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Vitamin B6 put to the test: could a common vitamin raise your pain tolerance?

NCT ID NCT06415383

Symptom relief Sponsor: University of Reading Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed This study
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This completed Phase 1 trial from the University of Reading tested whether taking high-dose vitamin B6 (100 mg daily) can increase how much heat and electric shock healthy adults can handle before feeling pain. 43 participants were randomly assigned to get either vitamin B6 or a placebo for a period, then their pain thresholds and tolerance were measured. The goal is to see if this common vitamin might offer a simple way to reduce pain sensitivity.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
Vitamin B6 (pyridoxal phosphate)
What this could lead to
If it works, this could point toward a simple, low-cost supplement for managing pain sensitivity.
What could go wrong
This is a small, early-phase study in healthy adults, not patients with chronic pain. Results may not apply to real-world pain conditions, and high-dose B6 can cause nerve damage with long-term use.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Phase 1

The first testing in people. Mainly checks safety and dose, usually in a small group.

Participants

43 people

The number who actually took part.

Started

May 2024

Finished

Jun 2025

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 years and older

Sex

Anyone

Healthy volunteers

Accepted

You do not need to have the condition being studied to take part.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Over the age of 18 years * Fluent speaker of English language Exclusion Criteria: * Under 18 years * Presence or history of chronic pain * Presence of neuropathic/nerve pain * Raynaud's syndrome * Using any vitamin supplementations that contain Vitamin B6 at more than the RDA, or combinations of B vitamins. * On any medication that is GABA agonistic * Any use of analgesic/anti-inflammatory medication up to 48 hours prior to any of the testing sessions. * Any heart conditions * Newly acquired tattoos on the pain stimulation site

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Conditions

The condition(s) this trial relates to.

Pain

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Pain

Contacts and locations

Locations

  • University of Reading

    Reading, Berkshire, RG6 6AL, United Kingdom

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