Could a common diabetes drug ease fibromyalgia pain?
NCT ID NCT05900466
First seen Mar 31, 2026 · Last updated Jun 22, 2026 · Updated 9 times
Summary
This study tests whether low-dose metformin, a common diabetes drug, can improve fibromyalgia symptoms by reducing inflammation in the body. Researchers will give 72 adults with fibromyalgia either metformin or a placebo daily for 8 weeks. The goal is to see if metformin safely reduces pain and other symptoms better than a placebo.
Disclaimer
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This is a summary of
the original study
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Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Contacts and locations
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Study contacts
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Contact
Phone: •••-•••-•••• Email: •••••@•••••
Locations
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University of Utah
RECRUITINGSalt Lake City, Utah, 84132, United States
Contact Phone: •••-•••-•••• Email: •••••@•••••
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
Metformin (low-dose extended-release tablets)
What this could lead to
If it works, this could point toward a new, affordable treatment option for fibromyalgia that targets inflammation.
What could go wrong
This is a small, early proof-of-concept study. Metformin may not improve symptoms more than placebo, and results may not apply to all patients.
Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.