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Could a gentle zap to the brain ease Parkinson's symptoms?

NCT ID NCT07534397

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now This study
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 26, 2026 · Last updated Sep 17, 2026 · Updated 3 times

Summary

This study will test whether a gentle, non-invasive brain stimulation technique called tDCS can improve verbal fluency, thinking, and motor control in people with Parkinson's disease. Twenty participants aged 50-90 with Parkinson's and a verbal fluency deficit will receive the stimulation. The goal is to see if this approach can help with everyday tasks like speaking and moving.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
transcranial direct current stimulation (tDCS) device
What this could lead to
If it works, this could point toward a non-invasive, drug-free way to ease cognitive and motor symptoms in Parkinson's disease.
What could go wrong
This is a very small, early-stage study (20 people) with no control group comparison yet. The effects may be small or not last, and tDCS may not work for everyone.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

About 20 people

The number the study aims to enrol. It can still change while the study runs.

Started

Sep 2026

Expected to finish

Oct 2027

An estimate. End dates often move.

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

50 to 90 years

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Diagnosed with PD having a verbal fluency deficit based on neuropsychological test (T-score \< 40 or a T-score \<-1.0 SD below the average T-score): Semantic Object Retrieval Test (SORT), COWAT (both letter and category fluency), Boston Naming Test (BNT), Rey Auditory Verbal Learning Test (RAVLT) * 50 - 90 years old * Capable of understanding and signing an informed consent (able to answer consent comprehension questions) * Fluent in speaking and reading English Exclusion Criteria: A potentially study-confounding, tDCS-contraindicated, or EEG-contraindicated psychological, neuropsychiatric, neurological, or other medical issues: * Montreal Cognitve Assessment (MOCA) score \<23, unless an accompanying study partner/caregiver is with them and we can obtain the written consent of both the participant and the participant's accompanying study partner/caregiver (i.e., the participant's spouse, adult child, parent, or adult sibling); * history of seizures; * unexplained episodes of loss of consciousness (as these may be related to brain alterations or epilepsy); * suffering from severe or frequent headaches; * unstable or uncontrolled neuropsychiatric illness; * severe traumatic brain injury (based on the Ohio State TBI Identification; Method); * brain tumor; stroke; present drug abuse/misuse; * brain tumor; * serious or life-threatening diseases, including congestive heart failure, chronic obstructive pulmonary disease, or active malignancy; * Huntington's disease; * stroke; * cranial implants or skull defects that affect tDCS administration; * implanted brain medical devices, including, deep brain stimulators (DBS); * implanted pacemakers; * any electrically, magnetically, or mechanically activated implants; * cardiac, neural, or medication implants; * vascular clips or other electrically sensitive support systems in the brain; * damaged skin at the sites of stimulation (the device should only be used on healthy, intact skin, as wounds may alter resistance to current); * skin conditions such as dermatitis, psoriasis, or eczema; * pregnant women; * diagnosis of just dysarthria; Use of medications that interact with or potentially interact with tDCS or EEG effects: * anti-convulsants; * carbamazepine; * sulpiride; * pergolide; * lorazepam; * rivastigmine; * dextromethorphan; * D-cycloserine; * flunarizine; * ropinirole; * citalopram; * stimulants; Additionally, non-English speakers will be excluded because not all of the screening forms, questionnaires, and tests are available in languages other than English.

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Conditions

The condition(s) this trial relates to.

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

How to take part

Only the study team decides who joins. These are the ways to reach them.

  1. The places running it

    1 site. The list below names each one and where it is.

  2. The official record

    ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.

    Open the record ↗

  3. A doctor treating you

    A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.

Contacts and locations

Locations

  • Callier Clinical Center, The University of Texas at Dallas

    RECRUITING

    Richardson, Texas, 75080, United States

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