Massage may soothe anxiety by calming brain circuits

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: 1. Male or female subjects aged ≥ 18 and \< 65 years old. 2. Medically stable. 3. Primary Diagnosis of GAD. 4. Hamilton Rating Scale for Anxiety (HAM-A) ≥15 5. Off concurrent psychotropic medication for at least 2 weeks prior to initiation of randomized treatment, OR stable on current medication for a minimum of 6 weeks (prior to initiation of randomized treatment) and willing to maintain a stable dose. 6. Ability to lie prone or supine for one hour at a time, given the nature of the massage intervention 7. Subjects must have a permanent domicile 8. Subjects must be able to comply with the research protocol 9. Able to provide informed consent and willing to sign an approved consent form that conforms to federal and institutional guidelines. Exclusion Criteria: 1. Current (within 3 months of screening visit) nicotine use, illicit drug use, regular or long-term medication use that, in the opinion of the investigator, could alter the results of the study 2. Pregnancy (per participant report, pregnancy testing not done for study) 3. Usually is asleep during the daytime (ie. due to working third-shift), or any other behaviors that routinely disrupt normal diurnal (daily) rhythms 4. Current (past month) rigorous dieting (defined as \<1200 calories per day for ≥2 consecutive days) 5. In the month before screening visit, excessive regular use of alcohol, as defined by either of the following, twice a month or more often: (a drink is one 5 ounce glass of wine or equivalent) 1. ingestion of 5 drinks or more in a 2 hour period 2. ingestion of 7 drinks or more in a 24 hour period 6. Initiation of psychotherapy or CAM interventions because of psychological distress within 90 days before screening visit. 7. Has a lifetime diagnosis of PTSD, bipolar disorder, OCD, psychotic disorders, OR a current diagnosis of an alcohol or substance use disorder 8. Meets criteria for current suicidal or homicidal ideation 9. Subjects who have massages on a regular basis. Regular massage usage will be defined as receiving on average 4 or more massages/year for the last 5 years 10. Subjects currently employing any other CAM manual therapy and/or holistic therapies to treat a perceived health problem 11. History of head injury or neurological disorder, that in the investigator's opinion would impact the data or preclude safe and successful completion of the study. 12. History of cancer that required chemotherapy and/or radiation treatment. 13. General contraindication to MRI - Because MRI uses a very strong magnet, subjects cannot have metals in their bodies or certain medical conditions. Subjects cannot have a cardiac pacemaker; hearing aid; any other implant metal in their body or eyes, including pins, screws, shrapnel, plates, teeth braces, or dentures. Subjects cannot have tattoos on their head, such as eyeliner or other permanent makeup, as they may make it impossible to get clear and usable images. 14. Medical, psychiatric, cognitive, or other conditions that may compromise the subject's ability to understand the subject information, give informed consent, comply with the study protocol, or complete the study. 15. Current participation in another research study (excluding large natural cohort trials such as 'All of Us')