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Platelet-Rich plasma may beat steroids for shoulder arthritis pain

NCT ID NCT05160441

Symptom relief Sponsor: Walter Reed National Military Medical Center Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed This study
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 26, 2026 · Last updated Jun 26, 2026

Summary

This study tested whether a shot of platelet-rich plasma (PRP) from a person's own blood works better than a common steroid shot for shoulder arthritis pain. Fifty adults with mild to moderate shoulder osteoarthritis received either a PRP or steroid injection. Researchers measured pain, function, and quality of life over time to see which treatment offers better relief.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
Platelet-rich plasma (PRP) injection and corticosteroid injection
What this could lead to
If PRP works better than steroids, it could offer a longer-lasting, safer option for easing shoulder arthritis pain without surgery.
What could go wrong
This is a small, completed Phase 3 trial with only 50 participants. PRP may not prove more effective than steroids, and results may not apply to everyone with shoulder arthritis.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Phase 3

Large-scale testing in a bigger group. Usually the last step before a treatment can be approved.

Participants

50 people

The number who actually took part.

Started

Sep 2022

Finished

May 2025

Lead sponsor

A government agency

The lead sponsor is a US federal agency other than the NIH.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 to 70 years

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * DEERS eligible * Male or female, aged 18 to 70 years (inclusive) * Presenting symptoms of shoulder pain caused by mild to moderate Shoulder OA as defined by Samilson Prieto criteria on a standard anterior-posterior (AP) Xray series * BMI \< 40 * Willing and able to give voluntary informed consent to participate in this investigation * Glenohumeral joint osteoarthritis that has been refractory to standard care treatments Exclusion Criteria: * Patients who have received shoulder intraarticular or subacromial injection(s) in the last 3 months * Patients who have undergone arthroscopic surgery on the study shoulder within the past year * Patients who have undergone arthroplasty on the study shoulder * Diabetes (Type 1 or II) * Inflammatory arthropathies * Fibromyalgia or chronic fatigue syndrome * Female patient who is pregnant or nursing * Patients taking narcotics * Patients with planned deployment or separation from the military within 12 months * Any other serious medical condition(s) that might preclude optimal outcome and/or interfere with participation such as intra-articular sepsis, bacteremia, fracture, joint instability, rheumatoid arthritis, osteoporosis, cancer, and coagulopathy * Patients who have had an adverse reaction to a previous corticosteroid or PRP injection either documented in the medical record or shared by the patient during screening

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Conditions

The condition(s) this trial relates to.

familial pityriasis rubra pilaris osteoarthritis Pain

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Corticosteroid Osteoarthritis of the shoulder Pain PRP

Contacts and locations

Locations

  • Walter Reed National Military Medical Center

    Bethesda, Maryland, 20889, United States

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