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Freezing pain away: new hope for rib fracture sufferers?

NCT ID NCT05865327

Symptom relief Sponsor: Sunnybrook Health Sciences Centre Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now This study
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 26, 2026 · Last updated Jun 26, 2026 · Updated 1 time

Summary

This pilot study tests a procedure called cryoneurolysis, which uses a tiny freezing tool to temporarily numb the nerves around broken ribs. The goal is to see if it's practical to run a larger study comparing this technique plus standard pain care to standard care alone. Twenty-four adults with 3 to 8 broken ribs on one side will be enrolled and followed for 3 months to track pain levels and medication use.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
cryoneurolysis (nerve freezing procedure)
What this could lead to
If this works, it could point toward a better way to manage severe pain from broken ribs, reducing complications and long-term pain.
What could go wrong
This is a very small pilot study (24 people) testing only if a larger trial is possible. It is not designed to prove the treatment works, and nerve freezing carries risks like temporary numbness or muscle weakness.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

About 24 people

The number the study aims to enrol. It can still change while the study runs.

Started

Oct 2023

Expected to finish

Dec 2025

An estimate. End dates often move.

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 to 100 years

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Aged ≥18 * Unilateral traumatic rib fractures (3 to 8) * Candidate for ESP block catheter * Within 48hrs of admission to hospital Exclusion Criteria: * Lack of patient consent; unlikely to comply with follow up * Unable to use Patient Controlled Regional Analgesia (Ventilated/sedated patients or Moderate to severe traumatic brain injury) * Chronic pain (opioid use \> 30mg oral morphine equivalent per day) * Substance use disorder * CrCl \< 50 * BMI \> 45 * Significant distracting injuries (unreduced long bone fractures, unstable pelvic or spine fractures and patients requiring trauma laparotomy- also preclude positioning for block placement (lateral decubitus or sitting up)) * Contraindications for ESP catheter placement (pre-existing medical/neurological/hematologic diseases, localized infection/trauma at site of intervention, allergy to amide local anesthetics) * Contraindications to CN (cryoglobulinemia, paroxysmal cold hemoglobinuria, multiple myeloma and cold urticarial). * Unable to return to Trauma Recovery Clinic (in-person or virtual) at 3 months

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Conditions

The condition(s) this trial relates to.

Accidental Injuries Acute Pain bone fracture Chronic Pain chronic pain syndrome injury Pain Rib Fractures

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Pain Pain, acute Pain, chronic Rib fracture multiple Rib fractures Rib; fracture, with flail chest Trauma Trauma injury

How to take part

Only the study team decides who joins. These are the ways to reach them.

  1. The places running it

    1 site. The list below names each one and where it is.

  2. The official record

    ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.

    Open the record ↗

  3. A doctor treating you

    A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.

Contacts and locations

Locations

  • Sunnybrook Health Sciences Centre

    RECRUITING

    Toronto, Ontario, M4N3M5, Canada

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