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Brain training for the spine: a new way to fight nerve pain?

NCT ID NCT05492188

Symptom relief Sponsor: Medical University of South Carolina Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now This study
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 24, 2026 · Last updated Jun 27, 2026 · Updated 2 times

Summary

This study tests whether training a spinal reflex can reduce neuropathic pain in people with spinal cord injury. Fifteen participants will undergo about 50 sessions of reflex training over 6.5 months. The goal is to see if changing this reflex can lower pain and improve sensation.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
reflex training (operant conditioning of cutaneous reflexes)
What this could lead to
If it works, this could offer a non-drug way to reduce chronic pain after spinal cord injury.
What could go wrong
This is a very small, early study with only 15 people. The training requires 50 visits over months, so it may be hard to stick with. Results may not apply to everyone.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

About 15 people

The number the study aims to enrol. It can still change while the study runs.

Started

Mar 2023

Expected to finish

Oct 2026

An estimate. End dates often move.

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 years and older

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: 1. neurologically stable (\>1 year post SCI) 2. medical clearance to participate 3. ability to stand with or without an assistive device for at least 3 minutes at a time 4. expectation that current medication will be maintained without change for at least 3 months (stable use of anti-spasticity medication is accepted) 5. For participants with neuropathic pain, the area of neuropathic pain must include lower leg. Exclusion Criteria: 1. motoneuron injury 2. known cardiac condition 3. medically unstable condition (incl. pregnancy) 4. cognitive impairment 5. uncontrolled peripheral neuropathy 6. frequent use of electrical spinal stimulation (either transcutaneous or epidural) for pain treatment 7. daily use of electrical stimulation to the leg 8. complete lack of cutaneous sensation around foot.

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Conditions

The condition(s) this trial relates to.

nervous system injury neuralgia Pain spinal cord injury

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Neurological injury Neuropathic pain Pain Spinal cord injuries

How to take part

Only the study team decides who joins. These are the ways to reach them.

  1. The places running it

    1 site. The list below names each one and where it is.

  2. The official record

    ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.

    Open the record ↗

  3. A doctor treating you

    A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.

Contacts and locations

Locations

  • Medical University of South Carolina

    RECRUITING

    Charleston, South Carolina, 29425, United States

More trials for these conditions

Other studies related to the condition(s) this trial covers.