GENERALIZED ANXIETY DISORDER

This study tests whether a computer-delivered therapy can help people who have both an anxiety disorder and alcohol use disorder. The program aims to reduce heavy drinking days and delay relapse. Researchers will enroll 256 adults in an addiction treatment program to see if this …

This study is testing a new internet-based cognitive behavioral therapy (ICBT) for young people aged 8 to 17 with anxiety disorders. The goal is to see if the online program can reduce anxiety severity over 12 weeks. Participants will complete questionnaires and attend follow-ups…

This study tests whether a single injection of RE104 can reduce anxiety symptoms in 64 adults with Generalized Anxiety Disorder (GAD). Participants will receive either RE104 or a placebo, and their anxiety levels will be measured using a standard scale. The goal is to see if RE10…

This study compares two approaches to treating anxiety in children and teens aged 8-17. In stepped care, everyone starts with internet therapy and gets in-person sessions only if needed. In stratified care, kids are assigned to internet or in-person therapy based on their needs. …

This study tests an experimental drug called ITI-1284 in adults with generalized anxiety disorder (GAD) who still have symptoms despite current treatments. About 570 participants will receive either the drug or a placebo to see if it reduces anxiety and is safe. The goal is to fi…

This study tests a new medication called crisugabalin for people with generalized anxiety disorder (GAD). About 216 adults in China will receive either crisugabalin, a placebo (dummy pill), or an existing drug (venlafaxine) for 8 weeks. The goal is to see if crisugabalin reduces …

This study tests whether a new drug, ITI-1284, can help adults with generalized anxiety disorder (GAD) whose current treatments aren't working well enough. About 705 participants will receive either ITI-1284 or a placebo alongside their usual therapy. The goal is to see if the dr…

This study tests a new, non-invasive treatment for people with generalized anxiety disorder who haven't gotten better with standard medications. The treatment uses low-intensity focused ultrasound to gently stimulate a deep brain area linked to anxiety, called the amygdala. 48 ad…

This study looks at whether Swedish massage or light touch can reduce anxiety symptoms in people with Generalized Anxiety Disorder (GAD). 46 adults will receive 12 sessions over 6 weeks and have their brain activity measured with fMRI before and after. The goal is to see if these…

This study tests whether delivering cognitive behavioral therapy (CBT) in person, via video, or a mix of both works best for children aged 5-18 with anxiety or OCD. About 500 participants will be randomly assigned to one of three delivery methods. The goal is to find ways to make…

This study tests a gentle, non-invasive brain stimulation method called cTBS to see if it can reduce anxiety in people with Generalized Anxiety Disorder. Forty adults will receive either real or placebo stimulation three times daily for a week. Researchers will use brain scans to…

This study aims to see if a carbon dioxide (CO2) challenge can help doctors identify patients with anxiety, OCD, PTSD, or panic disorder who are unlikely to improve with exposure-based therapy. Researchers will enroll 600 adults aged 18-70 and measure their response to CO2 before…

This study follows up to 10,000 medical students in Orleans, France, for up to 22 years to understand what leads to depression and other mental health problems. Researchers will compare students who enter medical school with those who don't, using yearly questionnaires. The goal …

This study uses transcranial magnetic stimulation (TMS) to map brain circuits in people with depression, OCD, anxiety, or schizophrenia. Researchers will stimulate different parts of the prefrontal cortex and test how it changes behavior. The goal is to understand which brain cir…

This study looks at how mindfulness-based stress reduction (MBSR) affects brain activity in people with generalized anxiety disorder (GAD). Researchers will compare MBSR to a stress education program in 150 adults aged 18–50. They will use brain scans and other measures to unders…