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New drug could replace standard infusions for nerve disorder

NCT ID NCT06920004

Disease control Sponsor: argenx Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now This study
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 27, 2026 · Last updated Sep 18, 2026 · Updated 6 times

Summary

This study tests a new medicine called empasiprubart against the standard treatment (IVIg) for people with chronic inflammatory demyelinating polyneuropathy (CIDP), a nerve disease that causes weakness and numbness. About 218 adults who have used IVIg before will receive either the new drug or IVIg for 6 months, then everyone gets empasiprubart for 2 years. The goal is to see if empasiprubart works better at reducing disability.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Phase 3

Large-scale testing in a bigger group. Usually the last step before a treatment can be approved.

Participants

About 218 people

The number the study aims to enrol. It can still change while the study runs.

Started

Aug 2025

Expected to finish

Sep 2030

An estimate. End dates often move.

Lead sponsor

A company

The lead sponsor is a pharmaceutical, biotech, or medical-device company.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 years and older

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Meets criteria for CIDP based on EAN/PNS Task Force CIDP guidelines, second revision (2021) * Has either typical CIDP or 1 of the following CIDP variants: motor CIDP, multifocal CIDP (also known as Lewis-Sumner syndrome), focal CIDP, or distal CIDP * Has responded to IVIg in the past 5 years * Receiving treatment with IVIg within a standard optimal maintenance dosing regimen, with a minimum weekly IVIg dose of at least 0.125 g/kg * Has residual disability and active disease Exclusion Criteria: * Besides the indication under study, known autoimmune disease or any medical condition that would interfere with an accurate assessment of clinical symptoms of CIDP or puts the participant at undue risk, including polyneuropathy of other causes * Meets the criteria for possible or sensory CIDP based on EAN/PNS Task Force CIDP guidelines, second revision (2021) * Use of other long-acting immunomodulatory treatment

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Conditions

The condition(s) this trial relates to.

chronic inflammatory demyelinating polyradiculoneuropathy polyneuropathy, inflammatory demyelinating, chronic

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Chronic inflammatory demyelinating polyneuropathy CIDP Cidp - chronic inflammatory demyelinating polyneuropathy

How to take part

Only the study team decides who joins. These are the ways to reach them.

  1. The study's own enquiry address

    This study publishes an address for enquiries. See it below .

  2. The places running it

    87 sites in 29 countries. The list below names each one and where it is.

  3. The official record

    ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.

    Open the record ↗

  4. A doctor treating you

    A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.

Contacts and locations

Study contacts

  • Contact

    Email: •••••@•••••

Locations

  • AP-HP - Hôpital Bicêtre

    RECRUITING

    Le Kremlin-Bicêtre, 94270, France

  • AP-HP - Hôpital de la Pitié Salpétrière

    ACTIVE_NOT_RECRUITING

    Paris, Paris, 75013, France

  • AUSL di Bologna - Ospedale Bellaria

    RECRUITING

    Bologna, 40139, Italy

  • Aomori Prefectural Central Hospital

    RECRUITING

    Aomori, 030-8553, Japan

  • Astra Kliinik

    RECRUITING

    Tallinn, 11315, Estonia

  • Azienda Ospedaliero-Universitaria Policlinico Umberto I

    RECRUITING

    Roma, 161, Italy

  • Azienda Ospedaliero-Universitaria Sant'Andrea

    RECRUITING

    Roma, 00189, Italy

  • Black Tusk Research Group

    ACTIVE_NOT_RECRUITING

    Vancouver, British Columbia, V6Z2C7, Canada

  • Brainaxy Clinic SRL

    RECRUITING

    Constanța, 900348, Romania

  • CHU de Bordeaux - Hôpital Pellegrin

    RECRUITING

    Bordeaux, 33076, France

  • CHU de Nice-Hôpital Pasteur

    RECRUITING

    Nice, 6001, France

  • CHU de Strasbourg - Hôpital de Hautepierre

    RECRUITING

    Strasbourg, 67200, France

  • CHU de Toulouse-Hôpital Pierre-Paul Riquet-Site de Purpan

    RECRUITING

    Toulouse, 31059, France

  • Centrum Medyczne Linden

    RECRUITING

    Krakow, 30-721, Poland

  • Centrum Medyczne Medyk

    RECRUITING

    Rzeszów, 35-210, Poland

  • Centrum Medyczne Medyk-al. Tadeusza Rejtana 53

    ACTIVE_NOT_RECRUITING

    Rzeszów, 35-210, Poland

  • Centrum Medyczne Neurologia Slaska

    RECRUITING

    Katowice, 40-689, Poland

  • Charité - Universitätsmedizin Berlin

    RECRUITING

    Berlin, 13353, Germany

  • Chiba University Hospital

    RECRUITING

    Chūōku, 260-8677, Japan

  • Clinical Research Center Sp. z o.o. Medic-R sp.k.

    RECRUITING

    Poznan, 61-731, Poland

  • Colorado Springs Neurological Associates

    RECRUITING

    Colorado Springs, Colorado, 80907, United States

  • Erlanger Health System

    RECRUITING

    Columbia, Maryland, 21044, United States

  • Fakultni nemocnice Brno

    RECRUITING

    Brno, Czechia

  • Fondazione Istituto Neurologico Nazionale Casimiro Mondino IRCCS

    RECRUITING

    Pavia, 27100, Italy

  • Fondazione PTV Policlinico Tor Vergata

    RECRUITING

    Roma, 133, Italy

    Contact Email: •••••@•••••

  • Galen Clinic - Lublin

    RECRUITING

    Lublin, 20-064, Poland

  • General Hospital Tsuchiura Kyodo Hospital

    RECRUITING

    Tsuchiura, 300-0028, Japan

  • Hadassah Medical Center- Ein Kerem

    RECRUITING

    Jerusalem, 9112001, Israel

  • Homestead Associates in Research Inc

    RECRUITING

    Homestead, Florida, 33033, United States

  • Hospital Alma Máter de Antioquia

    RECRUITING

    Medellín, 50012, Colombia

    Contact Email: •••••@•••••

  • Hospital General Universitario Gregorio Marañon

    RECRUITING

    Madrid, 28007, Spain

  • Hospital Neurologico de Colombia Fundacion Ivan Jimenez - El Neurologico

    RECRUITING

    Medellín, 50012, Colombia

    Contact Email: •••••@•••••

  • Hospital Universitario San Ignacio

    RECRUITING

    Bogotá, 110231, Colombia

    Contact Email: •••••@•••••

  • Hospital Universitario Vall d'Hebron

    RECRUITING

    Sant Andreu de la Barca, 08740, Spain

  • Hospital Universitario Virgen Macarena

    RECRUITING

    Seville, 41009, Spain

  • Hôpitaux Universitaires de Genève (HUG)

    RECRUITING

    Geneva, 1205, Switzerland

  • INECO Neurociencias Oroño

    RECRUITING

    Rosario, S2000DTP, Argentina

  • IRCCS Istituto Clinico Humanitas

    RECRUITING

    Rozzano, 20089, Italy

  • Inje University Haeundae Paik Hospital

    RECRUITING

    Busan, 48108, South Korea

  • Instituto Privado Kremer

    ACTIVE_NOT_RECRUITING

    Córdoba, X5004AOA, Argentina

  • Institutul National de Neurologie si Boli Neurovasculare Bucuresti

    RECRUITING

    Bucharest, 41914, Romania

  • Jefferson Health Honickman Center

    RECRUITING

    Philadelphia, Pennsylvania, 19107, United States

    Contact Email: •••••@•••••

  • Jichi Medical University Hospital

    RECRUITING

    Shimotsuke, 329-0498, Japan

    Contact Email: •••••@•••••

  • Juntendo Shizuoka University Hospital

    RECRUITING

    Izunokuni, 410-2295, Japan

  • Juntendo University Hospital

    RECRUITING

    Bunkyō City, 113-8431, Japan

  • Kepler Universitätsklinikum Linz - Med Campus III

    ACTIVE_NOT_RECRUITING

    Linz, Austria

  • Konkuk University Medical Center

    RECRUITING

    Seoul, 05030, South Korea

  • Leeds General Infirmary

    RECRUITING

    Leeds, LS1 3EX, United Kingdom

  • Liverpool Hospital

    ACTIVE_NOT_RECRUITING

    Liverpool, New South Wales, 2179, Australia

  • MICS Centrum Medyczne Bydgoszcz

    RECRUITING

    Bydgoszcz, 85-065, Poland

  • MedStar Washington Hospital Center

    RECRUITING

    Washington D.C., District of Columbia, 20010, United States

    Contact Email: •••••@•••••

  • National Neuromuscular Research Institute

    RECRUITING

    Irving, Texas, 75063, United States

  • National Neuroscience Institute

    RECRUITING

    Singapore, 308433, Singapore

  • NeuroCarePlus

    RECRUITING

    Houston, Texas, 77094, United States

  • Neurocentrum Bydgoszcz

    RECRUITING

    Bydgoszcz, 85-796, Poland

  • Ondokuz Mayis Universitesi Saglik Uygulama ve Arastirma Merkezi

    RECRUITING

    Samsun, 55200, Turkey (Türkiye)

  • Osaka Metropolitan University Hospital

    RECRUITING

    Osaka, 545-8586, Japan

  • Oslo Universitetssykehus HF, Ullevål

    RECRUITING

    Oslo, 450, Norway

  • PSEG Centro de Pesquisa Clinica

    RECRUITING

    São Paulo, 04038-002, Brazil

    Contact Email: •••••@•••••

  • Paradigm Health System

    RECRUITING

    Slidell, Louisiana, 70458, United States

  • Perelman Center for Advanced Medicine

    RECRUITING

    Philadelphia, Pennsylvania, 19104-5127, United States

    Contact Email: •••••@•••••

  • SP ZOZ Szpital Uniwersytecki w Krakowie

    RECRUITING

    Krakow, 30-688, Poland

  • Saga University Hospital

    RECRUITING

    Saga, 849-8501, Japan

  • Sahlgrenska University Hospital

    RECRUITING

    Gothenburg, 41346, Sweden

  • Salford Royal Hospital - PPDS

    ACTIVE_NOT_RECRUITING

    Salford, Lancashire, M6 8HD, United Kingdom

  • Samir Macwan, M.D., Inc.

    RECRUITING

    Rancho Mirage, California, 922701, United States

  • Seirei Hamamatsu Hospital

    RECRUITING

    Hiroshima, 430-8558, Japan

    Contact Email: •••••@•••••

  • Semmelweis Egyetem Genomikai Medicina és Ritka Betegségek Intézete

    RECRUITING

    Budapest, 1085, Hungary

  • Seoul National University Hospital

    RECRUITING

    Seoul, 03080, South Korea

  • Severance Hospital Yonsei University Health System

    RECRUITING

    Seoul, 03722, South Korea

  • Targu-Mures Emergency Clinical County Hospital

    RECRUITING

    Târgu Mureş, 540136, Romania

  • Tartu University Hospital

    RECRUITING

    Tartu, 50406, Estonia

  • The Barzilai University Medical Center

    RECRUITING

    Ashkelon, 78278, Israel

  • The Chaim Sheba Medical Center

    RECRUITING

    Tel Litwinsky, 52621, Israel

  • The National Hospital for Neurology and Neurosurgery - PPDS

    RECRUITING

    London, WC1N 3BG, United Kingdom

  • ULS de Santo António, EPE - Hospital de Santo António

    RECRUITING

    Porto, 4050-342, Portugal

  • Universitair Medisch Centrum Utrecht

    RECRUITING

    Utrecht, 3584 CX, Netherlands

  • University Clinical Center Nis

    RECRUITING

    Niš, 18 000, Serbia

  • University Clinical Center of Serbia - Dr Subotica 6

    RECRUITING

    Belgrade, 11000, Serbia

  • University Clinical Centre Maribor

    RECRUITING

    Maribor, 2000, Slovenia

  • University General Hospital ''ATTIKON'' - General Hospital of West Attica H AGIA VARVARA

    RECRUITING

    Chaïdári, 124 62, Greece

  • University General Hospital of Alexandroupolis

    RECRUITING

    Athens, 15562, Greece

  • University Medical Centre Ljubljana

    RECRUITING

    Ljubljana, 1000, Slovenia

  • University of Alabama

    RECRUITING

    Birmingham, Alabama, 35233, United States

  • University of Cincinnati Health

    ACTIVE_NOT_RECRUITING

    Cincinnati, Ohio, 45267-2827, United States

  • University of Michigan Hospital

    RECRUITING

    Ann Arbor, Michigan, 48109, United States

  • University of South Florida

    RECRUITING

    Tampa, Florida, 33616, United States

  • Universitätsklinikum AKH Wien

    RECRUITING

    Vienna, 1090, Austria

  • Universitätsklinikum Schleswig-Holstein - Campus Kiel

    RECRUITING

    Kiel, 24105, Germany

  • Univerzitna nemocnica MARTIN

    RECRUITING

    Martin, 036 59, Slovakia

  • Uniwersytecki Szpital Kliniczny Nr 1

    RECRUITING

    Szczecin, 71-252, Poland

  • Uniwersytecki Szpital Kliniczny Nr 1 im. Tadeusza Sokolowskiego Pomorskiego UM w Szczecinie

    RECRUITING

    Szczecin, 71-252, Poland

  • Uniwersyteckie Centrum Kliniczne Warszawskiego Uniwersytetu Medycznego

    RECRUITING

    Warsaw, 02-097, Poland

  • Visionary Investigators Network

    RECRUITING

    Miami, Florida, 33133, United States

  • Yamaguchi University Hospital

    RECRUITING

    Ube, 755-0067, Japan

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