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Botox shot may silence stubborn nerve pain in amputees

NCT ID NCT07431944

Symptom relief Sponsor: Charitable Organisation Charitable Fund Superhumans (Co Cf Superhumans) Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting This study
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study compares two injections—botulinum toxin (Botox) and local anesthetic—to see which better relieves pain from nerve damage (neuroma) after limb injury or amputation. About 100 adults with moderate to severe pain will receive one injection and be followed for 8 weeks. The goal is to find a longer-lasting pain relief option.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

About 100 people

The number the study aims to enrol. It can still change while the study runs.

Expected to start

Feb 2026

An estimate. Start dates often move.

Expected to finish

Dec 2026

An estimate. End dates often move.

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 to 50 years

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Age ≥18 years * History of limb trauma and/or limb amputation at least 3 months prior to enrollment * Clinical diagnosis of neuroma-related pain with focal tenderness and positive - - Tinel sign * Imaging confirmation of neuroma by ultrasound or MRI * Average pain intensity ≥4 on a 0-10 Numerical Rating Scale (NRS) during the week prior to screening * Stable analgesic regimen for at least 14 days prior to enrollment * Ability to provide written informed consent Exclusion Criteria: * Chronic pain condition unrelated to neuroma that predominates clinical symptoms * infection at or near the planned injection site * Known neuromuscular junction disorders (e.g., myasthenia gravis) * Pregnancy or breastfeeding * Botulinum toxin treatment within the previous 4-6 months * Planned surgical neuroma revision during the study period * allergy or hypersensitivity to botulinum toxin or local anesthetics

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Conditions

The condition(s) this trial relates to.

agnosia Chronic Pain Pain Phantom Limb

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Pain Pain management Phantom limb pain Phantom limb pain after amputation

How to take part

Only the study team decides who joins. These are the ways to reach them.

  1. The places running it

    1 site. The list below names each one and where it is.

  2. The official record

    ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.

    Open the record ↗

  3. A doctor treating you

    A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.

Contacts and locations

Locations

  • Superhumans War Trauma Center

    Lviv, Ukraine

More trials for these conditions

Other studies related to the condition(s) this trial covers.