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New study aims to tailor pain meds for underweight ICU patients

NCT ID NCT07301970

Knowledge-focused Sponsor: Fudan University Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now This study
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study looks at how the pain and sedation drug remifentanil behaves in low-weight patients in the intensive care unit who are on breathing machines. Researchers will measure drug levels in the blood and check vital signs like blood pressure. The goal is to find the right dose for this group to improve safety and effectiveness.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Participants

About 45 people

The number the study aims to enrol. It can still change while the study runs.

Started

Sep 2025

Expected to finish

Nov 2026

An estimate. End dates often move.

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Who is studied

Adult patients admitted to the Intensive Care Unit (ICU) requiring invasive mechanical ventilation who receive remifentanil for analgesia and sedation. The study population comprises two cohorts stratified by Body Mass Index (BMI): a low-body-weight group (BMI \< 18.5 kg/m²) and a normal-body-weight control group (18.5 kg/m² ≤ BMI \< 24 kg/m²).

Ages

Children (under 18), adults (18 to 64) and older adults (65 and over)

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Age: ≥18 years old, regardless of sex; * Normal weight: 18.5 kg/m² ≤ Body Mass Index (BMI) \< 24 kg/m² or Low weight: BMI \< 18.5 kg/m²; * Admitted to the intensive care unit (ICU); * Required invasive mechanical ventilation for more than 10 hours; * The subject or their legal guardian has fully understood the potential risks and benefits of participating in this study and has signed the informed consent form. Exclusion Criteria: * Pregnant women; * Presence of severe respiratory impairment or respiratory depression during the screening period; * Known hypersensitivity to remifentanil or any of the excipients; * Meeting other contraindications for opioid use

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Conditions

The condition(s) this trial relates to.

Critical Illness Pain

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Critical illness Pain

How to take part

Only the study team decides who joins. These are the ways to reach them.

  1. The places running it

    1 site. The list below names each one and where it is.

  2. The official record

    ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.

    Open the record ↗

  3. A doctor treating you

    A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.

Contacts and locations

Locations

  • Shanghai Minhang Central Hospital

    RECRUITING

    Shanghai, China

More trials for these conditions

Other studies related to the condition(s) this trial covers.