Why does stroke cause chronic pain? new brain study seeks answers
NCT ID NCT05335668
First seen Jun 27, 2026 · Last updated Jun 27, 2026
Summary
This study looks at why some stroke survivors develop long-term pain called central poststroke pain (CPP). Researchers will use brain scans to see how brain connections change in people with CPP. The goal is to better understand what causes this pain, which could lead to better treatments in the future. About 88 adults who have had a stroke affecting their sense of touch will take part.
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Study facts
What this study's own registry entry says, in plain language.
- Phase
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Not a phased trial
Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.
- Participants
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About 88 people
The number the study aims to enrol. It can still change while the study runs.
- Started
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Jul 2022
- Expected to finish
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Sep 2027
An estimate. End dates often move.
- Lead sponsor
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Other sponsor
The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.
Who can take part
This study's own entry requirements. Only the study team can say for certain whether you qualify.
- Ages
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18 to 75 years
- Sex
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Anyone
- Healthy volunteers
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Accepted
You do not need to have the condition being studied to take part.
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Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.
Inclusion Criteria patients: * Patients with a haemorrhagic or ischemic stroke affecting the somatosensory system as defined by both CT or MRI and clinical criteria * Patient age between 18-75 years * Signed written informed consent Exclusion Criteria patients: * Secondary stroke due to a cerebral vascular malformation or tumor * Patients with aphasic syndromes and impaired verbal communication, complete sensory-motor hemi-neglect and restrictions of the ability to report on their pain and cooperate during sensory testing * Patients with severe stroke NIHSS \> 14 and or Modified Rankin Scale (MRS) \> 3 * History of severe myelopathy or polyneuropathy with clinical sensory deficits and history of neuropathic pain * Widespread stroke size due to internal carotid artery-occlusion or more than one main territory (anterior, middle or posterior cerebral artery) * Contraindication for 7T MRI (metallic implant, tattoo, claustrophobia, etc.) * In case of women \< 45 years of age: pregnancy Inclusion Criteria for healthy volunteers * Informed consent as documented by signature * Age: ≥18 years and ≤ 75 years Exclusion criteria for healthy volunteers * Pregnancy and breastfeeding * Contraindication for 7T MRI (metallic implant, tattoo, claustrophobia, etc.)
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
How to take part
Only the study team decides who joins. These are the ways to reach them.
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The places running it
1 site. The list below names each one and where it is.
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The official record
ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.
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A doctor treating you
A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.
Contacts and locations
Locations
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Dep. of Neurosurgery, Bern University Hospital
RECRUITINGBern, 3000, Switzerland
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Other studies related to the condition(s) this trial covers.
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