University Of Utah

This study tests whether a two-shot pneumonia vaccine series (PCV20 and PPSV23) can help people with chronic lymphocytic leukemia (CLL) build a stronger immune defense against pneumococcal infections. About 61 adults with CLL who have not yet had treatment, or who are on a specif…

This early-stage trial tests whether giving a higher dose of focused radiation (stereotactic radiosurgery) to brain metastases is safe. About 50 people with 1 to 5 brain tumors who have never had brain radiation will receive an experimental dose on one tumor, while other tumors g…

This study tests whether adding a balloon pump (IABP) to standard ECMO support helps the heart recover better in people with severe cardiogenic shock. About 104 adults will be randomly assigned to get ECMO alone or ECMO plus the balloon pump. Researchers will measure heart functi…

This early-stage trial tests whether a special PET scan (FMISO) can identify oxygen-starved (hypoxic) areas in esophageal tumors. Patients with hypoxic tumors receive a higher radiation dose, while others get standard care. The goal is to see if this personalized approach is safe…

This study looks at a program called Building Healthy Families, designed to help children ages 5-13 who are overweight or obese, along with their parents. The program focuses on healthy eating, physical activity, and lifestyle changes for the whole family. Researchers want to see…

This early-stage trial is testing whether giving radiation therapy before a bispecific antibody drug (either epcoritamab or glofitamab) is safe and feasible for people with relapsed or refractory diffuse large B-cell lymphoma. The study will enroll 12 adults who have already trie…

This phase 2 trial tests the drug bortezomib in 22 men with metastatic castration-resistant prostate cancer that has a specific genetic change called PTEN deletion. The main goal is to see if bortezomib can lower PSA levels by at least 30%. Participants receive bortezomib injecti…

This phase II trial tests the drug pemigatinib (Pemazyre) in 27 adults with relapsed or refractory B-cell non-Hodgkin lymphomas, including mantle cell and marginal zone lymphoma. Participants take one pill daily in 28-day cycles. The main goal is to see if the drug can shrink tum…

This study will enroll 270 pregnant Native American and Alaska Native women with substance use disorders. Researchers will adapt standard pregnancy and addiction care to better fit Native cultural needs. The goal is to help mothers stay in treatment and attend follow-up visits af…

This study tests whether taking creatine supplements along with a twice-weekly home exercise program can help men with advanced prostate cancer maintain muscle mass and reduce fatigue. About 200 participants will follow the program for one year. The goal is to improve physical fu…

This study tests whether a shorter, lower-dose course of radiation after robotic surgery can improve quality of life for people with HPV-related throat cancer. About 42 adults who have had robotic surgery will receive a reduced radiation schedule. The goal is to see if this appro…

This study tests whether giving two drugs (loncastuximab tesirine and rituximab) before standard CAR-T cell therapy can improve outcomes for adults with large B-cell lymphoma that has come back or not responded to treatment. About 29 participants will receive this bridging therap…

This phase 2 trial tests a gentler way to start treatment for ultra-frail patients newly diagnosed with multiple myeloma. Instead of giving all three drugs at once, doctors begin with just isatuximab and dexamethasone, then slowly add lenalidomide after two cycles. The goal is to…

This early-phase trial tests whether a combination of two drugs (loncastuximab tesirine and rituximab) given after precise radiation to the brain is safe and effective for central nervous system lymphoma. The study enrolls 12 adults whose lymphoma has returned or who cannot recei…

This study tests a culturally tailored sleep program for Latino couples where one partner has sleep apnea and is starting CPAP therapy. The program includes three telehealth sessions to teach sleep skills and support. Researchers want to see if it improves CPAP use and sleep qual…

This study tests a mobile app called MyChildCMC, designed to help parents of children with complex medical conditions spot early warning signs of health problems. The app tracks symptoms and sends alerts to care coordinators. Researchers will compare app users to those receiving …

This study is for people whose melanoma has come back after standard treatment. Researchers want to see if giving two immunotherapy drugs (ipilimumab and nivolumab) before surgery can shrink the tumor and improve outcomes. About 25 adults will receive two cycles of these drugs, t…

This study tests an experimental daily pill called XL092 in men with advanced prostate cancer that has spread and is no longer controlled by standard hormone therapy or a targeted radiation treatment (lutetium-177 PSMA). The main goal is to see if the drug can stop the cancer fro…

This study tests whether taking nicotinamide (a form of vitamin B3) twice daily for one year can reduce the number of new non-melanoma skin cancers in people with chronic lymphocytic leukemia (CLL) who have already had at least one such skin cancer. About 86 participants will be …

This early-phase study tests a new device that uses focused ultrasound waves guided by MRI to partially destroy breast tumors in 34 women with breast cancer. The goal is to see if the procedure is safe and feasible before standard surgical removal. Participants will have half or …

This early-phase study tests a new type of CAR-T cell therapy for people with certain blood cancers (like leukemia and lymphoma) that have not responded to standard treatments. The therapy uses a patient's own immune cells, modified to target and attack cancer cells. The main goa…

This study looks at whether the diabetes drug metformin can help older adults regain muscle strength after a period of disuse, like bed rest. Researchers will give metformin or a placebo to 50 healthy adults aged 60 and older during recovery. The goal is to see if metformin impro…

This early-stage trial tests whether adding Tumor Treating Fields (TTFields) to standard chemoradiation and immunotherapy is safe for people with stage III non-small cell lung cancer that cannot be removed by surgery. About 30 participants will receive TTFields alongside their us…

This study tests whether two drugs, pirtobrutinib and rituximab, can shrink or eliminate tumors in people newly diagnosed with marginal zone lymphoma. About 23 adults will receive the combination and be checked for response after several cycles. The goal is to control the disease…

This study tests two drugs, cabozantinib and atezolizumab, in 33 men with a type of advanced prostate cancer that has spread and no longer responds to hormone therapy. The goal is to see if the combination can stop or shrink tumors. Participants must have non-measurable disease o…

This study tests two or three drugs (defactinib, avutometinib, and possibly encorafenib) in people with advanced melanoma that has spread to the brain. The goal is to see if these combinations can shrink brain tumors and how safe they are. About 33 adults whose melanoma worsened …

This study tests a personalized program to help people who have lost weight keep it off. About 30 adults who lost at least 7% of their body weight in the past 6 months will receive weekly texts, surveys, and possibly health coaching over 26 weeks. The goal is to see if this appro…

This study tests whether offering personalized financial incentives can help 80 adults with obesity stick to a weight-loss program. Participants attend virtual group classes, log their calories, and weigh themselves regularly. The goal is to see if tailored rewards improve diet t…

This study tests if men with metastatic hormone-sensitive prostate cancer who have a strong initial response to hormone therapy can safely take breaks from one of their medications (relugolix) to reduce fatigue. About 160 participants will either continue standard daily therapy o…

This early-phase study tests whether adding pegylated interferon alfa-2a after a stem cell transplant can help control myelofibrosis, a type of bone marrow cancer. About 18 adults with primary or secondary myelofibrosis will receive the drug after their transplant to find the saf…

This study looks at whether giving sex hormone therapy to men with low hormone levels can help their shoulder tendons heal better after surgery. About 58 men will receive either hormone pills or a placebo after rotator cuff repair. The goal is to see if the therapy improves tendo…

This study tests how well a levonorgestrel IUD works as emergency contraception (within 5 days of unprotected sex) or when started later in the menstrual cycle. About 1,400 people at Planned Parenthood clinics will choose to get the IUD and be followed for one month to see if the…

This study aims to make cervical cancer screening more convenient by offering HPV self-collection kits that women can use at home or in the clinic. Researchers will enroll 1,000 women aged 25-65 who are overdue for screening. The goal is to see how many women complete the test an…

This study is testing whether changes in platelet RNA can help doctors diagnose ovarian cancer earlier and more accurately. Researchers will collect blood samples from 245 women—those with ovarian masses and healthy volunteers—to see if this new approach works. If successful, it …

This pilot study is testing whether a personalized exercise regimen, delivered via telehealth, is feasible and safe for people with stage II or III non-small cell lung cancer who are receiving chemotherapy or immunotherapy and surgery. Twenty participants will follow a home-based…

This phase 2 trial tests whether the drug budesonide can prevent severe diarrhea in multiple myeloma patients receiving a stem cell transplant. About 120 adults will take either budesonide or a placebo for two weeks starting just before their transplant. The goal is to see if the…

This study will follow 10,000 adults with common joint and tendon problems—like knee arthritis, tennis elbow, or plantar fasciitis—who have not gotten relief from other treatments. Each participant receives an injection of their own concentrated platelets (PRP) and reports pain a…

This study tests whether low-dose metformin, a common diabetes drug, can improve fibromyalgia symptoms by reducing inflammation in the body. Researchers will give 72 adults with fibromyalgia either metformin or a placebo daily for 8 weeks. The goal is to see if metformin safely r…

This study tests a home-based telerehabilitation program for adults with lymphoma or myeloma who have received CAR-T cell therapy. Participants use a tablet or VR headset, along with a pulse oximeter and Fitbit, to follow personalized exercise and nutrition plans. The goal is to …

This study compares a shorter course of vaginal cuff brachytherapy (internal radiation) to the standard longer course for people with stage I-II endometrial cancer. The main goal is to see if the shorter treatment improves quality of life and reduces financial burden, while still…

This study is testing a new, noninvasive ultrasound device to see if it can reduce pain and other symptoms in people with fibromyalgia. About 50 adults with fibromyalgia will receive 6 treatment sessions over 2 weeks. Researchers will measure pain levels and symptom impact using …

This study tests whether acupuncture can relieve symptoms of Gulf War Illness, a condition causing long-term health problems in veterans who served in the Gulf region. Two hundred veterans will be split into two groups: one gets acupuncture twice a week for six months, the other …

This study tests a behavioral (non-drug) treatment to reduce nightmares in adults with REM sleep behavior disorder (RBD). Participants attend 7 video sessions, with a family member joining 2 of them. The goal is to see if the therapy lowers nightmare frequency and severity.

This study tests whether a headband with special semiconductors can help with memory and thinking problems (often called 'chemo brain') in people who have had breast or gynecologic cancer. About 50 participants will wear either the active headband or a placebo version for 18 hour…

This study tests if a tretinoin cream can help reduce the acne-like rash that often appears on the face during treatment with certain cancer drugs (panitumumab or cetuximab). About 25 adults with advanced solid tumors will apply tretinoin to one side of their face and a placebo c…

This study tests a powered neck brace (exoskeleton) in 10 people with ALS who have neck weakness. Participants will do simple tasks while wearing the device to see if it improves head movement and is comfortable. The goal is to help patients regain the ability to move their heads…

This study tests whether a new AI-powered algorithm can improve how people with chronic arm weakness from a stroke control a robotic arm brace. Participants will use both the standard control method and the experimental algorithm while moving blocks. The goal is to see if the new…

This study looks at whether mindfulness meditation can help people with chronic low back pain who also use opioids. Researchers will measure brain activity and pain ratings in 150 adults. Participants will either take meditation training or continue their usual care. The goal is …

This study tests whether a short educational video about safe opioid use can help breast reconstruction patients use fewer painkillers after surgery. About 68 women will be randomly assigned to watch the video or receive standard care. Researchers will track how many opioids they…

This study tests whether a 12-week home exercise program (aerobic and resistance training) can reduce fatigue in 80 people with metastatic breast cancer who are taking Enhertu. Participants exercise on their own, and researchers will measure changes in fatigue and how well people…

This study tests whether listening to short guided meditations during daily radiation therapy can help reduce anxiety in people with breast or gynecologic cancers. About 34 participants will either receive the meditation or standard care. The goal is to see if this simple, non-dr…

This study tests whether Reiki therapy can reduce anxiety and pain in people receiving brachytherapy for gynecologic cancers like endometrial or cervical cancer. About 70 participants will either receive Reiki or standard care during their treatment wait time. Researchers will co…

This study is testing a new lightweight, motorized prosthetic leg for people who have lost a leg above the knee. The goal is to see if it helps them walk, climb stairs, and move more easily compared to their current prosthesis. About 40 adults who already use a prosthetic leg wil…

This study tests a 12-week home-based rehabilitation program for men with advanced prostate cancer living in rural areas. The program includes exercise and support delivered via video calls to help manage side effects from hormone therapy and improve quality of life. About 30 par…

This study tests whether a single, quick radiation session can effectively treat painful bone metastases without the usual planning steps. About 40 adults with one or two painful bone spots will receive this streamlined treatment in just one visit. The goal is to see if this simp…

This study tests two approaches—mindfulness training and patient-centered pain management visits—to help adults with chronic pain who take long-term opioids. The goal is to reduce pain, improve quality of life, and lower the risk of opioid misuse. About 300 participants will be f…

This study looks at whether Swedish massage or light touch can reduce anxiety symptoms and change brain activity in people with generalized anxiety disorder. About 46 adults will receive one of two types of touch therapy twice a week for six weeks. Brain scans and questionnaires …

This study tests whether guarana, a natural plant extract, can reduce fatigue in people with neuroendocrine tumors or gynecologic cancers. About 86 participants will take guarana or a placebo for up to 42 days, and researchers will measure changes in fatigue using a standard ques…

This study tests whether a 5-day course of whole breast radiation works as well as a 9-day course for women with early-stage breast cancer. About 144 participants will be randomly assigned to one of the two schedules. The main goal is to see if the shorter treatment leads to simi…

This study tests a short self-help booklet designed for people recently diagnosed with certain cancers (breast, colorectal, gynecological, melanoma, or bladder) who still smoke. The goal is to see if the booklet is easy to use and helps increase their motivation to quit. About 10…

This study tests whether a non-invasive brain stimulation technique called repetitive transcranial magnetic stimulation (rTMS) can reduce nerve pain caused by chemotherapy in breast and gynecologic cancer survivors. About 19 women who have persistent pain after chemo will receive…

This study looks at whether text message reminders and physical activity coaching can help more people with osteoarthritis start and stick with a walking program. Researchers will enroll 346 adults aged 45 and older who have knee, hip, or spine arthritis. The goal is to reduce pa…

This study tests if a type of talk therapy called Emotional Awareness and Expression Therapy (EAET) can safely reduce widespread pain in people with lupus. About 30 adults with lupus and fibromyalgia will attend 8 weekly online sessions. Researchers will check if pain and other s…

This study tests whether a 5-minute guided meditation played during each radiation session can help reduce anxiety in people with brain tumors. About 30 adults will either listen to the meditation or receive standard care. Researchers will measure anxiety levels before and after …

This study looks at immune cells from the umbilical cord blood of premature babies to understand why some develop necrotizing enterocolitis (NEC), a severe gut infection. Researchers will compare cells from healthy full-term infants and preemies at risk. The goal is to learn more…

This study tests whether short educational videos can help young adults who survived childhood cancer learn about and get the HPV vaccine. The researchers will enroll 55 survivors aged 18-26 who haven't finished the vaccine series. Participants will watch the videos on Facebook a…

This study follows up to 600 people with leukodystrophy, a rare genetic disorder affecting the brain's white matter. Researchers aim to track how the disease progresses, improve diagnosis through genetic testing and brain scans, and evaluate outcomes like hospitalizations and res…

This study looks at how teenagers with a history of self-harm and suicide attempts learn and use coping skills in daily life. About 200 teens and a parent will practice two skills during discussions while their heart rate and sweat are measured. Some will also have brain scans. T…

This study watches how vision changes over two years in 50 people aged 65-90 with geographic atrophy (a form of dry age-related macular degeneration) who are already taking the drug pegcetacoplan. Researchers will use a special vision test that maps light sensitivity near damaged…

This study aims to improve emergency care for injured children in Tanzania by finding and fixing delays in the healthcare system. Researchers will work with local clinics and hospitals to create a better triage process, helping kids get the right care faster. About 284 patients, …

This study aims to find the genetic mutation that causes polycythemia (too many red blood cells) and thrombocytosis (too many platelets). Researchers will analyze blood samples from 200 participants to identify the faulty gene. The goal is to use this knowledge to design better t…

This study is testing a web-based platform called LEAD that helps people in the early stages of Alzheimer's or dementia talk about and document their end-of-life care preferences. The goal is to make it easier for them and their care partners to feel confident in making future me…

This study is testing a new approach called Functional Precision Oncology for people with triple-negative or HR-low/HER2- breast cancer at high risk of early recurrence. Researchers will take tumor samples and create personalized models in mice and lab dishes to find the best tre…

This study looks at how different patterns of light exposure and food intake affect the body's metabolism when sleep is reduced. Researchers will monitor 120 healthy adults aged 18-35 over 4-6 months, including three overnight clinic stays. The goal is to understand how these fac…

This study aims to understand how muscle health recovers after a period of disuse, like being in a cast. Researchers will immobilize one leg of healthy volunteers for two weeks, then measure muscle size and strength before and after. The study includes both younger (18-35) and ol…

This study looks at how immune cells in the blood change with age and cause inflammation. Researchers hope to understand this process so they can design better treatments to reduce age-related inflammation. The study involves healthy adults aged 18-35 and 65 and older, and includ…

This study is testing a new video game designed to help teenagers with congenital heart disease learn how to manage their own healthcare. The game teaches skills like talking to doctors, understanding medical information, and keeping track of appointments and medications. About 1…

This early-stage study tests whether tiny electrode arrays implanted in the arm nerves of three amputees can record nerve signals and provide a sense of touch. The goal is to see if these signals can be used to control a prosthetic hand more naturally. The study focuses on measur…

This study is testing a new decision support tool for parents and doctors of children with neuromuscular scoliosis who are considering surgery. About 110 parent-child pairs will either use the tool or receive usual care. Researchers will measure how the tool affects decision qual…

This study tests a 4-session virtual coaching program to help young adult cancer survivors (ages 26-39) better understand their health insurance, reduce financial stress, and improve follow-up care for cancer recurrence. About 300 participants who have finished initial cancer tre…

This study is creating a large database of information about children with hydrocephalus (a condition where fluid builds up in the brain). Researchers will collect details on diagnosis, treatments, and outcomes from multiple hospitals. The goal is to better understand the disease…

This study looks at whether scheduling automatic follow-up appointments after a child leaves the hospital is better than only seeing a doctor when needed. About 2,674 children hospitalized for pneumonia, urinary tract infections, skin infections, or stomach bugs will take part. T…

This study uses machine learning to analyze real-world data from over 144,000 people with advanced non-small cell lung cancer. The goal is to find which existing treatments work best for different patient groups, helping doctors make more personalized choices. Participants' healt…

This study looks at whether using behavioral nudges—like gentle reminders or small prompts—in recruitment emails can encourage more healthy adults to join a short interview study. About 120 English-speaking adults aged 18 and older will be randomly assigned to receive either stan…

This study follows 100 people with high-risk smoldering myeloma, a condition that may turn into active cancer. Researchers use advanced MRI scans and regular check-ups to track how the disease changes over two years. The goal is to better understand who progresses and how to impr…

This study is testing whether a digital chatbot can help underserved women better understand their mammogram results and follow through with recommended care. About 2,700 women who recently had a mammogram will be randomly assigned to get usual care or usual care plus the chatbot…

This study watches how early damage in age-related macular degeneration (AMD) grows over time. Researchers will use special eye scans to measure changes in the retina and see how they affect vision and daily life. The goal is to find better ways to detect and track the disease ea…