Could a new sedative protect newborn brains during cooling?
NCT ID NCT04772222
First seen Mar 20, 2026 · Last updated Jun 21, 2026 · Updated 13 times
Summary
This study tested a drug called dexmedetomidine in 50 newborns with brain injury who were undergoing cooling therapy. The goal was to see if it could provide sedation and pain relief as well as morphine, but with fewer risks. Researchers measured safety and drug levels in the blood to prepare for a larger future trial.
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This is a summary of
the original study
.
Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Contacts and locations
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Locations
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Intermountain Medical Center
Murray, Utah, 84107, United States
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McKay-Dee Hospital
Ogden, Utah, 84403, United States
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Primary Children's Hospital
Salt Lake City, Utah, 84113, United States
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University of Utah Health
Salt Lake City, Utah, 84132, United States
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Utah Valley Hospital
Provo, Utah, 84604, United States
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
Dexmedetomidine (a sedative and pain reliever that does not slow breathing)
What this could lead to
If it works, this could point toward a safer way to sedate newborns with brain injury during cooling therapy, reducing reliance on opioids.
What could go wrong
This is a small, early-phase trial with only 50 infants, so results may not apply broadly. The drug's safety and effectiveness in this specific group are still unproven.
Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.