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Brain scans reveal how laughing gas blunts pain and memory

NCT ID NCT06702631

Knowledge-focused Sponsor: Keith M Vogt Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed This study
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 25, 2026 · Last updated Aug 20, 2026 · Updated 5 times

Summary

This study uses brain scans to understand how low doses of nitrous oxide (laughing gas) change the way the brain processes pain and forms memories. Sixty healthy volunteers will receive mild electric shocks while breathing nitrous oxide or normal air, and their brain activity will be compared. The goal is to map which brain regions are involved, not to test a treatment.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
nitrous oxide
What this could lead to
If successful, this study could reveal how nitrous oxide changes pain perception and memory formation in the brain, guiding future pain treatments.
What could go wrong
This is a very early, small study in healthy volunteers, not patients. It measures brain activity, not real-world pain relief, so results may not apply to clinical settings.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Early phase 1

The earliest testing in people: a first look at safety, in a very small group.

Participants

34 people

The number who actually took part.

Started

Jan 2025

Finished

Jun 2026

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 to 59 years

Sex

Anyone

Healthy volunteers

Accepted

You do not need to have the condition being studied to take part.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * have none of the specific exclusion criteria * have a valid email address and valid phone number throughout the study * free from any non-MRI compatible implants Exclusion Criteria: * are pregnant or attempting to conceive * body mass index (BMI) \> 35 * significant memory impairment or hearing loss * sleep apnea * chronic pain or frequently taking pain medication (including tramadol) * any severe or poorly-controlled medical problem (hypertension, diabetes) * neurologic or psychiatric disease, including anxiety, and depression * severe cardiac disease * history of methylenetetrahydrofolate reductase (MTHFR) deficiency or variant mutation, as assessed by personal report * recent ear or eye surgery * being claustrophobic * have metal implants or non-removable metal piercings * having a history of adverse reaction to anesthetics * daily alcohol or heavy alcohol use; history of alcohol abuse * current daily smoker * regular or recent marijuana use (including prescribed/medical marijuana) * illicit drug use, i.e., street drugs * regularly taking: antiepileptics, antidepressants, anti-psychotics, antihistamines, anti-anxiety medication, stimulants, or sleep-aids

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Conditions

The condition(s) this trial relates to.

Amnesia Pain

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Amnesia Anesthesia Pain

Contacts and locations

Locations

  • University of Pittsburgh

    Pittsburgh, Pennsylvania, 15213, United States

More trials for these conditions

Other studies related to the condition(s) this trial covers.