Central nervous system disorder

When babies lack oxygen around birth, they can suffer lasting brain damage. No treatment currently repairs that injury. Researchers are testing whether oral sildenafil, a drug already used safely in babies for lung blood pressure, can help. In this Phase 2 trial, 60 newborns with…

Researchers are testing a gene therapy called NXL-001 in people who have lasting movement problems from an ischemic stroke. The study enrolls 9 adults, 2 to 12 months after their stroke, who have moderate to severe arm or leg weakness despite rehabilitation. Each participant rece…

Researchers are testing whether a new oral polio vaccine called nOPV2, given at birth, helps infants block type 2 poliovirus in their intestines. The trial enrolls 740 healthy newborns who have received standard injected polio vaccines. Scientists will check stool samples for sig…

This study tests whether valbenazine can reduce involuntary muscle movements (tardive dyskinesia) in adults who still have symptoms while taking or after stopping another similar drug. About 50 people with schizophrenia, bipolar disorder, or major depression will take valbenazine…

Researchers are testing whether adding terfenadine to standard first-line disease-modifying therapy is safe and may improve outcomes for adults with relapsing-remitting multiple sclerosis. About 100 participants aged 18 to 65 will be randomly assigned to receive either terfenadin…

This study tests whether adding low-dose radiation to the drug elranatamab can better kill cancer cells in people with multiple myeloma that has come back or not responded to treatment and has spread outside the bone. About 34 adults will receive the combination. The goal is to s…

This study tests an experimental drug called ABBV-1758 in about 210 people with Alzheimer's disease. The drug is given by IV or injection every 4 weeks for 24 weeks. Researchers are checking if it is safe and whether it can reduce amyloid plaques in the brain, a hallmark of Alzhe…

This study looks at the long-term safety and tolerability of the drug TAK-360 in people with narcolepsy (type 1 or 2) or idiopathic hypersomnia — conditions that cause severe daytime sleepiness. Participants who completed a previous TAK-360 study can join and will continue taking…

This phase 2 trial compares two standard radiation approaches for people with large brain metastases (tumors that spread from other cancers). One method gives two radiation doses a month apart; the other gives three daily doses. The study will track tumor control, side effects, a…

This early-phase trial tests whether transplanting healthy donor gut bacteria (washed microbiota transplantation) can improve autism and ADHD symptoms in 80 children aged 3-17. The approach targets the 'gut-brain axis,' since many children with autism have gut microbiome imbalanc…

This phase 2 trial is testing whether a combination of three drugs—nivolumab, ipilimumab, and cabozantinib—can help people with kidney cancer that has spread to the brain. The study will enroll 20 participants who have not had prior treatment for their brain metastases. The main …

This study will follow 36 people with spinal muscular atrophy (SMA) who receive a gene therapy called onasemnogene abeparvovec (ITVISMA) injected into the spinal fluid. The goal is to see how well it works and how safe it is in everyday medical practice. Participants must be at l…

This study tests a new drug called ARO-MAPT-SC in healthy people and those with early Alzheimer's. The goal is to check if it is safe and how the body processes it. Participants receive either the drug or a placebo by injection under the skin. The trial is still in early stages, …

This study tests whether adding the drug selinexor to standard chemotherapy (temozolomide) can better control recurrent glioblastoma, an aggressive brain cancer. About 97 adults whose tumor has returned after initial treatment will receive either the combo or chemotherapy alone. …

This study tests if a catheter-based device that closes a small pouch in the heart (left atrial appendage) can prevent strokes or blood clots in people with atrial fibrillation who are already taking blood thinners. About 4000 participants at high risk of stroke will be enrolled.…

Researchers at the University of California, Irvine are testing whether patients with brain metastases can safely skip immediate surgery or radiation and instead have their tumors monitored with regular imaging, cognitive tests, and quality-of-life questionnaires. All participant…

This early-phase trial will test whether a special form of resveratrol (JOTROL) is safe and tolerable for people with Parkinson's disease. About 30 participants will receive either a low dose, high dose, or placebo daily for three months. The study will also measure how the drug …

This study is testing whether placing stroke patients in a head-down position (Trendelenburg) before a clot-removal procedure can improve their recovery. Researchers will enroll 210 adults with a severe stroke caused by a large blocked artery. The goal is to see if this simple po…

Researchers at the University of South Carolina are testing a program that pairs nurses with community health workers to coach adults who have chronic conditions like diabetes, high blood pressure, heart disease, kidney disease, or a prior stroke. Each patient joins with a carepa…

This early-phase trial tests the safety of a drug called ERAS-801 in 10 adults with recurrent glioblastoma, a fast-growing brain cancer. The drug targets a protein called EGFR that is overactive in many of these tumors. Researchers will also check if the drug affects tumor activi…

This study tests whether the insomnia medication lemborexant (Dayvigo) can lower blood markers of brain damage in adults aged 40–65 with insomnia. Twenty participants will take the drug or a placebo for two weeks each, then have their blood tested for proteins linked to Alzheimer…

This phase 2 trial tests enasidenib, a daily pill that targets the IDH2 gene mutation, in 40 adults with rare cancers of the nasal cavity or skull base that have spread or come back. Participants take the drug once daily in 28-day cycles, and researchers will track how long the c…

This study tests whether adding an experimental mRNA vaccine (V940) to the immunotherapy drug pembrolizumab (Keytruda) can keep lung cancer from returning after surgery. It includes 680 people with stage II to IIIB non-small cell lung cancer whose tumors did not fully respond to …

This study follows 300 adults with Parkinson's disease, essential tremor, or dystonia who receive deep brain stimulation (DBS). DBS uses a device implanted in the chest to send electrical pulses to brain areas controlling movement. Researchers will track symptom severity, medicat…

This study is for people whose brain metastases have returned after initial radiation. It combines either laser ablation or surgery with a second round of targeted radiation. The goal is to control the disease and monitor side effects in 155 participants.

This Phase 3 trial tests whether adding a special radiation tile (GammaTile) during brain surgery improves survival for people with newly diagnosed glioblastoma, a fast-growing brain cancer. About 766 participants will be randomly assigned to standard treatment (surgery, radiatio…

This study offers NRX-101, a combination of two drugs, to adults aged 18-65 with treatment-resistant bipolar depression and suicidal thoughts. Participants receive the medication from their own psychiatrist and undergo regular check-ins on mood, suicidal ideation, and side effect…

This study tests whether a combination of two drugs, KarXT and KarX-EC, can improve cognitive impairment in people with mild to moderate Alzheimer's disease. About 586 participants will receive either the drug combo or a placebo. The trial measures changes in thinking, daily func…

This study tests a new medicine called empasiprubart against the standard treatment (IVIg) for people with chronic inflammatory demyelinating polyneuropathy (CIDP), a nerve disease that causes weakness and numbness. About 218 adults who have used IVIg before will receive either t…

This study tests a drug called sovateltide in 160 people who have had an ischemic stroke (a stroke caused by a blood clot). The goal is to see if the drug helps patients recover better and is safe. Participants receive either the drug or a placebo within 24 hours of their stroke,…

This study is testing whether combining a targeted drug (abemaciclib) with precise radiation (stereotactic radiosurgery) can better control brain tumors in people with a common type of breast cancer (HR+/HER2-). About 31 participants will receive both treatments along with hormon…

This early-stage trial tests a radioactive drug (Lu-177 edotreotide) in children aged 2 to 17 with cancers that have a specific marker (SSTR-positive). The goal is to find the right dose and check safety. About 20 children whose cancer has returned or not responded to prior treat…

Researchers are testing whether a home-use pulsed electromagnetic therapy device can slow cognitive decline in people with mild to moderate Alzheimer's disease, Lewy body dementia, or vascular dementia. About 48 participants will use the device three times a day for 15 minutes ov…

This phase 2 trial tests two immunotherapy drugs, nivolumab and relatlimab, in people with newly diagnosed glioblastoma, a fast-growing brain cancer. About 92 participants will receive the drugs before and after surgery to see if they are safe and help the immune system attack th…

This early-stage trial is testing the drug vorinostat in 15 girls and young women with Rett syndrome, a rare genetic disorder that affects brain development. Each participant will receive placebo and two different doses of vorinostat, acting as their own control. The study aims t…

This study tests two experimental drugs, REGN7508 and REGN9933, to prevent strokes in people with atrial fibrillation (an irregular heartbeat) who cannot or choose not to take standard blood thinners. About 2,628 participants will receive one of the drugs or a placebo to see if t…

This clinical trial tests an oral drug called SKY-0515 in 400 adults with Huntington's disease. The goal is to see if it can lower harmful proteins linked to the disease and improve symptoms like movement and thinking. Participants take the drug or a placebo daily for 18 months.

This phase 3 trial tests whether adding the experimental drug MK-2870 to the standard immunotherapy pembrolizumab helps people with advanced non-small cell lung cancer live longer compared to pembrolizumab alone. The study enrolls about 614 adults whose tumors have high PD-L1 lev…

This phase 3 trial tests whether adding the experimental drug sacituzumab tirumotecan (sac-TMT) to standard immunotherapy (pembrolizumab) and a targeted therapy (bevacizumab) helps people with metastatic cervical cancer live longer. About 1,000 participants whose cancer has sprea…

This study tests whether a special probiotic supplement can change fat-related molecules in the blood of people with ALS and frontotemporal dementia (FTD). Researchers will compare those taking the probiotic to those taking a placebo over 24 weeks. The goal is to see if the probi…

This study is testing whether a device that uses mild electrical pulses to stimulate arm muscles and the tongue can help stroke survivors regain arm movement. Researchers will enroll 288 participants, including stroke patients with arm weakness and healthy controls. The main goal…

This study tests whether combining a gentle brain stimulation technique (tDCS) with exercises that challenge both thinking and walking can improve how stroke survivors handle doing two things at once. Seventy-two participants who had a stroke at least six months ago will receive …

This phase 3 trial tests whether empasiprubart, given by IV infusion, can help adults with chronic inflammatory demyelinating polyneuropathy (CIDP), a nerve disorder that causes weakness and disability. The study will enroll 160 participants. For the first 6 months, some get the …

About one in four children with seizures does not respond well to standard treatments. This study collects data from people whose doctors have prescribed the ketogenic diet, a high-fat, low-carbohydrate regimen, to see how it affects brain electrical activity and metabolism. Rese…

This study tests whether a daily pill called BHV-8000 can slow the worsening of motor skills in people recently diagnosed with Parkinson's disease. About 550 adults aged 40 to 85 with early Parkinson's will receive either BHV-8000 (10 mg or 20 mg) or a placebo for up to 48 weeks.…

This study tests whether a simple, non-invasive treatment called remote ischemic conditioning (RIC) can help people recover better after a moderate stroke in the back part of the brain. RIC involves briefly inflating a blood pressure cuff on the arm to restrict blood flow, then r…

This study tests whether the drug pridopidine can slow the worsening of Huntington's disease (HD) in adults. About 400 participants will take either pridopidine or a placebo twice daily for one year, then everyone can receive pridopidine for two more years. The goal is to see if …

This study tests whether adding sacituzumab tirumotecan (Sac-TMT) to pembrolizumab helps people with advanced or recurrent endometrial cancer live longer without the cancer getting worse. About 1,100 participants with a specific type of endometrial cancer (pMMR) will receive eith…

This study tests whether two common heart medications—atorvastatin (a statin) and lisinopril (an ACE inhibitor)—can prevent or reduce heart damage caused by radiation therapy for chest cancers like breast, lung, and esophageal cancer. About 60 adults receiving chest radiation wil…

This study tests an experimental drug called NB-4746 in 80 people with ALS. The goal is to see if it is safe, how it moves through the body, and whether it can reduce a marker of nerve damage (NfL) in the blood. Participants are randomly assigned to receive either NB-4746 or a pl…

This study compares three oral medications used to prevent migraines: atogepant (a newer drug), topiramate, and propranolol (both older). About 1,335 adults with migraine will be randomly assigned to one of the three drugs for 12 weeks. Researchers will track headache frequency a…

This large phase 3 trial tests an experimental drug, REGN7508, against the standard blood thinner apixaban for preventing strokes in people with atrial fibrillation (an irregular heartbeat). The study will enroll over 15,000 participants to compare how well each drug prevents str…

This Phase 2 trial tests whether adding the experimental drug silevertinib to standard chemotherapy (temozolomide) helps people with a specific type of newly diagnosed glioblastoma live longer without their cancer worsening. The study includes 162 participants whose tumors have c…

This phase 3 trial is testing atogepant, a daily pill already approved for adults, to prevent episodic migraines in children aged 6 to 17. About 450 participants will receive either a low or high dose of the drug or a placebo for 12 weeks. The goal is to see if it safely reduces …

This study tests an oral medicine called GS3-007a for children with growth hormone deficiency. In the first part, kids receive different doses or a placebo for 14 days to check safety. In the second part, they take the chosen dose or a standard injection for 52 weeks to see how w…

This Phase 3 trial tests an oral drug called nizubaglustat (AZ-3102) in people aged 4 and older with Niemann-Pick type C disease, GM1 gangliosidosis, or GM2 gangliosidosis. The study lasts 18 months and compares the drug to a placebo to see if it is safe and can slow disease prog…

This early-stage trial is testing a long-acting injectable form of the drug cariprazine, called AX251, in 48 adults with stable schizophrenia. The study aims to see how the drug moves through the body and whether it is safe when given as a single shot at different doses. If resul…

This early-stage study tests an experimental drug called ALN-HTT02 in 66 adults with Huntington's disease. The drug is given as a single injection into the spine to see if it is safe and how it affects the body. The goal is to reduce levels of the harmful protein that causes the …

Researchers in China are studying whether newer flow diverter stents can safely and effectively treat wide-neck brain aneurysms. About 280 patients will receive one of these stents, which is threaded through blood vessels to the brain and left in place to redirect blood flow away…

This phase 2 trial tests a drug called BMS-986504 in people with advanced solid tumors that have lost a gene called MTAP. The drug is given alone or with other cancer medicines. The study aims to see if the drug shrinks tumors and how safe it is. About 260 adults will take part.

This study compares a stem cell transplant (using a person's own cells) against the best available medications for people with relapsing multiple sclerosis that hasn't responded to treatment. About 156 participants will be randomly assigned to one of the two approaches and follow…

This registry is collecting information from 1,500 people with Parkinson's disease who are receiving deep brain stimulation (DBS) with the Vercise system. The goal is to see how DBS affects quality of life in everyday practice, and to evaluate new programming tools. Participants …

This study tests an experimental oral drug called S241656 (BDTX-4933) in people with advanced solid tumors that have certain genetic changes (KRAS, BRAF, or other RAS/MAPK mutations). The trial has two parts: first, finding a safe dose, then testing how well it works alone or wit…

This trial tests a drug called selinexor combined with standard radiation in children and young adults with newly diagnosed diffuse intrinsic pontine glioma (DIPG) or high-grade glioma (HGG) that has a specific genetic change (H3 K27M mutation). The study has two parts: first, fi…

This trial tests whether adding endovascular treatment, a procedure to remove blood clots, to standard medical care improves recovery in people with a mild stroke caused by a blockage in the basilar artery. Participants receive either standard care alone or standard care plus the…

Researchers are testing efgartigimod, an intravenous drug that reduces certain antibodies, in adults with anti-NMDAR encephalitis, a rare autoimmune condition that causes psychiatric symptoms, seizures, and movement problems. The trial enrolls 20 participants who receive four wee…

This study tests whether giving tranexamic acid early after a traumatic brain injury can reduce harmful inflammation. Researchers will enroll 60 adults with mild or moderate head injuries. The goal is to see if this drug can help control the body's inflammatory response and impro…

This study will follow 130 people who had surgery for cancer that spread to the spine. Half will get radiation after surgery, half will not. Researchers want to see if radiation helps keep the cancer from coming back and improves how long patients live. The goal is to help doctor…

This phase 2 trial tests whether a 3-day course of high-dose corticosteroids (methylprednisolone or prednisone) can help heal ring-enhancing brain lesions in people with multiple sclerosis. Thirty adults with MS and a specific type of active lesion will be randomly assigned to re…

This phase 2 trial tests whether specially selected immune cells taken from a patient's own tumor, grown in large numbers in the lab, and given back along with the drug pembrolizumab (Keytruda) can shrink tumors in people with metastatic colorectal, pancreatic, ovarian, breast, o…

This study tests several experimental treatments for progressive supranuclear palsy (PSP), a rare brain disease that affects movement and thinking. About 440 people with early-stage PSP will receive one of the treatments or a placebo. The goal is to see if any of the treatments c…

This Phase 3 trial tests an oral drug called orelabrutinib against a placebo in about 990 people with non-active secondary progressive multiple sclerosis (MS). The goal is to see if the drug can delay worsening disability over 24 to 60 months. Participants are randomly assigned t…

This study looks at the best time to start blood thinners in people with atrial fibrillation who had a stroke and then emergency treatment to remove a clot. Some patients develop bleeding in the brain after the procedure, and doctors want to know if starting blood thinners early …

This study tests whether giving newborns plasma from people who recently recovered from chikungunya can prevent brain swelling or damage. The trial will include 60 newborns whose mothers were infected around the time of birth. Half will receive the plasma transfusion, and their o…

This study tests an experimental drug called NEO100 in people with a fast-growing type of brain tumor called high-grade meningioma that remains after surgery, has progressed, or returned. About 30 participants will take NEO100 four times daily in 28-day cycles. The main goal is t…

This trial tests whether Caplyta, a drug already used for other conditions, can reduce symptoms of social anxiety disorder in adults. Researchers will give 40 adults either Caplyta or a placebo every day for 8 weeks, with weekly clinic visits to track changes. The main question i…

This study tests an oral drug called NEO212 in people with specific brain tumors (astrocytoma, glioblastoma) or cancers that have spread to the brain. The goal is to find the safest dose and see if it helps control tumor growth. About 134 adults will take NEO212 alone or with sta…

This Phase 3 trial tests whether a simple injection of frexalimab every 4 weeks works as well as the standard IV infusion for adults with relapsing or non-active progressive multiple sclerosis. About 160 participants will be randomly assigned to one of the two methods. The study …

This study provides continued access to dabrafenib and/or trametinib for up to 100 patients with melanoma, lung cancer, or other solid tumors who were benefiting from these drugs in a prior Novartis or GSK trial. The main goal is to track long-term side effects and safety over ti…

This early study is testing whether a washed fecal transplant (WMT) can improve ADHD symptoms and related issues like sleep problems in children aged 3-17. The idea is that changing the gut bacteria might help the brain via the gut-brain axis. Fifty children will receive the tran…

This study is for people who have both an autoimmune disease (like rheumatoid arthritis, lupus, or multiple sclerosis) and an advanced cancer that has spread or cannot be removed by surgery. It tests the safety and effectiveness of the immunotherapy drug nivolumab, given alone or…

This study tests whether clemizole HCl (EPX-100) can safely reduce seizures when added to current treatments for Lennox-Gastaut syndrome, a severe form of epilepsy. About 260 children and adults aged 2 to 55 will receive either the drug or a placebo. The main goal is to measure c…

This early-phase trial tests a new radioactive drug called RYZ401 in people with neuroendocrine tumors and other solid tumors that have a specific protein on their surface. The drug delivers a powerful radioactive particle directly to cancer cells. The study aims to find the safe…

This early-phase trial tests a nasal spray called NEO100 (a purified natural compound) in 12 children with certain aggressive brain tumors. The goal is to see if it's safe, find the best dose, and check if the drug reaches the tumor. Participants will receive increasing doses, an…

This study follows 210 people with epilepsy who already have the Minder device implanted. The device helps doctors make better treatment decisions by detecting seizures that standard tests miss. Participants will be monitored every six months for two years to see how the device i…

This early-stage study tests a new drug called MTX325 in healthy volunteers and people with mild to moderate Parkinson's disease. The main goals are to check safety, how the body processes the drug, and whether it reaches the brain. If successful, MTX325 might one day slow the pr…

This study tests two experimental drugs, REGN7508 and REGN9933, in about 1,200 people with atrial fibrillation (an irregular heartbeat). The goal is to see if these drugs can prevent blood clots and strokes with less bleeding compared to the standard blood thinner apixaban. Parti…

This early-stage trial tests a new treatment for adults with a returning, aggressive brain cancer called glioblastoma. The therapy uses the patient's own immune cells, modified to recognize and attack the cancer, and delivers them directly into the brain. The main goals are to se…

This study tests a personalized treatment plan for children under 5 with a type of brain cancer called medulloblastoma. Doctors use the tumor's genetic makeup and the child's age to choose the best mix of chemotherapy and, if needed, radiation. The goal is to improve survival whi…

This study tests whether tirzepatide, a drug used for diabetes and weight loss, can lower brain pressure in people with idiopathic intracranial hypertension (IIH). IIH causes high pressure inside the skull, leading to headaches, ringing in the ears, and vision problems. The trial…

This study tests a drug called LHP588 in 300 people with mild-to-moderate Alzheimer's who also have a gum infection from P. gingivalis bacteria. The drug aims to target that bacteria to slow down memory and thinking decline. Participants take a daily capsule for up to 48 weeks, a…

This study tests an experimental drug called EPX-100 (clemizole) in 150 children and adults with Dravet syndrome, a severe form of epilepsy. The goal is to see if adding EPX-100 to current treatments can safely reduce the number of motor seizures. Participants will be randomly as…

This study tests whether the clot-busting drug tenecteplase can help people who have a stroke more than 4.5 hours ago, including those who wake up with stroke symptoms. About 1,325 adults with brain imaging showing salvageable tissue will be randomly assigned to receive tenectepl…

This phase 2 trial compares two treatment combinations for people with BRAF-V600 mutant melanoma that has spread to the brain. One group gets a targeted therapy (encorafenib and binimetinib) plus an immunotherapy (nivolumab), while the other gets two immunotherapies (ipilimumab a…

This phase 3 trial tests whether the oral drug orelabrutinib can slow disability progression in people with primary progressive multiple sclerosis (PPMS). About 705 adults aged 18–60 with PPMS will receive either orelabrutinib or a placebo for up to 5 years. The study measures ti…

Researchers are testing a vaccine that targets cytomegalovirus (CMV), a virus found in many glioblastoma tumors. The trial enrolls adults with newly diagnosed glioblastoma that lacks MGMT methylation and who have CMV antibodies. Participants receive the PEP-CMV vaccine along with…

This phase 3 trial is testing whether the drug pridopidine can slow the progression of amyotrophic lateral sclerosis (ALS) in 500 adults. Participants will take either pridopidine or a placebo daily for 48 weeks, followed by an open-label extension where everyone receives the dru…

This Phase 3 trial tests whether sovateltide, a drug that stimulates ETB receptors, can improve recovery after an acute ischemic stroke. About 514 adults aged 18-80 will receive either sovateltide or a placebo alongside standard care. The main goal is to see if more patients achi…

This study tests whether adding the drug ibrutinib to standard chemotherapy can better control primary central nervous system lymphoma (PCNSL) in people who are not eligible for a stem cell transplant. About 30 adults aged 65 or older or with other health issues will receive the …

This pilot study explores whether people with melanoma or non-small cell lung cancer that has spread to the brain can safely skip stereotactic radiosurgery (focused radiation) after having a brain tumor surgically removed. Instead of radiation, participants receive systemic thera…

This trial tests whether removing a brain bleed with a minimally invasive scope within hours of symptoms improves recovery. 300 adults with a specific type of brain bleed will be randomly assigned to either get the surgery plus standard care, or standard care alone. The study wil…

This Phase 2 study tests an investigational drug called emraclidine in about 268 adults with schizophrenia. The trial has two parts: Part A looks at how the drug moves through the body and its safety at different doses, while Part B measures whether it improves symptoms like hall…

This study tests a new combination of medicines (BPaLMZ) against the standard treatment for tuberculous meningitis, a serious brain infection. About 240 adults, including those living with HIV, will take part. The goal is to see if the new combo helps more people survive and reco…

This study tests a drug called DM199 in about 728 people who have had a moderate stroke and cannot get clot-removing treatments. The drug is given through a vein and then as shots under the skin for three weeks. Researchers want to see if it helps patients recover better than a p…

This study will test whether having a pharmacist review a patient's genetic test results can improve treatment for major depression. 220 adults in Pennsylvania who are starting or changing antidepressant medication will be randomly assigned to either receive this specialized medi…

This early-phase study tests a new two-drug combination for adults whose high-grade glioma (a fast-growing brain tumor) has returned after standard treatment. The drugs are temozolomide (a chemotherapy pill given daily at low doses) and abexinostat (an experimental drug that may …

This study tests a new biologic drug called ARGX-119 in children aged 5 to 17 with spinal muscular atrophy (SMA). About 60 participants will receive either ARGX-119 or a placebo by IV infusion for 24 weeks, alongside their usual SMA therapy. The goal is to find the best dose and …

This study tests two drugs—tarlatamab and temozolomide—in adolescents and adults with high-grade brain tumors that have a specific marker called DLL3. The goal is to see if the combination is safe and can shrink tumors. About 70 participants will be enrolled across multiple cente…

This early-stage trial tests a drug called ALN-APP (mivelsiran) in 60 adults with mild cognitive impairment or mild dementia due to early-onset Alzheimer's disease. The drug is given via a spinal injection to see if it safely lowers certain proteins linked to Alzheimer's in the b…

This early-stage study tests a new drug called ALN-5288 in 50 adults with mild cognitive impairment or dementia caused by Alzheimer's disease. The drug is given via a spinal injection and aims to safely reduce tau protein levels in the brain. The main goal is to check safety and …

This study tests whether a 5-day course of the steroid methylprednisolone can improve long-term recovery in adults with moderate to severe traumatic brain injury. 520 participants will receive either the drug or a placebo, added to standard care. Researchers will measure neurolog…

This Phase 2 trial is testing whether HB-1, a tablet combining two blood pressure medications (telmisartan and verapamil), can safely reduce PTSD symptoms. About 200 adults aged 18-65 with PTSD will receive either HB-1 or a placebo daily for 12 weeks. The main goal is to see if H…

Researchers are testing whether a balloon catheter coated with the drug sirolimus can safely open narrowed coronary arteries in adults with heart disease. The balloon inflates to press the drug into the artery wall, aiming to keep the vessel open without leaving a permanent stent…

This study is testing the long-term safety of an oral drug called Emrusolmin (TEV-56286) in 200 adults with multiple system atrophy (MSA), a rare and serious brain disorder. Participants who completed a prior trial will take the drug for about 100 weeks. The main goal is to see h…

This study tests a new automated method to fine-tune adaptive deep brain stimulation (aDBS) for people with Parkinson's disease. aDBS uses brain signals to adjust stimulation in real time, but setting it up is complex. The trial will compare automated aDBS to standard continuous …

This early study tests if deep brain stimulation (DBS) is safe and effective for people with severe depression that hasn't improved with other treatments. Twenty adults will have a device implanted in their brain and be monitored for five years. The device will be turned on and o…

This phase 3 study is testing the long-term safety of KarXT, a new drug for managing mania in people with bipolar I disorder. About 450 participants, including those who completed earlier studies and new volunteers, will take KarXT along with standard mood stabilizers like lithiu…

This study tests a drug called apitegromab in children under 2 years old who have spinal muscular atrophy (SMA), a genetic condition that causes muscle weakness. The drug works by blocking a protein that limits muscle growth. Researchers want to see if adding apitegromab to stand…

This phase 3 trial tests whether KarXT (a combination of xanomeline and trospium chloride) can prevent relapse in people with schizophrenia. Participants who have had a recent hospitalization for schizophrenia and still have symptoms will receive KarXT or a placebo. The study mea…

This trial is testing whether an experimental medication called centanafadine, taken once daily as extended-release capsules, can help adults with attention-deficit/hyperactivity disorder (ADHD) who also experience emotional dysregulation—difficulty managing emotions like irritab…

This trial tests whether adding robotic rehabilitation devices to standard physiotherapy can improve arm and leg function in adults with movement problems from stroke, spinal cord injury, traumatic brain injury, or orthopedic surgery. Participants will receive robotic-assisted se…

This study tests a drug called mirdametinib in children, adolescents, and young adults with low-grade glioma, a type of brain tumor. The drug is designed to cross into the brain and block a protein that helps tumors grow. The trial has two phases: Phase 1 finds the safest dose, a…

This study tests an experimental drug called ALN-SOD in people with ALS caused by a mutation in the SOD1 gene. The drug is given via spinal injection to target the root cause of the disease. The main goal is to check safety, but researchers will also measure effects on biomarkers…

This study tests whether a new drug, sacituzumab tirumotecan (Sac-TMT), given alone or with pembrolizumab, helps people with advanced triple-negative breast cancer live longer or keep their cancer from growing. About 1,000 adults whose cancer has spread and who have not had prior…

This study tests two different doses of an intravenous immune globulin (IGIV 10%) as maintenance therapy for adults with chronic inflammatory demyelinating polyneuropathy (CIDP), a nerve disorder causing weakness and numbness. About 161 participants will receive either a higher o…

This Phase 3 trial tests a single inhaled dose of alprazolam (a fast-acting sedative) to stop prolonged seizures in people aged 12 and older. The goal is to see if it can end a seizure within 90 seconds and prevent it from coming back for at least 2 hours. About 350 participants …

This study tests an experimental gene therapy called ASP2767 in people with open-angle glaucoma, a common eye disease that damages the optic nerve and can lead to vision loss. The therapy uses a harmless virus to deliver genes into the eye, helping retinal nerve cells produce pro…

This study tests a new drug called CBL0137 in children and young adults (ages 1 to 21) whose solid tumors, brain tumors, or lymphoma have returned or stopped responding to treatment. The goal is to find the best dose, check side effects, and see if the drug can shrink tumors. The…

This study tests whether giving a whole blood transfusion can help children under 5 with severe malaria and very low platelet counts survive. The trial is enrolling 132 children in Zambia. Researchers will compare death rates and blood changes between those who get a transfusion …

Researchers are testing whether an intravenous dose of the enzyme dornase alfa can reduce the body's inflammatory response after an acute ischemic stroke. The trial enrolls 36 adults who arrive at the hospital within 12 hours of symptom onset and have moderate to severe stroke sy…

This pilot study tests whether giving tenecteplase directly into brain arteries after thrombectomy can restore blood flow in acute ischemic stroke patients whose vessels remain partly blocked. Thirty adults with a large vessel blockage in the front of the brain receive the drug t…

Researchers compare two imaging strategies for planning left atrial appendage closure in adults with nonvalvular atrial fibrillation. Participants are randomly assigned to have their heart anatomy assessed either by transesophageal echocardiography or by cardiac CT angiography be…

Researchers are testing a radioactive gel called rhenium-186 obisbemeda in children and young adults, ages 6 to 21, whose ependymoma or high-grade glioma has come back or keeps growing after treatment. The gel is infused directly into the tumor through a thin tube, a method calle…

Researchers are testing whether intravenous tenecteplase, a clot-dissolving drug, can improve recovery for people with acute ischemic stroke when given 4.5 to 6 hours after symptoms begin. The trial enrolls adults with confirmed stroke and moderate to severe symptoms. Participant…

Researchers are testing a non-invasive device that uses focused ultrasound to target the hippocampus, a brain region involved in temporal lobe epilepsy. The study enrolls adults whose seizures continue despite medication. Participants receive ultrasound treatments twice a week fo…

Researchers are testing an experimental human monoclonal antibody called NG004 in people who have recently sustained an acute incomplete cervical spinal cord injury. Participants receive repeated injections of NG004 directly into the spinal fluid. The trial's main goal is to chec…

Researchers are testing a radioactive drug called rhenium-186 obisbemeda in adults whose solid-tumor cancer has spread to the leptomeninges, the tissues lining the brain and spinal cord. The drug is a nanoliposome carrying rhenium-186, a radioactive isotope, and it is given throu…

Researchers are testing stereotactic body radiation therapy (SBRT) in adults whose cancer has spread to the spine and is pressing on the spinal cord. SBRT delivers high doses of radiation precisely to the tumor while limiting damage to nearby tissue. The trial enrolls 50 particip…

Researchers in Belo Horizonte, Brazil, are testing iVIDAVC, a behavior-change program adapted from an Irish model, to help stroke survivors adopt healthier habits. The program combines an educational session, one-on-one coaching, and weekly group meetings led by a physiotherapist…

Researchers are studying whether a combination of blood tests, retinal imaging, and brain scans can improve the detection and staging of Alzheimer's disease in Chinese adults. The study enrolls 300 people, including those with probable Alzheimer's dementia and those without. Part…

This study tests whether a handheld device called the MasSpec Pen can tell the difference between cancerous MPNST, benign neurofibromas, and normal tissue during surgery. About 60 people with MPNST or neurofibroma will take part. The goal is to see if the device is safe and accur…

Researchers are testing a radioactive tracer called FMISO with PET/MRI scans to map oxygen levels inside malignant brain tumors. Adults with a suspected glioma receive the tracer by IV, then undergo brain scans that combine PET and MRI, sometimes with contrast dyes. The study che…

Researchers at Johns Hopkins University are studying whether neuromuscular ultrasound and MRI can serve as reliable markers of swallowing muscle problems in people with inclusion body myositis (IBM). The study compares imaging and clinical findings in 30 participants, including p…

This study tests whether a special ultrasound with a contrast dye can safely and effectively measure brain health in infants with hydrocephalus, a condition where fluid builds up in the brain. About 20 infants under 1.5 years old will receive an injection of the contrast agent th…

This study looks at two different lab tests (live-cell and fixed-cell) to see which one is better at diagnosing MOGAD, a rare autoimmune disease that affects the brain and nerves. Researchers will test 240 adults who are suspected of having MOGAD, along with people who have other…

This study is testing a new, quick MRI technique called Magnetic Resonance Fingerprinting (MRF) to better tell the difference between a brain tumor coming back and damage from radiation therapy (radiation necrosis). About 90 people will take part, including healthy volunteers, pa…

This study is testing a small device that fits in the ear to detect seizures by measuring brain waves. Researchers will first test it on 5 healthy people, then on 10 people with epilepsy who are already scheduled for a standard scalp EEG. The goal is to see if the in-ear device i…

Motor neuron disease (MND), including ALS, is hard to diagnose and often takes years to confirm. This pilot study uses a powerful 7 tesla MRI scanner to look for detailed brain features, called imaging biomarkers, that are specific to MND and its subtypes. Researchers will scan 3…

This study tests whether using two contrast agents (gadolinium and ferumoxytol) in one MRI session can improve the detection and diagnosis of brain and central nervous system abnormalities. About 150 participants with neurological symptoms or known brain lesions will undergo imag…

This study is testing a new DNA-based test called Delve Detect CSF that looks for germs in spinal fluid. The goal is to see if using this test early, instead of as a last resort, helps doctors diagnose brain infections faster. About 400 people with suspected brain infections will…

Researchers at Gødstrup Hospital are studying whether balance and dizziness problems in young children come from the inner ear's balance system. The study includes 30 children aged 6 months to 10 years who have delayed gross motor development or dizziness and balance issues. Chil…

Researchers at the University of California, San Francisco are testing whether a device called NIRSIT can measure depression severity by shining near infrared light through the forehead to track blood oxygen levels in the frontal lobe. The study compares adults diagnosed with Maj…

Researchers are testing a radioactive tracer called 18F/68Ga-GP1 that binds to a protein found on blood clots. Adults with suspected, newly diagnosed, or previously treated thrombi receive one intravenous injection and then undergo PET/CT or MRI imaging. The study measures how mu…

Researchers test whether a portable low-field MRI scanner in the emergency department can help diagnose ischemic stroke faster and guide treatment. The trial enrolls 60 adults who arrive within 6 hours of stroke symptoms and are eligible for clot-busting drugs or clot removal. By…

Researchers at Yale University are testing a PET imaging tracer called [18F]3F4AP to see whether it can measure demyelination, the loss of the protective myelin sheath around nerve fibers. The study includes healthy volunteers and people with conditions such as multiple sclerosis…

People who need emergency surgery after a traumatic event like a car crash or fall face a higher risk of developing post-traumatic stress disorder. This trial tests whether giving the sedative dexmedetomidine during surgery, with or without adding a non-invasive ear stimulation c…

This study tests a brain health service designed to assess and reduce dementia risk in people aged 55 to 85 who have subjective cognitive decline (memory concerns without objective impairment). Participants are randomly assigned to either a personalized 6-month program—combining …

This study tests whether a prenatal education program can help pregnant women learn about and avoid toxic chemicals found in contaminated seafood. The program teaches about seafood benefits, risks, and safe handling. Researchers will measure changes in knowledge and whether women…

This study tests a program called COACH that trains youth football coaches on safer practice planning to reduce head impacts and concussions. Researchers will track head impacts and cognitive changes in 880 players over a season. The goal is to see if the program is both practica…

Researchers are comparing two LDL cholesterol targets in adults who have had a small vessel occlusion stroke, a type of stroke caused by blocked small arteries deep in the brain. Participants receive standard cholesterol-lowering drugs, with or without ezetimibe or PCSK9 inhibito…

The VISTA trial compares two approaches for people who have had a stroke or mini-stroke caused by severe narrowing of an artery in the neck that supplies the back of the brain. Participants are randomly assigned to receive either a drug-eluting stent plus blood thinners or blood …

The CEST trial compares two timings for carotid revascularization, a procedure that clears a narrowed neck artery to prevent another stroke. It enrolls adults who have had recent stroke symptoms and an MRI-confirmed small area of brain injury in the territory of that artery. Part…

People who suffer spinal cord injuries face a high risk of dangerous blood clots, and doctors usually prescribe enoxaparin, a daily injection, to prevent them. This trial compares enoxaparin with apixaban, an oral blood thinner, in 60 adults recovering from spinal cord injury at …

This study looks at whether adjusting deep brain stimulation (DBS) can improve movement, speech, and swallowing in people already implanted with DBS for conditions like tremor, stroke, or traumatic brain injury. Researchers will test hand dexterity, grip strength, facial movement…

This study tests whether a nature-based healing meditation program can help friends and family caregivers who are grieving the loss of a loved one to cancer. The program includes six audio meditation modules available online. Researchers will measure how feasible and acceptable t…

Researchers at Hannover Medical School are testing whether intermittent theta-burst stimulation (iTBS), a non-invasive brain stimulation technique, can reduce negative symptoms and improve thinking in people with schizophrenia. The trial enrolls 60 adults aged 18 to 65 with a sch…

People with insomnia often feel pain more intensely and recover from muscle strain more slowly. This pilot trial tests whether repetitive transcranial magnetic stimulation (rTMS), a non-invasive technique that alters brain activity, can reduce pain sensitivity and speed recovery …

This study tests an accelerated form of Transcranial Magnetic Stimulation (TMS) for depression in pregnant and postpartum individuals. Instead of daily sessions for weeks, participants receive multiple treatments over just 5 days. The goal is to see if this faster approach is saf…

This study tests whether mentally practicing walking while watching videos of people walking can improve gait in people with multiple sclerosis. Twenty participants will either watch walking videos and imagine themselves walking, or watch nature scenes. Researchers will measure m…

This pilot study tests whether a faster schedule of non-invasive magnetic brain stimulation, called accelerated intermittent theta burst stimulation (iTBS), is practical and safe for adults with both PTSD and major depression. Participants receive six short sessions per day for f…

Researchers are testing whether transcranial random noise stimulation (tRNS), a non-invasive brain stimulation technique, can improve behavioral and psychological symptoms in people with early Alzheimer's disease. The trial enrolls 40 participants who receive either active tRNS o…

This Phase 3 trial tests whether fenfluramine (Fintepla) can reduce behavioral and emotional symptoms in people with Rett syndrome. About 200 participants will receive either the drug or a placebo for 14 weeks. The study measures changes in behavior, sleep, and overall condition …

This study looks at whether adding pelvic floor physical therapy before standard radiation treatment can help reduce pain and sexual problems in women with cervical, vaginal, vulvar, uterine, or anal cancer. About 20 participants will receive education on using a vaginal dilator …

Researchers test whether adding rectal ozone therapy to usual care can reduce numbness and tingling in people with chemotherapy-induced peripheral neuropathy. The trial enrolls 42 adults whose cancer is stable or in remission and who have had persistent numbness or tingling for a…

This study looks at how people recover from Cushing syndrome after surgery. Researchers want to understand what affects recovery and whether using a MUSE biofeedback headband can help ease withdrawal symptoms. The study will include 700 adults who are planning to have curative su…

This study tests whether wearing blue-blocking glasses at night can help teenagers (ages 12-18) with insomnia or delayed sleep phase disorder who are already receiving psychiatric care. Forty participants will wear the glasses or use real darkness for one week. The goal is to see…

Researchers are testing whether playing video games can reduce anxiety in adolescents aged 11 to 15 with elevated anxiety symptoms. The trial compares an action game designed to boost attention control, a casual puzzle game, and no game at all. Teens play at home online for six w…

Researchers test whether a brain-computer interface neurofeedback program can improve attention, memory, and thinking in children and teens aged 7 to 21 with acquired brain injury or epilepsy. Participants play 3D computer games while wearing an EEG headset that responds to their…

Researchers are testing whether an accelerated protocol of transcranial magnetic stimulation using the BTL-699-2 device can reduce anxiety symptoms in adults with generalized anxiety disorder. The trial enrolls 40 adults aged 22 and older who receive 16 stimulation sessions over …

Researchers are testing whether MLC901 (NeuroAiD II), a natural capsule, helps people recover after a mild to moderate ischemic stroke. The trial enrolls 80 adults aged 18 to 80 who are within 2 to 10 days of their stroke. Participants receive either MLC901 plus standard stroke c…

Researchers at the University of Washington are testing whether non-invasive spinal stimulation can temporarily reduce muscle stiffness and improve walking in people with cerebral palsy. The study includes 20 participants aged 4 to 65 who can walk for at least 10 minutes. Partici…

This study tests whether buspirone, a medication used for anxiety, is safe and effective for autistic youth aged 7 to 17 who also have anxiety disorders. Researchers will measure changes in anxiety symptoms over 16 weeks. The goal is to see if this drug can ease anxiety in this s…

This study tests whether a digital art therapy app called ARTCan is practical and acceptable for young adults aged 18-25 who survived childhood cancer. Participants use the app for 6 weeks to create art and complete mood surveys. The goal is to see if at least 10 out of 15 partic…

This trial tests an experimental drug called LTX-001 in adults with schizophrenia who are experiencing a sudden worsening of symptoms. Participants stay in a research unit for about five weeks and receive either LTX-001 or a placebo. The main goal is to see if the drug is safe an…

Many people who care for a family member with dementia struggle with sleep. This trial tests an 8-week program that combines a sleep self-help manual, cartoon videos, and weekly telephone coaching. Researchers randomly assign 120 caregivers to either the sleep program or an educa…

Researchers at Penn State are testing whether the BaSICS program reduces anxiety, depression, and suicide risk in 11- to 14-year-olds from low-income families who are waiting for mental health services. The program teaches coping skills, healthy identity development, and collecti…

Researchers are testing whether transcranial direct current stimulation, a gentle electrical current applied to the scalp, combined with a cognitive behavioural programme can reduce fatigue in people who have had a stroke. The trial enrolls 75 adults who had a stroke at least six…

People who lose arm and hand function after stroke or injury often need more therapy than clinics can provide. Researchers are studying ReHandyBot, a robotic device that guides hand and forearm exercises using virtual reality and touch feedback. The trial checks whether patients …

After a stroke, some people develop unilateral spatial neglect, where they ignore one side of their body or surroundings. Researchers are testing whether an immersive virtual reality program that involves playing a virtual piano can improve this condition. Adults with stroke and …

Researchers in South Punjab, Pakistan, are testing whether supervised aerobic exercise improves depression treatment. Adults aged 18 to 55 with moderate to severe depression receive either the antidepressant sertraline alone or sertraline plus three weekly sessions of cycling or …

This study tests whether giving coloring activities (nature scenes, geometric shapes, word searches, or free drawing) to adults waiting in the emergency department can lower their self-reported pain and anxiety. Researchers will measure changes using standard questionnaires. If e…

This study tests zavegepant (Zavzpret), a nasal spray already approved for migraines, in 200 adults who also take CGRP-targeting preventive medications. Researchers want to see if it provides headache relief within 2 to 4 hours and improves daily function. The goal is to find a s…

Researchers are testing a two-day group therapy program for military couples where one partner has PTSD. The program, called AIM-CBCT for PTSD, teaches couples skills to manage PTSD symptoms and improve their relationship. They compare it with a standard relationship education pr…

This trial is testing whether a digital therapy app called NDTx-03, used alongside usual care, can help children and adolescents aged 10 to 18 with autism spectrum disorder or social communication disorder better recognize and respond to social situations. The app combines cognit…

This study tests whether balance training tailored to each person's difficulty level is feasible for people with multiple sclerosis during a three-week inpatient rehabilitation stay. Participants are randomly assigned to either standard group training or individually tailored bal…

Researchers test whether a non-invasive brain stimulation called tACS can help people with schizophrenia better tell themselves apart from others. The trial delivers 10 Hz current to the medial prefrontal cortex for 20 minutes daily over five days. Participants include patients w…

This pilot study tests whether hippotherapy, a type of physical therapy using the natural movement of a horse, can improve mobility, gait, balance, and quality of life in people with Parkinson's disease. Participants will be randomly assigned to receive either hippotherapy sessio…

This study tests whether adding a non-invasive brain stimulation technique called repetitive transcranial magnetic stimulation (rTMS) to standard physical therapy can improve arm and hand function in people who have had a first ischemic stroke. Sixty-six adults aged 18 to 80 with…

This study tests whether taking branched chain amino acids (BCAAs) twice a day for three weeks can improve sleep in people with traumatic brain injury. Researchers will also check if the supplement is easy to take and if participants stick with it. The study involves 300 veterans…

This trial tests whether cannabidiol (CBD) can reduce symptoms of post-traumatic stress disorder (PTSD) in adults. Participants take either CBD or a placebo for 8 weeks, and researchers measure changes in PTSD symptoms using standard clinical assessments. The study aims to see if…

This study tests whether a new drug called TSND-201 can safely reduce PTSD symptoms in adults. About 300 people with PTSD will receive either one of two doses of TSND-201 or a placebo once a week for 4 weeks, then be followed for 8 more weeks. The goal is to see if the drug helps…

Researchers are testing a home-use pulsed electromagnetic therapy device in 40 people with mild to moderate Alzheimer's disease. Participants use the device three times a day for 15 minutes over 120 days. The study measures changes in thinking and memory using standard tests, wit…

This study tests whether personalizing the Healthy Minds Program app can improve well-being in people with mild depression. About 1500 participants will use the app for 4 weeks, with some getting personalized features like tailored module order or supportive text messages. The go…

This study tests a 16-week exercise program designed specifically for Hispanic people with multiple sclerosis who have walking problems. About 66 participants will either join the exercise group or a waitlist. The goal is to see if the program improves walking ability and quality…

This study tests whether a quick form of brain stimulation called SAINT can reduce symptoms of postpartum depression better than a fake treatment. It will include 192 women who are up to 12 months after giving birth and whose depression hasn't improved with standard care. The mai…

This study tests whether an online program called Man Therapy can help male military members with anger problems, including those who have had a mild traumatic brain injury. About 226 participants will either use the program right away or wait. Researchers will measure anger, PTS…

This pilot study tests whether a device called IVS3 is tolerable and easy to use for arm recovery in people who had a stroke at least 6 months ago. The device uses mirrored video to create the illusion that the affected arm is moving. Researchers will track how many sessions part…

This phase 3 trial tests whether a combination of two drugs, KarXT and KarX-EC, can safely reduce agitation in people with Alzheimer's disease. About 352 adults with Alzheimer's-related agitation will receive either the drug combo or a placebo for 14 weeks. The main goal is to se…

This study tests whether a simple injection of dextrose (sugar water) into the neck can reduce symptoms like anxiety, brain fog, and depression in people with PTSD who haven't improved after trying multiple medications and therapies. About 50 adults will receive either the dextro…

This study tests whether cannabidiol (CBD), a compound from cannabis, can reduce urinary incontinence in people with recent spinal cord injury. Twenty adults with at least two leaks per day will take a purified CBD drug (Epidiolex) twice daily for 90 days. The main goal is to see…

This study tests a new type of talk therapy called Identity-Based Transdiagnostic Therapy (IBTT) for young adults with anxiety or depression. It compares IBTT to a well-known therapy called the Unified Protocol (CBT-based). The goal is to see if IBTT is more engaging and effectiv…

This study will test whether a gentle, non-invasive brain stimulation technique called tDCS can improve verbal fluency, thinking, and motor control in people with Parkinson's disease. Twenty participants aged 50-90 with Parkinson's and a verbal fluency deficit will receive the st…

This study tests whether a non-invasive brain stimulation technique called repetitive transcranial magnetic stimulation (rTMS) can help people with schizophrenia spectrum disorder quit or reduce smoking. Fifty participants will receive active rTMS using either an F8 coil or an H …

This study tests whether virtual reality (VR) can help healthcare workers and COVID-19 patients with posttraumatic stress disorder (PTSD). Participants will use VR headsets during 10 therapy sessions over 5 weeks to safely revisit and overcome traumatic memories. The goal is to s…

This early study tests whether a surgically implanted device that stimulates the vagus nerve can boost the effects of talk therapy for people with chronic PTSD. Twenty adults who have not gotten better with standard treatments will receive either active or sham stimulation alongs…

This study compares the effectiveness, safety, and long-term benefits of commonly used insomnia medications, including prescription drugs like zolpidem and trazodone, and over-the-counter options like melatonin and diphenhydramine. Researchers will enroll 1,200 adults with chroni…

This study follows 60 people with essential tremor or Parkinson's tremor whose symptoms aren't well-controlled by medication. After receiving stereotactic radiosurgery—a precise dose of radiation to a small brain area—participants fill out questionnaires about their quality of li…

This phase 3 trial tests whether a combination of two drugs, KarXT and KarX-EC, can safely reduce agitation in people with Alzheimer's disease. About 352 adults will receive either the drug combo or a placebo for 14 weeks. The main goal is to see if agitation symptoms improve, as…

Researchers at Chang Gung Memorial Hospital are testing whether intermittent theta burst stimulation, a non-invasive form of brain stimulation, can help autistic people with minimal verbal ability or intellectual disability regulate their emotions and behavior. The study enrolls …

This study tests whether lumateperone (Caplyta) can help older adults (60+) whose depression hasn't improved with other treatments. One hundred participants will take either the drug or a placebo alongside their current antidepressant for 10 weeks. Researchers will measure change…

Researchers are testing an oral drug called LPCN 1154A as a possible treatment for severe postpartum depression. The trial enrolls women aged 15 to 45 who gave birth within the past 18 months and developed depression during pregnancy or shortly after delivery. Participants receiv…

This study tests whether playing gentle sounds during deep sleep can improve thinking and emotional control in young adults (ages 18-25) with anxiety, depression, and sleep problems. Participants will spend two nights in a sleep lab, once with tones and once without, and complete…

This study tests whether four short, guided conversations with a trained nurse can lower anxiety and improve breastfeeding confidence in mothers who have a planned C-section. About 160 women will be randomly assigned to either standard care or standard care plus these nurse-led c…

This study tests a medicated skin patch (dexmedetomidine) to see if it can reduce agitation in people with Alzheimer's dementia. About 150 adults living in care facilities will receive either the patch or a placebo for 96 hours. The goal is to measure changes in agitated behavior…

This study tests whether forced aerobic exercise (using a bike that helps move your legs) can improve arm and leg recovery after a stroke better than traditional therapy. About 66 people who had a stroke 3-9 months ago will take part. Researchers will also check if this approach …

Researchers are testing whether epidural electrical stimulation can improve bladder function in people with spinal cord injuries. The trial enrolls adults with injuries above T11 who have trouble urinating and rely on catheters. Participants receive an implanted spinal cord stimu…

This study tests a new version of a therapy called RTM-C for children aged 6-14 with PTSD. The treatment uses child-friendly language, games, and animated tools to help kids safely replay difficult memories and reduce fear. About 40 children and their parents will take part in up…

This study is testing the long-term safety of a combination of two drugs, KarXT and KarX-EC, for treating agitation in people with Alzheimer's disease. It is an open-label extension, meaning everyone knows they are getting the treatment. The study enrolls 600 participants who hav…

Researchers are testing whether a home-based program combining adapted exercise and mindfulness training can improve walking ability and sleep quality in people with rare neurodegenerative diseases such as leukodystrophy, ataxia, and adrenomyeloneuropathy. The study enrolls about…

Researchers are testing a once-weekly tablet of brexpiprazole against placebo in adults hospitalized for an acute episode of schizophrenia. The trial enrolls about 450 people aged 18 to 74 who need hospital care for a relapse. Over seven weeks, participants receive either the act…

Researchers are testing whether ketamine infusions combined with mindfulness-based cognitive therapy improve quality of life more than mindfulness therapy alone in adults who have both chronic pain and posttraumatic stress disorder. The pilot study enrolls 30 veterans and civilia…

This pilot trial tests whether a home-based, technology-supported hand training program can improve hand function in adults who had a stroke at least six months ago. Participants receive either remotely guided hand activities via video conferencing or a standard home exercise pam…

This early-stage study is checking if insulin nasal spray is safe for people with spinal cord injury. Up to 12 adults who had an injury at least 4 months ago will use the spray or a placebo daily for up to 24 days. Researchers will monitor side effects and see if virtual training…

Researchers are testing an experimental drug called OSU6162 in adults with bipolar disorder who are in a depressive phase and already taking a mood stabilizer. The trial aims to see whether the drug reduces depressive symptoms over eight weeks. Participants receive flexible doses…

This study tests whether squeezing a stress ball during wound cleaning (debridement) helps reduce pain, distress, and changes in heart rate or blood pressure in people with diabetic foot ulcers. About 84 adults with type 2 diabetes will be randomly assigned to use a stress ball o…

This phase 2 trial tests whether low intensity focused ultrasound, aimed at a deep brain region called the amygdala, can ease PTSD symptoms in 60 veterans. The treatment is non-invasive and uses sound waves similar to diagnostic ultrasound. Researchers will measure symptom change…

This study tests a behavioral training program that teaches people with chronic spinal cord injury to reduce a specific leg reflex. The goal is to decrease spasticity and improve walking speed and distance. 25 participants will train for about 6 months, with researchers measuring…

This early-stage study tests whether a single 25 mg dose of psilocybin can help people who still feel emotionally flat or uninterested in things despite taking antidepressants. About 90 adults aged 18-65 will receive either psilocybin or a placebo, and researchers will use brain …

This trial tests whether a mild electric current applied to a brain area linked to memory can improve verbal recall in people with relapsing-remitting multiple sclerosis. Participants will receive either active or sham stimulation during cognitive tasks, and their performance wil…

This study tests a mobile health app called iMHere 2.0 designed to help veterans with spinal cord injury and their family caregivers manage stress and improve well-being. Researchers will work with 100 participants to gather feedback and tailor the app to their needs. The goal is…

Care homes face shortages of trained staff, and more than half of residents have some form of dementia. Researchers are testing whether retired volunteers can lead a group music and discussion program called Making Connections Thru Music. The study enrolls 196 people: volunteers …

This pilot study tests whether a mild electrical current applied to the spinal cord (transcutaneous stimulation) can improve leg muscle strength, walking, and bladder function in 20 children with spina bifida (myelomeningocele). The children, aged 4-17, will receive stimulation w…

This study tests whether a single 25 mg dose of psilocybin, given with therapy, can ease depression in people with bipolar II disorder who haven't improved with standard treatments. About 90 adults aged 19-65 will receive either the full dose or a very low placebo dose, and their…

Trigeminal neuralgia causes sudden, severe facial pain that can send people to the emergency department. This observational study at a Spanish hospital follows 20 adults who receive intravenous lacosamide, an anti-seizure drug, as a rescue treatment for a pain flare. Researchers …

This study tests whether low-intensity focused ultrasound (LIFU), a gentle sound wave technique, can safely improve speech fluency in people who stutter. Twenty adults who stutter will receive LIFU or a sham treatment, and researchers will measure changes in stuttering severity a…

Researchers are testing a digital app called BRAIN that uses artificial intelligence to personalize cognitive stimulation for people with dementia. The app tailors activities to each person's interests and background, aiming to improve engagement, quality of life, and relationshi…

This study will enroll 400 youth aged 8-18 with chronic medical conditions who have experienced trauma. Participants will first receive group therapy using either SPARCS or UP, two evidence-based talk therapies. Those who still need help after group therapy will then receive indi…

This study tests whether a single injection of RE104 can reduce symptoms of depression or mixed depression and anxiety in people with adjustment disorder caused by a serious medical illness like cancer, ALS, multiple sclerosis, Parkinson's disease, or idiopathic pulmonary fibrosi…

This study tests whether a safe, at-home brain stimulation device called tDCS can help people with depression that hasn't improved with standard treatments. Ten participants will use the device at home under remote supervision for two weeks. The goal is to see if the approach is …

This study looks at how two parts of cannabis, THC and CBD, affect thinking and bladder symptoms in people with Multiple Sclerosis (MS). Thirty adults with MS will take either THC or CBD oil for 15 weeks and complete tests and questionnaires. The goal is to see if one compound he…

Researchers at San Diego State University are testing an 8-week online program that teaches intuitive eating principles to pregnant women with obesity. The program includes weekly video modules and workbook exercises, with optional office hours. The study will compare participant…

This trial asks whether adding gentle nerve mobilization to standard PNF exercises can improve facial symmetry and movement in people with Bell's palsy, a condition causing one-sided facial weakness. Adults aged 15 to 60 with moderate to severe Bell's palsy will be randomly assig…

Researchers are testing whether adding the experimental drug OSU6162 to an SSRI or SNRI antidepressant helps adults whose depression has not improved with those drugs alone. The trial enrolls 180 people aged 25 to 75 who meet criteria for major depressive disorder and have not re…

This early study tests a device that uses low-intensity focused ultrasound to calm overactive brain areas in people with drug-resistant temporal lobe epilepsy. Eight adults will receive up to three 10-minute ultrasound sessions. Researchers will track side effects and check if se…

This trial tests whether adding personalized feedback makes an ultra-brief online program more effective for adults with depression and anxiety. The program, called Things You Do, teaches skills to increase healthy actions like meaningful activities, healthy thinking, and social …

This study tests whether a smartphone app that helps improve sleep, along with a wearable activity tracker, can support brain health in older adults (65+) after hip or knee replacement surgery. The goal is to see if better sleep can reduce confusion or memory problems after surge…

Researchers are testing whether people with Parkinson's disease, epilepsy, or essential tremor can use visual neurofeedback to change abnormal brain activity linked to their symptoms. Participants already scheduled for deep brain stimulation surgery use their implanted electrodes…

Researchers are testing whether combining transcranial random noise stimulation (tRNS) with neurofeedback can improve attention in adults who have sustained a brain injury from stroke, trauma, or lack of oxygen. Participants receive sessions that pair 10 minutes of tRNS with 20 m…

Many people with Parkinson's disease develop problems with thinking and memory, and few treatments help. This trial tests whether deep brain stimulation delivered at a specific rhythm, called theta frequency, can improve working memory. Participants already have a stimulator impl…

This study tests an oral medication called ubrogepant, already approved for adults, to see if it safely and effectively treats migraine attacks in children and adolescents aged 6 to 17. About 1,059 participants with a history of migraine will receive either a low or high dose of …

This study tests whether a midwife-led digital follow-up program can reduce postpartum depression and improve breastfeeding success in women who had a C-section. About 104 women will either get the digital program or standard care. The goal is to see if extra support through phon…

This study tests whether pairing electrical stimulation of the brain's hand area with stimulation of a wrist nerve can improve hand and arm function in adults with hemiplegic cerebral palsy (hCP). Researchers will measure changes in muscle responses and dexterity tasks like movin…

This study tests a treatment called repetitive transcranial magnetic stimulation (rTMS) for people who have had a stroke more than six months ago and still feel very tired. Fatigue is a common problem after a stroke that can make daily activities hard. The researchers will give r…

This study tests a new drug called SPT-300 in 360 adults with major depressive disorder, with or without anxiety. Participants will receive either the drug or a placebo for 6 weeks to see if it reduces depression symptoms. The goal is to find a safe and effective new treatment op…

Researchers at the University of Missouri-Columbia are studying whether improving insomnia can lead to better alcohol outcomes in heavy-drinking adults. The trial enrolls 256 adults who meet criteria for alcohol use disorder and insomnia disorder. Participants receive five weekly…

Researchers are testing a computer-based program that aims to change how anxious children interpret ambiguous situations as threatening. The trial enrolls 72 youth ages 10 to 17 with generalized, separation, or social anxiety disorder. Participants are randomly assigned to either…

Researchers at the University of South Florida are testing whether stroke survivors with chronic aphasia can improve their spontaneous speech by listening to recordings of themselves and correcting mistakes. Participants complete language tasks and then use tablets and headphones…

This study tests a new way to use deep brain stimulation (DBS) for Parkinson's disease. Standard DBS helps movement but can sometimes cause thinking or mood problems. The researchers will add low-frequency stimulation to a different part of the brain while keeping the usual high-…

This study compares two medications, methylphenidate and guanfacine, to see which works better for treating ADHD in children ages 3 to 5. About 370 children with moderate to severe ADHD will take one of the drugs, and doctors will rate how much their symptoms improve. The goal is…

Researchers at Georgetown University are testing whether a mild electrical brain stimulation called transcranial random noise stimulation (tRNS) can boost the effects of visual training in people who have lost part of their vision from brain damage. The study includes 30 adults w…

This study tests a new medicine called ACP-211 in adults with major depression who haven't gotten better with standard antidepressants. About 153 people will receive either the drug or a placebo for 28 days. The main goal is to see if ACP-211 reduces depression symptoms more than…

Children and teens with spastic or dystonic quadriplegia from cerebral palsy often need surgery to control severe muscle tightness that interferes with comfort, movement, and care. Doctors at Boston Children's Hospital are tracking outcomes for two approaches: implanted baclofen …

This study tests whether a therapist-guided online cognitive-behavior therapy program can help reduce obsessive-compulsive disorder (OCD) symptoms in children and teens with autism. About 220 participants will receive the online treatment or a comparison condition. The goal is to…

Researchers are comparing two anticholinergic medicines, benzhexol and procyclidine, to see whether they ease tremor similarly in adults with tremor-predominant Parkinson's disease. About 88 people aged 40 to 70 who already take levodopa will be randomly assigned to add one of th…

Researchers are testing whether electroacupuncture can prevent migraines that strike around a woman's period. The trial enrolls 40 women aged 18 to 45 who have regular cycles and at least three headache days during each menstrual window. Participants receive either real electroac…

This study tests whether a new drug called HNK can quickly improve symptoms in people with major depression that hasn't responded to other treatments. About 50 adults aged 18 to 70 will receive four infusions of HNK and four of a placebo over several weeks, with their depression …

This study tests whether a deep brain stimulator (DBS) that automatically adjusts its settings can better control movement and sleep problems in people with Parkinson's disease. 24 adults aged 25-75 will have electrodes placed under the scalp to record brain signals. The device w…

People with treatment-resistant schizophrenia often take clozapine, a drug that can cause serious weight gain and metabolic problems. This pilot study tests whether a daily infusion made from the leaves of the Nitraria retusa plant can reduce those side effects. Thirty patients w…

Researchers test whether adding a predictive app to a continuous glucose monitor changes fear of low blood sugar, sleep quality, and diabetes distress in adults with type 1 or insulin-treated type 2 diabetes. Participants use the monitor alone for two weeks, then with the app for…

This study tests whether a daily fermented soy product, Haelan 951, can help ease hot flashes and improve sleep in women going through menopause. About 25 peri- and postmenopausal women aged 45-65 will take the product for 45 days and track their symptoms. The goal is to see if t…

This study tests a smartphone app called GAINS that guides caregivers step-by-step through teaching life skills to children with autism, similar to how a GPS gives driving directions. The app breaks down complex tasks into simple steps and provides audio and visual cues. Research…

Researchers at the University of Alberta are testing whether breathing pure oxygen for two minutes at a time can change sensation and movement in adults with long-standing, severe spinal cord injuries. The study enrolls 25 people aged 18 to 65 whose injuries occurred at least thr…

Researchers are testing whether blocking blood vessels in the middle meningeal artery with a liquid material called SQUID can reduce the number of migraine days in people with chronic resistant migraine. The study enrolls 30 adults aged 21 to 70 who have had chronic migraine for …

Researchers at the University of Louisville are studying children who have a cervical spinal cord injury that happened before or during birth. The study combines activity-based recovery training, which uses tasks like stepping and standing, with transcutaneous spinal cord stimula…

Researchers are testing whether giving a neuroprotective drug called 3-n-butylphthalide directly into the brain's arteries is safe and practical for people having a stroke caused by a blocked vessel. Participants are adults who are already scheduled for endovascular therapy, a pr…

Researchers are testing whether four weeks of intensive motor speech therapy can improve speech accuracy in children who have childhood apraxia of speech along with a rare genetic condition. The study enrolls up to 20 children aged 3 to 16. Each child receives 12 sessions of eith…

Researchers test whether an AI chatbot called Pai.ACT can help parents of young children with neurodevelopmental disorders like autism and ADHD. The chatbot delivers acceptance and commitment therapy, a type of talk therapy, and adapts its exercises to each parent's needs. The tr…

Researchers at the University of Rochester are testing a home-based computer program that trains people to detect visual stimuli in their blind field. The trial enrolls adults who have lost part of their vision because of damage to the brain's visual cortex, often from a stroke. …

Researchers are testing a group-based ketamine-assisted psychotherapy program designed for Spanish-speaking adults with depression. The trial enrolls 10 adults who have major depressive disorder and a Montgomery-Asberg Depression Rating Scale score of 20 or higher. Participants r…

Researchers are testing whether giving a neuroprotective drug called 3-n-butylphthalide directly into the brain's arteries is safe and practical for people who have had an ischemic stroke and cannot receive standard clot-removing therapy. The study enrolls 30 adults with moderate…

Researchers are testing whether Tai Chi training or acupuncture can reduce migraine attacks in Hong Kong Chinese women with episodic migraine. The trial assigns 132 participants to either 24 weeks of Tai Chi or a course of acupuncture. The team tracks migraine frequency and days,…

Researchers are testing whether a form of magnetic brain stimulation called intermittent theta-burst stimulation (iTBS) can improve anhedonia, the inability to feel pleasure, in people with major depression. The study compares stimulating two brain areas at once (the left dorsola…

Autistic teens are three to four times more likely to experience depression than their non-autistic peers, yet almost no depression treatment research has focused on autistic youth with below average cognitive abilities. This small study tests a 12-session behavioral activation t…

Researchers are testing an internet-delivered form of acceptance and commitment therapy for people aged 15 to 24 who have PTSD and chronic pain. Participants work through online modules on trauma education, facing avoided memories and situations, mindfulness, and acceptance, with…

Researchers are testing a device called the Pedal Pump, which pumps both feet for 10 minutes to mobilize the body and improve lymphatic flow. The trial enrolls 30 hospitalized patients with lower extremity edema caused by heart failure, chronic venous insufficiency, kidney diseas…

Researchers at the University of Washington are testing whether non-invasive electrical stimulation of the spinal cord through the skin, combined with intensive physical therapy, can improve walking and standing in people with spinal cord injuries. The trial enrolls 20 adults wit…

Researchers are building a large database of cognitive, behavioral, lifestyle, and genetic information from people with neurodegenerative diseases such as Parkinson's disease, multiple system atrophy, and progressive supranuclear palsy. The goal is to find biomarkers that help do…

This study follows 65 infants who had a stroke around birth, tracking their brain development and motor skills over two years. Researchers use MRI scans, brain stimulation, and movement tests to find markers of recovery. The goal is to understand how the brain heals, which could …

Deep brain stimulation uses implanted electrodes to send electrical pulses to specific brain regions, and doctors are still working out how to tune it for each patient. This study records brain activity while adults with neurological or psychiatric conditions perform cognitive an…

Researchers at The Hong Kong Polytechnic University are investigating how insomnia affects pain sensitivity and the soreness that follows exercise. The study compares healthy adults with insomnia to those without, measuring their responses to heat, pressure, and pinprick stimuli.…

This study is a registry that collects information on the safety and effectiveness of Medtronic medical devices already on the market. It will include up to 100,000 people who have or will receive a Medtronic product for conditions like heart, nerve, or digestive disorders. The g…

This study looks at children and teens ages 7-17 who have severe mood problems like chronic anger, sadness, or irritability, along with extreme tantrums. Researchers will use interviews, tests, and brain imaging to understand what happens in the brain. Up to 2,350 participants wi…

This study looks at whether a simple eye test can predict how well people with treatment-resistant depression will respond to a brain stimulation therapy called TMS. Researchers will measure how the pupils react to light before and after TMS treatment in 44 adults. The goal is to…

This natural history study is collecting information from up to 4,000 people with movement disorders (like Parkinson's disease or tremor) and their family members. Participants undergo exams, blood tests, and imaging, but receive no new treatments. The goal is to gather data that…

This study uses special PET scans to measure inflammation in the brains of people with Alzheimer's, Parkinson's, ALS, and other neurodegenerative diseases. Researchers will compare these scans to those from healthy volunteers to see if inflammation levels differ. The goal is to d…

This study investigates whether the bacteria causing Lyme disease can survive antibiotic treatment and cause ongoing symptoms. Researchers will follow 700 participants, including those with chronic Lyme disease, recovered individuals, and healthy volunteers, using blood tests, sp…

This study uses yearly PET scans to track amyloid protein buildup in the brains of 400 adults aged 55 and older over 5 years. Participants are already part of the Baltimore Longitudinal Study of Aging. The goal is to see how these brain changes relate to memory loss and other thi…

This study aims to find differences between organic tics (related to diagnosed disorders) and functional tics (caused by problems in brain-body communication). Researchers will use sensors to measure muscle activity and brain waves in 75 adults with tics and healthy volunteers. P…

This study looks at whether lying flat (0 degrees) or with the head raised (30 degrees or more) after a stroke clot removal procedure helps people recover better. About 2240 adults who had a stroke from a large blood vessel blockage will be randomly assigned to one of the two hea…

This study tests a new radioactive tracer to see if it can measure brain inflammation in people with Alzheimer's disease or mild cognitive impairment. Researchers will compare scans from 90 volunteers (patients and healthy older adults) to understand how inflammation relates to m…

This study looks at how deep brain stimulation (DBS) changes movement in people with conditions like Parkinson's disease or essential tremor. About 60 people scheduled for DBS surgery will have extra temporary electrodes placed on the brain to measure muscle activity during stimu…

Researchers are studying whether an ischemic stroke in the middle cerebral artery territory triggers inflammation and scarring in the heart muscle. The trial enrolls 44 adults with acute stroke and 24 people with stroke-like symptoms but no brain infarct as a comparison group. Pa…

This study looks at how people with moderate to severe traumatic brain injury (TBI) walk and navigate in complex, real-life-like virtual environments, such as streets with other people. Researchers want to understand the specific difficulties these individuals face during everyda…

This observational study looks at whether adults' sleep quality, sleep timing, and natural chronotype (morning vs. evening preference) are linked to how they share resources with others. Participants fill out sleep questionnaires, keep a 7-day sleep diary, and play a brief comput…

Researchers at The Hong Kong Polytechnic University are studying whether acute muscle pain from exercise changes sleep differently in people with insomnia compared to healthy sleepers. The study enrolls 80 adults aged 18 to 60, split into two groups: those with clinical insomnia …

Fibromyalgia causes widespread pain, fatigue, and trouble with daily activities, and these symptoms can shift from day to day even when their average level stays the same. Researchers at Mardin Artuklu University are studying 150 adults with fibromyalgia to see whether daily chan…

Researchers are studying whether blood levels of luteinizing hormone (LH) and human chorionic gonadotropin (hCG) are linked to the presence, severity, and long-term outcomes of endocrine disorders such as osteoporosis, thyroid disease, and adrenal gland problems. The study enroll…

Researchers at National Taiwan University Hospital are studying how the brain combines visual information with movement in people who have Parkinson's disease. They will compare 21 people with freezing of gait, 21 without it, and 21 healthy adults of similar age. Participants com…

Researchers are studying how well people who have had a stroke learn a complex arm and hand skill when they train with one arm versus both arms. Participants include healthy volunteers, people in the early days after a stroke, and people more than six months past a stroke. They p…

Researchers at Xiangya Hospital are building a tool that uses several types of brain monitoring to predict whether patients with severe acute brain injury will be awake, comatose, or deceased 90 days after ICU admission. The study enrolls 200 adults aged 18 to 80 with conditions …

This study tests whether spending more than 2 days in a kangaroo mother care (KMC) ward—where mothers hold their low birthweight babies skin-to-skin and get breastfeeding support—can lower the risk of postpartum depression. About 1,900 mothers and their preterm infants in Zambia …

This observational study aims to understand why some people are more impulsive or compulsive than others. Researchers will use brain scans, genetic tests, and behavioral surveys in 1,100 participants aged 6 to 80, including those with ADHD, OCD, autism, and conduct disorder. The …

This study looks at how social and lifestyle factors—like education, race, and income—affect a person's thinking and memory after a stroke. Researchers will interview 450 adults who had a stroke and review their brain scans and medical records. The goal is to understand why some …

This study looks at how body awareness (knowing where your body is in space), trunk (core) stability, and arm function are related in people with multiple sclerosis (MS). Researchers will measure these abilities in 50 adults with MS and compare them to healthy volunteers. The goa…

This study uses advanced brain scans (MRI and MEG) to better locate seizure-causing areas in people with epilepsy who are considering surgery. Researchers will also create a database of normal brain images from healthy volunteers. The goal is to improve surgical outcomes by compa…

This study screens 360 adults with neurodegenerative disorders like ALS, frontotemporal dementia, and progressive supranuclear palsy. Researchers will use medical history, physical exams, memory tests, movement analysis, MRI scans, and other tests to find common features and diff…

Researchers are studying blood proteins in people who have a severe ischemic stroke caused by a blocked artery in the front of the brain. All 800 participants receive endovascular treatment, a procedure that threads a catheter through blood vessels to remove the clot. The team me…

This study uses ultrasound, a safe imaging technique that uses sound waves, to get detailed pictures and measurements of nerves and muscles. Researchers aim to collect normal values from healthy adults and compare them with data from people who have neuromuscular disorders. The g…

This study looks at how well people hospitalized for a COPD flare-up perceive internal body signals — a skill called interoception — and whether that relates to their breathlessness, depression, and sleep quality. Researchers will assess 50 patients using questionnaires and clini…

This study looks at how ketamine affects the brain in people with major depression and healthy volunteers. Researchers use brain scans, blood tests, and other measures to understand why a single dose works quickly but briefly. The goal is to find biomarkers that could lead to bet…

This early-stage study is testing whether a contrast agent called mangafodipir can safely highlight areas where the blood-brain barrier is broken in people with drug-resistant epilepsy. Forty adults will undergo MRI scans with mangafodipir and gadolinium to see if these scans can…

This study at the National Institutes of Health is looking at 1,000 adults with known or suspected hormone gland (endocrine) disorders. The goal is to better understand these conditions and help train doctors. Participants may receive tests, treatments, or surgery as part of thei…

This study looks at a part of the brain called the posterior cingulate cortex (PCC) to understand how it helps us make memory-based decisions, like recognizing a picture we've seen before. Researchers will record brain activity from 130 epilepsy patients who already have brain mo…

This study looks at how exercise affects the way people with PTSD learn and remember emotional information. One hundred adults with PTSD from interpersonal violence will do either moderate or light cycling after recalling a traumatic memory. Researchers will measure anxiety, hear…

This study follows up to 2,500 people with thyroid problems like hyperthyroidism, hypothyroidism, or Graves' disease. Researchers will track how these conditions develop over time using standard medical tests and genetic samples. The goal is to better understand the natural histo…

This long-term observational study uses MRI scans to track how multiple sclerosis (MS) changes over time in up to 3750 people. Researchers will compare brain images and immune system markers in untreated patients, those on approved therapies, and healthy volunteers. The goal is t…

This early-stage study looks at how a new drug called ABBV-932 moves through the body when taken with another drug, itraconazole. Twenty healthy adults will take both drugs and have their blood levels measured. The goal is to check for side effects and see if itraconazole changes…

This study follows adults with a family history of genetic prion disease to see how and when the condition first appears. Participants undergo regular check-ins and genetic testing over many years. The goal is to map the natural course of the disease and identify early markers th…

Researchers are following thousands of people with Alzheimer's disease who receive lecanemab-irmb in routine care to see how often serious brain side effects occur. The study uses a national registry to track brain swelling, small bleeds, seizures, allergic reactions, strokes, an…

This observational study is recruiting 2400 people with immune-related central nervous system diseases, such as multiple sclerosis, along with healthy volunteers for comparison. Researchers will use MRI scans, lumbar punctures, blood tests, and neurological exams to track disease…

This international observational study will follow 50,000 people with Alzheimer's disease or related dementias for many years. Researchers will collect real-world data from routine doctor visits to track how the disease progresses and how treatments are used and tolerated. The go…

Researchers at a German university eye hospital collect and anonymize data from about 10,000 people with glaucoma, ocular hypertension, or suspected glaucoma. They study how often patients should return for check-ups and which treatments best lower eye pressure for each person. T…

This study looks at the long-term health of people who were cured of Cushing disease before age 21. Researchers want to understand how past high cortisol levels affect the body and mind years later. Participants will complete surveys and have check-ups every 5 years. The goal is …

Researchers want to know whether training one arm after a stroke can improve the other arm, and which brain regions make that possible. The study includes healthy adults, people in the early days after a stroke, and people with long-term stroke effects. Participants play serious …

This study aims to learn more about rare inherited disorders that affect the brain, spinal cord, muscles, and nerves. Researchers will collect medical history, perform exams, and run genetic tests on up to 3,500 participants. No new treatments are tested; the goal is to better un…

Researchers at the University of Miami are studying whether advanced eye imaging devices can reveal useful information about the eye in health and disease. The study has two parts: one observes the eyes of healthy people and people with conditions such as multiple sclerosis, dry …

This study will look at 54,000 adults having surgery with general anesthesia to see how different oxygen levels affect their recovery. Patients will receive lower, intermediate, or higher oxygen during their operation. The goal is to find which oxygen level reduces the risk of or…

This study aims to improve how doctors find and understand pheochromocytomas and paragangliomas, rare tumors that can cause dangerous high blood pressure. Researchers will use advanced imaging scans and genetic testing in up to 3,000 participants to learn more about these tumors.…

This study looks at whether learning about well-being can improve how romantic partners think and feel. About 2,000 couples with mild depression symptoms will take online surveys about their emotions and relationship satisfaction. The goal is to see if gaining knowledge about wel…

This study looks at how brief mental stress affects heart function and brain health in 450 adults aged 40-60. Participants complete two sessions: one with stress tests and heart monitoring, another with brain scans and memory tests. The goal is to understand links between stress …

This study looks at facial features of males aged 2 to 40 with creatine transporter deficiency (CTD), a genetic disorder that causes intellectual disability, seizures, and behavioral issues. Researchers will examine photos of participants to see if they share common facial traits…

This study follows people with rare genetic disorders that cause harmful substances to build up in the body, leading to brain damage. Researchers will monitor up to 200 participants over time using exams, surveys, and lab tests. The goal is to better understand how these diseases…

This study looks at how the brains of children with anxiety disorders work differently from healthy children. Researchers will use brain scans and thinking tasks to track changes over a year, before and after standard treatments like therapy or medication. The goal is to find pat…

This study enrolls people with endocrine tumors (such as thyroid, parathyroid, adrenal, or pancreatic tumors) who are scheduled for surgery or biopsy. Researchers collect samples of the tumor, nearby healthy tissue, blood, and urine to analyze genetic and molecular changes. The g…

This registry is following 4,000 people who have been treated with Medtronic devices for brain aneurysms or ischemic stroke. Researchers are tracking how well the devices work in everyday medical practice, including how often aneurysms are fully closed and how many patients regai…

This study looks at whether specific brain wave patterns (gamma oscillations) can help predict how well ketamine therapy works for people with treatment-resistant depression. Researchers will measure brain activity using EEG before and during ketamine treatment and track depressi…

This study looks at whether fidgeting—specifically using a smart fidget ball—can help adults with ADHD pay better attention and manage emotions. Researchers will measure processing speed, memory, and heart rate in 109 adults with ADHD. The goal is to see if simple movements can b…

This study looks at whether a device called the Minder, implanted under the scalp, can help doctors make better treatment plans for people with epilepsy whose standard brain wave tests (EEG) are not clear. About 210 adults with drug-resistant epilepsy will either get the Minder d…

This study follows 155 adults with CADASIL, a genetic condition that narrows small blood vessels and raises the risk of strokes and dementia, over nine years. Researchers will use brain scans, blood tests, and other exams to track how the disease changes blood vessels and thinkin…

This study is creating a large database of medical information and blood samples from 350 adults receiving metabolic radiotherapy for thyroid, prostate, or neuroendocrine cancers. The goal is to provide researchers with valuable data to better understand these treatments. No new …

This pilot study will give 70 children aged 6-13 either a daily almond butter snack or a chocolate spread snack for 8 weeks. Researchers will measure changes in gut and mouth bacteria, blood markers, and digestion. The goal is to see if almonds can improve gut health and reduce f…

Researchers at 24 hospitals in Japan are following 500 people who had an acute ischemic stroke while also living with active cancer. The study measures how often a second stroke occurs within three months and which clinical factors, such as cancer type, stroke features, and test …

This study follows 842 people with multiple sclerosis who are starting a new under-the-skin injection of ocrelizumab. Researchers will ask participants how satisfied they are with the injection after 1, 6, and 12 months. The goal is to understand patient experience, not to test t…

This study looks at how the Achilles tendon behaves during walking in people with spastic paresis, a condition causing muscle stiffness after stroke or spinal cord injury. Researchers will measure tendon stiffness, length, and volume using ultrasound and motion analysis. The goal…

This global study follows people with POLG-related disorders, a group of rare mitochondrial conditions, to understand how the disease progresses over time. By observing clinical changes in up to 300 participants of all ages, researchers aim to identify key milestones that could s…

This study aims to see if it is possible to measure brain activity patterns related to thinking and attention in people with chronic pain or depression, compared to healthy volunteers. Researchers will use non-invasive brain stimulation and computer tasks to record brain signals.…

This study follows 2,800 unpaid caregivers of people with chronic conditions like diabetes or inherited disorders. Researchers will survey and interview caregivers over up to 5 years to track changes in their health, stress, and social support. The goal is to understand how careg…

This study aims to understand why some people with depression don't get better with standard medications. Researchers will use brain scans to compare dopamine receptors in 45 people: those with treatment-resistant depression, those whose depression responds to treatment, and heal…

This study is testing a new technology called SmartMatch that analyzes tumor tissue from people with recurrent brain or spinal cord tumors. The goal is to see if SmartMatch can quickly identify which drugs might work best for each person's specific tumor. About 80 participants ag…

This study looks at how stopping cannabis use for 28 days changes brain activity and memory in people with psychosis and in cannabis users without psychosis. Participants are randomly assigned to either quit cannabis or continue using, and undergo brain scans before and after the…

This early study is testing whether adding the drug memantine (used for Alzheimer's) to a standard antidepressant can improve how the brain processes memories in people with major depression. Thirty adults aged 18-50 will take an SSRI for 11 weeks, and for the last 6 weeks they w…

Researchers want to know why older adults get distracted more easily. They are focusing on a small brain region called the locus coeruleus and its connections to other brain networks. The study will test whether two weeks of at-home tablet attention games can improve focus and st…

This study asks brain cancer patients about their experience with telemedicine compared to in-person visits. Researchers want to learn if patients feel they receive good care through virtual appointments. The goal is to improve how care is delivered to people with brain tumors.

This study looks at how a non-invasive brain stimulation technique called intermittent theta burst stimulation (iTBS) affects symptoms and blood markers in people with treatment-resistant depression. Fifty patients will receive iTBS sessions over four weeks, while fifty healthy v…

Researchers at Erasme University Hospital are studying how brain tumors disrupt the normal link between nerve activity and blood flow, a problem called neurovascular uncoupling. The trial enrolls 40 patients with glioblastoma, glioma, or astrocytoma before surgery. Participants u…

This study tests whether short episodes of breathing low-oxygen air can improve breathing strength in people with chronic spinal cord injury. Participants will try three different breathing sessions (low oxygen, low oxygen with extra carbon dioxide, and normal air) to see which w…

Researchers at the Luxembourg Institute of Health run a long-term observational study that gathers clinical, genetic, and digital data plus biological samples from people with Parkinson's disease and healthy volunteers. Participants include adults with typical Parkinson's or atyp…

This study tests whether a home-based computer training program can improve vision in people who have lost part of their visual field due to stroke, traumatic brain injury, or brain tumor. Researchers will use brain scans to understand how the brain changes with training. The stu…

This study compares two ways of delivering precise radiation to brain tumors that have spread from other cancers. One group gets the standard extra 2-millimeter safety margin around the tumor, while the other group gets no extra margin. The goal is to see if skipping the margin l…

This study is testing whether having additional MRI scans during radiation and chemotherapy can help doctors see how a high-grade glioma (a type of brain tumor) is changing. The goal is to use that information to adjust the treatment plan for each patient. About 80 adults with th…

This study is collecting information from 200 people with cerebral palsy, multiple sclerosis, stroke, fibromyalgia, or similar nerve disorders to see how the EXOPULSE Suit affects their balance and risk of falling over time. Participants will be followed routinely, and researcher…

This study gathers medical information from 200 adults with possible nerve, muscle, or autonomic nervous system disorders who are not already in other NIH studies. Participants undergo standard tests like nerve conduction studies, EMG, and physical exams. The data is stored anony…

This study follows 8,000 adults who have had a stroke to learn why some develop memory and thinking problems afterward. Researchers will track changes in cognition, brain scans, and blood samples over time. The goal is to help doctors identify who is at risk for dementia and pave…

Researchers at Emory University are testing whether a six-week course of the amino acid leucine changes glutamate levels and brain circuit activity in people with midlife depression. The trial enrolls 75 adults with moderate to severe depression and signs of inflammation. Partici…

This study looks at how the brain processes threats in people with PTSD. Researchers will use a mild electrical current (tACS) to gently stimulate brain areas and measure changes in brain activity and anxiety. The goal is to understand the brain mechanisms behind PTSD, not to tes…

OPERA is a large observational database that collects health records from people treated for chronic conditions such as HIV, liver disease, inflammatory bowel disease, heart disease, rheumatic disease, and neurodegenerative disease. Researchers use the records to study how these …

Researchers are following 10,000 registered nurses in Xiamen, China, to see how genes, lifestyle, and environment relate to common chronic diseases like high blood pressure, heart disease, stroke, diabetes, kidney disease, and some cancers. The study collects health and lifestyle…

This study tests an online training program called DERA for community health workers. The goal is to see if it improves their knowledge about dementia, reduces stigma, and boosts their confidence in helping people with dementia. About 100 community health workers will take the tr…

This study aims to see if proteins in the blood can predict who will develop Alzheimer's disease or memory problems. Researchers will follow 1,800 older adults, some with mild forgetfulness or dementia, and track their cognitive health over time. The goal is to develop and valida…

Researchers at the University of Idaho are studying whether an 8-week mindfulness program focused on self-compassion or 8 weeks of vitamin D supplements can reduce stress in mothers of preterm infants. The trial enrolls 500 mothers and measures stress hormones, self-compassion, a…

Researchers are studying whether blood proteins and metabolites can predict who responds to transcranial magnetic stimulation (TMS) for treatment-resistant depression. About 55 adults whose depression has not improved with at least two antidepressants receive 20 sessions of inter…

Researchers are building a large database of high-resolution MRI scans from stroke patients in China to study the fatty plaques inside brain arteries. The study enrolls adults who recently had an ischemic stroke and have a specific plaque in a major brain artery. By tracking thes…

Researchers are studying how aging and spinal cord injury affect two nerve pathways that help control leg movement: the corticospinal and reticulospinal tracts. The trial enrolls adults with chronic spinal cord injury and healthy controls. Participants receive transcranial magnet…

Researchers at the University of Rochester are testing a program called FMF Connect Pro that trains mental health providers to screen for prenatal alcohol exposure, diagnose fetal alcohol spectrum disorders, and support caregivers through a companion app. The study compares two t…

Researchers at six Italian headache centers are following about 800 adults with trigeminal autonomic cephalalgias, a group of rare headaches that includes cluster headache, paroxysmal hemicrania, SUNCT, SUNA, and hemicrania continua. The study observes routine care rather than as…

Researchers are studying how attachment styles and social cognition relate to post-traumatic stress disorder in French military personnel. The trial compares military personnel with PTSD to those without it, looking at biological, psychological, and social factors that may contri…

Women with spinal cord injury often deal with urinary incontinence, but most research has focused on women after menopause. This pilot study asks whether the natural drop in estrogen after ovulation could make incontinence more frequent. Twenty-four women will track their menstru…

Researchers are studying how posterior fossa brain tumors affect physical abilities and daily life in children aged 7 to 10. The study compares 60 children, some with these tumors and some healthy, on walking endurance, balance, muscle strength, and gait. Children also answer qua…

Researchers at Ariel University are studying how the level of food processing and nutritional quality affect how much people eat, how fast they eat, how full they feel, and their blood sugar. Forty adults in Israel with a body mass index between 20 and 40 will eat three laborator…

Researchers at Georgia State University are studying how transcranial magnetic stimulation (TMS) affects reading speed and accuracy. About 50 adults with typical reading skills will receive either excitatory, inhibitory, or sham stimulation to a brain region called the supramargi…