Complex hereditary spastic paraplegia
MONDO:0015150A hereditary spastic paraplegia that is part of a larger syndrome.
Also known as: Complex HSP, Complex SPG, Complex familial spastic paraplegia, complicated HSP, complicated SPG, complicated familial spastic paraplegia, complicated hereditary spastic paraplegia, syndrome associated with hereditary spastic paraplegia
9 clinical trials for this condition and its sub-types, 1 tagged with Complex hereditary spastic paraplegia itself.
Follow this condition to get notified about new trialsWhere it sits in the disease tree
Browse by category →Sub-types of Complex hereditary spastic paraplegia
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Hereditary spastic paraplegia 11 1 trial
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Hereditary spastic paraplegia 15 1 trial
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Hereditary spastic paraplegia 26 1 trial
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Hereditary spastic paraplegia 63 1 trial
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MASA syndrome 0 trials
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Troyer syndrome 0 trials
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13 sub-types
- Autosomal dominant spastic paraplegia type 9 0 trials Sub-types →
- Hereditary spastic paraplegia 17 0 trials
- Hereditary spastic paraplegia 29 0 trials
- Hereditary spastic paraplegia 36 0 trials
- Hereditary spastic paraplegia 38 0 trials
- Spastic paraplegia 18a, autosomal dominant 0 trials
- Spastic paraplegia, intellectual disability, nystagmus, and obesity 0 trials
- Spastic paraplegia-Paget disease of bone syndrome 0 trials
- Spastic paraplegia-epilepsy-intellectual disability syndrome 0 trials
- Spastic paraplegia-facial-cutaneous lesions syndrome 0 trials
- Spastic paraplegia-nephritis-deafness syndrome 0 trials
- Spastic paraplegia-neuropathy-poikiloderma syndrome 0 trials
- Spastic paraplegia-precocious puberty syndrome 0 trials
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Hereditary spastic paraplegia 18 0 trials
2 sub-types
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Hereditary spastic paraplegia 23 0 trials
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Hereditary spastic paraplegia 24 0 trials
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Hereditary spastic paraplegia 25 0 trials
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Hereditary spastic paraplegia 27 0 trials
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Hereditary spastic paraplegia 32 0 trials
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Hereditary spastic paraplegia 39 0 trials
1 sub-type
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Hereditary spastic paraplegia 43 0 trials
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Hereditary spastic paraplegia 44 0 trials
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Hereditary spastic paraplegia 45 0 trials
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Hereditary spastic paraplegia 46 0 trials
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Hereditary spastic paraplegia 49 0 trials
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Hereditary spastic paraplegia 53 0 trials
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Hereditary spastic paraplegia 54 0 trials
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Hereditary spastic paraplegia 55 0 trials
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Hereditary spastic paraplegia 57 0 trials
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Hereditary spastic paraplegia 61 0 trials
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Hereditary spastic paraplegia 64 0 trials
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Hereditary spastic paraplegia 74 0 trials
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Hereditary spastic paraplegia 75 0 trials
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Spastic ataxia 2 0 trials
Most studied deeper sub-types
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Can ultrasound make botox injections more precise for stiff muscles?
Disease control Recruiting nowThis trial tests whether using ultrasound to guide botulinum toxin injections into spastic leg muscles works better than the standard method of relying on touch and anatomical landmarks. Researchers will give 40 adults with spastic paraplegia two rounds of injections, one with ea…
Phase 4 • Sponsor: Universidade Federal Fluminense • Aim: Disease control
Last updated Sep 05, 2026 00:00 UTC
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Can a massive natural history study unlock the secrets of rare movement disorders?
Knowledge-focused Recruiting nowThis study follows thousands of people with ataxia, hereditary spastic paraplegia, and spastic ataxia, rare conditions that cause progressive problems with walking, balance, and coordination. Researchers will track how symptoms evolve using clinical exams, patient reports, digita…
Sponsor: Heidelberg University • Aim: Knowledge-focused
Last updated Sep 03, 2026 00:00 UTC
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Scientists launch major study to unravel mysterious metabolism disorders
Knowledge-focused Recruiting nowThis study aims to learn more about rare disorders that affect how the body processes chemicals called pyrimidines and purines. These disorders can cause problems in the brain, blood, kidneys, and immune system, ranging from mild to life-threatening. Researchers will compare test…
Sponsor: National Human Genome Research Institute (NHGRI) • Aim: Knowledge-focused
Last updated Aug 21, 2026 00:00 UTC
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Scientists hunt for genetic clues to rare paralysis disorder
Knowledge-focused Recruiting nowThis study aims to uncover the genetic causes of hereditary spastic paraplegia (HSP), a group of rare neurological diseases that cause progressive muscle stiffness and weakness. Researchers at Boston Children's Hospital will analyze DNA from 200 people with HSP to find genetic va…
Sponsor: Boston Children's Hospital • Aim: Knowledge-focused
Last updated Jun 27, 2026 11:03 UTC
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Scientists launch major effort to track rare nerve disease in children
Knowledge-focused Recruiting nowThis study collects health information and biological samples from up to 700 people under 30 with early-onset hereditary spastic paraplegia (HSP). Researchers aim to better understand how the disease progresses over time and create a registry for future studies. Participants prov…
Sponsor: Boston Children's Hospital • Aim: Knowledge-focused
Last updated Jun 27, 2026 11:02 UTC