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Can Mountain-Air breathing boost leg strength after spinal injury?

NCT ID NCT07739992

Symptom relief Sponsor: Milap Sandhu Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now This study
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jul 31, 2026 · Last updated Jul 31, 2026

Summary

This trial tests whether brief, controlled episodes of breathing lowered oxygen — similar to being on a tall mountain — can improve leg strength and reaction time in people with incomplete spinal cord injury. Participants will receive different doses of this low-oxygen therapy or a sham version, and researchers will measure ankle force and response speed to find the most effective dose. The study also looks at how the body responds to low oxygen to understand why results may vary between individuals.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
Acute intermittent hypoxia (AIH) — brief, controlled episodes of breathing lowered oxygen through a mask, compared with sham (room air)
What this could lead to
If it works, this could point toward a simple, drug-free breathing technique to boost leg strength and movement speed in people with incomplete spinal cord injury.
What could go wrong
The trial is small and early, and it is testing different doses to see which works best — so it may not find a clear winner. Breathing low oxygen carries risks like low blood oxygen levels, and people with certain health conditions are excluded.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

About 40 people

The number the study aims to enrol. It can still change while the study runs.

Started

Jul 2026

Expected to finish

Jul 2028

An estimate. End dates often move.

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 to 75 years

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Chronic Spinal Cord Injury (\>6 months) * Motor incomplete SCI classified as AIS C or D * Volitional ankle plantarflexion strength in at least one leg Exclusion Criteria: * Uncontrolled hypertension (outside 140/90 and 90/60) * Concurrent medical illness * Traumatic brain injury * Cardiovascular complications * Pulmonary complications * Metabolic dysfunction * Continued use of anti-spasticity medications * Previously diagnosed obstructive sleep apnea

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Conditions

The condition(s) this trial relates to.

spinal cord injury

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Spinal cord injuries (SCI)

How to take part

Only the study team decides who joins. These are the ways to reach them.

  1. The places running it

    1 site. The list below names each one and where it is.

  2. The official record

    ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.

    Open the record ↗

  3. A doctor treating you

    A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.

Contacts and locations

Locations

  • Shirley Ryan AbilityLab

    RECRUITING

    Chicago, Illinois, 60611, United States

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