Brain cancer breakthrough? GammaTile trial aims to boost survival
NCT ID NCT07195591
First seen Oct 31, 2025 · Last updated Jun 22, 2026 · Updated 27 times
Summary
This Phase 3 trial tests whether adding a special radiation tile (GammaTile) during brain surgery improves survival for people with newly diagnosed glioblastoma, a fast-growing brain cancer. About 766 participants will be randomly assigned to standard treatment (surgery, radiation, and chemo) or standard treatment plus GammaTile. The study is currently recruiting and will compare overall survival between the two groups.
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Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Contacts and locations
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Study contacts
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Contact
Phone: •••-•••-•••• Email: •••••@•••••
Locations
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Allegheny Health Network
RECRUITINGPittsburgh, Pennsylvania, 15212, United States
Contact
Contact Phone: •••-•••-•••• Email: •••••@•••••
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Brown University Health
RECRUITINGProvidence, Rhode Island, 02903, United States
Contact
Contact Email: •••••@•••••
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HonorHealth Scottsdale Osborn Medical Center
RECRUITINGScottsdale, Arizona, 85251, United States
Contact
Contact Email: •••••@•••••
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Jersey Shore University Medical Center | Hackensack
RECRUITINGNeptune City, New Jersey, 07753, United States
Contact Email: •••••@•••••
Contact
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Westchester Medical Center
RECRUITINGValhalla, New York, 10595, United States
Contact Email: •••••@•••••
Contact
Contact
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
GammaTile (radiation-emitting tiles placed during surgery), external beam radiation, and temozolomide chemotherapy
What this could lead to
If successful, this could offer a more effective way to control glioblastoma by delivering radiation directly to the tumor site during surgery, potentially extending survival.
What could go wrong
This is an early-stage Phase 3 trial, and results may not confirm a benefit. Adding GammaTile could increase side effects like brain swelling or infection, and the treatment still requires ongoing chemotherapy.
Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.