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New surgery could help paralyzed patients move again

NCT ID NCT04936620

Disease control Sponsor: St George's, University of London Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now This study
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 26, 2026 · Last updated Jul 07, 2026 · Updated 3 times

Summary

This study tests whether a surgical procedure called duroplasty can improve recovery after a severe spinal cord injury in the neck. The surgery involves opening the tough membrane around the cord and stitching in a patch to give the swollen cord more space. Researchers will compare standard surgery plus duroplasty to standard surgery alone in 222 adults, measuring changes in movement, sensation, and quality of life over a year.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
Duroplasty (surgical procedure to expand the dura around the spinal cord)
What this could lead to
If it works, this could become a new standard surgical treatment to improve recovery after severe spinal cord injury.
What could go wrong
This is a mid-stage trial with 222 participants, so results are not yet proven. The surgery carries risks like infection or further injury, and it may not improve outcomes more than standard care.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

About 222 people

The number the study aims to enrol. It can still change while the study runs.

Started

Oct 2021

Expected to finish

Jun 2028

An estimate. End dates often move.

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

16 years and older

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: 1. Age ≥16 years 2. Severe cervical (C2 - T1) traumatic spinal cord injury (AIS grade A-C) 3. Deemed to require and be suitable for surgery that includes laminectomy by local surgeon 4. Surgery within 72 hours of traumatic spinal cord injury 5. Able to provide informed consent or consultee declaration or proxy consent. Exclusion Criteria: 1. Dural tear due to traumatic spinal cord injury 2. Life-limiting or rehabilitation-restricting co-morbidities 3. Thoracic or lumbar traumatic spinal cord injury 4. Other central nervous system disease

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Conditions

The condition(s) this trial relates to.

palsy spinal cord injury

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Spinal cord injuries

How to take part

Only the study team decides who joins. These are the ways to reach them.

  1. The places running it

    29 sites in 12 countries. The list below names each one and where it is.

  2. The official record

    ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.

    Open the record ↗

  3. A doctor treating you

    A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.

Contacts and locations

Locations

  • 12 de Octubre University Hospital

    RECRUITING

    Madrid, Spain

  • Aarhus University Hospital

    RECRUITING

    Aarhus, Denmark

  • Addenbrooke's Hospital

    RECRUITING

    Cambridge, United Kingdom

  • BG Unfallklinik Frankfurt am Main

    RECRUITING

    Frankfurt, Germany

  • Hadassah Medical Center

    RECRUITING

    Jerusalem, Israel

  • Hull Royal Infirmary

    RECRUITING

    Hull, United Kingdom

  • Kepler University Hospital

    RECRUITING

    Linz, Austria

  • Klinik und Poliklinik für Neurochirurgie Universitätsklinikum Frankfurt, 60596 FRANKFURT AM MAIN

    RECRUITING

    Frankfurt, Germany

  • Kuopio University Hospital

    RECRUITING

    Kuopio, Finland

  • Leeds General Infirmary

    RECRUITING

    Leeds, United Kingdom

  • Masaryk Hospital

    RECRUITING

    Ústí nad Labem, Czechia

  • Midlands Centre for Spinal Injuries,

    ACTIVE_NOT_RECRUITING

    Oswestry, United Kingdom

  • National Spinal Injuries Centre

    ACTIVE_NOT_RECRUITING

    Aylesbury, United Kingdom

  • North West Regional Spinal Injuries Centre

    ACTIVE_NOT_RECRUITING

    Southport, United Kingdom

  • Pinderfields Hospital

    ACTIVE_NOT_RECRUITING

    Wakefield, United Kingdom

  • Queen Elizabeth Hospital Birmingham

    RECRUITING

    Birmingham, United Kingdom

  • Queen Elizabeth University Hospital

    RECRUITING

    Glasgow, United Kingdom

  • Queen's Medical Centre

    RECRUITING

    Nottingham, United Kingdom

  • Royal Infirmary of Edinburgh

    RECRUITING

    Edinburgh, United Kingdom

  • Salford Royal

    RECRUITING

    Salford, United Kingdom

  • Shaare Zedek Medical Centre

    RECRUITING

    Jerusalem, Israel

  • Sheffield Teaching Hospitals NHS Foundation Trust

    RECRUITING

    Sheffield, United Kingdom

  • Skåne University Hospital

    RECRUITING

    Lund, Sweden

  • St George's Hospital

    RECRUITING

    London, United Kingdom

  • St Mary's Hospital

    RECRUITING

    London, United Kingdom

  • St Polten University Hospital

    RECRUITING

    Sankt Pölten, Austria

  • The London Spinal Cord Injury Centre

    ACTIVE_NOT_RECRUITING

    London, United Kingdom

  • The Royal London Hospital

    RECRUITING

    London, United Kingdom

  • The Walton Centre

    RECRUITING

    Liverpool, United Kingdom

  • UZ Leuven

    RECRUITING

    Leuven, Belgium

  • Union Hospital, Tongji Medical College, Huazhong University of Science and Technology

    RECRUITING

    Wuhan, Hubei, China

  • University Hospital Salzburg

    RECRUITING

    Salzburg, Austria

  • University Medical Centre Ljubljana

    RECRUITING

    Ljubljana, Slovenia

  • Universität Klinik für Neurochirurgie

    RECRUITING

    Innsbruck, Austria

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