Nervous system injury

This study tests whether giving tranexamic acid early after a traumatic brain injury can reduce harmful inflammation. Researchers will enroll 60 adults with mild or moderate head injuries. The goal is to see if this drug can help control the body's inflammatory response and impro…

This study tests whether a 5-day course of the steroid methylprednisolone can improve long-term recovery in adults with moderate to severe traumatic brain injury. 520 participants will receive either the drug or a placebo, added to standard care. Researchers will measure neurolog…

This trial tests whether adding robotic rehabilitation devices to standard physiotherapy can improve arm and leg function in adults with movement problems from stroke, spinal cord injury, traumatic brain injury, or orthopedic surgery. Participants will receive robotic-assisted se…

This trial tests whether a powered leg exoskeleton called ZEPU AI9 can safely and effectively help people with walking difficulties caused by stroke, incomplete spinal cord injury, or orthopedic surgery. Participants will be randomly assigned to receive either exoskeleton-assiste…

This trial tests whether adding a robotic leg-training device (ZEPU-AI5) to standard rehab can safely improve walking, strength, and balance in adults aged 18–60 with lower-limb problems from stroke, incomplete spinal cord injury, or orthopedic surgery. Participants will receive …

This study tests whether a robotic device called ZEPU-AI3 can safely help people with lower limb weakness from stroke, spinal cord injury, or orthopedic surgery improve their walking. Participants receive either standard rehabilitation alone or standard rehab plus robot-assisted …

This trial tests whether robotic devices that guide arm and leg movements can safely improve strength, coordination, and daily function in adults with movement problems from stroke, spinal cord injury, brain injury, or orthopedic conditions. Participants will use the devices thre…

This study tests a robotic device called ZEPU-AI1 that helps people with leg weakness practice standing and walking. The trial includes adults aged 19 to 60 who have walking problems from stroke, spinal cord injury, or orthopedic surgery. Half of the participants will use the rob…

This pilot trial asks whether adding a robotic hand-training device to standard rehabilitation is safe, practical, and helpful for people with arm and hand motor problems caused by stroke, incomplete spinal cord injury, traumatic brain injury, or orthopedic conditions. Participan…

Researchers are testing an experimental human monoclonal antibody called NG004 in people who have recently sustained an acute incomplete cervical spinal cord injury. Participants receive repeated injections of NG004 directly into the spinal fluid. The trial's main goal is to chec…

This study tests whether a special tilt-table with robotic leg movers (called Erigo) helps people with severe brain injuries recover better than traditional tilting. The table slowly brings patients upright while moving their legs, which may improve blood flow, muscle tone, and a…

This pilot study tests whether a virtual-reality system controlled by muscle activity can help improve arm and hand movement in people recovering from stroke or spinal cord injury. Participants use a wearable device that detects muscle signals through sensors on the skin and prov…

This trial is testing a robotic exoskeleton called ABLE Kids to see if it is safe and practical for children who have trouble walking due to conditions like cerebral palsy, spinal cord injury, or muscle weakness. Fifteen children will use the device in up to ten one-hour training…

This trial tests whether a device that sends mild electrical pulses to the spinal cord can help people with a cervical spinal cord injury breathe more independently. Twenty adults with a C1-C5 injury who need a ventilator will have electrodes implanted near the injury site and re…

This early study tests a single treatment of EG110A injections into the bladder muscle for adults with spinal cord injury who still have bladder leaks despite standard care. The goal is to see if the treatment is safe and can reduce incontinence. Sixteen participants will be foll…

This study tests a brain implant that records and stimulates brain areas to help adults with severe paralysis (from spinal cord injury, ALS, or stroke) control assistive devices like computers or wheelchairs. The main goal is to check safety, and researchers will also see if part…

This study is testing whether cooling the body to 33°C (just below normal) for 48 hours soon after a cervical spinal cord injury can improve nerve recovery and function. Researchers will enroll 120 adults aged 18-70 with severe but non-penetrating injuries. The cooling is deliver…

This early study tests whether a brain-computer interface can detect a person's intention to move their hand and then trigger electrical stimulation in the spinal cord to help produce that movement. Three adults with chronic spinal cord injury will have temporary spinal electrode…

This trial compares two common IV fluids—normal saline and balanced crystalloid—to see which one leads to better recovery in people with moderate to severe traumatic brain injury (TBI). Participants receive one of the fluids during their hospital stay, and their neurological outc…

This study tests whether adding a collagen scaffold called Miro3D to standard wound care helps acute and chronic wounds heal better than standard care alone. About 70 adults with soft tissue wounds or pressure ulcers will be randomly assigned to one of two groups. The main goal i…

This trial is testing an implantable wireless brain-computer interface (BCI) in people with tetraplegia caused by cervical spinal cord injury. The device is designed to read brain signals and translate them into commands to control external devices, such as a computer cursor or a…

This study tests whether an AI-powered chatbot can guide a personalized walking program for people with mild traumatic brain injury (mTBI). Participants follow a 12-week exercise plan with wearable fitness trackers, receiving real-time feedback and motivational messages via a mob…

This trial tests whether transcutaneous spinal cord stimulation (TSCS) can help stabilize blood pressure in people recently hospitalized with a spinal cord injury. After such injuries, blood pressure often swings between dangerously low and high levels, which can interfere with r…

This study tests whether combining cognitive training with brain stimulation (rTMS or tDCS) can improve thinking skills in veterans who have persistent symptoms after mild traumatic brain injury. Participants will receive 16 sessions of training with either real or sham stimulati…

This study tests whether functional electrical stimulation (FES) can help people who have had a stroke or traumatic brain injury regain handwriting skills. Participants are randomly assigned to receive FES during handwriting practice or standard therapy. Using motion capture tech…

This trial tests whether a non-invasive spinal cord stimulation device that turns on and off based on muscle signals can improve hand and arm function in people with spinal cord injury. Participants will receive both closed-loop stimulation (which responds to their own muscle act…

This study tests whether exercise using electrical stimulation can improve muscle strength and endurance in people with lower limb paralysis from conditions like spinal cord injury, stroke, or multiple sclerosis. Participants will use devices that send electrical signals to their…

This trial asks whether giving children a low-dose ketamine infusion after heart surgery can protect their brains from damage. Children aged 1 to 60 months undergoing surgery for certain congenital heart defects will receive either ketamine at one of two doses or no ketamine. Res…

This study tests whether breathing a low-oxygen gas mixture (mild intermittent hypoxia) can help prevent blood pressure problems in people with spinal cord injuries. The 24 participants will have motor-incomplete injuries above the 12th thoracic vertebra and signs of autonomic dy…

This trial tests whether Angiotensin (1-7), a synthetic version of a natural protein fragment, is safe and effective for people with moderate to severe traumatic brain injury (TBI). Participants receive a daily injection for 21 days, along with blood tests, MRI scans, and cogniti…

This trial compares two blood pressure medications—midodrine and droxidopa—against compression stockings and a placebo to see which best stabilizes blood pressure in people with spinal cord injury. Participants have a traumatic injury between C1 and T6, are at least a year post-i…

This trial tests whether a new type of deep brain stimulation (DBS) can better relieve chronic pain that hasn't responded to other treatments. Unlike traditional DBS, which delivers constant stimulation, this approach uses a device that adapts stimulation in real time based on br…

This trial is testing whether vitamin D supplements can improve bone density, body composition, strength, walking speed, and physical performance in people hospitalized with neurological disorders like stroke, spinal cord injury, or traumatic brain injury. Participants will recei…

This study tests an implanted electrical stimulation device designed to improve movement, standing, and walking in people with paralysis from spinal cord injury, stroke, multiple sclerosis, or traumatic brain injury. The device sends electrical signals to muscles in the trunk and…

This study tests whether a precise, individualized version of a common spinal surgery can safely improve function and reduce pain in people with cervical spinal stenosis. Researchers will compare outcomes in 500 patients who receive the standardized open-door procedure with a tit…

This study tests whether giving a continuous infusion of concentrated salt water (hypertonic saline) early after severe traumatic brain injury can improve survival and daily living independence at 6 months. About 760 patients with a low Glasgow Coma Scale score and high risk of b…

This trial investigates whether a robotic system can improve the accuracy of bone realignment and fixation in orthopaedic trauma surgery. Adults with fractures will receive surgery assisted by the R-Universal® robot, which uses 3D navigation to guide precise movements. The goal i…

This study tests whether clemastine, an allergy medicine, is safe for premature babies with white matter injury—a common brain injury in infants born early. Researchers will give the drug by mouth to 24 babies born at or before 32 weeks and now between 35 and 41 weeks old. The go…

This trial investigates whether a surgically implanted device that delivers personalized electrical stimulation to the spinal cord can improve upper limb function in people with spinal cord injury. Twenty participants with injuries at or above the T4 level will receive the implan…

This study tests a robot-assisted, gamified rehabilitation program for children aged 7-16 with acquired brain injury. The program combines 15 supervised hospital sessions with 15 home-based sessions on a tablet, guided by an interactive avatar. Researchers will measure improvemen…

This trial tests whether an implantable brain-computer interface (BCI) can help people with tetraplegia from spinal cord injury regain hand function. Participants receive a surgically implanted BCI that reads brain signals and controls pneumatic gloves to assist with grasping and…

This study investigates whether combining electrical stimulation of the abdominal and back muscles with specific breathing exercises can improve the strength of an unaided cough in people with acute spinal cord injury. Participants will use a device called the Xcite system to del…

This study looks at whether a 9-week program led by a dietician can help people with chronic spinal cord injury lose body fat and improve how their body uses insulin. Twenty adults who use wheelchairs will take part in telehealth sessions and have their body composition and insul…

This study tests a surgically implanted device that uses mild electrical pulses to stimulate muscles in the legs and trunk. The goal is to help people with paralysis from spinal cord injury, stroke, or other conditions exercise, stand, step, and improve balance. Ten participants …

This study looks at children under 18 who need emergency surgery for a type of brain bleed called an extradural hematoma after a head injury. Researchers will track their recovery using a standard scale for childhood head injuries. The goal is to understand which factors lead to …

This study tests whether a non-invasive technique called transcutaneous spinal electrical stimulation (TSES) can improve how well people with spinal cord injury respond to exercise. Participants will do cycling-like leg exercises with and without TSES to see if it boosts oxygen u…

This trial tests whether robot-assisted therapy using the ArmeoSpring exoskeleton improves arm and hand function more than conventional occupational therapy in people with cervical spinal cord injury. Each participant receives both therapies in random order, allowing direct compa…

This study tests a program called TBI-RECOVER that screens for brain injury and provides special support in substance use treatment. About 900 adults in outpatient therapy will take part. The goal is to see if the program helps people stay in treatment longer and feel better.

This study tests whether a non-invasive electrical stimulation device placed on the skin over the spinal cord is safe and practical for people with spinal cord injury. It includes 30 adults with either non-traumatic spinal cord injury (from cervical myelopathy) or traumatic injur…

This study investigates whether a home-based, telehealth-supported program combining blood flow restricted exercise and transspinal stimulation can improve hand and arm function in people with chronic, incomplete tetraplegia. Participants will perform task-specific activities whi…

This study tests whether a surgical procedure called duroplasty can improve recovery after a severe spinal cord injury in the neck. The surgery involves opening the tough membrane around the cord and stitching in a patch to give the swollen cord more space. Researchers will compa…

This study tests a new exercise program for people with spinal cord injury. It combines arm cycling with electrical stimulation to the legs, plus high-intensity interval training, after a muscle-strengthening prep phase. The goal is to see if this program improves heart fitness, …

This study tests a structured problem-solving approach called CO-OP (Cognitive Orientation to daily Occupational Performance) for adults who have had a stroke or traumatic brain injury. Participants learn a 'Goal-Plan-Do-Check' strategy to tackle everyday tasks like dressing or c…

This study is testing whether stem cells taken from a person's own bone marrow and then given back through the veins and nose can improve brain and nerve function. It includes 500 people with various conditions like stroke, Parkinson's, Alzheimer's, and nerve damage. The goal is …

This early-stage trial tests a brain-computer interface called BrainGate for people with paralysis from conditions like ALS or spinal cord injury. A small sensor is placed in the brain to interpret movement-related signals, allowing users to control a tablet computer just by thin…

This trial investigates the safest time to restart direct oral anticoagulants (DOACs) after a traumatic brain bleed. Many older adults who fall and hit their head are on blood thinners for conditions like atrial fibrillation, and stopping them raises the risk of stroke or clots. …

This study tests a daily pill called vibegron to see if it safely improves bladder control in children aged 2 to 18 with neurogenic detrusor overactivity (NDO), a condition where the bladder contracts too often due to nerve damage. Participants must already use a catheter to empt…

This study tests a special sealant called Immiseal that is applied during brain or spine surgery to prevent leaks of cerebrospinal fluid. It is used along with standard repair methods to create a watertight seal. The study follows adults aged 18 to 75 who need dural repair after …

This study tests an implanted spinal cord stimulator (ARC-IM System) to help people with chronic spinal cord injury manage dangerously low blood pressure and fainting. Sixty participants will receive the implant and be randomly assigned to active or sham stimulation for 3 months,…

This trial tests a fully implantable brain-computer interface (BCI) in one person with a severe spinal cord injury (C1-C4). The device reads brain signals to control digital devices like computers or tablets. Researchers will visit the participant at home 1-3 times per week for a…

This pilot study is testing whether galantamine, a drug already approved for Alzheimer's disease, can safely reduce inflammation and treat metabolic syndrome in people with chronic spinal cord injury. The study will enroll 60 adults who use wheelchairs and have obesity-related wa…

This phase II trial tests whether keeping fluid balance neutral (close to zero) is safe and feasible for adults with traumatic brain injury in the ICU. 88 participants will be randomly assigned to either a neutral fluid strategy or standard care for 5 days. The goal is to see if …

This study tests hyperbaric oxygen therapy—breathing pure oxygen in a pressurized chamber—for people with severe traumatic brain injury. Researchers will compare different oxygen pressures to see which works best. The goal is to improve long-term recovery and reduce brain swellin…

This early study tests whether a daily supplement called gamma-glutamylcysteine (GGC) can boost the brain's natural antioxidant levels in people who have had repeated head impacts, such as retired NFL players and military veterans. The 30 participants will take GGC tablets for a …

This study tests the safety and feasibility of the BrainGate2 system, a brain-computer interface. Tiny sensors are placed in the brain area that controls movement, allowing people with tetraplegia (paralysis of all four limbs) to control a computer cursor or other assistive devic…

This study tests whether a drug called 4-AP, taken twice daily, can boost recovery of leg movement in people with spinal cord injury. Participants also receive a type of brain stimulation and leg training. The goal is to improve walking and muscle strength. The study involves 27 …

This early-stage trial tests whether deep brain stimulation (DBS) of a brain region called the mesencephalic locomotor region can improve walking in people with incomplete spinal cord injury. Five participants will receive a DBS implant and be followed for safety and walking abil…

This study is testing whether nerve transfer surgery can help people with cervical spinal cord injury regain hand function. Forty participants who have already chosen to have the surgery will be followed for two years, with regular tests of hand strength, sensation, and movement.…

This study tests two non-invasive therapies to help people with chronic cervical spinal cord injury regain arm and hand function. Ten participants will try both therapies, each for two months, combined with rehabilitation. The goal is to see which works best and tailor treatments…

This study is testing a wireless brain implant that lets people with severe spinal cord injuries control external devices just by thinking. The device is placed in the brain with a small surgery. Researchers will check how well participants can perform tasks using only their brai…

This study tests whether low-intensity focused ultrasound (tFUS) can help people with severe traumatic brain injury who have not fully recovered consciousness. Researchers will compare real tFUS to a sham (fake) treatment in 60 participants, measuring changes in consciousness usi…

This study tests a brain implant that records activity from the motor cortex and stimulates the sensory cortex. It aims to help people with severe arm or hand impairment—due to spinal cord injury, stroke, or amputation—control external devices like computers. The trial focuses on…

This early study tests whether combining electrical stimulation cycling with blood flow restriction cuffs is safe and doable for people with chronic spinal cord injury. Six adults will try the 20-minute exercise sessions over 6 weeks. The goal is to see if this approach can be us…

This study looks at whether having surgery sooner or later after a traumatic spinal cord injury leads to better recovery. Researchers will compare how much nerve function improves in 100 adults who get either early or delayed surgery. The goal is to find the best timing to help p…

This small pilot study tests whether cutting a fibrous strand at the end of the spinal cord (filum terminale) can relieve symptoms of occult tethered cord syndrome better than medical management alone. Twenty people aged 2 to 80 who have not improved with standard care will be ra…

This study tests whether vitamin D3 supplements can reduce inflammation and improve recovery in adults with mild-to-moderate traumatic brain injury. Researchers will give different doses of vitamin D3 or a placebo to 240 participants and track their blood markers and neurological…

This study tests whether a custom 3D-printed external skull cap can prevent Sunken Flap Syndrome, a condition where the brain sinks after part of the skull is removed. 72 patients who had decompressive craniectomy will either wear the cap or not, and researchers will compare brai…

This study looks at whether giving less intravenous (IV) fluid to critically ill children with traumatic injuries leads to fewer complications. Currently, there is no standard for how much fluid these children should receive. The trial will enroll 250 children aged 6 months to 15…

This study tests whether a non-invasive spinal cord stimulation device, used while exercising on an arm bike, can improve blood pressure and heart function in people with chronic spinal cord injury. Sixteen adults with paralysis at or above the T6 level will receive either real o…

This study is testing whether epidural stimulation—a device placed near the spinal cord—can improve walking, standing, and bladder function in people who have had a spinal cord injury within the past year. Sixteen participants will receive stimulation combined with stand training…

This early study tests a device called Mechanical Tissue Resuscitation (MTR) that is designed to drain excess fluid from the brain area after a person has had part of their skull removed or repaired. The trial will include 11 people who need a drain as part of their standard care…

This study tests whether regular sessions of passive heat therapy (like sitting in a warm room or bath) can improve blood vessel health in people with spinal cord injury. About 48 adults will either receive heat therapy or a placebo for 60 minutes, 4 times a week for 8 weeks, mos…

This early-stage study tests whether a mixture of viruses (called phages) that specifically kill E. coli bacteria is safe for people with spinal cord injuries who have bacteria in their bladder. Thirty adults will receive the phage solution directly into the bladder twice daily f…

This study tests whether a home-based computer cognitive training program (RehaCom) can improve attention and memory in adults with acquired brain injury, including stroke. Thirty participants will either receive the home program plus weekly in-person sessions, or standard in-per…

This study compares two common seizure medications, levetiracetam and lacosamide, to see which works better at preventing early seizures after a traumatic brain injury. Researchers will also track side effects like agitation and sedation. The trial plans to enroll 600 adults with…

This study tests whether a smart glove can help people with brain disorders (like stroke or brain injury) improve arm and hand function from home. Forty adults with lasting arm weakness will either use the smart glove for guided exercises or do standard home therapy. The goal is …

This early study is testing a device called ARC-IM Therapy, which delivers electrical impulses to the lower spinal cord, to see if it can help people with spinal cord injury regain the ability to walk. The trial will include 12 adults with recent or long-term injuries. The main g…

This early-stage trial tests whether draining fluid from the spine (external lumbar drainage) is safe and doable for people with severe traumatic brain injury who have high pressure inside the skull. Thirty adults aged 18-65 will receive either standard care alone or standard car…

This early study tests a device that reads brain signals and stimulates the spinal cord to help people with cervical spinal cord injury move their arms and hands. Three participants will have electrodes implanted in their brain and over their spinal cord. The goal is to see if th…

This early study tests a brain-computer implant that reads brain signals to help people with severe paralysis (from ALS, stroke, or spinal cord injury) communicate. The device aims to decode imagined speech and allow control of computers. Only 2 participants will be enrolled to c…

This study tests whether baricitinib, a drug used for arthritis, can help people recover from moderate to severe traumatic brain injuries that involve bleeding in the brain. About 100 adults will receive the drug or a placebo within 24 hours of injury. The main goal is to see if …

This pilot study is testing whether a noninvasive device that sends mild electrical pulses through the skin to the spinal cord can help improve arm and hand function in people with stroke or spinal cord injury. Researchers will measure changes in nerve activity and movement skill…

This study looks at whether long-term electrical stimulation of the spinal cord can help people with chronic spinal cord injuries regain voluntary movement. Researchers will measure changes in muscle activity with and without the stimulation. The study involves 50 adults with sta…

This study tests a method to fine-tune epidural spinal cord stimulation in 100 adults with complete spinal cord injuries between C6 and T10. The goal is to help them regain voluntary leg movement and improve functions like blood pressure control. Participants must be at least 22,…

This study tests whether a spinal cord stimulator — a device that sends mild electrical pulses to the spinal cord — can help people with long-term bladder and bowel problems after a spinal cord injury. Ten adults with injuries older than 6 months will have the device implanted an…

This study tests whether a simple, home-based technique called remote ischemic conditioning can improve heart health in people with spinal cord injury. Participants will use a blood pressure cuff to briefly restrict blood flow to an arm, then release it, repeating this several ti…

This study tests whether starting leg cycling within the first week after a traumatic spinal cord injury can reduce complications like pneumonia and pressure sores, and improve nerve recovery. About 102 adults with recent spinal cord injuries will take part. The goal is to see if…

This study tests whether freezing specific nerves (cryoneurolysis) can reduce shoulder pain and improve movement in people with spasticity from conditions like stroke or brain injury. Fifty adults will either receive one session of nerve freezing or one session of Botox injection…

This study tests a new brain-computer interface called MindEx that uses four small chips implanted in the brain to help people with severe paralysis control a computer or tablet just by thinking. The goal is to improve independence and quality of life by allowing users to type, p…

This Phase 3 trial tests whether a single injection of tranexamic acid, given within 3 hours of a mild head injury, can reduce brain bleeding, disability, and death in adults aged 50 and older. The study aims to enroll 5,000 participants and compares the drug to a placebo. If suc…

This study is testing a robotic exoskeleton called TWIICE Rise to see if it is safe and practical for people with spinal cord injury to use for walking. The trial involves 15 participants and will take place in clinics, homes, and community settings. The goal is to assess how wel…

This study is testing a small device called KeyGrip that is implanted in the arm to help people with cervical spinal cord injury regain hand function. The device uses mild electrical pulses to activate paralyzed muscles, allowing hand opening and closing. Researchers will measure…

This early study tests whether a common diabetes pill, glyburide, can safely protect the spinal cord from further damage after a traumatic injury. Researchers will enroll 12 adults with acute spinal cord injury to check safety and see if the drug helps preserve nerve function. Th…

This early-stage trial tests a new device designed to deliver OPC1 cells directly into the spinal cord of people with traumatic spinal cord injuries. The study will enroll 10 participants with either recent or chronic injuries. The main goal is to see if the device and injection …

This study tests two non-invasive techniques to improve breathing in people with chronic spinal cord injury. Participants will receive spinal cord stimulation and breathe special air mixtures to strengthen breathing muscles. The study involves 20 adults with incomplete spinal cor…

This study is for adults over 21 with chronic spinal cord injury (more than a year) who have lost motor function. Researchers will implant a spinal cord stimulator and combine it with advanced robotic rehabilitation to see if it can improve movement, like walking. The main goal i…

This study tests whether a daily 30-minute nerve stimulation (TTNS) can prevent bladder overactivity that can damage kidneys after spinal cord injury. 114 patients with acute spinal injury will receive either real or sham stimulation for 6-9 weeks. The goal is to see if the treat…

This study tests whether a special egg yolk powder called Salovum can help people with severe traumatic brain injury. Half of the 20 participants get Salovum, the other half get a placebo. Researchers will measure brain pressure, oxygen levels, and inflammation to see if the trea…

This early study tests the safety and function of a brain-computer interface (BCI) implanted by a robot in people with severe paralysis. The device aims to let users control external devices like computers or phones using their thoughts. The trial enrolls 15 adults with quadriple…

This study tests whether a combination of a wearable robot suit, electrical spinal stimulation, and muscle-strengthening exercises can help people with complete spinal cord injury walk on their own. Twenty adults with paralysis from the chest down will train for months to see if …

This trial tests a device implanted in the arm that stimulates paralyzed muscles to help people with cervical spinal cord injury pick up and release objects. The study involves 13 participants and focuses on safety and how well the device improves hand function. It is an early-st…

This study tests a fully implanted neuroprosthetic device designed to improve hand, reach, and trunk function in people with cervical spinal cord injuries. Thirty participants will receive the device and be evaluated on their ability to perform daily activities with and without i…

This study tests a new spinal implant system (ARC-IM Lumbar) in 8 people with chronic spinal cord injury who already have a spinal implant. The goal is to improve walking, bladder, bowel, and sexual function, and make the system easier to use at home. Participants will be followe…

This Phase 2 trial tests whether sildenafil citrate (the drug in Viagra) can improve blood vessel function in the brain of people who had a traumatic brain injury (TBI) at least 6 months ago. Researchers will give different doses (20, 40, or 80 mg) or a placebo to 160 adults aged…

This study is testing a surgically implanted device that uses small electrical currents to stimulate nerves and muscles in the trunk and hips. The goal is to help people with spinal cord injury improve their seated posture, balance, breathing, reaching, and ability to push a whee…

This study tests a brain implant that records brain signals to help people with locked-in syndrome control a computer. Two participants will have 128 electrodes placed on their brain surface. Researchers will train them to use the system at home for one year, aiming for accurate …

This study tests whether a migraine drug called Eletriptan (TZ-161) can help people with recent spinal cord injuries. 28 adults with thoracic spinal cord injury will receive either the drug or a placebo for 6 days, alongside standard care. The goal is to check safety and see if i…

Researchers at a Baghdad hospital are comparing four trauma severity scoring systems, ISS, NISS, RTS, and TRISS, to see which one best predicts whether an injured patient will die in the hospital. The study follows 150 trauma patients admitted to the emergency department, calcula…

Researchers at Yale University are testing a PET imaging tracer called [18F]3F4AP to see whether it can measure demyelination, the loss of the protective myelin sheath around nerve fibers. The study includes healthy volunteers and people with conditions such as multiple sclerosis…

This study aims to create an objective way to diagnose and monitor light sensitivity by measuring facial features, pupil reactions, and nerve responses to light. Researchers will compare 120 people with and without light sensitivity (due to traumatic brain injury or migraine) to …

This study is testing whether a new ultrasound device called SYLVER can measure blood flow in the brain as accurately as the standard CT scan. It involves 50 ICU patients with brain injuries or bleeding. If it works, doctors could monitor brain health at the bedside without movin…

This study tests a digital tool called Neuralix, designed to assess memory and thinking skills in adults who have had moderate to severe head trauma. Researchers will check how well the battery detects cognitive issues in patients and compare results with healthy volunteers to se…

This study investigates whether a bedside ultrasound of the head, called cranial point-of-care ultrasound (cPOCUS), can accurately detect brain injuries in children who would normally receive a CT scan or MRI. The goal is to see if this safe, fast, and radiation-free tool could h…

This study tests whether two proteins in the blood, GFAP and UCH-L1, can help identify children with traumatic brain injury after a head injury. Researchers will compare blood levels of these proteins in children with different severities of head injury and check whether they mat…

This study will test a portable, low-field MRI machine to see how well it detects brain injuries from lack of oxygen or blood flow in children. About 200 kids in intensive care will get both a portable and a standard MRI. The goal is to find out if the portable version is accurat…

This study tests whether a portable, low-field MRI machine can detect brain injuries in children who are on ECMO (a heart-lung bypass machine). The MRI is brought to the bedside, avoiding the need to move critically ill children. Researchers will scan children at several time poi…

This study is testing a new device called Traq™ that measures how well both eyes work together, including fixation and eye movement speed. The goal is to see if these measurements can help tell apart people who have had a recent mild traumatic brain injury (concussion) from those…

This study looks at whether a simple blood test, called the fibrinogen-to-albumin ratio, can predict if someone with a traumatic brain injury will develop acute respiratory distress syndrome (ARDS), a serious lung condition. Researchers will measure these proteins in the blood of…

This study tests whether a very powerful 7 Tesla MRI can detect tiny brain injuries in people with post-concussion syndrome after a mild head trauma. Researchers will scan 100 patients one week after their injury and compare the results to standard tests. The goal is to see if th…

This study is testing a new device that scans the eyes to find signs of mild traumatic brain injury (TBI). The device looks at how the eyes move and focus, which can be affected by a brain injury. Researchers will scan 60 people with a recent head injury and 20 healthy volunteers…

This study is testing whether a set of computerized attention tests can identify attention problems caused by a concussion in young rugby players aged 11 to 25. Thirty athletes who recently had a concussion will take the tests, and their results will be compared to those of 60 at…

This study is testing whether a simple saliva test can help detect concussions in professional rugby players. Researchers will measure specific proteins and genetic material in saliva before and after matches, and compare them with impact data from special mouthguards. The goal i…

This study is testing whether a portable virtual reality headset can help diagnose and monitor traumatic brain injury (TBI) by measuring how the pupils react to light. Researchers will compare pupil responses in 150 people: those with mild to moderate TBI, those with other injuri…

This study is testing whether a new digital test battery, Mindmore Distance, can accurately assess thinking and memory skills in people with neurological conditions like stroke, Parkinson's, or multiple sclerosis. Researchers will compare results from home-based computer tests wi…

This study is testing a new device called TES HT100 that uses low-power electromagnetic waves to screen for brain injuries in adults coming to the emergency room with mild head trauma or certain neurological symptoms. The device is non-invasive, takes about 5 minutes, and gives a…

This study is testing a new device called Crainio that uses infrared light to measure pressure inside the skull without needing to insert a probe into the brain. Researchers will enroll 54 adults with traumatic brain injury who already require standard invasive monitoring. The go…

This study is working on a new way to diagnose concussions in athletes using a simple saliva test. Researchers will measure specific molecules in the saliva of 80 male athletes (professional, amateur, and occasional) before, during, and after exercise. The goal is to find reliabl…

This study is testing a new, 10-minute MRI sequence (3D FGAPSIR) to see if it can find more spinal cord lesions in people with multiple sclerosis than standard scans. Researchers will enroll 200 adults already scheduled for a spinal MRI. The goal is to improve detection of spinal…

This study looks at whether a blood test measuring two brain injury markers can safely rule out the need for a CT scan in people with mild traumatic brain injury. Researchers will compare a new management pathway using this test to standard care in 1,000 emergency room patients. …

This study tests a device called SENSE that uses low-power electromagnetic pulses to check for bleeding or swelling in the brain after a traumatic injury. Researchers will compare the device's results to standard CT scans in 150 adults, including those with and without brain inju…

This study is testing a device called HeadPulse that monitors brain signals to see if it can objectively detect when a concussion has fully resolved. Researchers are enrolling 150 people aged 4 and older, mostly athletes, who have had a concussion. The goal is to develop a tool t…

This study tests a program called COACH that trains youth football coaches on safer practice planning to reduce head impacts and concussions. Researchers will track head impacts and cognitive changes in 880 players over a season. The goal is to see if the program is both practica…

People who suffer spinal cord injuries face a high risk of dangerous blood clots, and doctors usually prescribe enoxaparin, a daily injection, to prevent them. This trial compares enoxaparin with apixaban, an oral blood thinner, in 60 adults recovering from spinal cord injury at …

This study tests whether giving a single dose of a common antibiotic soon after a breathing tube is placed can prevent lung infections and improve survival in ICU patients with severe brain injuries. Researchers will enroll 3,300 adults on ventilators due to stroke, trauma, or la…

This trial tests whether giving an inhaled medication called dornase alfa to severely injured patients on breathing machines can lower their risk of developing acute respiratory distress syndrome (ARDS), a serious lung condition. The drug is thought to break down DNA fragments re…

This study tests a decision support tool called CAPP-FIT to help prevent pressure injuries in people with spinal cord injury. About 808 veterans from 7 VA clinics will use a survey to identify risks, and providers get a report with recommended actions. The goal is to see if the t…

This study looks at whether adjusting deep brain stimulation (DBS) can improve movement, speech, and swallowing in people already implanted with DBS for conditions like tremor, stroke, or traumatic brain injury. Researchers will test hand dexterity, grip strength, facial movement…

This study tests whether taking branched chain amino acids (BCAAs) twice a day for three weeks can improve sleep in people with traumatic brain injury. Researchers will also check if the supplement is easy to take and if participants stick with it. The study involves 300 veterans…

This study tests whether an online program called Man Therapy can help male military members with anger problems, including those who have had a mild traumatic brain injury. About 226 participants will either use the program right away or wait. Researchers will measure anger, PTS…

This study tests whether cannabidiol (CBD), a compound from cannabis, can reduce urinary incontinence in people with recent spinal cord injury. Twenty adults with at least two leaks per day will take a purified CBD drug (Epidiolex) twice daily for 90 days. The main goal is to see…

Researchers are testing whether epidural electrical stimulation can improve bladder function in people with spinal cord injuries. The trial enrolls adults with injuries above T11 who have trouble urinating and rely on catheters. Participants receive an implanted spinal cord stimu…

This early-stage study is checking if insulin nasal spray is safe for people with spinal cord injury. Up to 12 adults who had an injury at least 4 months ago will use the spray or a placebo daily for up to 24 days. Researchers will monitor side effects and see if virtual training…

This study tests a behavioral training program that teaches people with chronic spinal cord injury to reduce a specific leg reflex. The goal is to decrease spasticity and improve walking speed and distance. 25 participants will train for about 6 months, with researchers measuring…

This study tests a mobile health app called iMHere 2.0 designed to help veterans with spinal cord injury and their family caregivers manage stress and improve well-being. Researchers will work with 100 participants to gather feedback and tailor the app to their needs. The goal is…

Researchers are testing whether combining transcranial random noise stimulation (tRNS) with neurofeedback can improve attention in adults who have sustained a brain injury from stroke, trauma, or lack of oxygen. Participants receive sessions that pair 10 minutes of tRNS with 20 m…

Researchers at Georgetown University are testing whether a mild electrical brain stimulation called transcranial random noise stimulation (tRNS) can boost the effects of visual training in people who have lost part of their vision from brain damage. The study includes 30 adults w…

Researchers at the University of Alberta are testing whether breathing pure oxygen for two minutes at a time can change sensation and movement in adults with long-standing, severe spinal cord injuries. The study enrolls 25 people aged 18 to 65 whose injuries occurred at least thr…

Researchers at the University of Louisville are studying children who have a cervical spinal cord injury that happened before or during birth. The study combines activity-based recovery training, which uses tasks like stepping and standing, with transcutaneous spinal cord stimula…

This study tests a small, home-use device that sends mild electrical pulses to a nerve in the leg (tTNS) to improve bladder control in 20 children with spina bifida who have neurogenic bladder. Half the kids will use the real device, half a sham device, for 30 minutes daily, 5 da…

This study tests whether simple exercises (like drinking water and breathing in a certain way) can improve sleep quality in 60 U.S. service members with obstructive sleep apnea. Some participants have also had a traumatic brain injury. The goal is to see if these exercises reduce…

Researchers at the University of Washington are testing whether non-invasive electrical stimulation of the spinal cord through the skin, combined with intensive physical therapy, can improve walking and standing in people with spinal cord injuries. The trial enrolls 20 adults wit…

This study tests whether taking high-dose branched chain amino acids (BCAAs) can help teens and young adults recover from a concussion more quickly. Researchers will compare recovery rates at 28 days between those taking BCAAs and those taking a placebo. The trial aims to enroll …

This study is for people with chronic back or leg pain who are already scheduled to get a spinal cord stimulator. Researchers want to see if a new method called telefitting can find the best stimulation settings faster and more effectively. Participants will try different stimula…

This study tests whether combining a gentle brain stimulation technique called tDCS with computer-based cognitive training can improve thinking and memory in people still having symptoms 3 to 12 months after a mild concussion. Thirty adults will receive 10 sessions over about 3 w…

This study tests whether high-dose aerobic exercise (over 150 minutes per week at a safe intensity) helps teens aged 13–18 recover faster from a concussion compared to standard care. Researchers will track symptom resolution, brain inflammation markers, and changes in anxiety and…

This study tests a new type of talk therapy for veterans and service members who have both PTSD and a mild or moderate traumatic brain injury. The therapy focuses on relaxation, stress management, and problem solving instead of asking patients to relive their trauma. The goal is …

This study tests whether a 12-week remote Qigong program is feasible and acceptable for adults with spinal cord injury who have chronic neuropathic pain. Participants will be randomly assigned to either practice Qigong via video or complete a short daily pain survey. The goal is …

This study tests a 12-week program where a person with traumatic brain injury and a close supporter work with a therapist to improve communication and emotional support. The goal is to reduce isolation and improve health. The study involves 60 participants and focuses on whether …

This study tests a 12-session group program called ENGAGE-TBI for adults who had a traumatic brain injury (TBI) at least 6 months ago. The program, led by an occupational therapist and a TBI survivor, focuses on social skills and problem-solving. Researchers want to see if it's p…

This study explores whether hypnosis can help people with stroke, traumatic brain injury, or multiple sclerosis improve their attention and reduce fatigue. About 48 participants will receive hypnosis sessions alongside standard care, while researchers monitor brain activity with …

This trial tests whether a more intensive exercise program with in-person follow-up and repeated treadmill tests helps people with post-concussion symptoms and headaches recover better than a program with only phone-based follow-up. Participants will exercise at a level just belo…

This study tests whether psilocybin (the active ingredient in magic mushrooms) is safe and tolerable for veterans with spinal cord injury who also have depression. Thirty participants will receive low, medium, or high doses and be monitored for side effects like pain, muscle spas…

This trial explores whether combining cognitive training with a gentle electrical brain stimulation technique, called tDCS, can help improve working memory in people who have had a moderate to severe head injury. Participants will go through a 5-month program that includes memory…

This study looks at whether starting physical therapy two weeks after cervical spine surgery helps adults with degenerative myelopathy recover walking, balance, and strength better than waiting six weeks. Twenty participants will be randomly assigned to start rehab at either two …

This study tests a smartphone app called CALM that teaches veterans with traumatic brain injury and PTSD strategies to improve focus, planning, and self-control. One hundred veterans and a family member or friend will be randomly assigned to use the app or receive brain health ed…

This study is testing a new online exercise program made specifically for people with chronic brain injury. Researchers want to see if it helps them be more active and feel more confident about exercising. Sixty adults with chronic brain injury will take part; half will use the n…

This trial tests whether brief, controlled episodes of breathing lowered oxygen — similar to being on a tall mountain — can improve leg strength and reaction time in people with incomplete spinal cord injury. Participants will receive different doses of this low-oxygen therapy or…

This trial tests whether a 3-month, home-based walking program can improve thinking skills like memory and processing speed in adults with traumatic brain injury (TBI). Participants will either start walking right away or wait 3 months. The study focuses on safety and whether peo…

This study follows veterans who completed 40 sessions of hyperbaric oxygen therapy (HBOT) for traumatic brain injury, post-concussive symptoms, or PTSD. Researchers want to see if improvements in thinking, mood, and daily function persist or even grow after treatment stops. Parti…

This study tests whether an 8-week virtual program of yogic breathing and meditation can improve breathing, fatigue, emotional well-being, and quality of life in adults with spinal cord disorders. Participants attend two coach-guided sessions per week via Zoom and complete questi…

This study tests whether a 12-week home-based shoulder strength training program can reduce pain and improve function in manual wheelchair users with spinal cord injury. Forty participants will start training either 3 or 12 months after leaving rehab. Researchers will track pain,…

Some people with severe traumatic brain injury appear unresponsive but may still be aware—a hidden state called cognitive motor dissociation. This pilot trial tests whether gentle electrical pulses delivered through clips on the left ear, stimulating two nerves at once (the vagus…

This study tests a non-invasive device that stimulates the vagus nerve (a key nerve in the body) to see if it can improve memory and reduce PTSD symptoms in veterans with mild traumatic brain injury. One hundred veterans will receive either active stimulation or a sham (fake) tre…

This study looks at whether daily growth hormone shots for 6 months can improve quality of life in veterans who have both mild traumatic brain injury and adult growth hormone deficiency. About 172 veterans aged 21-55 will receive either the hormone or a placebo. The main goal is …

This study tests whether training the brain-to-muscle pathway using transcranial magnetic stimulation (TMS) can improve arm and hand movement in people with incomplete spinal cord injury. Participants will undergo 30 sessions where TMS is used to strengthen the connection between…

This study tests whether watching projected arm movements (visual illusion) combined with physical exercise can improve hand and arm function, sensation, and pain in people with incomplete cervical spinal cord injury. Participants will be assigned to one of four groups: visual il…

This study tests a new treatment called ACTIVE that combines counseling (Acceptance and Commitment Therapy) with balance exercises for people with mild traumatic brain injury. Researchers want to see if it helps reduce dizziness and anxiety better than standard balance therapy al…

This pilot study tests a wearable device called MedRhythms that uses shoe sensors and headphones to deliver real-time rhythmic cues (like a musical beat) to help people with incomplete spinal cord injury improve their walking. Fifteen participants will use the device during super…

This study tests whether high-intensity walking therapy helps people with incomplete spinal cord injury walk better than standard rehab. About 25 adults who had a spinal injury within the past year will take part. Their walking speed, endurance, and daily activity will be measure…

This study tests whether sitting in front of a bright lightbox for 60 minutes each morning can improve sleep and overall well-being in veterans who have traumatic brain injury, post-traumatic stress disorder, and chronic pain together—known as the polytrauma clinical triad. The t…

This study tests whether early, symptom-guided therapy can prevent long-term complaints after mild traumatic brain injury. About 655 adults aged 18-70 will receive either physical/occupational therapy, psychoeducation by phone, or usual care. The goal is to reduce post-concussion…

This study tests whether a non-invasive brain stimulation technique called rTMS can reduce nerve pain, depression, and sleep problems in people with spinal cord injury. Researchers will compare two different rTMS protocols against a placebo in 63 adults. Participants continue the…

This study tests whether taking creatine supplements after a concussion helps people recover faster. Twenty adults aged 18–35 with a recent concussion will either take creatine or follow their usual diet. Researchers will track how many days it takes to become symptom-free and co…

This study tests a sleep health program for teens aged 10-19 who recently had a concussion. The goal is to see if better sleep helps symptoms go away faster and improves sleep quality, mood, and school engagement. Participants will be randomly assigned to the sleep program or sta…

This study tests whether adding robot-assisted arm and hand exercises to standard occupational therapy helps people with cervical spinal cord injury regain upper-limb function. Thirty participants will be randomly assigned to receive either standard therapy alone or standard ther…

This study tests whether 2-3 ten-minute visits from a trained therapy dog can reduce pain, anxiety, depression, and anger in adults hospitalized after a traumatic injury. Researchers will compare patients who get dog visits to those who only get a visit from a dog handler. The go…

This study compares two remote training programs for 300 people who have had a mild traumatic brain injury (concussion) and struggle with emotional awareness and regulation. One program teaches participants to recognize and label their emotions, while the other focuses on general…

This study tests whether electrical stimulation of the lower spinal cord, combined with rehabilitation, can help people with incomplete spinal cord injuries walk short distances and improve bladder and sexual function. Fourteen adults with stable, incomplete injuries will receive…

This study tests whether a low-volume nose resistance breathing exercise using an Acapella device plus an incentive spirometer can improve lung function and reduce shortness of breath, cough, and phlegm in people with cervical spinal cord injuries. Forty-two inpatients aged 18–38…

This study tests whether dialectical behavior therapy (DBT), a type of talk therapy, can help people with acquired brain injury manage emotional distress and challenging behaviors. 77 participants will receive standard care for 5 months, then DBT for 5 months, then follow-up. Res…

This study tests whether applying mild electrical stimulation to the skin over the spine, starting just 3 days after a traumatic spinal cord injury, is safe and might help patients recover movement. Fifteen adults with acute spinal cord injury will receive either real or sham sti…

This study tests a live, group tele-exercise program (TEEMS) for people with spinal cord injury. Researchers want to see if it improves exercise confidence, physical activity, and quality of life compared to watching pre-recorded exercise videos. The program is fully virtual to m…

This pilot study is testing whether a home-based virtual reality exercise program called VR-Move can improve fitness and quality of life in people with spinal cord injuries. Sixteen participants will use the VR system three times a week for 12 weeks. The goal is to provide an acc…

This small study tests whether a gentle, non-invasive brain stimulation technique called tACS can reduce nerve pain in people with spinal cord injury. Fourteen participants will receive either real or sham stimulation for 20 minutes. Researchers will measure pain levels and heart…

This study tests two different therapies to help people with ongoing memory problems after a concussion. One is traditional cognitive rehabilitation, and the other is a new cognitive-behavioral therapy (CBT) approach. Researchers want to see which one works better for improving h…

This study tests whether daily training with colored lights can reduce light sensitivity in people who have had a traumatic brain injury. Twenty participants will use a device at home for 20 minutes a day, first with a blue light and then with a red light, or vice versa. Research…

This study tests whether daily symptom tracking via smartphone can help teens with concussion get quicker access to specialty care. About 210 teens aged 13-18 who visit the emergency department with a concussion and are at high risk for long-term symptoms will report their sympto…

This study tests whether a week of accelerated brain stimulation (25 sessions over 5 days) can quickly reduce PTSD symptoms. It involves 132 adults with PTSD, including those with traumatic brain injury. The goal is to see if this fast-paced treatment works better than a placebo …

This study tests whether community health workers can help caregivers of people with traumatic brain injury (TBI) during the move from rehab to home. About 126 adult caregivers will get either standard support or extra help from a health worker starting before discharge. The goal…

This study tests whether giving calcitonin early after a spinal cord injury can lower the chance or severity of nerve pain. About 126 adults with a recent spinal injury will receive either calcitonin or a placebo. Researchers will track pain levels and side effects for up to a ye…

This study tests a powered leg brace called the Nomad in 36 people who have trouble walking due to conditions like stroke, multiple sclerosis, or spinal cord injury. Participants will use the brace at home for three months to see if it improves their walking speed, balance, and q…

This study tests two types of gentle stimulation—magnetic or electrical—applied over the lower back to help control bladder overactivity in people with spinal cord injury. Forty adults aged 18-65 who still have bladder leaks despite medication will receive 20 sessions over four w…

This pilot study tests whether a daily 10-minute paced breathing exercise (inhale 4 seconds, exhale 6 seconds) can help children and teens aged 9-18 recover from a concussion. Twenty participants will either do the breathing exercises at home for four weeks or receive usual care.…

This study tests whether a smartphone app and e-coaching can help people with spinal cord injury stick to exercise guidelines. About 50 participants will use either a basic or interactive app, and those who struggle may get extra coaching. The goal is to find the best way to boos…

This study tests whether a soft robotic glove called Carbonhand can help people with hand weakness from injury or nerve conditions perform daily activities at home. Five participants will use the glove for six weeks while researchers measure arm activity, grip strength, and well-…

This study tests a non-invasive device that sends mild electrical pulses to the ear to stimulate the vagus nerve. Researchers want to see if it can improve attention and memory in 30 veterans with traumatic brain injury, depression, or PTSD. Participants will try both the real st…

This study tests whether a 12-week pelvic floor muscle training program is practical and helpful for people with motor-incomplete spinal cord injury. Thirty participants will do exercises five times a week. Researchers will track how many people join, stick with the program, and …

This study tests a cognitive training program called GOALS for veterans who have had a mild traumatic brain injury (mTBI) and still have trouble with attention and daily tasks. The program teaches mindfulness and goal-management skills through real-life activities. Researchers wi…

This study compares a single dose of methadone to the standard drug remifentanil for pain control after brain surgery. About 40 adults having elective brain surgery will be randomly assigned to one of the two drugs. The goal is to see if methadone provides better pain relief and …

This small pilot study tests whether a combination of buspirone (an anxiety medication) and melatonin (a sleep aid) can improve depression and thinking problems in people who have had a traumatic brain injury. Ten adults with mild or moderate TBI and depression will take the comb…

This study tests a new approach for treating depression in people who have had a mild traumatic brain injury (concussion). Participants will receive a personalized cognitive training program combined with either real or sham brain stimulation over 4 weeks. The goal is to see if t…

This study is testing whether a web-based platform called Cognishine can help adults with cognitive and speech problems after a brain injury or stroke. Instead of using paper exercises, patients will do therapy on a tablet or computer. The goal is to see if this digital approach …

This study tests whether giving extra oxygen early after a spinal cord injury can help recovery. It involves 12 adults with recent traumatic spinal cord injuries who are on a breathing machine. The goal is to see if this treatment is safe and feasible, and if it improves oxygen l…

This study tests a safe, non-invasive treatment called transauricular vagus nerve stimulation (taVNS) for people with chronic whiplash. It uses mild electrical pulses through the ear to calm the nervous system and may reduce pain, disability, and stress. The trial will enroll 40 …

This study tests whether a semi-elemental liquid diet (a pre-digested formula) reduces stomach and bowel issues like vomiting, diarrhea, and bloating in patients with severe traumatic brain injury. About 100 adults will receive either the special formula or standard liquid nutrit…

This study is testing whether a non-invasive procedure called repetitive transcranial magnetic stimulation (rTMS) can safely reduce depressive symptoms in U.S. military service members and veterans who have had a concussion or mild traumatic brain injury. About 198 participants w…

This study tests whether a low glycemic diet and lower-body electrical stimulation can prevent blood pressure from dropping too low after meals in people with chronic spinal cord injury. Thirteen participants will try both a low and high glycemic diet, with and without electrical…

This study tests if a non-invasive spinal cord stimulation can improve blood pressure control in people with chronic spinal cord injury. Researchers will place electrodes on the skin over the spinal cord and stimulate different sites to see which works best. The goal is to help p…

This study looks at whether adding morning bright light therapy to cognitive training can improve thinking, daily function, and sleep in 144 veterans who have both mild traumatic brain injury and PTSD. Participants will receive either the light therapy or a placebo light device. …

This study tests whether a structured cognitive rehabilitation program (On-TRACC) helps adults with lasting memory, attention, and thinking problems after a mild traumatic brain injury or concussion. Participants will receive six telehealth sessions of either On-TRACC or a genera…

This study tests a new hands-free, self-balancing exoskeleton designed to help people with spinal cord injury walk again. Ten adults with paralysis or weakness in their legs will train with the device over several sessions. The goal is to see if the exoskeleton is safe and helps …

This study tests a portable virtual reality system that guides eye exercises to help veterans with mild traumatic brain injury improve their eye coordination. About 80 veterans will be split into two groups: one receiving active therapy and the other a sham version. The goal is t…

This study tests a magnetic brain stimulation technique called iTBS in 55 veterans aged 22-65 who have had a mild traumatic brain injury and struggle with impulsivity or suicidal thoughts. The treatment involves applying magnetic pulses to the front of the head over several sessi…

This study looks at whether pelvic floor muscle training is practical and helpful for people recovering from a spinal cord injury during inpatient rehab. Researchers will recruit 50 participants to do pelvic floor physiotherapy five times a week for six weeks. The goal is to see …

This study tests whether giving fluoxetine (Prozac) immediately after a serious injury can prevent depression, PTSD, and reduce pain and opioid use. About 200 adults with fractures or other bodily trauma will receive either fluoxetine or a placebo during their hospital stay. The …

This study tests whether using mild electrical pulses in the rectum can help people with spinal cord injury empty their bowels more quickly. Many with spinal cord injury have slow bowel movements and rely on a finger to stretch the rectum. The trial compares the usual method with…

This study looks at whether two physical therapy techniques—pulsed wound irrigation and electrical stimulation—can help heal pressure injuries (bedsores) in people with spinal cord injuries. Forty adults in rehab will receive one of three treatments: both techniques, irrigation a…

This study tests a safe, non-invasive technique called transcranial alternating current stimulation (TACS) to see if it can improve cognitive flexibility and decision-making in people who have had a mild to moderate traumatic brain injury (TBI). Researchers will enroll 30 adults …

This study tests whether goal-oriented cognitive training delivered via video calls can help veterans with mild to moderate traumatic brain injury (TBI) improve attention, planning, and daily functioning. 80 veterans with lasting cognitive difficulties will participate remotely. …

This study tests whether daily treatments with slightly elevated carbon dioxide (hypercapnia) can improve breathing and reduce sleep apnea in Veterans with spinal cord injury. About 30 adults with chronic spinal cord injury or able-bodied people with sleep apnea will receive the …

This study tests whether a brief behavioral treatment for insomnia (BBTi) — guided by a nurse or through a mobile app — can improve sleep, mood, and thinking in people recovering from traumatic brain injury (TBI). About 93 participants with chronic TBI and insomnia will be assign…

This study tests whether non-invasive spinal stimulation, used at home with exercise, can safely improve arm and hand function in people with recent cervical spinal cord injury. 46 participants will be randomly assigned to start the program immediately or after a 12-week delay. T…

This early study tests whether a 10-week brain stimulation and feedback training program can strengthen the connection between the brain and wrist muscles in people with chronic cervical spinal cord injury. Eleven adults with weak wrist extension will receive non-invasive brain s…

This study tests whether using mild electrical pulses on the belly muscles during a bowel program can cut down the time it takes. Fifteen adults with chronic spinal cord injury (above T11) will try the device at home and track their bowel routine times, quality of life, and any c…

This pilot study tests whether focused shockwave therapy can safely reduce arm spasticity in people with spinal cord injury. Twelve participants will receive three weekly sessions of sound waves applied to the forearm and elbow muscles. Researchers will measure changes in muscle …

This study looks at whether using special prismatic lenses along with computer brain games can help improve thinking and behavior in people who have had a traumatic brain injury. About 50 adults will take part, with half getting the lenses plus games and the other half getting ga…

This study tests whether breathing low oxygen, along with spinal cord stimulation and walking practice, can improve walking for people with chronic spinal cord injury. About 60 adults with some walking ability will take part. The goal is to see if these combined treatments can he…

This study is for adults aged 18–80 with chronic spinal cord injury who can already walk a little. It combines short periods of breathing low oxygen, spinal cord stimulation, and walking practice to see if it helps them walk better. The goal is to improve walking speed and endura…

This study tests a brain implant that lets people with severe paralysis control a tablet computer using only their thoughts. The goal is to help them communicate, use apps, and control smart devices, improving their quality of life. Up to 5 participants will be implanted and foll…

This study is testing a small, wearable device that sends a barely noticeable electrical current behind the ears to see if it can improve balance and walking in people still struggling with dizziness weeks after a concussion. About 32 adults aged 18 to 55 with persistent symptoms…

This study tests whether a gentle electrical stimulation of the spinal cord, combined with breathing exercises, can improve lung function in people with chronic spinal cord injury. About 36 adults will be split into three groups: breathing training alone, stimulation alone, or bo…

This study tests whether ketamine or fentanyl is better for pain relief in trauma patients with signs of shock. About 994 adults will receive one of the two drugs in the ambulance. Researchers will track survival at 24 hours and side effects like low oxygen or blood pressure.

This pilot study tests a 12-week workshop called STEP-Home-SP for veterans who recently left military service. The workshop teaches emotional regulation and problem-solving skills to help with reintegration and reduce suicide risk. Researchers will enroll 120 veterans to see if t…

This study tests whether a gentle electrical current applied to the skin over the spinal cord (called transcutaneous spinal cord stimulation) can safely improve walking in children aged 3 to 16 with incomplete spinal cord injury. Twenty children will receive either real stimulati…

This study explores whether a virtual reality version of a mindfulness program called VA CALM can help veterans with spinal cord injuries manage chronic pain. Ten veterans will try the program, and researchers will see if it's practical and acceptable. The goal is to make mindful…

This study tests a structured rehabilitation program for active-duty soldiers who have had a mild traumatic brain injury (concussion). The program includes low-intensity aerobic exercise, balance, and cognitive activities tailored to each soldier's symptoms and job demands. Resea…

This study is testing whether a mild electrical stimulation on the ear (called tAN) is safe and practical for patients in the ICU who have a traumatic brain injury. The researchers will check if the device can reduce inflammation in the blood and monitor changes in vital signs li…

This study tests if a gentle electrical pulse to the wrist nerve can safely help thinking and memory in people with recent traumatic brain injury. About 30 adults aged 18-64 with moderate injury will receive either real or sham stimulation. The goal is to see if this simple, non-…

This study tests a guided online version of cognitive behavioral therapy for insomnia in 80 people who have had a moderate or severe traumatic brain injury at least a year ago and currently have insomnia. Participants will either receive the online therapy (6 modules over 6-9 wee…

This study tests whether a gentle brain stimulation technique called tDCS can improve motor and thinking skills in children aged 10-15 who have had a mild concussion. Ten participants will receive tDCS and be evaluated with balance, coordination, and brain imaging tests. The goal…

This study is testing a non-invasive device called PNRT that uses gentle light and motion to help people with lingering dizziness and other symptoms after a mild traumatic brain injury. Researchers will enroll 80 adults to see if the device is safe, tolerable, and can reduce dizz…

This study tests a new rehab approach for people with incomplete spinal cord injury. It combines electrical muscle stimulation with augmented reality games during walking exercises. 70 adults aged 18-45 will be split into two groups: one gets the high-tech training, the other get…

This study tests a bilingual program called 1stBIEN for Hispanic children (ages 3-17) recovering from traumatic brain injury. The program provides in-person education, mobile videos, and a navigator to help families access outpatient care and school support. Researchers will meas…

This study tests whether a gentle, non-invasive brain stimulation (tDCS) combined with computer-based brain games can improve attention, memory, and decision-making in veterans aged 65 and older who have had a mild traumatic brain injury. Participants will do exercises from home …

This study tests a new rehab program called STAR-C for people with lasting cognitive issues after a mild traumatic brain injury (concussion). It compares three groups: in-person therapy, online therapy via telehealth, and a waitlist that gets no treatment. The goal is to see if S…

This pilot study compares a nerve-freezing technique called cryoneurolysis to standard Botox injections for treating pain and stiffness caused by spasticity in people with brain or spinal cord injuries, multiple sclerosis, or stroke. Fifty adults will be randomly assigned to rece…

This study tests whether combining a powered exoskeleton (a robotic leg brace) with functional electrical stimulation (small muscle zaps) can improve walking speed in people with chronic spinal cord injury. About 34 participants with incomplete injuries will be randomly assigned …

This study tests whether playing a virtual reality walking game at home can help reduce neuropathic pain in adults with chronic spinal cord injury. 250 participants with complete injuries will use a VR headset to see virtual legs walking from a first-person view. They will play t…

This study tests whether adding gentle electrical stimulation to physical therapy can help people who have had a severe stroke and developed muscle weakness in the ICU. About 24 participants will receive either standard therapy or therapy combined with functional electrical stimu…

This study tests whether adding a non-invasive spinal cord stimulation technique (TSCS) to standard rehabilitation can improve arm and hand function in people with a recent spinal cord injury. About 18 adults with cervical-level injuries will receive either real or sham stimulati…

This study tests a web-based program called webSTAIR, which teaches emotion regulation and relationship skills, for female veterans who have experienced military sexual trauma or intimate partner violence and also have a brain injury. The goal is to see if it helps them manage em…

This pilot study tests a new program called CRISP to help young adults aged 18-29 recover from concussion and manage headaches. The program focuses on support and recovery strategies. Researchers will measure how acceptable the treatment is and track changes in headache severity …

This study tests a safe, non-invasive brain stimulation technique (tDCS) that people can use at home while doing computer-based attention exercises. The goal is to see if it can improve complex attention in 160 active-duty service members and veterans who had a mild traumatic bra…

This study is testing a special suit called the Neuro20 that uses mild electrical pulses to stimulate muscles in the arms, legs, chest, and back. Researchers want to see if wearing it during therapy sessions can improve walking ability, muscle performance, and heart health in peo…

This study tests whether a technique called high-definition transcranial direct current stimulation (HD-tDCS) can improve word-finding difficulties in people who had a traumatic brain injury at least a year ago. The device delivers a very low electrical current through electrodes…

This study tests whether wearable sensors that give real-time feedback during physical therapy can help people with mild traumatic brain injury recover balance and movement better than standard therapy. About 100 adults aged 18-60 who are still having symptoms 2 weeks to 6 months…

This study tests whether taking probiotics or prebiotics daily for eight weeks can ease stomach and bowel problems in people with chronic spinal cord injury. Fifty participants will try both supplements in a crossover design, with a four-week break in between. The researchers wil…

This study tests whether a low-level electric current applied to the scalp (tDCS) can improve verbal retrieval in military veterans who have had a mild or moderate traumatic brain injury. 136 participants will receive either real or sham stimulation while doing memory tasks. The …

This study tests a short behavioral program called PST-Concussion for Veterans who have had a mild traumatic brain injury (concussion) and still feel distressed or have trouble thinking clearly. The program teaches problem-solving skills, goal-setting, and coping strategies in a …

This study tests whether an online program called SCI&U, which pairs people with trained peer health coaches, can help those recently discharged from inpatient rehab after a spinal cord injury. Participants will have up to 14 one-hour video sessions covering health topics like bl…

This study looks at whether combining a memory-training program with aerobic exercise can help people with moderate to severe traumatic brain injury (TBI) improve their learning and memory. Sixty adults with TBI will be randomly assigned to either memory training plus aerobic exe…

This study tests a wearable robotic arm exoskeleton to help people with spinal cord injuries improve arm and hand function. Nine tetraplegic inpatients will use the device for 12 weeks alongside standard rehab. Researchers will measure changes in arm strength, movement, and daily…

This study tests whether gentle electrical stimulation on the back can help stabilize blood pressure in people who recently had a spinal cord injury. Participants will undergo sit-up tests with and without stimulation to see if it prevents dizziness and keeps blood pressure in a …

This study tests whether mild electrical stimulation on the back can help stabilize blood pressure in people with chronic spinal cord injury who experience dizziness or fainting when sitting up. Five participants will have their blood pressure measured while tilted on a table, wi…

This study follows 65 infants who had a stroke around birth, tracking their brain development and motor skills over two years. Researchers use MRI scans, brain stimulation, and movement tests to find markers of recovery. The goal is to understand how the brain heals, which could …

This study looks at how deep brain stimulation (DBS) changes movement in people with conditions like Parkinson's disease or essential tremor. About 60 people scheduled for DBS surgery will have extra temporary electrodes placed on the brain to measure muscle activity during stimu…

This study looks at how people with moderate to severe traumatic brain injury (TBI) walk and navigate in complex, real-life-like virtual environments, such as streets with other people. Researchers want to understand the specific difficulties these individuals face during everyda…

Researchers at Xiangya Hospital are building a tool that uses several types of brain monitoring to predict whether patients with severe acute brain injury will be awake, comatose, or deceased 90 days after ICU admission. The study enrolls 200 adults aged 18 to 80 with conditions …

This study looks at how the Achilles tendon behaves during walking in people with spastic paresis, a condition causing muscle stiffness after stroke or spinal cord injury. Researchers will measure tendon stiffness, length, and volume using ultrasound and motion analysis. The goal…

This study tests whether short episodes of breathing low-oxygen air can improve breathing strength in people with chronic spinal cord injury. Participants will try three different breathing sessions (low oxygen, low oxygen with extra carbon dioxide, and normal air) to see which w…

This study tests whether a home-based computer training program can improve vision in people who have lost part of their visual field due to stroke, traumatic brain injury, or brain tumor. Researchers will use brain scans to understand how the brain changes with training. The stu…

Researchers are studying how aging and spinal cord injury affect two nerve pathways that help control leg movement: the corticospinal and reticulospinal tracts. The trial enrolls adults with chronic spinal cord injury and healthy controls. Participants receive transcranial magnet…

This study aims to see if a specially designed education module helps people with spinal cord injury (SCI) learn about their increased risk for heart disease, obesity, and metabolic problems. Researchers will enroll 250 adults with SCI and measure changes in knowledge, body weigh…

Women with spinal cord injury often deal with urinary incontinence, but most research has focused on women after menopause. This pilot study asks whether the natural drop in estrogen after ovulation could make incontinence more frequent. Twenty-four women will track their menstru…

This study looks at whether unconscious patients with brain injuries who show brain activity in response to music and language on an EEG are more likely to wake up and recover. Researchers will monitor 300 adults in the ICU, along with healthy volunteers, to see if these brain si…

This study looks at 40 veterans with chronic spinal cord injury to find any remaining nerve connections below their injury. Researchers will use MRI scans and non-invasive stimulation to measure these connections. The goal is to understand who might benefit from future treatments…

This study is testing a new device that aims to measure pressure inside the skull from the outside, avoiding the need for surgery. Currently, doctors must drill a hole in the skull to monitor intracranial pressure (ICP) in patients with conditions like traumatic brain injury or s…

This study is testing whether a mobile health app system can help people with chronic conditions like spinal cord injury, cerebral palsy, spina bifida, or traumatic brain injury improve their self-management skills and wellness. About 160 participants will use the app for one yea…

This study will compare live music therapy to recorded music in 10 children aged 1-18 with disorders of consciousness after severe brain injury. Over 10 days, researchers will measure changes in consciousness using a simple checklist and video recordings. Parents will also share …

This study is building a detailed collection of medical information and biological samples from 105 people with spinal cord injury. Researchers will track how injuries change over time, what complications arise, and how the body responds. The goal is to create a research platform…

This study follows over 2,500 teens aged 11 to 17 who come to the emergency room with a mild traumatic brain injury (mTBI). Researchers want to see if they develop new or worsening depression or anxiety in the months after injury. Teens and their parents fill out questionnaires a…

This study is looking at 800 veterans to see if mild traumatic brain injury (concussion) increases the risk of dementia later in life. Researchers will test memory, brain waves, brain scans, and proteins in blood and spinal fluid. The goal is to find early warning signs of diseas…

This study follows 185 adults in the Netherlands who are hospitalized with serious trauma injuries. Researchers will ask them to fill out short questionnaires about their quality of life, pain, fatigue, and daily functioning at several points over a year. The goal is to see wheth…

This study looks at adults who had a traumatic brain injury at least a year ago. Researchers want to see whether those with growth hormone deficiency have worse quality of life, fatigue, mood, and sleep than those without it. Participants complete questionnaires and a test for gr…

This study will test a new way to assess concussion in football players by having them perform cognitive and motor tasks right on the field, like counting whistles while dribbling. Researchers aim to standardize these 'ecological' tests so they can be used as a baseline before th…

This study will use a non-invasive ultrasound test called Transcranial Doppler to measure blood flow in the brains of 125 children in the Pediatric Intensive Care Unit. Researchers want to see how brain blood flow changes during critical illness and whether those patterns relate …

This study looks at whether people with long-term spinal cord injury who also have a condition called autonomic dysreflexia (sudden high blood pressure) have changes in their heart structure. Researchers will use MRI scans to compare two groups: 24 people with high-level injury a…

This study looks at adults with serious brain injuries from stroke, trauma, or bleeding who need a breathing machine. Researchers want to see if certain machine settings are linked to how severe the brain injury is. About 19 people will take part, and no new treatments are being …

This study looks at whether specific proteins released into the blood after a traumatic brain injury or cardiac arrest can help doctors assess damage and predict recovery. Researchers will collect blood samples from patients starting in the ambulance or emergency department and c…

This study will measure a protein called BD-tau in the blood of 100 people who have had an acute ischemic stroke. Researchers will take blood samples every hour for 48 hours to see how the protein levels change over time. The goal is to better understand brain injury patterns and…

This study aims to understand and improve fertility in men with spinal cord injury. Researchers will collect and analyze semen samples from participants to assess sperm count, motility, and other factors, and correlate these with patient characteristics. The goal is to help men w…

This study explores whether a measure called perfusion index (PI), taken from a pulse oximeter on the ear, finger, or toe, can reliably predict changes in blood pressure in people with spinal cord injury (SCI) during a cool temperature challenge. Participants with SCI and healthy…

This study explores whether two computer-based tasks can measure decision-making fatigue in people who have had a mild to moderate traumatic brain injury (TBI). Researchers will compare results from TBI patients with those from healthy volunteers to see if the tasks are practical…

This study tracks 90 coma patients in intensive care to see if their body's natural daily rhythms (like sleep-wake cycles) return as they wake up. Researchers will measure behavior, eye movements, temperature, and urine biomarkers every few hours. The goal is to better understand…

This study investigates how epidural spinal cord stimulation (EES) influences communication between the brain, spinal cord, and muscles in people with spinal cord injury. Researchers will record electrical signals from the spine, brain, and muscles during temporary stimulation to…

This study looks at 150 people who have had a brain injury from a stroke, bleed, or trauma. Researchers will track their sleep quality and mental health symptoms for up to a year using wrist monitors, brain activity sensors, and questionnaires. The goal is to understand if poor s…

This study monitors brain electrical activity and blood flow in critically ill patients with acute brain injury who are on a breathing machine. Researchers adjust the machine's pressure settings and perform lung reopening maneuvers, then use EEG and ultrasound to see how the brai…

This pilot study tests whether StimolIrpinia, a multimedia collection of local images, videos, and cultural information, can support cognitive rehabilitation in people with severe acquired brain injury. Ten hospitalized patients will use the tool in six 30-minute sessions over tw…

This study looks at whether a history of mild traumatic brain injury (like a concussion) is linked to biological changes in people with mild memory problems. Researchers will use a gentle brain stimulation technique and blood tests to explore this connection. The study involves 7…

This study compares two methods of training therapists to deliver an online emotion regulation program (Online EmReg) to people with traumatic brain injury (TBI). One group of therapists receives a 3-hour workshop only, while the other gets the workshop plus 3 months of bi-weekly…

This study investigates how the community of bacteria in the mouth and gut changes after sepsis or severe trauma in people who have been in the intensive care unit. Researchers will compare these patients to healthy individuals to see if microbiome disruption is linked to ongoing…

This study follows 500 children aged 8-17 who have had a concussion within the past week. Researchers track their symptoms, fatigue, social interactions, thinking skills, school needs, and biological markers like saliva inflammation and puberty hormones over a year. The goal is t…

This study tests whether gentle muscle vibrations can help the brain form new connections after a stroke or traumatic brain injury. Researchers will measure brain and spinal cord activity in 56 participants before, during, and after a 5-week vibration treatment. The goal is to un…

This study looks at whether a new blood test can help emergency room doctors better assess patients with mild traumatic brain injury (TBI). The test checks for brain injury markers in the blood and may reduce the need for CT scans. Researchers will study how well the test works i…

This study collects and stores brain tissue from adults who have had a traumatic brain injury and require surgery to remove a bruise on the brain. Researchers will analyze the tissue to understand the molecular and cellular processes involved in brain damage and repair. The goal …

This study looks at whether starting body-weight-supported treadmill training (BWSTT) at different times within the first 6 months after a spinal cord injury affects walking ability. 108 participants will be randomly assigned to start therapy within 60 days, 3 months, 6 months, o…

This study looks at whether a person's personality before a brain injury or stroke influences how well they recover thinking and memory skills. Researchers will follow 250 adults with severe acquired brain injury or stroke, testing their cognitive abilities, daily functioning, an…

This study follows 130 adults with moderate to severe traumatic brain injury to see if early problems with brain blood flow regulation are linked to thinking and memory problems one year later. Participants undergo brain scans and cognitive tests over the first year after injury.…

This study looks at whether two different training programs can improve emotional health in people who have had a moderate to severe traumatic brain injury. About 48 adults will take part in 8 one-on-one sessions over a month, learning either to recognize emotions or adopt health…

This study looks at whether certain proteins in the blood can help doctors monitor severe traumatic brain injury and predict who might benefit from hyperbaric oxygen therapy. Researchers will analyze blood samples from 150 patients already enrolled in a larger trial testing diffe…

This study compares brain health in 300 former professional football players (ages 29-59) to a similar group of men who did not play football. Participants will undergo cognitive tests, balance and eye-movement exams, sleep assessments, and high-resolution MRI scans. The goal is …

This study looks at 200 children with minor head trauma to see if family education, income, and health literacy influence parents asking for a CT scan. Doctors already have a rule (PECARN) to decide when a CT is needed, but parents sometimes request one anyway. The goal is to und…

Researchers at the University of Minnesota are developing a new scale to measure mental body representation—how people perceive and are aware of their bodies—in adults with spinal cord injury. The study involves 80 participants, including those with and without neuropathic pain, …

This early-phase study tests whether pairing brain stimulation with spinal cord stimulation can strengthen the signals that control hand muscles. Researchers will study healthy volunteers, people with spinal cord injury, and those with cervical myelopathy. The goal is to understa…

This observational study tests whether a non-invasive headband called fNIRS can measure brain activity in healthy adults and in people with disorders of consciousness, such as coma, after severe brain injury. Participants wear the headband while receiving gentle touch, listening …

This observational study is recruiting 140 people to see if a history of concussions or playing contact sports is more common in those with REM sleep behavior disorder (RBD) compared to those without. RBD causes people to physically act out their dreams. Participants will answer …

This study follows 2000 adults who are in a coma or have disorders of consciousness after serious brain injuries like stroke, cardiac arrest, or trauma. Researchers collect medical records and later interview survivors or their caregivers about physical and emotional recovery. No…

This study looks at how brain activity changes as people recover from a moderate to severe traumatic brain injury (TBI). It also tests whether giving a gentle electrical stimulation to the brain (called anodal transcranial electrical stimulation) early after injury can improve th…

This study is testing whether a robotic ultrasound device can safely and effectively monitor blood flow in the brains of people with severe traumatic brain injury. The device is designed to work automatically for long periods, even in hospitals with little ultrasound experience. …

This early-stage study tests a brain implant called BrainGate in just 3 people with severe paralysis or speech loss from conditions like ALS or spinal cord injury. The goal is to see if the device is safe and can let users control a computer cursor or other tools by thought alone…

This study looks at records of 500 patients admitted to intensive care units in Colombia to find out what factors are linked to death after severe trauma. Researchers will compare trauma patients with other ICU patients using a discharge database. The goal is to better understand…

This study tests a new way to stimulate the brain and a nerve in the arm at the same time to encourage the spinal cord to adapt and improve hand movement. It involves 20 healthy adults who will receive non-invasive stimulation while researchers measure muscle responses. The goal …

This study tests whether morning bright light therapy can improve sleep in 300 veterans with traumatic brain injury. Researchers will measure changes in inflammation, energy production in cells, and brain cleaning systems. The goal is to understand how better sleep might support …

After brain surgery, many patients need a breathing machine in the ICU. This study will follow 220 such patients to see how the natural bacteria in their lungs change over time. Researchers will collect airway samples and use advanced lab tests to link those changes to the risk o…

This study looks at how doctors decide to use brain CT scans for people with mild head injuries in emergency rooms. Many CT scans come back normal, exposing patients to unnecessary radiation and increasing costs. Researchers will analyze data from 2,500 adults across Italy to und…

This study looks at whether a breathing technique called acute intermittent hypoxia (AIH) increases spasticity (muscle tightness) in people with chronic spinal cord injury. Ten adults with incomplete spinal cord injury will receive AIH and have their reflexes and muscle stiffness…

This study is testing whether a non-invasive brain stimulation technique called iTBS, combined with computer-based attention training, can improve focus and daily functioning in people with persistent attention problems after a mild traumatic brain injury (mTBI), with or without …

This study uses a special PET scan to look at dopamine pathways in the brains of people who are in a coma after a severe head injury. Researchers will compare three groups: coma patients, patients who have recovered from coma, and healthy volunteers. The goal is to understand how…

This study tests a new computer system called SeeMe that can detect tiny movements in people with severe traumatic brain injury (TBI). Current exams may miss these movements, leading to misdiagnosis. The study will involve 60-80 TBI patients and aims to see if SeeMe can find sign…

This study follows 250 adults aged 65 and older who have had a mild traumatic brain injury (TBI), often from a fall. Researchers will check their thinking, physical abilities, mood, and sleep at 2 weeks, 3 months, 6 months, and 1 year after the injury. The goal is to understand h…

This study looks at how sleep problems—like trouble falling asleep or waking up often—affect people who have had a traumatic brain injury (TBI). Researchers will track sleep with a movement monitor and ask participants about their daily life and mental health. The goal is to unde…

This study is testing a new, non-invasive brain monitor (Neurosteer) in 100 ICU patients who are on breathing machines and sedatives. The monitor is a small device placed on the forehead that measures brain activity. Researchers want to see if it can accurately track levels of se…

This early study tests whether a brain implant can help people with severe paralysis from conditions like ALS, spinal cord injury, or stroke control devices using their thoughts. The implant records brain signals to decode text or synthesized speech. Only 3 adults will participat…

This study tests whether brain-computer interfaces (BCIs) can be used at home by children aged 5-18 with severe physical disabilities, such as cerebral palsy or brain injury. Families receive a BCI kit and participate in 12 virtual coaching sessions over 3-6 months. The goal is t…

This study explores whether a non-invasive brain-computer interface (BCI) can help people with motor disorders, such as spinal cord injury or stroke, control assistive devices using their thoughts. Researchers will record brain signals with EEG and use machine learning to interpr…

This study looks at how different types of anesthesia change blood flow and oxygen use in the brains of children. Up to 1,000 kids having an MRI scan will be asked to join. The goal is to learn more, not to test a new treatment.

This study aims to better understand the link between motor (movement) and cognitive (thinking) problems in people with brain damage from conditions like cerebral palsy or stroke. Researchers will assess 400 participants aged 3 to 90 using robotic tools and standard tests. The go…

This study looks at how a traumatic brain injury (TBI) can lead to heart problems like irregular heartbeat or heart failure. Researchers will use MRI scans to see if damage to certain brain areas disrupts the network that controls the heart. By studying 90 people with mild to mod…

This study will track how often and how intensely patients with moderate to severe brain injury are moved or exercised while in intensive care units in Scandinavia. Researchers want to see if more movement is linked to better outcomes and safety. About 198 adults on breathing mac…

This study tests a non-invasive light sensor placed on the back to monitor blood flow to the spinal cord during major aortic surgery. The goal is to see if it can quickly detect problems that could lead to paralysis. About 120 adults having planned aortic repair will take part. I…

This study looks back at the last 10 years in Denmark to understand how many people use breathing machines at home through a tube in their windpipe. Researchers will track which diseases lead to this need and how many patients survive one year after starting. The goal is to spot …

This study looks at how spinal cord injury changes the gut's nervous system and intestinal barrier. Researchers will take colon biopsies from 40 people with spinal cord injury and compare them to healthy controls. The goal is to understand gut problems after injury and find possi…

This study tests whether a remote training program can help manual wheelchair users improve their skills. Researchers will train peer coaches, then enroll 132 wheelchair users to receive either remote feedback training or be placed on a waitlist. The goal is to see if remote trai…

This study is developing a checklist to help doctors decide when it's safe to skip a CT scan for head injuries in patients taking blood thinners. Researchers will study 4,000 emergency department patients to find out which symptoms or signs reliably rule out serious brain bleedin…

This study looks at how spinal cord stimulation combined with physical training can change the way nerves work in people with spinal cord injuries. Researchers will measure brain-to-muscle signals and reaction times in 120 participants to understand if these changes lead to bette…

This study follows 110 people with moderate to severe traumatic brain injury (TBI) for up to 3 years to see how their brains change compared to healthy individuals. Participants will give blood samples, have MRI scans, and take thinking and memory tests. The goal is to measure ho…

This study compares two types of spinal stimulation—transcutaneous (through the skin) and epidural (implanted via surgery)—to see how they help people with spinal cord injury generate leg force and stand with support. Sixty adults aged 22-75 who cannot stand independently will pa…

This study looks at how a 2-week, personalized therapy program helps children aged 4-12 with conditions like cerebral palsy, autism, or genetic disorders. Kids get about 2.5 hours of tailored therapy each day, focusing on skills like movement, attention, and communication. The go…

This study aims to see if updated criteria for activating trauma teams can reduce mistakes—either calling a team when not needed (over-triage) or missing a serious case (under-triage). Researchers will compare data from 5,000 trauma patients before and after the new rules were pu…

This study follows 350 adults with major injuries admitted to intensive care. Doctors will use a non-invasive bedside ultrasound to check blood flow in the kidneys and liver at several time points. The goal is to see if certain ultrasound patterns are linked to acute kidney injur…

This study looks at how eating a high-fat meal affects pain sensitivity and inflammation in people with chronic spinal cord injury. Researchers will compare a high-fat meal to a moderate-fat meal in 40 adults. They aim to understand links between body composition, diet, and pain.

This study looks at how changes in muscles and the brain are linked in aging and diseases like ALS, Alzheimer's, and Parkinson's. Researchers will compare healthy older adults with those who have these conditions to find early signs of disease. The goal is to better understand ri…

This study examines the role of the plantaris, a small calf muscle, in children having surgery for tight ankles (equinus). Researchers will randomly change the order of tendon cuts during surgery to measure how much each contributes to ankle movement. The goal is to understand if…

This study looks at two different methods to check consciousness in people with severe brain injuries. The goal is to see if a shorter, simpler test works as well as the longer standard one. About 110 patients will take part, and the results could help doctors make better treatme…

This study will enroll 188 trauma patients in Iraq to see how well three scoring systems (EMTRAS, REMS, and GAP) predict who will die, need a breathing tube, or stay longer in the hospital. Researchers will calculate each patient's score upon arrival and track their outcomes. The…

This study tests whether a simple procedure called remote ischemic preconditioning (RIPC) — briefly restricting blood flow to an arm or leg — can reduce brain injury after non-cardiac surgery. The trial will include 216 older adults at risk for postoperative delirium. Researchers…

This study looks at how a concussion (mild traumatic brain injury) before age 6 might change brain structure and behavior. Researchers will use MRI scans to compare 30 children who had a concussion with 30 children who had a limb injury. The goal is to better understand the short…

This study compares two scoring systems (TTSS and TRISS) to see which better predicts outcomes like death or ICU admission in people with chest injuries. Researchers will assess 150 patients in the emergency room and track their hospital course. The goal is to find the most accur…

This observational study looks at how acquired brain injury affects speech and breathing in adults with dysarthria. About 100 participants will have their voice recorded and take breathing tests. The goal is to find better ways to identify the severity and type of dysarthria, hel…

This study explores whether breathing slightly higher levels of carbon dioxide (CO2) can safely increase the movement of proteins from the brain into the blood, which may indicate better waste clearance. Researchers will compare healthy adults and those with a history of traumati…

This study aims to understand how upper-limb assistive devices—like grasping gloves, mealtime aids, and robotic arms—impact the daily lives of people with motor impairments. Researchers will interview and survey 150 regular users (including those with stroke, spinal cord injury, …

This study looks at a condition called augmented renal clearance (ARC), where the kidneys work too fast and flush out medications before they can help. It involves 512 adults in intensive care with severe brain injuries, strokes, seizures, or meningitis. Researchers will measure …

This study aims to understand how muscles change over time in children with spastic cerebral palsy. Researchers will use 3D ultrasound to measure muscle size, length, and quality in 229 children. The goal is to link these changes to brain injury and treatments, helping improve fu…

This study watches 148 adults with acute brain injury who have a drain in their head. Researchers will check fluid from the brain to see if changes in a substance called lactate can signal an infection early. The goal is to learn more, not to test a new treatment.

This study compares Advanced Trauma Life Support (ATLS) training for doctors against usual care to see if it improves survival in adult trauma patients. Over 4,000 patients from hospitals in India will take part. The goal is to find out if this widely used training actually saves…

This study tests whether combining non-invasive brain and spinal cord stimulation during a movement task can improve hand function and thinking in people with stroke or spinal cord injury. 45 participants will receive both types of stimulation separately and together to see if th…

This study looks at whether monitoring specific brain wave patterns (called spreading depolarizations) in real time can help doctors choose treatments to reduce these events after severe traumatic brain injury. About 72 people who need emergency brain surgery will be randomly ass…

This study is testing a new questionnaire called the Pressure Relief Frequency Scale (PReFS) to see if it can reliably help wheelchair users with neurologic disorders (like spinal cord injury, stroke, or traumatic brain injury) decide how often they need to relieve pressure to pr…

This study looks at whether intensive upper-limb training, started within 13 weeks of a cervical spinal cord injury, can trigger changes in the brain and nerves that improve arm and hand function. Researchers will measure brain activity, nerve signals, and motor skills in 44 part…

This study tests whether cognitive remediation—brain exercises with coaching—can improve thinking skills and reduce aggression in 30 forensic inpatients with conditions like psychosis, ADHD, or substance use. Participants will do exercises and be compared to an active control gro…

This study follows 60 infants at high risk for Cerebral Visual Impairment (CVI), a brain-based vision problem often missed until later childhood. Researchers will collect data from clinical exams, brain scans, and vision tests up to 24 months of age. The goal is to create a model…

This study tests two types of brief, low-oxygen breathing treatments in 18 adults with recent spinal cord injury (2 weeks to 6 months after injury). The goal is to see which treatment better improves breathing strength and cough function. Researchers will also look at genetic dif…

This study tests a brain implant that reads signals from the brain to help people who have lost the ability to speak fluently communicate through a computer just by trying to talk. It involves up to 2 participants with conditions like spinal cord injury or ALS. The main goal is t…

This study watches 250 adults who are unconscious after a cardiac arrest to see if early brain tests can predict when they will wake up. Researchers use tools like EEG and ultrasound to monitor the brain. The goal is to find reliable signs of recovery, not to test a new treatment…

This study looks at why blood vessels may not work as well after a spinal cord injury, which can raise the risk of heart attacks and strokes. Researchers will measure blood flow and study tiny particles from blood vessel cells in 40 adults with and without spinal cord injuries. T…

This study is testing several non-invasive methods—like pupil checks, EEG, and ultrasound—to see if they can detect life-threatening brain swelling earlier than current methods. Researchers will monitor 720 patients with acute brain injuries in the ICU. The goal is to find reliab…

This study looks at how spinal cord injury (SCI) affects a person's sense of their own body, known as embodiment. Researchers will use questionnaires and brain scans (fMRI) to compare 80 people with and without SCI. The goal is to understand why some people with SCI feel disconne…

This study uses powerful MRI scanners to look at the brains and spinal cords of 700 people, including healthy volunteers and those with conditions like multiple sclerosis, Alzheimer's, and Parkinson's. The goal is to understand why some brains stay healthy while others decline. R…

This study tests whether a simple clinical score can help doctors decide when to safely remove breathing tubes from brain-injured patients who are still unconscious. The trial will include 660 adults with acute brain injuries who have been on a ventilator for more than 48 hours. …

This study is testing a new monitor that tracks brain pressure over time in patients with serious brain injuries like trauma or bleeding. Researchers want to see if the pressure measurements can predict who will survive or recover well. The study will enroll 250 adults and follow…