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Estrogen levels linked to injection pain during anesthesia

NCT ID NCT06929416

Knowledge-focused Sponsor: Konya City Hospital Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed This study
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 26, 2026 · Last updated Jun 26, 2026

Summary

This study looked at 90 women to see if higher estrogen levels make propofol injection more painful. One group had high estrogen from IVF treatment, the other had normal levels. Researchers measured pain using a simple scale. The goal is to understand how hormones affect pain and improve comfort during anesthesia.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

What this could lead to
If successful, this could help doctors predict and reduce pain from propofol injections based on a patient's estrogen levels.
What could go wrong
This is a small, observational study that only looks for a link, not a treatment. Results may not apply to all patients or lead to immediate changes in care.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Participants

90 people

The number who actually took part.

Started

May 2025

Finished

Sep 2025

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Who is studied

The study population consists of adult female patients aged 18 to 45 years, with ASA physical status I or II, who are scheduled for elective surgical procedures under general anesthesia. Participants will be divided into two groups based on their preoperative serum estradiol levels: one group will include women undergoing IVF procedures with supraphysiological estrogen levels, and the other will consist of patients with normal estrogen levels undergoing unrelated elective surgeries.

Ages

18 to 45 years

Sex

Female participants only

Healthy volunteers

Accepted

You do not need to have the condition being studied to take part.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Female patients aged between 18 and 45 years * American Society of Anesthesiologists (ASA) physical status I or II * Scheduled for surgery under general anesthesia * Availability of a preoperative serum estradiol (E2) level * For Group 1: Undergoing IVF procedure with supraphysiological E2 levels (\>350 pg/mL) * For Group 2: Undergoing elective surgery with normal E2 levels (15-350 pg/mL) Exclusion Criteria: * ASA physical status III or IV * Pregnant patients * Perimenopausal women * Male patients * Patients younger than 18 or older than 45 years * History of psychiatric disorders * Patients undergoing emergency surgery

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Conditions

The condition(s) this trial relates to.

Pain

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Assisted reproductive techniques Estradiol Pain

Contacts and locations

Locations

  • Konya City Hospital

    Konya, 42020, Turkey (Türkiye)

More trials for these conditions

Other studies related to the condition(s) this trial covers.