Palsy

This trial is testing a robotic exoskeleton called ABLE Kids to see if it is safe and practical for children who have trouble walking due to conditions like cerebral palsy, spinal cord injury, or muscle weakness. Fifteen children will use the device in up to ten one-hour training…

This trial tests whether using ultrasound to guide botulinum toxin injections into spastic leg muscles works better than the standard method of relying on touch and anatomical landmarks. Researchers will give 40 adults with spastic paraplegia two rounds of injections, one with ea…

This study tests a brain implant that records and stimulates brain areas to help adults with severe paralysis (from spinal cord injury, ALS, or stroke) control assistive devices like computers or wheelchairs. The main goal is to check safety, and researchers will also see if part…

This trial is testing an implantable wireless brain-computer interface (BCI) in people with tetraplegia caused by cervical spinal cord injury. The device is designed to read brain signals and translate them into commands to control external devices, such as a computer cursor or a…

This early study tests a brain implant system called BiCNS in 5 people with tetraplegia (paralysis from the neck down). The implant records brain signals and may allow users to control assistive devices like a robotic arm. The main goal is safety—making sure the device stays in p…

This early feasibility trial tests a system that implants tiny electrodes in the brain areas controlling movement and sensation, paired with electrodes in the arm and shoulder to stimulate paralyzed muscles. The goal is to let people with tetraplegia (paralysis of the arms and ha…

This trial tests whether a virtual reality (VR) gamified rehabilitation program, using Xbox Kinect, can improve functional mobility, balance, and trunk control in children with spastic diplegic cerebral palsy. Forty-two children aged 7-15 years with GMFCS levels II and III will b…

This trial compares two rehabilitation approaches—Modified Constraint-Induced Movement Therapy and Mirror Therapy—to see which better improves grip strength, manual dexterity, and spasticity in children with spastic hemiplegic cerebral palsy. The study involves 42 children aged 5…

This program gives children with brain disorders like cerebral palsy or stroke access to umbilical cord blood infusions. The treatment uses donated cord blood cells to help repair brain damage. Kids up to age 26 with normal immune function may qualify. The goal is to improve symp…

This trial compares two rehabilitation approaches—neurodevelopmental technique (NDT) and mirror therapy—to see which better improves coordination, leg function, and walking ability in people recovering from a sub-acute stroke. Forty adults aged 45 to 65 with hemiplegia (weakness …

This study tests an implanted electrical stimulation device designed to improve movement, standing, and walking in people with paralysis from spinal cord injury, stroke, multiple sclerosis, or traumatic brain injury. The device sends electrical signals to muscles in the trunk and…

This trial investigates whether playing virtual reality-based balance games can improve mobility and brain function in adults with cerebral palsy. Participants will receive standard physical therapy plus either VR games or traditional balance exercises over 8 weeks. Researchers w…

This study tests a wearable rehabilitation robot designed for stroke survivors with severe leg paralysis. The robot guides patients through motor relearning and passive stretching exercises while they are still in bed during the early acute phase after a stroke. The goal is to se…

This study tests two rehabilitation methods—proprioceptive neuromuscular facilitation (PNF) and task-oriented training (TOT)—alone or combined, to improve arm and hand function in children aged 6–12 with spastic diplegic cerebral palsy. Sixty-three participants will receive 45-mi…

This study tests whether robot-assisted hand training can improve hand function and brain activity in children with cerebral palsy. Participants use a device called Amadeo that moves their fingers in exercises and games. The trial measures changes in brain signals, hand strength,…

This study tests a surgically implanted device that uses mild electrical pulses to stimulate muscles in the legs and trunk. The goal is to help people with paralysis from spinal cord injury, stroke, or other conditions exercise, stand, step, and improve balance. Ten participants …

This trial tests a single injection of MELPIDA, a gene therapy that delivers a working copy of the AP4M1 gene directly into the spinal fluid of children with SPG50. SPG50 is a rare genetic condition that causes muscle stiffness, intellectual disability, and developmental delays. …

This trial tests a modified leg therapy for children ages 6 to 8 with hemiplegic cerebral palsy, a condition that affects one side of the body. The therapy uses a knee scooter to encourage use of the weaker leg during walking tasks. Researchers will measure changes in walking pat…

This study investigates whether a home-based, telehealth-supported program combining blood flow restricted exercise and transspinal stimulation can improve hand and arm function in people with chronic, incomplete tetraplegia. Participants will perform task-specific activities whi…

This study tests whether adding immersive virtual reality (VR) games to standard physical therapy helps teenagers with spastic diplegic cerebral palsy improve their balance and coordination more than therapy alone. Forty adolescents aged 10 to 19 will be randomly assigned to rece…

This study tests whether a surgical procedure called duroplasty can improve recovery after a severe spinal cord injury in the neck. The surgery involves opening the tough membrane around the cord and stitching in a patch to give the swollen cord more space. Researchers will compa…

This trial compares two rehabilitation techniques—constraint-induced movement therapy (CIMT) and proprioceptive neuromuscular facilitation (PNF)—to see which better improves hand dexterity in children with cerebral palsy. The study includes children aged 8 to 13 with moderate men…

This study compares two rehabilitation techniques—mirror therapy and modified constraint-induced movement therapy—to see which better improves arm function in people who had a stroke. Sixteen participants with hemiplegia (weakness on one side) will be randomly assigned to one of …

This early-stage trial tests a brain-computer interface called BrainGate for people with paralysis from conditions like ALS or spinal cord injury. A small sensor is placed in the brain to interpret movement-related signals, allowing users to control a tablet computer just by thin…

This study tests whether combining task-oriented training with functional electrical stimulation (FES) can improve balance and ankle strength in children aged 6-9 with hemiparesis (weakness on one side). Thirty-six children will participate in a structured exercise program three …

This trial tests a fully implantable brain-computer interface (BCI) in one person with a severe spinal cord injury (C1-C4). The device reads brain signals to control digital devices like computers or tablets. Researchers will visit the participant at home 1-3 times per week for a…

This early study tests a device that reads brain signals and stimulates the spinal cord to help people with chronic stroke move their arms and legs again. Only 3 participants will be implanted with electrodes on the brain and spine. The main goal is to check safety, but researche…

This study tests a brain-computer implant (Stentrode) for people with paralysis from motor neuron disease or similar conditions. The device is placed in a blood vessel near the brain and aims to let users control computers or assistive devices with thought. The trial focuses on s…

This pilot study is testing whether galantamine, a drug already approved for Alzheimer's disease, can safely reduce inflammation and treat metabolic syndrome in people with chronic spinal cord injury. The study will enroll 60 adults who use wheelchairs and have obesity-related wa…

This study tests whether placing a deep brain stimulation (DBS) device in the cerebellum is safe for 10 children and young adults (ages 7-25) with severe dyskinetic cerebral palsy. The device delivers electrical pulses to try to improve movement and spasticity. Researchers will a…

This study tests whether a smart ankle-foot orthosis (a brace that gives feedback on walking) can improve mobility in 60 children with cerebral palsy. Some participants can also choose to receive a single injection of 5-Azacitidine, a drug used in cancer, to see if it boosts the …

This study tests the safety and feasibility of the BrainGate2 system, a brain-computer interface. Tiny sensors are placed in the brain area that controls movement, allowing people with tetraplegia (paralysis of all four limbs) to control a computer cursor or other assistive devic…

This early-stage trial tests whether deep brain stimulation (DBS) of a brain region called the mesencephalic locomotor region can improve walking in people with incomplete spinal cord injury. Five participants will receive a DBS implant and be followed for safety and walking abil…

This study is testing whether nerve transfer surgery can help people with cervical spinal cord injury regain hand function. Forty participants who have already chosen to have the surgery will be followed for two years, with regular tests of hand strength, sensation, and movement.…

This study tests whether a 16-week program of spinal stimulation (using electrodes on the skin) combined with walking or activity training can improve movement in children with cerebral palsy. Some participants can also choose to receive a single injection of a drug called 5-Azac…

This study tests a brain implant that records activity from the motor cortex and stimulates the sensory cortex. It aims to help people with severe arm or hand impairment—due to spinal cord injury, stroke, or amputation—control external devices like computers. The trial focuses on…

This study looks at whether giving iron supplements to children with low iron before hip surgery can reduce their need for blood transfusions and improve recovery. The trial includes 180 children aged 0-18 who are scheduled for a specific type of hip surgery, many of whom have ce…

This study tests whether a telehealth program that coaches parents to use adaptive standers can improve physical activity, sleep, and endurance in children ages 1-6 with severe motor delays (like cerebral palsy). Twenty children and their parents will take part in 8 weeks of stan…

This study tests whether starting a personalized home therapy program early (before age 2) can improve motor skills in babies at high risk for cerebral palsy. Researchers will compare children who receive this early program with those who get standard care. The goal is to see if …

This early study tests a device that reads brain signals and stimulates the spinal cord to help people with cervical spinal cord injury move their arms and hands. Three participants will have electrodes implanted in their brain and over their spinal cord. The goal is to see if th…

This phase 3 trial tests a one-time gene therapy called MELPIDA for children with SPG50, a rare genetic disease that causes progressive paralysis and developmental delays. The study will give the treatment via a spinal injection to 24 children aged 4 months to 6 years and compare…

This study tests whether injecting a child's own bone marrow cells into the spine, combined with rehabilitation, can improve motor function in children with cerebral palsy from birth injuries. Sixty children aged 1 to 6 years will be randomly assigned to receive either the cell t…

This early study tests a brain-computer implant that reads brain signals to help people with severe paralysis (from ALS, stroke, or spinal cord injury) communicate. The device aims to decode imagined speech and allow control of computers. Only 2 participants will be enrolled to c…

This study tests a method to fine-tune epidural spinal cord stimulation in 100 adults with complete spinal cord injuries between C6 and T10. The goal is to help them regain voluntary leg movement and improve functions like blood pressure control. Participants must be at least 22,…

This study tests whether a virtual version of the Abecedarian Approach, an early childhood education program, can help children ages 0-5 who had a brain injury from lack of oxygen (HIE) or were born very prematurely. Researchers will enroll 225 families and measure parent satisfa…

This study tests whether giving botulinum toxin (Botox) injections early can prevent shoulder bone deformities in babies with obstetrical brachial plexus palsy, a nerve injury at birth. About 62 babies aged 10-11 months will receive either the injection or a sham procedure. The g…

This study tests whether freezing specific nerves (cryoneurolysis) can reduce shoulder pain and improve movement in people with spasticity from conditions like stroke or brain injury. Fifty adults will either receive one session of nerve freezing or one session of Botox injection…

This study tests a new brain-computer interface called MindEx that uses four small chips implanted in the brain to help people with severe paralysis control a computer or tablet just by thinking. The goal is to improve independence and quality of life by allowing users to type, p…

This early study tests a device called the Bidirectional Neural Bypass System in up to 7 people with tetraplegia (paralysis from the neck down). The device is designed to let users move and feel their hand and wrist again by bypassing the damaged spinal cord. Researchers will mea…

This study looks at whether nerve transfer surgery can improve arm function and quality of life in people with high-level cervical spinal cord injuries (tetraplegia). Thirty participants will receive standard nerve transfer surgery and be followed for up to 4 years. The goal is t…

This study is testing a robotic exoskeleton called TWIICE Rise to see if it is safe and practical for people with spinal cord injury to use for walking. The trial involves 15 participants and will take place in clinics, homes, and community settings. The goal is to assess how wel…

This study tests a surgery that moves a nerve from the neck to help people with arm weakness after a stroke. It is for those whose arm has not improved with rehab. The goal is to see if the surgery can improve arm movement and control.

This study tests a new device called SSMD to help people with arm weakness after a stroke or traumatic brain injury. About 150 adults will use the device in supervised sessions over 5-6 weeks. The goal is to see if it improves arm movement better than standard electrical stimulat…

This early-stage trial tests a new device designed to deliver OPC1 cells directly into the spinal cord of people with traumatic spinal cord injuries. The study will enroll 10 participants with either recent or chronic injuries. The main goal is to see if the device and injection …

This study is testing a personal exoskeleton that lets people with spinal cord injury walk hands-free and stay balanced on their own. Twelve participants with injuries at or above the T6 level will train with the device over several sessions. The goal is to see if the exoskeleton…

This study tests a hands-free, self-balancing exoskeleton designed to help people with spinal cord injury walk and perform everyday activities. The trial will enroll 24 participants who will train with the device over several sessions. Researchers will measure how quickly they ca…

This study tests whether a child's own bone marrow stem cells can safely improve movement and muscle control in cerebral palsy caused by lack of oxygen at birth. Fifty-eight children aged 1 to 10 will be split into two groups: one gets stem cell infusions right away, the other wa…

This study tests whether a daily 30-minute nerve stimulation (TTNS) can prevent bladder overactivity that can damage kidneys after spinal cord injury. 114 patients with acute spinal injury will receive either real or sham stimulation for 6-9 weeks. The goal is to see if the treat…

This study tests whether adding a preventive procedure (bilateral foraminotomy) during standard neck decompression surgery can lower the risk of C5 palsy, a rare complication that causes arm weakness and pain. About 480 adults with cervical myelopathy (spinal cord compression) wi…

This study tests whether midodrine, an oral medication that raises blood pressure, can help intensive care unit (ICU) patients stop needing intravenous (IV) vasopressors sooner. About 870 adults with dangerously low blood pressure who are already improving will receive either mid…

This study looks at how well a special intensive therapy called ACQUIRE Therapy works for children with motor problems caused by conditions like cerebral palsy, autism, or brain injury. The therapy involves many hours of play-based exercises each day, often with a cast or splint …

This early study tests the safety and function of a brain-computer interface (BCI) implanted by a robot in people with severe paralysis. The device aims to let users control external devices like computers or phones using their thoughts. The trial enrolls 15 adults with quadriple…

This study tests a therapy called VOJTA for children aged 2 to 6 with ataxic cerebral palsy, a condition that affects balance and coordination. The therapy uses gentle pressure on specific body areas to activate natural movement patterns. Researchers will compare VOJTA to standar…

This study tests whether dynamic surface exercise training (exercises on unstable surfaces like physio balls) can improve mobility, balance, and coordination in children aged 5-8 with diplegic cerebral palsy. 14 children will be randomly assigned to either the dynamic surface exe…

This study tests whether a child-friendly core exercise program, delivered via video, can improve balance and mobility in children aged 6-12 with spastic cerebral palsy. Half of the 54 participants will do the Fun-Core exercises at home 3 times a week for 8 weeks, while the other…

Neuralink is testing a brain-computer interface called the N1 Implant, placed by a robot, to help people with severe paralysis communicate. The study will enroll 6 adults with conditions like ALS or spinal cord injury who cannot speak or use their hands well. The main goal is to …

This study tests a wearable robotic exoskeleton designed to improve walking in children aged 3 to 17 with conditions like cerebral palsy, spina bifida, muscular dystrophy, or incomplete spinal cord injury. The device fits on the legs and can assist or resist movement during walki…

This study is testing a surgically implanted device that uses small electrical currents to stimulate nerves and muscles in the trunk and hips. The goal is to help people with spinal cord injury improve their seated posture, balance, breathing, reaching, and ability to push a whee…

This study tests a program called Therapy Together, where caregivers lead hand therapy exercises for young children with cerebral palsy who have limited use of one hand. The program lasts 8 weeks and aims to improve hand function and daily skills. Researchers will compare these c…

This study tests whether a smartphone's built-in accelerometer can reliably measure walking patterns in children aged 6 to 12 with unilateral spastic cerebral palsy. Thirty-five children will walk 10 meters at a comfortable speed while a smartphone secured at their lower back rec…

This study is testing whether simple wearable devices can accurately screen for sleep disorders in children with cerebral palsy. About 140 children aged 6 to 15 will wear the devices at home and then undergo a standard hospital sleep test. The goal is to see if the wearable metho…

This study is creating and testing a new questionnaire for caregivers to identify hip pain in children with quadriplegia who cannot communicate verbally. Researchers will first develop the questionnaire with input from experts and parents, then test it with 100 caregivers. The go…

This study is testing a new portable X-ray machine called Dynamic Digital Radiography (DDR) that takes 15 images per second to show how the lungs move and blood flows. Researchers at Brigham and Women's Hospital will use it on 230 ICU patients with various lung conditions to see …

This study tests whether giving magnesium sulphate to pregnant women at high risk of preterm birth can protect their babies from cerebral palsy. About 138 women between 32 and 35 weeks of pregnancy will receive either magnesium or a placebo before delivery. Researchers will then …

Researchers at the University of Washington are testing whether non-invasive spinal stimulation can temporarily reduce muscle stiffness and improve walking in people with cerebral palsy. The study includes 20 participants aged 4 to 65 who can walk for at least 10 minutes. Partici…

This study tests whether adding a non-invasive brain stimulation technique called repetitive transcranial magnetic stimulation (rTMS) to standard physical therapy can improve arm and hand function in people who have had a first ischemic stroke. Sixty-six adults aged 18 to 80 with…

This study tests a behavioral training program that teaches people with chronic spinal cord injury to reduce a specific leg reflex. The goal is to decrease spasticity and improve walking speed and distance. 25 participants will train for about 6 months, with researchers measuring…

This trial asks whether adding gentle nerve mobilization to standard PNF exercises can improve facial symmetry and movement in people with Bell's palsy, a condition causing one-sided facial weakness. Adults aged 15 to 60 with moderate to severe Bell's palsy will be randomly assig…

This study tests whether pairing electrical stimulation of the brain's hand area with stimulation of a wrist nerve can improve hand and arm function in adults with hemiplegic cerebral palsy (hCP). Researchers will measure changes in muscle responses and dexterity tasks like movin…

Children and teens with spastic or dystonic quadriplegia from cerebral palsy often need surgery to control severe muscle tightness that interferes with comfort, movement, and care. Doctors at Boston Children's Hospital are tracking outcomes for two approaches: implanted baclofen …

This trial tests whether botulinum toxin type A injections can improve lower-lip asymmetry in children with hemifacial microsomia, a condition where the lower lip moves unevenly during smiling or speaking. The study enrolls children under 18 with this condition and a crooked-mout…

This pilot study tests whether the Voiceitt app can help people with speech impairments caused by conditions like cerebral palsy, stroke, ALS, or Parkinson's disease communicate more effectively. Participants use the app to see if it improves speech clarity and daily communicatio…

This clinical trial investigates whether photobiomodulation, a non-invasive light therapy, can reduce muscle spasticity in adults who have had a stroke. About 42 participants with spastic hemiparesis will receive either active light therapy or a placebo treatment on their calf mu…

This study tests whether extracorporeal shock wave therapy (ESWT) can reduce spasticity—stiff, tight muscles—in the wrists of people who had a stroke at least six months ago. Researchers will give 32 participants either ESWT plus standard rehab or just standard rehab. They will u…

This study tests whether an intensive, activity-based walking training program can improve movement and quality of life for young children with cerebral palsy who cannot walk on their own. Nineteen children will either receive the training or continue usual care. The goal is to s…

This trial tests whether a home-based system combining a humanoid robot with virtual reality games can improve arm function in children with cerebral palsy. About 60% of these children have impaired arm use, and doing enough daily exercises is often boring and hard to stick with.…

This study tests whether adding a mild brain stimulation technique (tDCS) to a standard arm therapy (constraint-induced therapy) helps people who had a stroke more than therapy alone. Forty adults with chronic stroke and mild-to-moderate arm weakness will be randomly assigned to …

This trial tests whether delivering electrical pulses to spinal nerves can temporarily calm spastic muscles in children with cerebral palsy. Researchers will stimulate the dorsal root nerves during a planned surgery and measure muscle responses. The goal is to see if this stimula…

This study tests whether psilocybin (the active ingredient in magic mushrooms) is safe and tolerable for veterans with spinal cord injury who also have depression. Thirty participants will receive low, medium, or high doses and be monitored for side effects like pain, muscle spas…

This study tests whether special speech strategies, like pointing to letters or using rhythm, can help children with cerebral palsy speak more clearly. About 100 kids ages 7 to 17 will practice these techniques with a speech therapist and then have their speech recorded. The goal…

This study tests whether using a small electrical stimulation device on the skin near the genitals can help people with spinal cord injury control bowel accidents. Twelve participants will use the device at home for 6-8 hours daily over 4 weeks. The goal is to see if this approac…

This study tests a wearable ankle robot designed for early rehabilitation in patients with traumatic brain injury. The robot guides motor relearning and provides passive or active movement training, even for paralyzed patients. Researchers will measure improvements in ankle movem…

This study tests whether a free online program from the World Health Organization, called 'Doing What Matters in Times of Stress,' can help reduce anxiety and depression in employees of small and medium-sized Dutch companies. About 518 workers with elevated stress levels will eit…

This study tests a new, smarter electrical stimulation system to help people who have had a stroke walk better. The system uses a computer to adjust stimulation in real time, aiming to correct footdrop (when the foot drags). About 20 participants will compare this new system to a…

This study tests a new approach called ENGAGE, where children with disabilities (like autism or cerebral palsy) help set their own therapy goals. About 96 kids aged 5-12 and their therapists will be split into two groups: one using ENGAGE and the other using usual therapy. Resear…

This study tests whether training the brain-to-muscle pathway using transcranial magnetic stimulation (TMS) can improve arm and hand movement in people with incomplete spinal cord injury. Participants will undergo 30 sessions where TMS is used to strengthen the connection between…

This study tests whether a training program for therapists can help them use powered mobility devices with young children (ages 12-32 months) who have severe cerebral palsy. Therapists will learn how to use the devices during everyday routines at home or in early childhood settin…

This study tests a wearable neuroprosthesis that uses mild electrical stimulation to help stroke survivors open their hand. Two participants will use the device at home for one year to see if it improves daily activities and quality of life. The goal is to understand how well the…

This study tests whether a powered leg brace called Agilik can help children with cerebral palsy who walk with bent knees (crouch gait). Forty children will either use the device at home for 2 months or receive standard therapy. Researchers will measure changes in walking enduran…

This study tests whether repetitive transcranial magnetic stimulation (rTMS) can improve heart rate variability and quality of life in people who have had a stroke. 44 participants will receive either real or sham rTMS for 4 weeks. The goal is to see if this brain stimulation can…

This study compares a home-based telerehabilitation program (Tele-CPASS) to standard in-person therapy for improving arm and hand function after a stroke. Forty-two recent stroke survivors with arm weakness will be randomly assigned to receive 20 hours of either remote or in-pers…

This study tests a therapy called HABIT-ILE, which uses structured hand and leg exercises, to see if it can improve both motor skills and cognitive functions like memory and attention in children with spastic cerebral palsy. 42 children will receive 90 hours of therapy and be com…

This pilot study tests whether a 10-week treadmill training program combined with blood flow restriction (using cuffs on the legs) can safely improve walking speed in 13 children aged 8 to 18 with cerebral palsy. The children will walk on a treadmill three times a week, gradually…

This study tests whether gentle vibration on the face and neck can reduce drooling and improve muscle tone in children with cerebral palsy. Twenty children will receive either vibration plus standard therapy or a sham treatment. The goal is to see if this simple approach can ease…

This study tests whether using virtual reality at home can help people with recent facial palsy (within the last year) reduce involuntary facial spasms called synkinesis. About 100 participants will either use a VR self-rehabilitation program or follow standard rehabilitation exe…

This study tests whether adding a wearable vibratory device to standard physiotherapy helps improve arm function in people with hemiplegia (paralysis on one side) after a stroke. Thirty adults who had a stroke 3 to 6 months ago will be split into two groups: one gets usual therap…

This study tests whether home-based video games can improve speech clarity and arm movement in children with cerebral palsy. Fifteen children aged 8-17 will play specially designed computer games for 30 minutes a day, 5 days a week, for 8 weeks. Researchers will measure changes i…

This study tests whether a non-invasive sound wave procedure (focused ultrasound) can safely improve movement and quality of life in 10 children and young adults (ages 8-22) with dyskinetic cerebral palsy. The treatment targets a small area in the brain to reduce involuntary move…

This study is testing whether a non-invasive brain stimulation technique called rTMS, when combined with standard rehabilitation, can improve leg movement and reduce muscle stiffness in children with spastic diplegic cerebral palsy. The study will include 20 children aged 5 to 18…

This study tests a special hand device that helps people who had a stroke and cannot open their hand to grab things. The device is designed to let users control it themselves to pick up, move, and release objects like a glass or spoon. Researchers will compare how well 30 partici…

This early study tests a new spring made from surgical stitches to help people with facial nerve palsy close their eyelid. The spring is placed under the skin near the eyelid center, without attaching to bone. Ten adults who cannot blink due to nerve damage will try it, aiming to…

This study tests whether a gentle, quick spinal manipulation can improve heart rate variability in children with cerebral palsy. Twenty children will each receive both the real procedure and a sham (fake) version on separate days. Researchers will measure changes in heart rate pa…

This study tests whether adding motor imagery (mentally practicing movements) and action observation (watching movements) to standard physical therapy can improve gross motor function, upper limb skills, and quality of life in children with unilateral cerebral palsy. Forty-eight …

This study compares two types of therapy—sensory integration therapy and standard physical therapy—to see which one helps children with athetoid cerebral palsy improve their gross motor skills (like walking and balance). About 26 children aged 6 to 12 will take part. The goal is …

This study tests whether adding a sensory walkway to standard physical therapy can improve walking in children aged 5-7 with spastic diplegic cerebral palsy. 44 participants will either receive conventional therapy alone or conventional therapy plus sensory walkway training for t…

This study tests whether combining mirror therapy with a soft robotic glove can improve hand function in people who have had a stroke and have weakness on one side. 104 participants will be randomly assigned to receive either standard rehab, mirror therapy alone, the robotic glov…

This study tests a powered leg brace called the Nomad in 36 people who have trouble walking due to conditions like stroke, multiple sclerosis, or spinal cord injury. Participants will use the brace at home for three months to see if it improves their walking speed, balance, and q…

This study looks at whether a three-month stay focused on adapted physical activity can improve the physical fitness and quality of life of children with chronic illnesses, rare diseases, or disabilities who have become physically deconditioned. About 50 children aged 8 to 18 wit…

This study is testing a device called SynPhNe that stroke survivors can use at home to retrain their hand function. The goal is to see if it improves hand movement compared to standard care alone. The study will include 40 adults who had a stroke at least 6 months ago and have mo…

This study tests whether a non-invasive technique called transcutaneous spinal cord stimulation (tSCS), combined with specific arm and hand exercises, can improve upper limb function in children and young people (ages 12-21) with hemiplegic cerebral palsy. The treatment involves …

This study looks at whether a 10-week plan with a leucine supplement is practical for children with spastic cerebral palsy. It also checks for early signs of muscle growth using ultrasound. Only 5 children will take part to see if they can stick with the supplement and if it affe…

This study tests whether a new AI-powered algorithm can improve how people with chronic arm weakness from a stroke control a robotic arm brace. Participants will use both the standard control method and the experimental algorithm while moving blocks. The goal is to see if the new…

This study tests whether a 24-week Frame Running training program can improve physical function, daily activity, and quality of life in children aged 8-18 with cerebral palsy or similar physical disabilities. Participants start with a low-intensity 12-week period, then move to a …

This study tests a noninvasive spinal cord stimulation (tSCS) to improve walking and reduce muscle stiffness in 15 adults with hereditary spastic paraplegia (HSP), a rare nerve condition. Participants receive stimulation through skin electrodes on the lower back twice a week for …

This study tests a robot suit called Bambini Kids that helps children with cerebral palsy move their legs in a more natural way. The goal is to see if it is safe and can improve walking and daily activities. About 30 children aged 2 to 10 will take part. The robot provides repeti…

This study tests whether intradermal acupuncture (tiny needles placed under the skin) can improve eye surface symptoms like dryness and irritation in people with long-term facial paralysis. Researchers will compare the real acupuncture to a placebo needle in 78 adults aged 18-65.…

This study tests a new hands-free, self-balancing exoskeleton designed to help people with spinal cord injury walk again. Ten adults with paralysis or weakness in their legs will train with the device over several sessions. The goal is to see if the exoskeleton is safe and helps …

This study tests a new therapy called MOBILE to help children with cerebral palsy walk better. Fourteen children will try the therapy for 30 hours over 6 weeks. The goal is to see if the therapy is acceptable and helpful for children and families in a community setting.

This study is testing a device called MyHand 2 that helps people who have had a stroke use their affected hand better. The device is worn on the hand and assists with movement. Researchers want to see if it is easy to use and helpful for daily tasks. The study involves 60 adults …

This study tests whether doing eye exercises in virtual reality can help people with certain eye nerve palsies move their eyes more. The VR scene moves with the person's head while they do visual tasks. The goal is to see if this improves eye movement range. The study involves 40…

This study tests whether a mild, non-invasive electrical stimulation on the back (transcutaneous spinal cord stimulation) can reduce spasticity—stiff, tight muscles—in children with cerebral palsy. Researchers will compare spinal cord activity in 30 children with CP and typically…

This study tests whether a non-invasive brain stimulation technique called rTMS, followed by intensive arm training, can reduce muscle stiffness (spasticity) in children aged 7–18 with hemiplegic cerebral palsy. Twenty participants will receive either real or sham rTMS over 10 da…

This study looks at whether walking on a treadmill can improve how stroke survivors move. Many people who have had a stroke walk unevenly and have different skin temperatures on their affected side. The researchers will measure changes in walking speed, endurance, and body heat p…

This study tests whether a non-invasive device that gently stimulates a nerve in the ear can improve breathing muscle strength in people who had a stroke 1-3 years ago. Researchers will measure lung function in 50 participants before and after treatment. If successful, TAVNS coul…

This study tests whether adding task-specific electrical stimulation to standard physical therapy can improve upper limb gross motor skills in children aged 2 to 6 with spastic quadriplegia cerebral palsy. Thirty children will be split into two groups: one gets standard therapy, …

This early study tests whether a 10-week brain stimulation and feedback training program can strengthen the connection between the brain and wrist muscles in people with chronic cervical spinal cord injury. Eleven adults with weak wrist extension will receive non-invasive brain s…

This study tests whether a two-week intensive rhythmic dance program can improve learning ability in children with cerebral palsy. Six children aged 6-17 will take dance classes and be assessed repeatedly on motor, cognitive, and social goals. The goal is to see if dance, which c…

This study looks at whether adding whole-body vibration (standing on a vibrating platform) right before serial casting can improve ankle movement in children with cerebral palsy. About 45 kids aged 3-17 will do exercises with or without vibration before getting their weekly cast.…

This study tests whether remote ischemic conditioning (RIC) — brief cycles of cutting off and restoring blood flow to a limb — combined with balance training can improve balance and spinal reflexes in children with cerebral palsy (CP). Sixteen children aged 8-17 with mild to mode…

This study tests whether whole-body electrical muscle stimulation (WB-EMS) can help adults with neuromuscular diseases like ALS, SMA, and muscular dystrophy exercise safely. Because these conditions weaken the nerves that control muscles, traditional exercise is often too hard. W…

This study tests a brain implant that lets people with severe paralysis control a tablet computer using only their thoughts. The goal is to help them communicate, use apps, and control smart devices, improving their quality of life. Up to 5 participants will be implanted and foll…

This study looks at whether adding a single session of whole-body vibration to treadmill training can improve walking and reduce muscle stiffness in children with cerebral palsy. About 20 kids aged 6-17 who can walk will participate. The goal is to see if combining these therapie…

This small safety trial tests whether a non-invasive device that stimulates the vagus nerve through the ear can safely improve hand and arm function in 10 adolescents with spastic cerebral palsy. Participants will use the device during upper limb rehabilitation sessions. The main…

This early study tests whether a device that sends electrical pulses to muscles and the spinal cord can improve arm, hand, or leg movement in people with paralysis from spinal cord injury, stroke, or other nerve damage. Up to 64 participants will attend sessions five times a week…

This study tests whether adding neuromuscular electrical stimulation (NMES) to standard facial exercises helps people who have facial paralysis after a stroke. About 130 adults with first-time stroke and central facial palsy will be randomly assigned to receive either usual train…

This study tests two new methods to improve hand function in children with cerebral palsy: a virtual reality system called Leap Motion that uses hand-tracking games, and neuromuscular electrical stimulation (NMES) that uses mild electrical pulses to activate muscles. Thirty child…

This study is testing whether targeted ankle resistance training and a smart ankle assist device can improve walking in children with cerebral palsy (ages 8-21). Researchers will measure changes in walking speed, muscle activity, and endurance. The goal is to find better ways to …

This study compares two modern therapies—mirror therapy and virtual reality (VR)—to see which better improves arm function in people with hemiplegia after a stroke. Forty-two participants aged 18-75, who had a stroke 6-12 months ago, will be randomly assigned to one session of ei…

This study is testing a wearable robotic hand orthosis called MyHand-SCI for people with C6-C7 spinal cord injury. The device is designed to assist with hand and finger movement. Researchers will enroll 40 participants to evaluate how usable and helpful the device is. The goal is…

This study tests whether simple brain gym exercises—like drinking water, cross crawls, and deep breathing—can improve balance and quality of life in children aged 6 to 8 with spastic diplegia, a type of cerebral palsy. Forty-four children will be split into two groups: one doing …

This study tests whether immersive virtual reality (VR) therapy can improve cognitive, motor, and social skills in children aged 8 to 18 with ADHD, autism, or cerebral palsy. Participants will use the CAREN VR system, which provides interactive exercises with visual, sound, and t…

This study is testing whether Korean integrative medicine, including Chua therapy, can help people with Bell's palsy recover facial movement and emotional well-being. Researchers will follow 100 adults aged 19-69 who have had facial palsy for less than three weeks. The main goal …

This study tests whether adding playful nerve-gliding activities to standard physical therapy can improve hand grip strength and dexterity in children with cerebral palsy. About 34 children aged 6-12 will be split into two groups: one gets routine therapy plus play-based hand exe…

This study tests a 12-week supervised rehabilitation program for people with two rare genetic conditions that cause walking and balance problems (spastic ataxias). The program includes twice-weekly therapy sessions and once-weekly pool exercises. Researchers want to see if it red…

This study tests whether psilocybin, a psychedelic substance, is safe for people who had a stroke at least a year ago. Researchers will monitor blood pressure and other vital signs in 20 participants. The goal is to see if psilocybin can help with lingering symptoms like weakness…

This study looks at whether a robotic walking trainer, called Trexo, can help people with walking problems from conditions like cerebral palsy or brain injury. About 120 participants will use the robot in a hospital setting to see if it's practical and helps them reach their pers…

This study tests a new therapy that combines a brain-computer interface (BCI) with electrical stimulation to help children with cerebral palsy move their arms and hands. Eight children aged 12 to 17 will wear a cap that reads their brain signals, and when they imagine moving thei…

This study is testing a personal exoskeleton that helps people with spinal cord injury stand, walk, and move without using their hands. The device is self-balancing, so users don't need crutches or a walker. Researchers will see if 24 participants can complete walking tests and e…

This study tests whether wearable robotic gloves and virtual reality exercises can improve hand and arm function in people who have had a stroke. About 42 adults aged 30-60 with lasting hand weakness will be randomly assigned to standard therapy, therapy with a robotic glove, or …

This study looks at whether adding virtual reality therapy to standard rehabilitation and action observation therapy can improve arm and hand function in people who had a stroke 6 weeks to 6 months ago. About 38 adults will be split into two groups: one gets standard care plus ac…

This study tests an intensive 2-week rehabilitation program for children and teens with cerebral palsy. The program combines two proven therapies: one that encourages use of the weaker hand and another that trains both hands together. Researchers want to see if this approach impr…

This study tests whether a suprascapular nerve block (a numbing injection) plus physical therapy can improve shoulder joint awareness and reduce pain in stroke survivors with hemiplegic shoulder pain. Fourteen participants will be randomly assigned to receive either the nerve blo…

This study tests whether a wearable trunk brace, called the SPIO Core-Max Expedition TLSO, can improve head, trunk, and arm function in infants aged 6 to 18 months with cerebral palsy. Thirty infants will wear the brace for 2 hours daily over 6 months, and researchers will measur…

This study tests whether kinesio taping (a special elastic tape) or PNF (a type of movement therapy) better helps stroke survivors with hand weakness. Fifty-four adults who had a stroke 6 to 24 months ago will receive one or both treatments 3 days a week for 8 weeks. Researchers …

This study tests a new physical therapy program for children with cerebral palsy who have a crouched walking pattern. The therapy focuses on correcting pelvic tilt and strengthening the soleus muscle in the calf, which is often overlooked. Forty children aged 4 to 10 will partici…

This study tests a procedure called cryoneurolysis, which uses cold to temporarily block nerves that cause painful muscle tightness in the shoulder and elbow. It is for people with cerebral palsy who have not found relief from other treatments. The goal is to see if it helps them…

This study tests whether a mixed-reality video game called Bootle Blast can help children aged 6–17 with hemiplegic cerebral palsy improve their arm and hand skills through home-based play. About 46 participants will either start the game right away or wait 12 weeks while continu…

This study tests a new home-based program that uses a special treadmill and virtual reality to help children with conditions like cerebral palsy, muscle diseases, or obesity improve their walking. About 30 children aged 6 to 17 will try the program at home for at least 3 sessions…

This study tests whether a 12-week functional power training program (MegaPower) helps children with cerebral palsy achieve their personal participation and activity goals better than usual care. The trial will include 66 children aged 4-12 who can walk with or without help. Rese…

This study looks at two different calf-stretching programs for adults with cerebral palsy who have tight calf muscles and walk slowly. Forty participants will be assigned to one of two stretching routines for one year. The goal is to see if either program can improve walking spee…

This study tests a treatment that uses precise radiation beams to target nerves in the back, aiming to reduce muscle tightness (spasticity) caused by stroke, spinal cord injury, or cerebral palsy. About 22 people will be randomly assigned to receive either the real treatment or a…

This study looks at whether botulinum toxin type A injections can improve hand and leg function and quality of life in 30 children aged 8 to 17 with spastic hemiparetic cerebral palsy. Participants receive one injection and are followed for 12 weeks. The goal is to see if this tr…

This study tests a structured exercise program called task-oriented circuit training in 34 children aged 5-12 with hemiplegic cerebral palsy. The program includes 14 stations targeting walking, balance, and strength. Researchers will measure improvements in walking distance and d…

This study tests whether gentle electrical stimulation of a nerve in the genital area can improve bowel control in people with spinal cord injury. Researchers will measure how the rectum and anus respond to the stimulation using a small balloon. The goal is to see if this non-inv…

This study tests whether combining a mild nerve stimulation (taVNS) with intensive hand therapy (CIMT) can improve arm function in infants aged 8-24 months who have one-sided weakness due to brain injury. Ten infants will receive 40 hours of therapy over two weeks, and researcher…

This study tests whether adding a robotic glove to standard hand therapy (CIMT) can improve hand dexterity and grip strength in children aged 6-12 with hemiplegic cerebral palsy. Half of the 34 participants will receive CIMT alone, while the other half will also use a robotic glo…

This study tests a 10-week hand strength training program for 14 children aged 6-12 with spastic cerebral palsy. The goal is to see if it improves their grip strength and ability to manipulate objects in their hand. Researchers will measure changes using a dynamometer and the Mel…

This study tests whether adding a special exercise program (kinesiotherapy) to standard physical therapy can improve arm movement and daily living skills in children aged 8-13 with hemiplegic cerebral palsy. 28 children will be split into two groups: one gets kinesiotherapy plus …

This study tests a non-invasive brain stimulation technique called iTBS to see if it can improve balance and leg movement in people who had a stroke more than six months ago. Researchers will measure changes in walking and brain activity. The goal is to find a safe, practical way…

This study tests a special therapy called Cognitive Sensory Motor Training (CSMT) to see if it can improve hand and arm function in children with cerebral palsy. The therapy combines physical tasks with mental exercises to boost coordination and sensory awareness. Researchers wil…

This study tests whether adding a mild electrical stimulation to the skin of the affected hand (called SAES) can improve hand function in children aged 6-18 with hemiparesis (one-sided weakness) due to cerebral palsy or stroke. 34 participants will be randomly assigned to receive…

This study tests whether a non-invasive brain stimulation technique called intermittent theta burst stimulation (iTBS) can improve arm and leg movement in people who had a stroke more than six months ago. 48 participants will receive either real or sham stimulation over 15 sessio…

This study tests whether ankle braces made with 3D scanning and printing work as well as those made the old-fashioned way with plaster casts. About 50 people aged 8 and older with leg weakness from conditions like cerebral palsy, stroke, or spinal cord injury will try both types …

This study tests a new early intervention program for infants aged 4-10 months who are at risk of developing cerebral palsy. The program combines weekly home sessions with caregiver training to support the baby's development and reduce challenges. Researchers will check if the pr…

This study looks at whether a special therapy done at home through video calls can help infants with cerebral palsy use their weaker arm more. About 267 babies aged 4 to 13 months will be assigned to different sequences of the therapy or standard care. The goal is to see if the t…

After a stroke, many people lose the ability to open their affected hand. This study tests three different non-invasive brain stimulation methods combined with hand therapy to see which works best. Researchers will enroll 63 adults who had a stroke 6 to 24 months ago and compare …

This study tests a motor training program called 'Let's Move' for infants aged 3-8 months who are at high risk for cerebral palsy. The program involves weekly sessions alternating between clinic visits and video telehealth at home for 16 weeks. Researchers want to see if the prog…

This study tests whether a soft back brace that supports the natural curve of the lower back can improve posture, balance, and walking speed in children with cerebral palsy. Twenty-five children aged 6 to 15 with mild to moderate mobility issues will be tested with and without th…

This study tests whether adding mild electrical pulses to leg muscles during stationary cycling helps people with stroke-related leg weakness improve their heart fitness and walking ability. Thirty adults who had a stroke within the past year will cycle three times a week for eig…

This study tests a new non-invasive brain stimulation technique called mirror-PAS, which combines visual and motor signals to promote brain plasticity. Researchers will compare it to standard brain stimulation in 36 people with stroke-related arm weakness or phantom limb pain. Th…

This study tests a special neck brace designed to help children with cerebral palsy improve their head and neck control. The brace uses sensors, springs, and small motors to support and gently guide head movements during training. Researchers will enroll 30 children and measure c…

This study tests whether serious games (special video games that combine movement and thinking) can improve balance, memory, and quality of life in 30 children with cerebral palsy. Kids play daily for 30 minutes over 10 days, alongside their usual rehab. Researchers will measure …

This study compares three different robotic exoskeletons to see which one helps stroke survivors walk better. Researchers will enroll 96 people who had a stroke 3 to 8 months ago and have weakness on one side. Participants will use the devices during gait training, and the goal i…

This study screens 360 adults with neurodegenerative disorders like ALS, frontotemporal dementia, and progressive supranuclear palsy. Researchers will use medical history, physical exams, memory tests, movement analysis, MRI scans, and other tests to find common features and diff…

This global study follows people with POLG-related disorders, a group of rare mitochondrial conditions, to understand how the disease progresses over time. By observing clinical changes in up to 300 participants of all ages, researchers aim to identify key milestones that could s…

This study is collecting information from 200 people with cerebral palsy, multiple sclerosis, stroke, fibromyalgia, or similar nerve disorders to see how the EXOPULSE Suit affects their balance and risk of falling over time. Participants will be followed routinely, and researcher…

This study asks 500 adults with cerebral palsy to fill out questionnaires about their memories of botulinum toxin injections they received as children. Researchers want to learn how effective and painful the treatments felt, how well doctors communicated, and what coping strategi…

This observational pilot study tests whether wearable eye-tracking glasses can reliably record gaze during two-handed tasks in children aged 6 to 12 years, including 20 with cerebral palsy and 20 with typical development. Each child attends one session, wears the glasses, and per…

This trial is testing a device that has not been approved by the U.S. FDA. The sponsor and many details are not publicly available. The study is currently in an early phase to gather information about the device's use and safety.

This study is testing whether a mobile health app system can help people with chronic conditions like spinal cord injury, cerebral palsy, spina bifida, or traumatic brain injury improve their self-management skills and wellness. About 160 participants will use the app for one yea…

This study collects and stores medical information from people treated for orthopaedic conditions like osteoarthritis, scoliosis, and cerebral palsy. Researchers at the University of Florida will gather data during routine clinical care to create a resource for future research. T…

This study uses a special robot called IntelliArm to measure how arm stiffness, spasticity, and movement change during recovery from a first stroke. Researchers will track 56 people who had a stroke less than a month ago, measuring their arm function with standard tests and robot…

This study follows thousands of people with ataxia, hereditary spastic paraplegia, and spastic ataxia, rare conditions that cause progressive problems with walking, balance, and coordination. Researchers will track how symptoms evolve using clinical exams, patient reports, digita…

This observational study will follow 50 children aged 5 to 8 with non-progressive congenital ataxia, a rare condition that affects movement and coordination. Researchers will use detailed exams, brain scans, and genetic testing to better understand the disorder and its impact on …

This trial tests a brain-computer interface called CortiCom, which is surgically placed on the brain's surface to record signals related to speech and arm movement. The goal is to see if these signals can be decoded to control software and devices, potentially helping people with…

This study aims to learn more about rare disorders that affect how the body processes chemicals called pyrimidines and purines. These disorders can cause problems in the brain, blood, kidneys, and immune system, ranging from mild to life-threatening. Researchers will compare test…

This study uses safe brain imaging techniques (NIRS and EEG) to see how the brain controls movement in people with and without cerebral palsy. Researchers will compare brain activity patterns and test whether biofeedback training can help people with cerebral palsy improve their …

This study creates a global registry for people with mitochondrial disorders—rare diseases that affect energy production in cells. By collecting health data from 6,000 participants worldwide, researchers aim to understand how these diseases progress and identify the best ways to …

This study is testing a new leg exoskeleton designed by the NIH to help children and young adults with muscle weakness from conditions like cerebral palsy or spinal cord injury. Researchers want to see how well the device works in different real-world settings, like walking on a …

This study looks at whether placebos—given openly or hidden—can change brain activity and improve movement in people who had a stroke at least six months ago. Researchers will use brain scans and motor tests to measure effects. The goal is to understand how placebos work in the b…

This study aims to create and validate a Turkish version of a short neurological exam called the BRIEF-HINE for babies at high risk of brain problems. Researchers will test 120 infants aged 3 to 12 months who have conditions like premature birth or brain injury. The goal is to se…

This pilot study investigates whether children with cerebral palsy walk differently in a gait lab compared to daily life. Researchers think that being watched (the Hawthorne effect) and the absence of everyday distractions (dual-tasks) may cause lab results to be misleading. By t…

This study tests whether gentle muscle vibrations can help the brain form new connections after a stroke or traumatic brain injury. Researchers will measure brain and spinal cord activity in 56 participants before, during, and after a 5-week vibration treatment. The goal is to un…

This study uses MRI scans to look at brain and spinal cord structure and function in people with cerebral palsy who experience chronic pain. Researchers hope to find patterns in the brain that are linked to pain and sensory issues. Participants aged 8 and older with cerebral pals…

This study is testing how the drug trihexyphenidyl is processed in the bodies of 40 children aged 5-17 with dystonic cerebral palsy. Researchers want to see if a child's genetic makeup changes how the drug works, which could help create personalized dosing plans. Participants wil…

This study looks at how children and young adults with cerebral palsy move, using special sensors like ultrasound, brain wave caps, and muscle stickers. Researchers want to learn more about movement to improve robotic leg braces that could help people walk better. Participants wi…

This study is translating a questionnaire about brachial plexus birth palsy into Turkish and checking if it works well. 50 adults with this condition will fill out the new Turkish version along with other standard surveys. The goal is to provide a reliable tool for Turkish-speaki…

This study follows adults who had shoulder tendon transfer surgery as children for obstetric brachial plexus palsy, a nerve injury during birth. Researchers will measure pain, arm movement, strength, and social appearance anxiety in 80 participants and compare them to healthy pee…

This early-phase study tests whether pairing brain stimulation with spinal cord stimulation can strengthen the signals that control hand muscles. Researchers will study healthy volunteers, people with spinal cord injury, and those with cervical myelopathy. The goal is to understa…

This study looks at how children with cerebral palsy (CP) adapt their walking when given feedback from a treadmill, sensors, and a wearable exoskeleton. Researchers want to understand how kids learn new movement patterns and whether training or surgery can improve their walking. …

This early-stage study tests a brain implant called BrainGate in just 3 people with severe paralysis or speech loss from conditions like ALS or spinal cord injury. The goal is to see if the device is safe and can let users control a computer cursor or other tools by thought alone…

This study tests a new way to stimulate the brain and a nerve in the arm at the same time to encourage the spinal cord to adapt and improve hand movement. It involves 20 healthy adults who will receive non-invasive stimulation while researchers measure muscle responses. The goal …

This registry collects information from people with inherited retinal diseases, like retinitis pigmentosa and Stargardt disease. Participants share their symptoms, family history, and genetic test results online. The goal is to help researchers understand these rare diseases and …

This study is building a large database of health information from 5,000 people with ALS and other motor neuron diseases. Participants share details like symptoms, test results, and disease progression during regular clinic visits. The de-identified data is then shared with resea…

This study uses eye-tracking technology to see how people with facial palsy pay attention to faces with abnormal movement, compared to healthy volunteers. Researchers want to understand if patients focus differently on the affected side of the face. The goal is to learn more abou…

Cerebral palsy (CP) is a brain injury that affects movement, but diagnosing it can take up to 2 years. This study follows 600 high-risk infants (premature, brain-injured, or with abnormal exams) across Irish hospitals. Researchers will use EEG sleep tests, protein markers, and co…

This study is looking at whether the brains and spinal cords of adults with cerebral palsy shrink or change over time, which might explain why some people lose function as they age. Researchers will collect and compare past and new MRI scans from 30 adults with CP across the U.S.…

This study aims to develop a way to measure facial muscles using MRI scans in people with facial paralysis. Currently, doctors rely on subjective scales to assess muscle function, but this method could provide objective measurements like muscle thickness and volume. The goal is t…

This study compares four types of nerve blocks used during arthroscopic shoulder surgery to see which one causes the least temporary diaphragm paralysis and leads to better recovery. Researchers will measure breathing function, pain levels, opioid use, and overall recovery qualit…

This study looks at how muscles grow and change in children with cerebral palsy (CP) by examining tiny samples from leg muscles. Researchers will compare these microscopic findings with muscle images and movement tests. The goal is to better understand why muscles in CP develop d…

This study tests whether brain-computer interfaces (BCIs) can be used at home by children aged 5-18 with severe physical disabilities, such as cerebral palsy or brain injury. Families receive a BCI kit and participate in 12 virtual coaching sessions over 3-6 months. The goal is t…

This study looks at muscle problems, metabolic issues, and chronic inflammation in adolescents and young adults (ages 14-30) with moderate to severe spastic cerebral palsy. Researchers will compare them to less affected and healthy peers, then have the more affected group do a 12…

This study looks at how botulinum toxin (Botox) injections change muscle structure in children with spastic cerebral palsy. Using advanced imaging like MRI and 3D ultrasound, researchers will measure muscle size, fat content, and stiffness in 51 children. The goal is to understan…

This study aims to better understand the link between motor (movement) and cognitive (thinking) problems in people with brain damage from conditions like cerebral palsy or stroke. Researchers will assess 400 participants aged 3 to 90 using robotic tools and standard tests. The go…

This study is testing whether a smartphone app can accurately measure how children with cerebral palsy move, like jumping and walking. Researchers will compare the app's results with standard motion-capture systems. The goal is to make it easier and cheaper to assess motor skills…

This study tests whether a remote training program can help manual wheelchair users improve their skills. Researchers will train peer coaches, then enroll 132 wheelchair users to receive either remote feedback training or be placed on a waitlist. The goal is to see if remote trai…

This study looks at 72 children aged 5 to 8 with hemiplegic cerebral palsy to see how well they can use their affected arm and how that relates to their participation in everyday activities. Researchers will measure arm movement quality and compare it to how much the children tak…

This study measures how hard children with conditions like neuromuscular disease, scoliosis, or heart problems work to breathe. Researchers use a thin tube placed through the nose into the esophagus to measure breathing muscle strength and effort. The goal is to better understand…

This pilot study explores whether adding sound and touch to a standard movement-observation therapy can better activate the brain's mirror neuron system in children with cerebral palsy. Twenty kids with CP and 20 typically developing peers, aged 7-25, will watch videos of actions…

This study looks at videos and sounds from babies to find early clues about conditions like cerebral palsy and autism. About 46 infants who were in the NICU will have their movements and cries recorded at home. Researchers hope to identify patterns that could lead to earlier dete…

This study is creating a detailed registry of 500 people with hereditary spastic paraplegia (HSP), a rare disorder that causes progressive leg stiffness and weakness. Researchers will collect medical history, genetic data, and patient feedback over time to better understand how t…

This study tests whether small wearable sensors (called IMUs) placed in shoes and on the body can accurately measure how children walk. Researchers will first check the sensors in healthy children aged 7–17, then in children with cerebral palsy who can walk without aids. The goal…

This study looks at how a 2-week, personalized therapy program helps children aged 4-12 with conditions like cerebral palsy, autism, or genetic disorders. Kids get about 2.5 hours of tailored therapy each day, focusing on skills like movement, attention, and communication. The go…

This study aims to uncover the genetic causes of hereditary spastic paraplegia (HSP), a group of rare neurological diseases that cause progressive muscle stiffness and weakness. Researchers at Boston Children's Hospital will analyze DNA from 200 people with HSP to find genetic va…

This study is collecting health data and blood samples from 100 people with specific types of hereditary spastic paraplegia (SPG4 and SPG5A). The goal is to create a shared database and biobank to better understand how the disease progresses. This information will help prepare fo…

This study is creating a shared database of children who have received deep brain stimulation (DBS) for movement disorders like dystonia, epilepsy, or Tourette syndrome. By pooling data from multiple hospitals, researchers hope to answer key questions about who benefits most and …

This study collects health information and biological samples from up to 700 people under 30 with early-onset hereditary spastic paraplegia (HSP). Researchers aim to better understand how the disease progresses over time and create a registry for future studies. Participants prov…

This study looks at whether using a short-acting paralytic drug (succinylcholine) instead of a longer-acting one (rocuronium) can prevent patients from being awake while paralyzed during emergency breathing support. About 3,090 adults on ventilators in emergency departments will …

This study examines the role of the plantaris, a small calf muscle, in children having surgery for tight ankles (equinus). Researchers will randomly change the order of tendon cuts during surgery to measure how much each contributes to ankle movement. The goal is to understand if…

This study tests a new training method for caregivers of infants with brachial plexus birth injury (a nerve injury that can cause arm weakness). The goal is to see if the training helps caregivers feel more confident and do daily stretching exercises more consistently, which may …

This study looks at a special clinic called TLC that helps adults with conditions like cerebral palsy, spina bifida, and developmental disabilities get better, coordinated care. Many of these people face a 'cliff' when they leave children's healthcare and struggle to find adult d…

This study is testing whether wearable sensors can accurately measure how people climb stairs. Researchers will compare sensor data to traditional stopwatch timing in healthy volunteers and people with conditions like cerebral palsy, Parkinson's disease, and stroke. The goal is t…

This observational study aims to understand how infants and toddlers develop thinking, language, movement, and social skills in the first few years of life. Researchers will assess 1,200 children aged 16 days to 42 months using standardized tests and parent questionnaires. The go…

This study is testing whether hand and arm assessments done over video calls are as good as those done in person for children with cerebral palsy. About 100 kids aged 6 to 17 will complete assessments both virtually and in a clinic, and researchers will compare the results. If vi…

This study looks at how small electrical pulses to the brain or arm nerves can help restore sensation in people with spinal cord injuries. Participants already have tiny electrodes implanted as part of a larger study. Researchers will test different stimulation patterns to see wh…

This study looks at how babies' brains develop after an injury around birth. Researchers will use fun games and brain wave tests (EEG) to see if they can predict which children might have trouble with thinking and memory later. About 100 babies, both healthy and those with brain …

This study looks at how ankle-foot orthoses (AFOs) change the way leg muscles work in 30 children with cerebral palsy (ages 6–17). Researchers will measure muscle activity while children walk barefoot and with their prescribed AFO, both on a treadmill and overground. The goal is …

This study aims to understand how muscles change over time in children with spastic cerebral palsy. Researchers will use 3D ultrasound to measure muscle size, length, and quality in 229 children. The goal is to link these changes to brain injury and treatments, helping improve fu…

This registry collects information from up to 15,000 people with cerebral palsy in Switzerland, tracking their diagnosis, treatments, and outcomes over time. Researchers will use this data to study the condition and improve care. Participants must have a confirmed CP diagnosis an…

This study aims to find genes that cause eye misalignment (strabismus) and related conditions involving the cranial nerves and brainstem. Researchers will analyze DNA from up to 20,000 participants with these disorders. The goal is to better understand the genetic causes, which c…

This research study follows the cognitive development of infants, both healthy and those who had a brain injury around birth. Researchers will use online games and parent questionnaires to measure attention, thinking, and language skills. The goal is to better understand how thes…

This study from the University of Calgary is testing a robotic gait trainer called the Trexo in 50 people who have trouble walking due to conditions like cerebral palsy. Researchers want to understand how different settings on the robot (like endurance vs. strength mode) affect h…

This study looks at children with spastic cerebral palsy to see if ultrasound images of their muscles can predict how well they can move. Researchers will measure muscle thickness, stiffness, and blood flow, and compare these to standard tests of motor function. The goal is to fi…

This study is creating a large registry and tissue bank for people with mitochondrial disorders. Researchers will collect medical information and samples from up to 1,000 participants, including those diagnosed with or suspected to have a mitochondrial disease. The goal is to gat…

This study uses MRI scans of babies during natural sleep to understand how the brain develops in both healthy infants and those at risk for cerebral palsy. Researchers will follow about 200 infants from 3 months to 2 years old, using advanced imaging and motor skill tests. The go…

This study looks at how well people tolerate a new blended tube feed over 28 days. It includes up to 50 children and adults who need tube feeding due to conditions like cerebral palsy or cancer. Researchers will track gut symptoms and how much of the formula is taken each day.

This study looks at how children with cerebral palsy control their trunk and center of mass while walking. Researchers will measure body movements using small sensors as children walk on a special track. The goal is to better understand balance problems in these children, which c…

This study looks at whether a regular beat in music helps children with cerebral palsy and typical development learn dance moves. Researchers will teach 68 kids a short dance with and without a steady rhythm, then check how well they remember it. The goal is to understand if rhyt…

This study looks at whether monitoring blood pressure through the femoral artery (in the groin) is better than the usual radial artery (in the wrist) during and after heart surgery. The goal is to see if femoral monitoring reduces the need for strong blood pressure medications an…

This study is working to create better methods for evaluating how children with and without stroke or cerebral palsy use their arms and hands. Researchers will observe 80 children, including those with perinatal stroke and typically developing infants, using video and play-based …

This study looks at whether a child's ability to imagine movements is connected to how well they walk, balance, and move in daily life. Researchers will test 99 children with diplegic cerebral palsy aged 5 to 18. No treatment is given; the goal is simply to understand the relatio…

This study tests a brain implant that reads signals from the brain to help people who have lost the ability to speak fluently communicate through a computer just by trying to talk. It involves up to 2 participants with conditions like spinal cord injury or ALS. The main goal is t…

This study aims to learn how the binding of RNA with DNA (called R-loops) is linked to amyotrophic lateral sclerosis type 4 (ALS4) and other inherited neurological disorders. Researchers will observe up to 330 people aged 5 and older, including those with ALS4, related conditions…

This study explores how electrical stimulation of the spinal cord can help people with cervical spinal cord injury regain arm and hand function. Researchers will place electrodes on the spinal cord during surgery and test different stimulation patterns. The goal is to find the be…

This study looks at how a routine exercise program can help the brain rewire itself after a stroke. Researchers will measure changes in genes and proteins linked to brain repair in 48 stroke survivors with weakness on one side. The goal is to understand the biological effects of …

This study reviews medical records of 34 hemiplegic patients who received botulinum toxin injections for muscle spasticity between 2017 and 2020. Researchers will analyze which muscles were injected, dosages used, and how spasticity and function changed over time. No new treatmen…

This study looks at how children aged 8 to 17, both with and without cerebral palsy, use their brains to find their way around in a virtual reality game. By recording brain activity with EEG, researchers hope to understand why spatial navigation skills differ in children with CP.…

This study uses fMRI to look at brain and spinal cord activity in people who have had a stroke and have weakness on one side. Participants will perform a simple shoulder movement while being scanned. The goal is to understand which neural pathways are used for movement after a st…

This study looks at how the spine and pelvis line up when children with cerebral palsy sit. Researchers will take X-rays of 100 children aged 4 to 17 who have limited walking ability. The goal is to better understand these alignments and create a standard way to take these X-rays…

This study aims to build a computer model that helps doctors predict developmental problems in babies diagnosed with brain injury, especially those at risk for cerebral palsy. Researchers will collect data from standard medical tests and ask parents to fill out two online questio…

This study follows 100 infants diagnosed with or at high risk for cerebral palsy from birth to age 2. Researchers will track changes in motor skills, speech, cognition, and more to understand how the condition naturally progresses. The goal is to gather knowledge that could impro…

This study follows 500 children with cerebral palsy who are having leg or spine surgery. Researchers will track their pain and opioid use for a year after surgery using surveys and sensory tests. The goal is to find out who develops chronic pain and why, so doctors can better pre…