University Of Utah

This early-stage study tests whether high-dose Vitamin C is safe for people with two rare inherited blood disorders—Pyruvate Kinase Deficiency (PKD) and a form of G6PD deficiency. Both conditions cause red blood cells to break down too quickly, leading to anemia. The study will e…

This study tests whether patient navigation—a series of coaching sessions—helps pregnant women with opioid use disorder stay in care and reduce drug use. About 429 pregnant women will be randomly assigned to either usual care or patient navigation. The goal is to see if this supp…

This study tests different strategies to help adults with obesity (BMI 30 or higher) enroll in digital weight management programs at community health centers. About 5,354 participants will be offered text messages, clinic support, and repeated chances to join. The goal is to see …

This study tests two drugs, mosunetuzumab and pirtobrutinib, given together to people with Waldenstrom macroglobulinemia (a rare blood cancer) that has returned or not responded to prior therapy. The goal is to find a safe dose and see how well the combination controls the diseas…

This study looks at whether estrogen patches can help post-menopausal women recover better from rotator cuff surgery. About 58 women will receive either estrogen or placebo patches after their operation. The goal is to see if estrogen improves shoulder pain, strength, and functio…

This study tests two drugs, loncastuximab tesirine and rituximab, as a first treatment for a rare blood cancer called post-transplant lymphoproliferative disorder (PTLD) that can occur after an organ transplant. The first part finds the safest dose, and the second part checks how…

This study compares two emergency contraception pills: levonorgestrel plus piroxicam (an anti-inflammatory drug) versus levonorgestrel alone. About 1,458 women aged 16-35 who had unprotected sex within 72 hours will participate. The goal is to see if adding piroxicam reduces preg…

This early-phase study tests whether adding the drug ropeginterferon alfa-2b to the standard treatment ruxolitinib is safe for people with myelofibrosis, a type of bone marrow cancer. About 15 adults already on a stable dose of ruxolitinib will receive the combination. The main g…

This study aims to see if a new blood test can accurately detect lung cancer by analyzing RNA from platelets. Researchers will collect blood samples from 240 adults with lung cancer or suspicious lung nodules. The goal is to validate whether this AI-powered test can distinguish b…

This study aims to find the best ways to increase lung cancer screening among current and former smokers aged 50-80 in community health centers. About 19,000 participants will receive text messages and clinic support to complete eligibility checks and low-dose CT scans. The goal …

This study will test a new multilingual chatbot called LIFT-UP designed to help people living in poverty quit smoking. Researchers will interview 22 adults who smoke at least 3 cigarettes daily and are motivated to quit. The goal is to see if the chatbot is easy to use and helpfu…

This pilot study will test whether having a paracentesis (draining fluid from the belly) at home can improve symptoms in 20 women with cancer-related malignant ascites. Participants will have the procedure at home, and researchers will measure symptom changes using a simple surve…

This study tests a non-medication therapy called Imagery Rehearsal Therapy to see if it can reduce nightmares in adults with narcolepsy. About 80 participants will receive the therapy and complete three assessments, with half starting right away and half later. The goal is to imp…

This study will test different ways to give rural tribal members their personal environmental exposure results, like radon and indoor air pollution. About 112 participants will have monitors installed in their homes and then receive feedback in various formats and from different …

This study tests a new chatbot designed to help cancer patients and their caregivers in rural areas find clear information about insurance, travel costs, and other financial aspects of cancer care. About 60 participants will be randomly assigned to use either a hybrid chatbot or …

This study will test a new breathing support system in 25 healthy volunteers. The goal is to see how accurately the system measures breath volume, rate, and carbon dioxide levels, and how comfortable it is to use. This is not a treatment study—it aims to gather information to imp…

This study tests whether a new educational tool helps patients on blood thinners (anticoagulants) better understand their medication. About 68 adults who are new to or currently taking these drugs will use either the new materials or standard ones and then answer surveys. The mai…

This study looks at three ways to give oxygen during colonoscopy sedation to prevent breathing pauses and low oxygen levels. About 280 adults will be randomly assigned to standard continuous oxygen, a device that delivers oxygen only when they inhale, or a mask that keeps the air…

This study explores whether a non-invasive, painless skin measurement called electrical bioimpedance can help monitor acute myeloid leukemia (AML) and myelodysplastic syndrome (MDS). About 25 adults who are already scheduled for a bone marrow biopsy will also receive this skin te…