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Hypnosis and VR tested as pain relief without drugs

NCT ID NCT04869553

Symptom relief Sponsor: Lille Catholic University Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed This study
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 26, 2026 · Last updated Jun 26, 2026

Summary

This study tested whether hypnosis or virtual reality can reduce pain during repeated medical procedures like wound dressing. 52 patients received standard pain care, standard care plus hypnosis, or standard care plus virtual reality in a random order. The goal was to see if these distraction methods improve comfort and lower stress during painful treatments.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
hypnosis and virtual reality
What this could lead to
If it works, this could offer simple, drug-free ways to reduce pain during medical procedures like wound dressing.
What could go wrong
This is a small, completed study with only 52 participants, so results may not apply to everyone. The effect may be small or no better than usual care.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

52 people

The number who actually took part.

Started

Jan 2022

Finished

May 2024

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

15 years and older

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Patients undergoing care interventions of a given type (e.g. wound dressings/mobilization/…) recognized as painful (pain VAS \>3 despite the usual analgesic protocol) * Repetition of the same type of intervention at least three times within a month of interval after inclusion * Patient age ≥15 years * Informed consent from patient or legal guardian * Beneficiary of the French healthcare fund Exclusion Criteria: * MEOPA's administration during painful treatment as part of the study * Cognitive or psychiatric disorders preventing the patient from communicating with caregivers or understanding their instructions * Any other concomitant nervous system, cardiac, or pulmonary disease that might affect the autonomous nervous system: (myocardial infarction, myocardial disorder (e.g. dilated or hypertrophic cardiomyopathy), class 3 or 4 heart failure, cardia dysrhythmia, including atrial fibrillation, conduction disorder, mechanical ventilation) * Non-sinusal rhythm, extrasystoles, altered ECG signals related to heart disease * Mandatory drug therapy that might affect the autonomous nervous system and NRV such as beta-blockers, muscarinic receptor blockers (mainly atropine, scopolamine), vasopressin agents * Contraindication for use of the virtual reality headset and/or hypnosis. Neurological disorder incompatible with use of the virtual reality headset and/or hypnosis (balance disorders/seizures…) * Contraindication for using surface electrodes preventing collection of the main endpoint data * Any disorder or disability preventing execution of the virtual reality or hypnosis techniques (deafness/blindness) * Judicial protection status

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Conditions

The condition(s) this trial relates to.

agnosia Pain

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Pain

Contacts and locations

Locations

  • Centre Mutualiste de Kerpape

    Ploemeur, 56275, France

  • Fondation ILDYS - Site de Perharidy

    Roscoff, 29684, France

  • Hôpital Léon Bérard

    Hyères, 83418, France

  • Pôle MPR Saint Hélier

    Rennes, 35043, France

  • USSAP - Centre Bouffard Vercelli

    Perpignan, 66962, France

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