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Your personality may shape how you recover from a brain injury

NCT ID NCT07119827

Knowledge-focused Sponsor: Universita di Verona Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now This study
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jul 02, 2026 · Last updated Jul 02, 2026

Summary

This study looks at whether a person's personality before a brain injury or stroke influences how well they recover thinking and memory skills. Researchers will follow 250 adults with severe acquired brain injury or stroke, testing their cognitive abilities, daily functioning, and personality changes over a year or more. The goal is to understand if certain personality traits help or hinder recovery, which could lead to more personalized rehabilitation plans.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

What this could lead to
If successful, this could help doctors predict recovery patterns and tailor rehabilitation based on a patient's personality.
What could go wrong
This is an observational study, so it cannot prove cause and effect. Personality is just one of many factors influencing recovery.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Participants

About 250 people

The number the study aims to enrol. It can still change while the study runs.

Started

May 2025

Expected to finish

May 2028

An estimate. End dates often move.

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Who is studied

Consecutive patients admitted to the Neurorehabilitation Unit (UOC) of AOUI Verona (and collaborating centers) will be enrolled in this study.

Ages

18 to 80 years

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * diagnosis of one of the following two conditions: * Severe Acquired Brain Injury (sABI) of traumatic or non-traumatic etiology; the term sABI includes acute brain injuries of traumatic or non-traumatic origin (vascular, infectious, metabolic, or anoxic), in which the patient initially presents with a coma state (Glasgow Coma Scale - GCS less than 8) and simultaneously exhibits motor, sensory, cognitive, and/or behavioral impairments. * Ischemic or hemorrhagic stroke without features of Severe Acquired Brain Injury (sABI) (Glasgow Coma Scale \[GCS\] score ≥ 8 and no alteration of consciousness). * Time from injury between: * 7 and 90 days for Severe Acquired Brain Injury (sABI) patients * 3 and 30 days for stroke patients * Level of Cognitive Functioning (LCF) score ≥ 6 for sABI patients * Signed informed consent for study participation * Presence of a support family member (caregiver) able to assist with completing the personality questionnaire (HEXACO Adjective Scale, HAS) Exclusion Criteria: * Pre-existing neurological pathology * Severe aphasia or severe inattention that precludes administration of the tests required by the protocol, as identified during cognitive screening. * Patients with a language barrier due to insufficient proficiency in Italian. * Particularly vulnerable populations: The following patients will be excluded from the study: patients in emergency situations.

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Conditions

The condition(s) this trial relates to.

Behavior brain injury Cognition Disorders Neurologic Manifestations stroke disorder

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

ICTUS SABI Severe acquired brain injury

How to take part

Only the study team decides who joins. These are the ways to reach them.

  1. The places running it

    1 site. The list below names each one and where it is.

  2. The official record

    ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.

    Open the record ↗

  3. A doctor treating you

    A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.

Contacts and locations

Locations

  • Sezione medicina fisica e riabilitativa dipartimento di neuroscienze, verona

    RECRUITING

    Verona, VR, 37135, Italy

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