Skin rash at the study site. Purpura. Pregnancy. Current oral corticosteroid use. Hemodialysis. Administration of a second medication or an injection containing two or more medications during the study. \-
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
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Feng Yuan Hospital, Ministry of Health and Welfare
Fengyuan, Taiwan
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