Baylor College Of Medicine

This study is testing a new medical tube called the Pathfinder® Overtube. It is designed to make colonoscopy procedures for removing large or difficult polyps faster and safer by providing better stability for the doctor's tools. Researchers will compare this new device to the st…

This early-stage trial is testing the safety of a new two-part treatment for people with advanced HER2-positive solid tumors that have stopped responding to standard therapies. First, a specially designed virus is injected directly into one tumor to help alert the immune system. …

This early-stage study is testing the safety of a two-part treatment for advanced sarcomas that have stopped responding to standard therapies. Doctors take a patient's own immune cells, genetically modify them to recognize and attack cancer cells, and then infuse them back. These…

This study is testing a new care model called OPTIMISE, designed to improve overall health for cancer patients who also have other chronic conditions like diabetes or high blood pressure. It focuses on better communication and coordination between a patient's cancer doctor and th…

This early-stage study is testing a new treatment for people whose lymphoma or leukemia has returned or hasn't responded to standard therapies. Doctors take a patient's own immune cells (T-cells), genetically modify them in a lab to better recognize and attack cancer cells, and t…

This early-stage trial is testing a new type of cell therapy for aggressive brain tumors that have returned or stopped responding to standard treatments. Doctors take a patient's own immune cells (T cells), genetically modify them in a lab to better recognize and attack cancer ce…

This study is testing a new cell therapy for children with neuroblastoma that has come back or hasn't responded to other treatments. Doctors take a patient's own immune cells, modify them in a lab to better find and attack cancer cells, and then infuse them back into the patient …

This early-stage study tests a new type of cell therapy for lymphoma linked to Epstein-Barr virus (EBV). Researchers take a patient's own immune cells, modify them with a gene called C7R to help them survive longer, and infuse them back to attack the cancer. The main goals are to…

This early-stage study is testing a new version of a cancer treatment called CAR-T cell therapy for people whose lymphomas have returned or not responded to standard treatments. Researchers are using pre-made immune cells from healthy donors, modified to better target a protein (…

This study is testing whether some patients with chronic myeloid leukemia (CML) who have been in a stable, deep remission for years can safely stop their daily medication. Researchers want to see if these patients can remain cancer-free without treatment, which would spare them f…

This study is testing whether a new tool, called a traction device, can help doctors remove large or difficult-to-reach colon polyps more effectively. The device is designed to gently pull on tissue during a special endoscopic procedure, potentially making the process quicker and…

This study is collecting information on how well a new surgical tool works for a procedure to treat a rare swallowing disorder called achalasia. It will follow 40 patients who are already scheduled to have the standard surgery. The goal is to see if the new tool is safe and effec…

This early-stage study is testing a new type of personalized cell therapy for adults with advanced solid tumors that have a specific marker called GPC3. Doctors take a patient's own immune cells, genetically modify them in a lab to better recognize and attack cancer, and then inf…

This study is testing if giving a higher, weekly dose of a protein called albumin can better control a dangerous fluid buildup in the abdomen (ascites) for people with advanced liver cirrhosis. It will compare the standard care to standard care plus weekly albumin infusions in 10…

This early-stage study is testing a new treatment for multiple myeloma and related conditions. Doctors take a patient's own immune cells, train them in a lab to recognize and attack cancer cells, and then infuse them back into the patient. The main goals are to find the safest do…

This early-stage study is testing a new type of cell therapy for adults with a recurrent, aggressive brain cancer called glioblastoma. Doctors take a patient's own immune cells (T cells), genetically modify them in a lab to recognize and attack cancer cells, and then inject them …

This early-stage study is testing a new cell therapy for adults and children with T-cell leukemia or lymphoma that has come back after a stem cell transplant. Doctors take a patient's or their donor's immune cells, modify them in a lab to better target the cancer, and infuse them…

This study aims to test and validate a standard care plan for managing unborn babies diagnosed with a lower urinary tract obstruction (LUTO), a serious blockage in the bladder. It will enroll 50 pregnant women to follow this detailed plan, which includes specialized monitoring, p…

This large study is testing whether a newer pacemaker technique (His or Left Bundle Branch Pacing) works better than the standard method (Biventricular Pacing) for people with heart failure and a weak heart pump. It will enroll over 2,100 adults to see which method is more effect…

This study is testing a new way to treat certain lymphomas linked to the Epstein-Barr virus (EBV). Doctors take a patient's own white blood cells, train them in a lab to recognize and attack EBV-infected cancer cells, and then infuse them back into the patient. The main goals are…

This study compares two different surgical entry techniques used during laser surgery for twin-to-twin transfusion syndrome, a serious pregnancy complication. Researchers want to see which method causes fewer problems with the membranes separating after surgery. The study involve…

This study is testing a new type of stent graft device to repair dangerous bulges (aneurysms) in the body's main artery, the aorta. The device is inserted through a small incision in the groin and has special holes or branches to keep blood flowing to vital organs. Researchers ar…

This study is testing if a single chemotherapy drug (cytarabine) works as well or better than the current standard two-drug combination (vinblastine/prednisone) for treating Langerhans cell histiocytosis (LCH), a rare cancer. It will enroll 124 children and young adults up to age…

This early-phase study is testing a new cell therapy for adults and children with aggressive T-cell leukemias or lymphomas that have returned or not responded to standard treatments. Doctors take a patient's own immune cells, genetically modify them in a lab to better recognize a…

This study is testing whether guided psilocybin sessions combined with therapy can safely and effectively treat PTSD in US military veterans. Fifteen veterans will receive two psilocybin sessions alongside psychotherapy. Researchers will measure changes in PTSD symptoms, depressi…

This study is testing two different drug combinations given before surgery for pleural mesothelioma, a cancer often linked to asbestos exposure. The goal is to see if these treatments can better control the cancer and keep it from coming back after surgery. Researchers will compa…

This study is for people who need a stem cell transplant but don't have a perfectly matched donor. Researchers are testing a way to prepare stem cells from a 'half-matched' family donor to lower the risk of a dangerous complication where donor cells attack the patient's body. The…

This study is testing a new surgery performed on babies while they are still in the womb to repair a serious birth defect called complex gastroschisis, where the intestines develop outside the body. The goal is to see if this early repair is safe and possible, and if it helps bab…

This early-phase study is testing a new, experimental cell therapy called TRICAR-ALL for children and young adults (ages 1-25) whose B-cell acute lymphoblastic leukemia (ALL) has come back or hasn't responded to standard treatments. Doctors take a patient's own immune cells (T ce…

This study aims to understand if genetic conditions play a role in a serious newborn brain injury called HIE. Researchers will offer detailed genetic testing (genome sequencing) to 25 newborns with HIE who are receiving cooling therapy and their parents. The goal is to see how of…

This study is testing a new mobile, AI-assisted camera device designed to help doctors better see and identify early signs of esophageal cancer during a routine screening procedure. The goal is to see if this technology can make cancer detection more accurate and reduce the numbe…

This study is testing a new wireless sensor, called FlowSense, that sticks to the skin like a bandage. It aims to monitor fluid flow in brain shunts for people with hydrocephalus, a condition involving dangerous fluid buildup. The goal is to provide a quick, bedside check of shun…

This study is testing whether a simple educational video and flyer can help patients collect cleaner urine samples. Cleaner samples lead to more accurate test results, which helps doctors avoid prescribing antibiotics when they aren't needed. Researchers will compare patients who…

This study is testing a new education program that combines food assistance with parenting guidance about feeding practices. The program is designed for parents of young children to help prevent childhood obesity and establish healthy eating habits. Researchers want to see if thi…

This study is testing a 30-day mobile health program designed to help Hispanic adolescents (ages 12-18) with overweight improve their health. Researchers want to see if using a special smartphone app, along with a smart scale, can help participants track and improve their physica…

This study is testing whether a gentle, non-invasive electrical stimulation delivered to the ear can improve attention and memory problems in veterans who have a traumatic brain injury (TBI). Participants will try both a real and a fake (placebo) version of the stimulation during…

This study aims to help mothers who are feeling depressed, anxious, or stressed while their baby is in the hospital. It provides emotional support to help mothers bond with their babies and connects families to practical resources like food assistance and health insurance. The go…

This study is testing if a short, intensive form of talk therapy (cognitive behavioral therapy) can better help veterans and service members with PTSD and anxiety disorders. Researchers are comparing two delivery methods—individual sessions over two weeks versus group sessions ov…

This small pilot study is testing whether combining two painless, non-invasive brain stimulation techniques can help manage difficult behavioral and emotional symptoms in people with Alzheimer's disease. The study aims to see if the treatment process is practical for patients and…

This study is testing whether wearing special light glasses for 30 minutes each weekday can help reduce fatigue and improve attention and thinking skills in children and teens who have survived a brain tumor. It's a small pilot study with 40 participants to see if this approach i…

This study aims to understand how the brain processes social and emotional information in people with severe, treatment-resistant depression or epilepsy. Researchers will use electrodes temporarily implanted in the brain for clinical care to record and gently stimulate brain acti…

This study provides advanced genetic testing and virtual doctor visits for seriously ill newborns in Texas hospitals, especially those with fewer resources. Researchers will test 200 infants over five years to try to find a genetic cause for their illness. They also want to learn…

This study aims to understand if a simple, non-invasive skin scan can accurately measure how many fruits and vegetables a baby or toddler eats. Researchers will follow 208 healthy children from 4 to 24 months old, checking their diet, taking a small blood sample, doing the skin s…

This study aims to understand how brain activity relates to mood, particularly in depression. Researchers will record brain signals directly from 58 participants who are already undergoing monitoring for epilepsy or treatment for severe depression. Using advanced computer analysi…

This study aims to help develop a future hookworm vaccine by first creating a safe, controlled infection model. Healthy adult volunteers who have never had hookworm will have a small number of larvae applied to their skin to see how their bodies react. Researchers will monitor sa…

This study aims to measure precisely how a sedative drug called dexmedetomidine affects the amount of inhaled anesthesia (sevoflurane) needed to keep children asleep during surgery. Researchers will enroll 180 children between 1 month and 3 years old to test two different doses. …

This study aims to understand TANGO2-related disorder, a rare genetic condition that can cause severe muscle breakdown and dangerous heart rhythms. Researchers will collect medical information and tissue samples from 300 people with the condition to track how the disease progress…

This study aims to understand how the body processes a nutrient called arginine in teenagers with type 2 diabetes. Researchers will test if giving extra arginine can help the pancreas produce more insulin. The goal is to gather knowledge that could lead to new, low-cost ways to m…

This study aims to find better ways to detect, prevent, and treat tuberculosis (TB) in people living with HIV. It will test new screening tools, compare different preventive treatment delivery methods, and analyze costs to improve care for 6,500 participants. The goal is to gener…