University Of Utah

This study tests a drug called pemigatinib in 27 adults with certain types of B-cell non-Hodgkin lymphoma that have returned or not responded to at least two prior treatments. The main goal is to see how many patients have their tumors shrink or disappear after seven cycles of tr…

This study tests whether men with metastatic hormone-sensitive prostate cancer can safely take breaks from hormone therapy (relugolix) once their PSA levels drop very low. The goal is to see if intermittent treatment reduces fatigue and maintains cancer control compared to contin…

This study tests whether adding axatilimab to nivolumab can help control Hodgkin lymphoma that has returned or not responded to prior treatments. About 9 adults who have already tried at least one other therapy, including a PD-1 inhibitor, will receive the combination. The main g…

This study tests a personalized approach to predict and prevent early return of triple-negative breast cancer. Researchers will analyze each patient's tumor to find the best treatment and use mouse models to see if the cancer is likely to come back. About 80 adults with high-risk…

This study is for people with HPV-related throat cancer who have had robotic surgery. It tests whether a shorter, lower-dose course of radiation can maintain cancer control while improving quality of life. About 42 participants will receive the experimental radiation schedule and…

This study tests the drug bortezomib in men with a specific genetic form of advanced prostate cancer (PTEN deletion) that has stopped responding to hormone therapy. The main goal is to see if bortezomib can lower PSA levels, a marker of cancer activity. Participants receive borte…

This study looks at whether giving sex hormone therapy to men with low hormone levels can help their shoulder tendons heal better after surgery. About 58 men will receive either hormone pills or a placebo after rotator cuff repair. The goal is to see if the treatment improves ten…

This study tests two or three drugs (defactinib, avutometinib, and possibly encorafenib) in people with advanced melanoma that has spread to the brain. The goal is to see if these combinations can shrink brain tumors and are safe. About 33 adults whose melanoma has gotten worse a…

This study tests whether giving two drugs (loncastuximab tesirine and rituximab) before standard CAR-T cell therapy can improve outcomes for adults with relapsed or hard-to-treat large B-cell lymphoma. About 29 participants will receive the drug combo as a "bridge" to control the…

This early-phase study tests a new type of CAR-T cell therapy for people with certain blood cancers (like leukemia and lymphoma) that have not responded to other treatments. The therapy uses a patient's own immune cells, modified to attack cancer cells, and is made with a new man…

This study tests a 'go-slow' treatment for ultra-frail patients newly diagnosed with multiple myeloma. Instead of starting all drugs at once, patients begin with just two medications and add a third after two months. The goal is to see if this gentle approach helps patients stick…

This early-phase trial tests whether combining two drugs—cabozantinib (a targeted therapy) and 177Lu-PSMA-617 (a radioactive molecule that seeks out cancer cells)—is safe and effective for men with advanced prostate cancer that no longer responds to hormone therapy. About 33 part…

This study tests whether the diabetes drug metformin can help older adults regain muscle after a period of disuse, such as bed rest. Fifty healthy adults aged 60 and older will take either metformin or a placebo during recovery. The goal is to see if metformin improves muscle reg…

This early-stage study tests a new device that uses focused ultrasound waves guided by MRI to partially destroy breast tumors. About 34 women with breast cancer will have half of one tumor ablated before their standard surgery. The goal is to see if the procedure is safe, tolerab…

This study looks at how well the levonorgestrel 52 mg IUD works as emergency contraception (after unprotected sex) or when started later in the menstrual cycle. About 1,400 people from Planned Parenthood clinics across the U.S. will choose to get the IUD as part of their regular …

This study tests a mobile app called MyChildCMC that helps parents of children with complex medical conditions spot early warning signs of illness. The goal is to prevent emergency room visits and hospital stays. About 360 children ages 1-18 and their parents will use the app dai…

This study tests a daily oral drug called XL092 in 32 adults with metastatic castration-resistant prostate cancer that has worsened after treatment with 177Lu-PSMA-617. The main goal is to see if the drug can stop the cancer from growing for at least 16 weeks. Researchers will al…

This study tests a short self-help booklet designed for people recently diagnosed with certain cancers (breast, colorectal, gynecological, skin melanoma, or bladder) who also smoke. The goal is to see if the booklet is easy to use and helps increase their motivation to quit smoki…

This study tests whether a single, quick radiation session without the usual planning scan can safely ease pain from bone metastases. About 40 adults with one or two painful bone spots will get this streamlined treatment in just one visit. The goal is to see if it works as well a…

This study tests a home-based exercise and nutrition program for 40 adults with lymphoma or myeloma who are about to receive CAR-T cell therapy. The program uses a web portal and smart technology to guide patients through personalized workouts and meal plans while monitoring thei…

This study tests whether a headband with special semiconductors can help with memory and thinking problems (chemo brain) after cancer treatment. About 50 breast or gynecologic cancer patients who finished chemotherapy within 90 days will wear the headband for 18 hours a day for 3…

This study will follow 10,000 adults with joint or tendon problems (like knee arthritis or tennis elbow) who receive a platelet-rich plasma (PRP) injection. Researchers will track pain, physical function, and satisfaction for one year to see how well PRP works. Participants must …

This study tests whether combining mindfulness training with patient-centered pain management visits can help adults with chronic pain who are on long-term opioids. The goal is to reduce pain, improve quality of life, and lower the risk of opioid misuse. About 300 participants wi…

This study is testing whether a personalized exercise program, delivered via telehealth, is practical for people with stage II or III lung cancer who are receiving treatments like chemotherapy or immunotherapy. Researchers will track how many patients join and stick with the prog…

This study tests a 12-week home-based exercise and support program for men with advanced prostate cancer living in rural areas. The goal is to see if this remote program is easy to use and helps improve quality of life. About 30 participants will take part, all receiving standard…

This study tests whether a drug called budesonide can prevent severe diarrhea in people with multiple myeloma who are getting a stem cell transplant. About 120 adults will be randomly assigned to receive either budesonide or a placebo alongside standard care. The goal is to see i…

This study tests if a tretinoin cream can help reduce the acne-like rash that some cancer patients get from their treatment. About 25 adults with advanced solid tumors will apply the cream to one side of their face and a placebo to the other. Researchers will compare the rash sev…

This study tests whether combining brain, nerve, and hand stimulation can strengthen the connection between the brain and weak hand muscles in people who had a stroke at least six months ago. Researchers will measure changes in brain-to-muscle signals and hand movement. The goal …

This study tests whether a 5-minute guided meditation played during each radiation session can lower anxiety in people with brain tumors. About 30 adults will either listen to the meditation or receive standard care. Researchers will measure anxiety levels before and after each t…

This study tests two strategies to help people with osteoarthritis (OA) get more active and manage pain. Researchers will compare different text-message approaches to see which one gets more people to join physical activity counseling, and then whether joining a walking program h…

This study tests whether guarana, a natural plant extract, can improve fatigue in people with neuroendocrine tumors or gynecologic cancers. About 86 participants will receive either guarana or a placebo for up to 42 days. Researchers will measure changes in fatigue and quality of…

This study looks at whether Swedish massage or light touch can reduce anxiety symptoms in people with Generalized Anxiety Disorder (GAD). About 46 adults will receive either massage or light touch twice a week for 6 weeks. Researchers will use brain scans (fMRI) and questionnaire…

This study tests whether brief guided meditation sessions during daily radiation therapy can help reduce anxiety in people with breast or gynecologic cancers. About 34 adults will be randomly assigned to either listen to a guided meditation during treatment or receive standard ca…

This study compares a shorter course of internal radiation (vaginal cuff brachytherapy) to the standard longer course for people with stage I-II endometrial cancer. The goal is to see if the shorter treatment improves quality of life and reduces financial burden. About 188 partic…

This study tests whether a non-invasive brain stimulation technique called repetitive transcranial magnetic stimulation (rTMS) can reduce nerve pain caused by chemotherapy in breast and gynecologic cancer survivors. About 19 women with persistent pain will receive rTMS treatments…

This study tests a behavioral (non-medication) treatment to reduce nightmares in adults with REM Sleep Behavior Disorder (RBD). Twenty people with RBD and their family members will join video sessions to learn techniques. The goal is to see if this approach can lower nightmare fr…

This study tests a web-based tool called LEAD that helps people in the early stages of Alzheimer's or dementia talk about and document their end-of-life wishes with a care partner. The goal is to see if the tool improves decision-making confidence and reduces anxiety for both the…

This study looks at how muscles recover after a period of not being used, comparing younger (18-35) and older (60-85) healthy adults. Participants will have one leg immobilized for two weeks, then undergo testing to measure muscle size and strength changes. The goal is to underst…

This study looks at how different patterns of light exposure and food intake affect metabolism when people don't get enough sleep. Researchers will track 120 healthy adults aged 18-35 over 4-6 months, including three overnight stays. The goal is to understand how these factors in…

This study looks at whether scheduling automatic follow-up appointments after a child leaves the hospital works better than letting parents decide when to call. About 2,674 children hospitalized for infections like pneumonia or urinary tract infections will take part. The goal is…

This study looks at how immune cells in the blood change as we age and how that leads to chronic inflammation. Researchers will compare healthy younger adults (18-35) with older adults (65+) using blood tests, an oral glucose tolerance test, and leg strength measures. The goal is…

This study tests whether watching a short educational video about safe opioid use helps breast reconstruction patients use fewer pain pills after surgery. About 68 women having breast reconstruction after mastectomy will be randomly assigned to watch the video or receive usual ca…

This study looks at how teenagers who have hurt themselves learn and use coping skills in daily life. About 200 teens and their parents will practice skills together while researchers measure heart rate, sweat, and brain activity. The goal is to find out what helps teens use thes…

This study follows 100 adults with high-risk smoldering myeloma to learn how the disease naturally progresses. Participants receive close monitoring with special whole-body MRI scans and standard care. The goal is to track serious complications and quality of life over two years,…

This study is testing a new decision support tool for parents and doctors of children with neuromuscular scoliosis (a curved spine due to nerve or muscle problems). About 110 parent-child pairs will either use the tool or receive usual care. The goal is to see if the tool helps f…

This study tests a new video game designed to help teenagers with congenital heart disease learn skills to manage their own healthcare, like talking to doctors and keeping track of appointments. About 150 teens, their parents, and doctors will try the game and give feedback. The …

This study is testing whether tiny electrodes placed in the arm nerves of people with amputations can record nerve signals and provide a sense of touch and movement. Three participants will have the electrodes implanted for up to 30 days to see if they can control a prosthetic ha…

This study tests whether offering personalized financial incentives can help people with obesity stick to a weight-loss program. Eighty adults will receive tailored rewards for tracking their food intake and weighing themselves regularly. The goal is to see if this approach impro…

This study is testing whether a digital chatbot can help women who have had a mammogram better understand their results and follow through with recommended next steps. Researchers will enroll 2,700 women who recently had a mammogram at the University of Utah. Half will get the us…

This study looks at how mindfulness meditation can help people with chronic low back pain who take opioids. Researchers will use brain scans to see how meditation changes pain signals. The goal is to understand the brain mechanisms behind pain relief, not to test a new treatment.…