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Could a common painkiller boost the Morning-After pill?

NCT ID NCT07449299

Disease control Sponsor: University of Utah Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting This study
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study compares two emergency contraception pills: levonorgestrel plus piroxicam (an anti-inflammatory drug) versus levonorgestrel alone. About 1,458 women aged 16-35 who had unprotected sex within 72 hours will participate. The goal is to see if adding piroxicam reduces pregnancy rates more effectively, especially in women weighing 75 kg or more.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Phase 3

Large-scale testing in a bigger group. Usually the last step before a treatment can be approved.

Participants

About 1,458 people

The number the study aims to enrol. It can still change while the study runs.

Expected to start

Mar 2027

An estimate. Start dates often move.

Expected to finish

Nov 2031

An estimate. End dates often move.

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

16 to 35 years

Sex

Female participants only

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Between 16-35 years old and desire LNG for EC * Unprotected intercourse within 72 hours * Biologically capable of pregnancy * Regular menstrual cycle 21-35 days long with known LMP +/- 3 days * Working cell phone number that receives text messages (for Aim 3 participants phone with capability to download and use the Oova application and submit data) * Fluent in English and/or Spanish * Willing to comply with the study requirements including 1-month urine pregnancy test * No known contraindications to oral LNG or piroxicam - For secondary outcome assessing pregnancy risk for participants receiving study drug on day of ovulation or later - are currently using a menstrual cycle tracking application and can demonstrate according to the application that they are on the day of ovulation or post ovulation. Exclusion Criteria: * Current pregnancy (+urine pregnancy test in clinic) * Breastfeeding, post abortion or postpartum without resuming menstruation * Use of hormonal contraception (including oral EC) within seven days of enrollment * Use of NSAIDs (ibuprofen, naproxen, celecoxib, diclofenac, aspirin) in the prior week * Highly effective contraception including permanent contraception (including partner with vasectomy), IUD, or contraceptive implant * Allergy to LNG or piroxicam * Desires UPA for EC History of stroke, myocardia infarction, ischemic heart disease, uncontrolled hypertension, congestive heart failure, peptic ulcer disease, renal or hepatic failure. Currently taking anticoagulants, corticosteroids, cyclosporine, lithium, methotrexate, or tacrolimus.

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As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Contraception Cox-2 inhibitor Emergency contraception

How to take part

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  1. The official record

    ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.

    Open the record ↗

  2. A doctor treating you

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