HYPOXIC ISCHEMIC ENCEPHALOPATHY

This study tests a drug called sovateltide for newborns with hypoxic-ischemic encephalopathy (HIE), a serious brain injury from lack of oxygen at birth. The drug aims to help the brain repair itself and reduce the risk of death or long-term disability. About 40 full-term babies w…

This study tests a new medicine called RLS-0071 in 70 newborns who have moderate to severe brain injury from lack of oxygen at birth (HIE). All babies will receive standard cooling therapy, and some will also get the study drug or a placebo. The goal is to see if the drug is safe…

This study tests whether higher doses of the drug levetiracetam can safely stop seizures in newborns. About 133 babies at risk of seizures will receive the medicine and be monitored with continuous EEG. The goal is to find the most effective dose that causes the fewest side effec…

This study tests whether adding melatonin to standard cooling treatment can help protect the brains of newborns with HIE (a birth injury from lack of oxygen). About 70 full-term babies will receive different doses of melatonin to find the safest and most effective amount. The goa…

This study looks at how to best give hydrocortisone (a steroid) to newborns who have low blood pressure while being cooled for birth asphyxia. About 50 full-term babies will receive the drug, and researchers will measure how their bodies process it. The goal is to find the right …

This study looks at children aged 4 to 12 with conditions like cerebral palsy, autism, or genetic disorders. They receive 2.5 hours of personalized therapy each day for two weeks. Researchers track changes in skills like movement, attention, and communication to see if the progra…

This study follows 130 patients with severe brain injuries (from stroke, trauma, or lack of oxygen) who are in a coma or minimally conscious state. Researchers will use brain scans, electrical tests, and regular check-ups to find clues that predict if and when a patient might reg…

This study offers genome sequencing to 25 newborns diagnosed with HIE (a severe brain condition from lack of oxygen at birth) who are undergoing cooling therapy. Researchers want to find out how often genetic changes cause or contribute to HIE. The goal is to learn which babies m…

This study watches children from birth to 18 years old who need anesthesia for an MRI. It measures how different anesthetics change blood flow and oxygen use in the brain. The goal is to learn, not to treat. Up to 1,000 children will join.

This study looks at whether simple, painless eye tests can help doctors understand how well babies with hypoxic-ischemic encephalopathy (HIE) will develop. Researchers will compare eye function and brain scans in 125 newborns to see if eye exams can predict future health. The goa…

This study looks at how caffeine is processed in newborns who have brain injury from lack of oxygen at birth. Sixteen babies will receive caffeine while undergoing cooling therapy. The goal is to find the right dose and check for safety issues like seizures or low blood sugar.