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Which archwire sequence straightens teeth faster and hurts less?

NCT ID NCT07758556

Knowledge-focused Sponsor: Foundation University Islamabad Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed This study
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Aug 11, 2026 · Last updated Aug 14, 2026 · Updated 3 times

Summary

This trial compares two different sequences of nickel-titanium (NiTi) archwires used in braces to see which one aligns teeth faster, causes less discomfort, and leads to less root shortening. It involves 60 people aged 12-35 who need full orthodontic treatment for crowding. Participants will be monitored for the number of visits needed for alignment and will score their pain levels. The goal is to find a more efficient and comfortable approach to straightening teeth.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
NiTi archwires (two different sequences)
What this could lead to
If one sequence proves faster and less painful, it could become the preferred standard for orthodontic alignment, improving patient experience and treatment efficiency.
What could go wrong
This is a small, early-stage trial (60 participants) comparing two sequences; results may not apply to all patients or orthodontic practices. Pain and root resorption are subjective and variable, and the trial does not measure long-term outcomes.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

60 people

The number who actually took part.

Started

Dec 2024

Finished

Sep 2025

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

12 to 35 years

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: Age range 12-35 years. * Both male and female patients. * Medically-fit patients with no medical condition associated with root resorption risk. * No previous history of orthodontic treatment. * Patients requiring complete upper and lower orthodontic treatment with fixed appliance. * Angle class I, II, and III malocclusion with crowding in both maxillary and mandibular anterior dentition. * Healthy permanent dentition with adequate oral hygiene and no periodontal diseases; before the start of orthodontic treatment. Exclusion Criteria: Cleft lip \& palate patients * Syndromic patients * Patients with bone pathologies * Habits such as smoking * Patients with parafunctional habits or history of pre-existing root resorption * Patients taking drugs which inhibit or accelerate tooth movement * Tooth or teeth with periapical infection. * Patients with pain from any other medical or dental condition that may have affected their reported discomfort scores were excluded * Endodontically treated mandibular or maxillary anterior teeth * Presence of blocked-out tooth that did not allow for placement of the bracket or full AW engagement at the initial bonding.

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Conditions

The condition(s) this trial relates to.

external pathological resorption Pain root resorption

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

External root resorption Pain Speed of alignment Speed of alignment, pain, external root resorption

Contacts and locations

Locations

  • FUI

    Islamabad, Punjab Province, 43000, Pakistan

  • FUI

    Islamabad, Punjab Province, 46000, Pakistan

  • Foundation University Islamabad

    Islamabad, Punjab Province, 04403, Pakistan

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