University Of Utah

This study looks at whether using two metal implants (plates or rods) to fix a broken thigh bone near the knee is better than using just one in people aged 60 and older. The goal is to see which approach helps patients heal and move better. About 80 participants will be followed …

This early-phase study aimed to see if the drug N-803 is safe and tolerable for adults with B-cell non-Hodgkin lymphoma who had already received CAR T-cell therapy. Participants had to have responded to CAR T treatment. The study was withdrawn before enrolling anyone, so no resul…

This study tests whether adding the drug nivolumab after standard chemo-radiation can help keep bladder cancer from coming back. About 200 adults with localized muscle-invasive bladder cancer who cannot have bladder removal surgery are taking part. The main goal is to see how man…

This study looks at whether combining two minimally invasive glaucoma surgeries (Hydrus microstent and iTrack canaloplasty) along with cataract surgery can lower eye pressure better than cataract surgery alone. Researchers will review records of 100 patients with open-angle glauc…

This early-phase study tests a combination of two drugs—nivolumab (an immunotherapy) and Radium-223 (a radioactive drug)—in 39 men with advanced prostate cancer that has spread to bones and no longer responds to hormone therapy. The main goals are to check safety and see if the t…

This study tests a program called FAMS-T1D for young adults aged 18-24 with type 1 diabetes. The program helps them set goals and get support from a friend or family member. Researchers want to see if it improves blood sugar levels, self-care, and reduces diabetes-related distres…

This study tests a drug called enfortumab vedotin, alone or with other medicines, in men with advanced prostate cancer that no longer responds to hormone therapy. The goal is to see if it can shrink tumors or lower cancer markers. About 34 men who have already tried chemotherapy …

This study tests whether giving immunotherapy (durvalumab) and chemotherapy at different times works better than the usual schedule for people with advanced non-squamous lung cancer. About 43 adults who have not had these treatments before will be randomly assigned to one of two …

This study is testing a program called Paso a Paso, designed to help Spanish-speaking adults at risk for diabetes prevent the disease. About 45 participants will take part to see if the program is practical and effective. The goal is to help people lose weight and lower their blo…

This study tests whether metformin, a common diabetes drug, can prevent muscle loss and insulin resistance in healthy adults aged 60 and older during 5 days of bed rest. Researchers will measure changes in muscle size and insulin sensitivity. The goal is to find a simple way to p…

This study follows 150 adults who had a procedure called Intracept, which uses heat to target a nerve in the spine thought to cause chronic low back pain. Researchers want to see if patients report less disability and better daily function three months after the procedure. The go…

This study looks at whether watching short videos with coping strategies can help patients feel less pain and distress after surgery for abdominal cancer. About 95 adults will be assigned to one of three video-based approaches, including mindfulness or other support techniques. P…

This study tests whether non-drug treatments like physical therapy and counseling, delivered through telehealth, can help adults with chronic back pain feel better and rely less on opioids. About 500 people from community health centers in Utah are taking part. The goal is to fin…

This study compares two ways to numb the arm before setting a broken wrist: a hematoma block (injecting numbing medicine into the fracture site) and a Bier block (using a tourniquet and IV medicine). About 500 adults with a displaced distal radius fracture will take part. The goa…

This study aimed to see if a special video game, controlled by breathing in and out, could help children aged 4-11 feel less anxious when getting anesthesia through a mask. The game was designed to encourage steady breathing and distract kids from fear. However, the study was wit…

This early-phase study looks at whether the diabetes drug metformin can help older adults regain thigh muscle and function after a hip fracture. Sixty people aged 60 and older who had surgery for a hip fracture will take either metformin or a placebo daily for 4 months. The main …

This study looks at whether massage and light touch therapies can change brain activity and help reduce anxiety. About 46 healthy adults will be randomly assigned to receive either Swedish massage or light touch therapy twice a week for six weeks. Brain scans before and after the…

This study looks at how well a new hip replacement stem (Insignia) fits inside the bone and whether it stays secure over time. About 100 adults getting a first-time hip replacement will have their X-rays checked for tiny gaps that could signal loosening. The goal is to see if the…

This study tests whether a program tailored to each hospital's needs can reduce unnecessary antibiotic use when patients leave the hospital. About 40 hospitals will either use the program or continue their usual practices. The goal is to see if the customized approach leads to fe…

This study aimed to understand how T cells contribute to blood vessel aging and heart disease risk. It planned to give a single injection of abatacept to healthy older adults and measure changes in artery function. However, the study was withdrawn before enrolling any participant…

This study looks at whether Fitbit activity monitors can help measure physical function in people with cervical myelopathy, a condition where the spinal cord in the neck is compressed. Researchers will compare step counts from Fitbits with standard questionnaires before and after…

This study looks at whether special stretching exercises for the vocal folds can help people change their pitch range and keep their voice steady. Researchers will test 120 adults who do not have voice problems and have no professional singing or speaking training. The goal is to…

This study tests whether a short educational website can help people who stopped taking their cholesterol-lowering statin due to muscle symptoms make an informed decision about restarting it. About 816 participants will either use the website or receive usual care. The goal is to…

This small pilot study tested whether leaving the placenta in place after delivery (conservative management) could be a safe alternative to hysterectomy for patients with placenta accreta, a condition where the placenta grows too deeply into the uterus. Only 4 participants were e…

This study tracks the physical stress that orthopedic surgeons experience while performing surgery. Researchers will measure the surgeons' heart rates before and during operations to see how their bodies respond. The goal is to better understand the demands of surgery on the medi…

This study looks at cells from spine surgery patients to find which ones are best at making bone. The goal is to improve healing after spinal fusion and reduce the need for repeat surgeries. About 60 adults having spine surgery will take part. Researchers will study a small piece…

This study checks how often tiny glaucoma stents are not in the right position after surgery and whether that affects eye pressure. About 116 adults who had cataract and stent surgery in the past two years will get one extra eye exam and imaging. The goal is to learn how stent pl…

This study looks at 60 adults with a specific type of ankle fracture (Weber B) to compare three standard stress tests that measure how unstable the ankle is. The tests are gravity stress, manual stress, and weight-bearing stress. The goal is to see if one method gives different r…

This study looks at whether a web-based decision aid helps parents of unborn or newborn babies with life-threatening congenital heart disease make informed medical choices. About 135 parents will be randomly assigned to use the decision aid alone or with an extra values-clarifica…

This study looks at whether special MRI scans can be used safely during surgery to remove brain tumors called gliomas. About 53 adults with suspected gliomas will take part. Some will get the advanced scans before and during surgery, while others will have standard care. The goal…

This study looks at how sleep and daily body rhythms impact memory and thinking in couples over age 50, where one partner has mild memory problems. Researchers will track sleep patterns and test memory using smartphone tasks. The goal is to understand how sleep habits shared by p…

This study looks at whether parts of walking boots can be safely reused for people healing from foot or ankle injuries. About 60 patients will be followed to check for skin problems like blisters or rashes. The goal is to see if reusing these boots is safe and to help reduce medi…

This study was designed to test whether giving methadone during breast reconstruction surgery could lower the need for other opioids and improve pain control afterward. It was planned for women who had mastectomies for breast cancer or prevention. However, the study was withdrawn…

This study looks at how femoroacetabular impingement (FAI) changes the way the hip joint moves. Researchers will compare movement patterns between people with FAI and those without. The goal is to better understand the condition, not to test a treatment. About 36 participants wil…