Can a 2-Day therapy session help veterans with PTSD?
NCT ID NCT05843695
First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 2 times
Summary
This study is testing two different ways of delivering intensive cognitive behavioral therapy (CBT) to veterans with PTSD and anxiety disorders. One format is individual therapy over two weeks, and the other is group therapy over two days. Both are compared to standard care. The goal is to see which approach improves anxiety symptoms and quality of life the most. The trial is currently recruiting 306 veterans.
What this could mean
Our plain-language read of the trial. This is informational only, not medical advice or a prediction.
- Active substance
- cognitive behavioral therapy (CBT)
- What this could lead to
- If successful, this could show that a short, intensive therapy format works as well as or better than standard care for veterans with PTSD and anxiety, potentially making treatment more accessible.
- What could go wrong
- This is a behavioral intervention study, not a drug trial, so results depend heavily on participant engagement and therapist skill. The intensive format may not suit everyone, and long-term benefits are still being measured.
This is an AI summary of the original study and may miss details. Read our disclaimer.
Study facts
What this study's own registry entry says, in plain language.
- Phase
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Not a phased trial
Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.
- Participants
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About 306 people
The number the study aims to enrol. It can still change while the study runs.
- Started
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Sep 2023
- Expected to finish
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Mar 2027
An estimate. End dates often move.
- Lead sponsor
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Other sponsor
The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.
Who can take part
This study's own entry requirements. Only the study team can say for certain whether you qualify.
- Ages
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18 years and older
- Sex
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Anyone
- Healthy volunteers
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Not accepted
This study is not open to healthy volunteers. The entry requirements below say who it is open to.
Show the full entry requirements Hide the full entry requirements
Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.
Inclusion Criteria: * Veteran/Service Member at least 18 years old * Current diagnosis of at least one anxiety-based disorder: Posttraumatic Stress Disorder, Panic Disorder, Social Anxiety Disorder, Generalized Anxiety Disorder, Other Specified Trauma- and Stressor-Related Disorder, Other Specified Anxiety Disorder, and Unspecified Anxiety Disorder (based on ADIS-5) * Moderate-to-poor life enjoyment and satisfaction as indicated by a score of 47 or lower on the QLES-Q-SF * Stable on psychotropic medication for 4 weeks before study participation * Willing to be randomized to treatment condition Exclusion Criteria: * Active symptoms of mania or psychosis at baseline (based on ADIS-5) * Depression with active suicidal ideation and intent that would preclude treatment (based on ADIS-5 \& BDI-II) * Moderate-to-severe cognitive impairment as indicated by the SLUMS (a score below 20) * Veterans/Service Members with comorbid substance/alcohol use or dependence are study eligible but must agree to reduce and limit their use of substances during the active course of treatment, particularly during exposure exercises. If they do not agree to this, they will be excluded * Undergoing concurrent transdiagnostic CBT specifically targeting any of the above-mentioned disorders
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
How to take part
Only the study team decides who joins. These are the ways to reach them.
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The places running it
1 site. The list below names each one and where it is.
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The official record
ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.
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A doctor treating you
A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.
Contacts and locations
Locations
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Michael E. DeBakey VA Medical Center
RECRUITINGHouston, Texas, 77030, United States
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