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Magnetic pulses to the brain may curb suicidal thoughts in veterans

NCT ID NCT05647044

Symptom relief Sponsor: VA Office of Research and Development Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now This study
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This study tests a magnetic brain stimulation technique called iTBS in 55 veterans aged 22-65 who have had a mild traumatic brain injury and struggle with impulsivity or suicidal thoughts. The treatment involves applying magnetic pulses to the front of the head over several sessions to see if it safely improves symptoms and daily functioning. It is an early-stage trial to gather safety and effectiveness data for future larger studies.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
intermittent theta burst stimulation (iTBS) - a magnetic pulse device applied to the head
What this could lead to
If it works, this could point toward a new, non-drug treatment for impulsivity and suicidal thoughts in veterans with mild traumatic brain injury.
What could go wrong
This is a very early Phase 1 trial with only 55 participants, so results may not apply broadly. The treatment is not yet proven effective for these specific symptoms, and there is a small risk of seizure or discomfort from the magnetic pulses.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Phase 1

The first testing in people. Mainly checks safety and dose, usually in a small group.

Participants

About 55 people

The number the study aims to enrol. It can still change while the study runs.

Started

May 2024

Expected to finish

Mar 2028

An estimate. End dates often move.

Lead sponsor

A government agency

The lead sponsor is a US federal agency other than the NIH.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

22 to 65 years

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * 22-65 years of age * can read and speak English * meets criteria for mTBI according to the symptom attribution and classification (SACA) scale * Has a C-SSRS (suicidal ideation rating) of \>1 within the past month * Has a history of impulsivity documented in the medical chart and/or a score of \>20 on the UPPS-P negative urgency impulsivity subscale Exclusion Criteria: * Has contraindications to iTBS (i.e., epilepsy) * Has contraindications to MRI (i.e., claustrophobia, ferromagnetic metal implants) * Has an active substance use disorder per the DSM-V criteria * Has a history of moderate to severe TBI * Has a history of non-traumatic neuroinjury (i.e., stroke, neurosurgery, hemorrhage) * Has a history of, or current psychosis not due to an external cause * Is pregnant * Has an active, unstable medical condition * Is within 12 weeks of a major surgery or operation * Is within 1 year of TBI

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Conditions

The condition(s) this trial relates to.

Brain Concussion brain disorder Brain Injuries, Traumatic brain injury Craniocerebral Trauma Impulsive Behavior psychiatric disorder Risk-Taking Self-Injurious Behavior Suicidal Ideation Suicide Suicide, Attempted traumatic brain injury

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Impulsivity Mild traumatic brain injury Suicidal ideation

How to take part

Only the study team decides who joins. These are the ways to reach them.

  1. The places running it

    1 site. The list below names each one and where it is.

  2. The official record

    ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.

    Open the record ↗

  3. A doctor treating you

    A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.

Contacts and locations

Locations

  • Edward Hines Jr. VA Hospital, Hines, IL

    RECRUITING

    Hines, Illinois, 60141-3030, United States

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