University Of Utah

This study tests ways to help more parents in rural areas get their children (ages 9-17) the HPV vaccine, which prevents certain cancers. About 1,455 parents and caregivers are taking part. The goal is to see if simple clinic-based reminders and conversations can increase vaccina…

This phase II study tests two staggered schedules of the immunotherapy drug durvalumab combined with standard chemotherapy (pemetrexed and carboplatin) in 43 adults with advanced non-squamous non-small cell lung cancer. The goal is to see if changing the timing of the drugs impro…

This early-phase study tests two drugs together—nivolumab (Opdivo) and Radium-223 (Xofigo)—in 39 men with metastatic castration-resistant prostate cancer that has spread to the bones. The main goals are to check safety and see if the combination can reduce tumor DNA in the blood.…

This study tests a combination of two drugs, nivolumab and axatilimab, in adults with classical Hodgkin lymphoma that has returned or not responded to at least one prior treatment, including anti-PD-1 therapy. The main goal is to see if the combination shrinks or controls the can…

This study aimed to see if the drug N-803 is safe and tolerable for people with B-cell non-Hodgkin lymphoma who had already received CAR T-cell therapy. It planned to enroll adults whose cancer had responded to CAR T treatment. However, the study was withdrawn before any particip…

This phase 2 trial is testing whether surgery and radiation can help men whose prostate cancer has come back and spread to a few spots in the body. About 20 participants will receive either surgery to remove the spread tumors or targeted radiation, or both. The main goal is to se…

This early-phase trial is testing whether adding ipilimumab (Yervoy) to the standard drug osimertinib (Tagrisso) is safe and effective for people with a specific genetic form of advanced lung cancer (EGFR-mutated NSCLC). The study involves 24 adults whose cancer is stable on osim…

This study reviews 100 patients with open-angle glaucoma who had two minimally invasive surgeries (Hydrus microstent and iTrack canaloplasty) along with cataract surgery. Researchers want to see if this combination lowers eye pressure and reduces the need for glaucoma medications…

This early-phase trial tests whether metformin, a widely used diabetes drug, can prevent muscle loss and insulin resistance in healthy older adults during five days of bed rest. Researchers will measure changes in muscle size and insulin sensitivity. The study involves 64 partici…

This early-stage trial tests whether combining three drugs—tazemetostat, zanubrutinib, and an anti-CD20 antibody—is safe and can shrink tumors in adults with certain types of B-cell non-Hodgkin lymphoma that have come back or not responded to prior treatments. About 24 participan…

This early-phase study tests whether adding losartan (a blood pressure medicine) to a shorter, higher-dose radiation treatment can help people with pancreatic cancer that is hard to remove surgically. The main goal is to check for side effects and find the safest dose. About 22 a…

This study tests a program called Share plus for adults aged 60+ with type 1 diabetes and their care partners. The program helps them better use continuous glucose monitor data together. Researchers want to see if it improves blood sugar control and reduces diabetes-related stres…

This early-phase study tests a combination of three drugs (tremelimumab, durvalumab, and belinostat) in people with advanced bladder cancer that has spread or cannot be removed surgically. The main goal is to find the safest dose and understand side effects. About 9 adults who ha…

This study tests a combination of two drugs—cabozantinib (a targeted therapy) and 177Lu-PSMA-617 (a radioactive drug)—in men with advanced prostate cancer that no longer responds to hormone therapy. The goal is to find the safest dose and see if the combination can slow cancer gr…

This study tests a drug called cobimetinib in people with a rare blood cancer (CMML) that has certain gene mutations. The goal is to see if the drug can shrink or control the cancer. Fourteen adults with either new or treatment-resistant CMML will take the drug daily in 3-week-on…

This study tests a drug called enfortumab vedotin, alone or with other medicines, in men with advanced prostate cancer that no longer responds to hormone therapy. The goal is to see if the drug can shrink tumors, lower PSA levels, or improve cancer markers. About 34 men who have …

This study tests whether the immunotherapy drug nivolumab, given after standard chemo-radiation, can help prevent bladder cancer from coming back. About 200 adults with localized muscle-invasive bladder cancer who cannot have bladder removal surgery are taking part. The main goal…

This study tests a program called FAMS-T1D that helps young adults (ages 18-24) with type 1 diabetes set goals and get support from a friend or family member. The goal is to see if this approach improves blood sugar control, reduces diabetes distress, and helps the support person…

This study tests a program called "Paso a Paso" designed to help Spanish-speaking adults at risk for diabetes. About 45 participants will take part to see if the program is practical and effective. The goal is to prevent diabetes by helping people lose weight and manage blood sug…

This pilot study is testing whether memantine, a drug already used for Alzheimer's, can improve arm and leg function after an ischemic stroke. Twenty participants with arm weakness will receive either memantine or a placebo for several weeks. The study measures motor skills and t…

This study follows 150 people who have already had the Intracept Procedure, a treatment that uses radiofrequency energy to disable a nerve in the spine thought to cause chronic low back pain. Researchers will track how much their pain-related disability improves over time using s…

This study tests whether a device called the Shoulder Pacemaker can help people recover better after reverse shoulder replacement surgery. About 100 adults aged 18 to 80 will either receive standard physical therapy or therapy plus the device three times a week for three months. …

This study tests whether a simple vocal exercise—humming or singing through a straw—can help people with voice fatigue or hoarseness expand their pitch range and stabilize their voice. Researchers will measure participants' lowest and highest pitches at different volumes before a…

This study is testing a new surgical technique for total shoulder replacement that does not cut any muscles or tendons. Researchers want to see if this approach leads to better pain relief, motion, and strength in people with shoulder arthritis. Fifty patients will be followed af…

This study tests whether non-drug treatments like physical therapy and counseling, delivered via telehealth, can help people with chronic back pain feel better and rely less on opioids. About 500 adults from community health centers in Utah will take part. The goal is to find eff…

This study tests whether a new type of screw (Bone Bolt) reduces pain better than standard screws after surgery for a specific pelvic fracture (LC-1). About 100 adults aged 18-80 will take part. The main goal is to see if the Bone Bolt leads to lower pain scores in the days after…

This study tests whether 30 sessions of UVA-1 light therapy can improve daily life for people with scleroderma, morphea, or skin hardening from graft-versus-host disease. Researchers will ask patients how they feel and measure hand movement before and after treatment. The goal is…

This study looks at whether a special pain injection given around the knee during surgery can lower pain for people with a tibial plateau fracture (a break in the top of the shinbone). About 150 adults with this type of fracture will receive the injection, and their pain scores w…

This study compares two ways to numb the wrist during a broken bone repair: a hematoma block (injecting numbing medicine into the fracture site) and a Bier block (using a tourniquet and IV numbing medicine). 500 adults with a broken wrist will be enrolled to see which method prov…

This study tests an 8-week remote program for couples where one partner has had a stroke. The program uses positive psychology techniques to help both the survivor and their carepartner manage anxiety and depression. Researchers hope it will improve emotional well-being and quali…

This study tests a shoulder pacemaker device in 20 people with scapular dyskinesia or posterior shoulder instability. The device is used during rehabilitation to see if it reduces pain and improves shoulder function. The goal is to ease symptoms, not to cure the condition.

This study looks at whether watching short videos with coping strategies can help people feel less pain and distress after surgery for abdominal cancer. About 95 adults will be assigned to one of three video-based approaches, including mindfulness or other support methods. They w…

This small study tests a procedure called radiofrequency ablation for people with chronic shoulder pain that hasn't improved with standard treatments like physical therapy or injections. The treatment uses heat to calm the nerves that send pain signals from the shoulder joint. Te…

This study tests a new device (Trident cannula) against a standard one for treating neck pain caused by small joints in the spine. About 80 adults with long-term neck pain will receive a procedure using either device. The goal is to see if the new device works just as well but wi…

This pilot study looks at whether the diabetes drug metformin can help older adults regain thigh muscle and function after a hip fracture. Sixty people aged 60 and older who had surgery for a hip fracture will take either metformin or a placebo daily for 4 months. The goal is to …

This study planned to test a computer game that children control by breathing in and out. The goal was to make anesthesia induction less frightening and encourage good breathing. The study was withdrawn before any children took part.

This study tests whether a local injection of multiple pain medicines works as well as regional anesthesia (numbing a larger area) for controlling pain after ankle fracture surgery. Researchers will compare pain scores, complications, and costs in 200 adults with rotational ankle…

This study compares giving oxygen only when a patient breathes in (on-demand) versus the usual constant flow during procedures. Researchers want to see if on-demand oxygen keeps oxygen levels higher and improves carbon dioxide monitoring. About 100 relatively healthy adults will …

This study was designed to see if giving methadone during breast reconstruction surgery helps patients use fewer opioids for pain afterward. It planned to enroll women having autologous breast reconstruction after mastectomy. However, the trial was withdrawn before any participan…

This study looks at how the body's inflammatory response after a specific type of knee fracture might be linked to developing arthritis later. Researchers will measure inflammatory markers in the joint fluid and blood of 60 adults with a tibial plateau fracture. They will also us…

This study compares two recovery plans for people who had surgery for a specific type of knee fracture (unicondylar tibial plateau fracture). One group will start putting weight on their leg after 6 weeks, while the other follows the standard 10-week wait. Researchers will measur…

This study looks at cells from 60 spine surgery patients to find which ones are best at making bone. The goal is to improve healing after spinal fusion and lower the chance of needing another surgery. Researchers will test a small piece of bone graft taken during the operation.

This study looks at whether rotator cuff disease runs in families. Researchers will collect DNA, medical history, and family history from 400 people to understand genetic risk factors. The goal is to build a resource for future studies, not to test a new treatment.

This study follows children who had a hip socket (acetabular) fracture to see how they heal over time. Researchers will track fracture patterns, treatments, and any long-term problems using questionnaires and medical records. The goal is to learn which treatments work best and cr…

This pilot study looks at whether using two metal implants (instead of one) to fix a broken thigh bone near the knee helps older adults heal better. Researchers will enroll 80 people aged 60 and older across five sites to see if a larger trial is possible. The main goals are to c…

This study was designed to see if certain immune cells (T cells) contribute to age-related blood vessel problems that raise heart disease risk. It planned to give a single injection of abatacept to adults aged 55-75 and measure changes in artery function and inflammation. However…

This study looks at how a single session of Swedish massage or light touch therapy changes brain activity, heart rate, blood pressure, and mood in healthy adults. Thirty participants will be randomly assigned to receive either massage or light touch. Brain scans (MRI) are done be…

This study develops and tests a computer tool that helps pharmacists screen patients for opioid medication risks. Researchers will compare pharmacies using the tool to those using standard care. The goal is to see if the tool lowers patients' risk of opioid abuse.

This study looks at whether reusing walking boot parts is safe for people recovering from foot or ankle injuries. About 60 participants will be randomly assigned to receive either new or reused boot components. The main goal is to check for skin problems like blisters or rashes, …

This study looks at a specific type of blood vessel growth (type 1 MNV) that can occur under the retina in people with age-related macular degeneration (AMD). Researchers want to find out if these vessels actually help preserve vision rather than harm it. About 73 adults aged 50 …

This study looks at whether special MRI scans can be used safely during surgery to remove brain tumors called gliomas. Researchers will try two advanced imaging techniques before and during the operation. The goal is to see if these scans are possible and to track any complicatio…

This study tracks the physical stress on orthopedic surgeons during surgery by measuring their heart rate. Researchers will compare heart rates before and during operations to see how demanding the work is. The study includes up to 8 surgeons and reviews charts of up to 750 patie…

This study looks at how skin temperature changes in people with a leg amputation and diabetes, especially while walking. Researchers will measure walking patterns, blood flow, and skin temperature to understand what raises the risk of tissue damage. The goal is to find ways to im…

This study compares genetic differences and muscle gene activity in people who develop acute compartment syndrome after a leg fracture versus those who do not. Researchers will measure a protein called myostatin in muscle tissue. The goal is to better understand why some people g…

This study aims to find genetic factors that may increase the risk of infection after hip or knee replacement surgery. Researchers will analyze DNA from 150 people from families with a history of such infections. The goal is to use this information to create personalized care pla…

This study compares four different approaches to managing suicide risk in 120 adults who have had suicidal thoughts and past suicide attempts. Participants are randomly assigned to one of four interventions, and researchers measure changes in suicidal thoughts and behaviors befor…

This study looks at how well a new hip replacement stem (Insignia) fits and stays in place over time. Researchers will review X-rays from 100 adults getting a first-time hip replacement to check for any signs of loosening. The goal is to see if the stem is safe and effective for …

This study looks at whether massage and light touch therapies can change brain activity and help reduce anxiety. About 46 healthy adults will be randomly assigned to receive either Swedish massage or light touch therapy twice a week for six weeks. Brain scans (MRI) before and aft…

This study looks at how sleep and daily body rhythms impact memory and thinking skills in couples where one partner has mild memory problems. Researchers will track 340 couples over time using smartphone tests and surveys. The goal is to understand if poor sleep in one partner af…

This study looks at how a hip condition called femoroacetabular impingement (FAI) changes the way the hip joint moves. Researchers will compare 36 people with FAI to those without it. The goal is to better understand the mechanics behind the condition, which may help improve futu…

This study looks at whether a web-based decision aid can help parents of unborn or newborn babies with life-threatening congenital heart disease make informed choices and feel less stressed. About 135 parents will be randomly assigned to use the decision aid alone or with an extr…

This study looks at whether Fitbit activity monitors can help measure physical function in people with cervical myelopathy (a spine condition) before and after decompression surgery. Researchers will compare Fitbit step counts with standard questionnaires to see if the monitors p…

This study tests whether a hospital-customized plan (ROAD Home) reduces unnecessary antibiotic use at discharge for adults with pneumonia or urinary tract infections. Forty hospitals are randomly assigned to either use this tailored approach or continue their usual practices. The…

This study looks at 116 adults who had glaucoma stent surgery up to 2 years ago. Researchers use a special eye scan (OCT) to see if the tiny stents are correctly positioned and how that affects eye pressure. The goal is to understand what makes the surgery work best long-term.

This study aims to understand how diet affects the eyes and skin by measuring natural pigments called carotenoids. Researchers will use non-invasive methods to check levels in the eye and skin, and also test blood in some participants. Anyone age 7 or older having a routine eye e…

This study looks at three common stress tests used to check ankle joint stability after a specific type of ankle fracture (Weber B). The goal is to see if these tests give different measurements of how much the ankle joint space widens. Sixty adults with this fracture will have a…

This pilot study tests whether leaving the placenta in place after delivery (conservative management) is a safe and effective alternative to hysterectomy for women with placenta accreta spectrum, a condition where the placenta grows too deeply into the uterine wall. Four particip…