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Zapping tremors: radiation may offer new hope for Parkinson's and essential tremor patients

NCT ID NCT01734122

Symptom relief Sponsor: Vanderbilt University Medical Center Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now This study
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 24, 2026 · Last updated Sep 17, 2026 · Updated 3 times

Summary

This study follows 60 people with essential tremor or Parkinson's tremor whose symptoms aren't well-controlled by medication. After receiving stereotactic radiosurgery—a precise dose of radiation to a small brain area—participants fill out questionnaires about their quality of life and tremor severity every 3 months for a year. The goal is to see if this non-surgical approach can meaningfully reduce shaking and improve daily functioning.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
stereotactic radiosurgery (focused radiation to the brain)
What this could lead to
If successful, this could show that radiosurgery improves quality of life and reduces tremor for people whose medication isn't enough.
What could go wrong
This is a small, observational study with no comparison group, so results may not prove radiosurgery is better than other treatments. Risks include potential side effects from brain radiation.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Participants

About 60 people

The number the study aims to enrol. It can still change while the study runs.

Started

Feb 2013

Expected to finish

Sep 2029

An estimate. End dates often move.

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Who is studied

This trial enrolls persons with essential tremor or Parkinsonian tremor that is inadequately controlled by medications.

Ages

18 years and older

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Must be certified by a neurologist as having essential tremor or Parkinsonian tremor that is insufficiently controlled by medication alone. * Preference to receive radiation treatment for tremor treatment, rather than surgical DBS implantation or surgical thalamotomy * At least 18 years old Exclusion Criteria: * Contraindications to cranial radiation (such as prior radiation to the thalamus) * Inability to have a MRI of the brain * Prior surgical thalamotomy treatment (but contralateral deep brain stimulator \[DBS\] is permitted) * Estimated life expectancy less than 1 year

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Conditions

The condition(s) this trial relates to.

essential tremor Parkinson disease Tremor

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Essential tremor Parkinson disease Quality of life Radiosurgery Tremor

How to take part

Only the study team decides who joins. These are the ways to reach them.

  1. The places running it

    1 site. The list below names each one and where it is.

  2. The official record

    ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.

    Open the record ↗

  3. A doctor treating you

    A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.

Contacts and locations

Locations

  • Vanderbilt University Medical Center

    RECRUITING

    Nashville, Tennessee, 37232, United States

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