GLIOBLASTOMA

This study tests a combination of three drugs (pembrolizumab, olaparib, and temozolomide) in adults whose glioblastoma brain tumor has come back after prior treatment. The goal is to see if this mix can boost the immune system's attack on the tumor and slow or stop its growth. Ab…

This study tests methimazole, a drug normally used for thyroid conditions, in people with progressive glioblastoma (a fast-growing brain cancer). The goal is to see if it can slow tumor growth and improve survival. About 19 participants will receive increasing doses to find the s…

This program provides access to an experimental drug called AVM0703 for people with various solid tumors or blood cancers who have not responded to other treatments. It is available in the US upon a doctor's request. So far, 37 patients have received the drug, and side effects ha…

This study tests whether combining an antidepressant (trimipramine) with two cancer drugs (atezolizumab and bevacizumab) can help people with recurrent glioblastoma, an aggressive brain cancer. About 59 participants will receive the treatment for up to 2 years. The goal is to slo…

This study tests a treatment plan for people whose brain tumors (gliomas) have come back after standard care. The approach uses laser heat to destroy tumor tissue, followed by a short course of focused radiation. The goal is to see if this combination is safe and can help control…

This early-stage study tests a new treatment for children and young adults (up to age 21) with certain brain tumors that have come back or not responded to standard therapy. The treatment uses the patient's own immune cells, modified to target a protein called B7-H3 on tumor cell…

This study tests a new gene therapy (HSV-tk) plus valacyclovir, given together with radiation and chemotherapy, for people newly diagnosed with aggressive brain cancers called glioblastoma or anaplastic astrocytoma. The goal is to see if this combination improves survival and slo…

This early-stage study tests a new drug called RZ-001 combined with valganciclovir in people with glioblastoma, a serious brain cancer. The goal is to find a safe dose and see if the treatment can shrink tumors or help people live longer. About 43 adults with a specific tumor mar…

This study tests whether adding a cannabis-based mouth spray (Nabiximols) to standard chemotherapy can help people with a returning, aggressive brain tumor called glioblastoma live longer. About 120 adults whose tumor has returned after initial treatment will be randomly assigned…

This early-stage trial tests a new cell therapy called E-SYNC CAR T cells for people with a specific form of glioblastoma, an aggressive brain cancer. The treatment uses a patient's own immune cells, modified in a lab to better recognize and attack the tumor. About 20 adults will…

This early-stage study tests an experimental pill called GLIX1 in 30 adults whose high-grade glioma (a fast-growing brain tumor) has returned or worsened after standard treatments. The main goals are to find a safe dose and check for side effects. Participants take the pill daily…

This early-phase study tests whether giving the immunotherapy drug ipilimumab before standard surgery and chemoradiation is safe and helps control glioblastoma, a fast-growing brain cancer. About 16 adults with newly diagnosed glioblastoma will receive up to 2 doses of ipilimumab…

This study tests whether adding two different drug combinations after radiation can help children and young adults with high-grade gliomas (including DIPG) live longer. One group receives ribociclib plus everolimus, and another receives ribociclib plus temozolomide, based on the …

This study tests a combination of experimental drugs and tumor treatment fields in people whose glioblastoma (a fast-growing brain cancer) has come back or worsened after initial treatment. The goal is to see if these treatments can help control the cancer and improve survival. A…

This early-phase trial tests two existing drugs—senicapoc and perampanel—alone and together for newly diagnosed glioblastoma, the most common and aggressive adult brain cancer. The goal is to find safe doses and see if the drugs reach the tumor. About 36 adults will receive the d…

This study tests whether adding focused ultrasound (NaviFUS) to the standard drug Avastin can help people with recurrent glioblastoma, an aggressive brain cancer. About 32 adults whose tumor has returned after prior treatment will be randomly assigned to receive Avastin alone or …

This early-phase study tests a new drug called Peposertib alongside radiation and chemotherapy for people with a fast-growing brain cancer (glioblastoma). The goal is to find the safest dose and see if the drug reaches the brain. About 29 adults with newly diagnosed or returning …

This study tests a drug called ivonescimab in people whose glioblastoma (a type of brain cancer) has come back after standard treatment. The first part finds the safest dose, and the second part checks if that dose can help control the cancer. About 45 adults with recurrent gliob…

This early-phase study tests whether adding the drug azeliragon to standard chemoradiotherapy can help the immune system fight glioblastoma, an aggressive brain cancer. About 12 adults with newly diagnosed tumors will receive either standard treatment or standard treatment plus a…

This study tests whether using a patient's own tumor cells to screen drugs can lead to more effective, personalized treatment for glioblastoma, a severe brain cancer. About 240 adults with newly diagnosed glioblastoma will either receive standard care or standard care plus a pers…

This early-phase study tests an oral drug called ONC206 in 102 adults with brain tumors that have come back or are rare. The main goal is to find the safest dose and understand side effects. Participants take the drug by mouth on a weekly schedule, and researchers monitor for any…

This study tests a new treatment for glioblastoma, a serious brain cancer. It combines an investigational drug (5-ALA) with a non-invasive ultrasound device to target tumor cells. About 103 people with newly diagnosed glioblastoma will be randomly assigned to get either the activ…

This early-phase trial tests an experimental drug called RSC-1255, given alone or with hydroxychloroquine, in adults with advanced solid tumors (such as lung, colon, pancreatic, or brain cancer) that have not responded to or cannot tolerate standard treatments. The study has two …

This study tests a new way to deliver a standard brain cancer drug (bevacizumab) using focused ultrasound and microbubbles in 10 people whose glioblastoma has returned. The goal is to see if this combination is safe and can help control tumor growth for longer. Participants must …

This early-stage study tests whether combining a precise laser treatment (LITT) with the chemotherapy drug lomustine is safe and doable for adults whose glioblastoma has come back. About 20 participants will receive the laser procedure followed by chemo within a week. The main go…

This study tests a drug called PLX038 in adults with brain or spinal cord tumors, especially those with changes in the MYC or MYCN genes. The goal is to see if the drug can shrink tumors or slow their growth. Participants receive the drug through an IV every 3 weeks and are follo…

This study tests several new drugs, alone or with standard chemotherapy, for people newly diagnosed with glioblastoma, an aggressive brain cancer. About 460 adults will be assigned to different treatment arms to see if the drugs help them live longer compared to standard therapy.…

This early-stage trial tests whether adding the drug ibrutinib to a chemotherapy and immunotherapy combination can help children and young adults (ages 6–25) with brain cancers that have come back or not responded to standard treatment. The study aims to find the safest dose of i…

This study tests a new approach for people with a fast-growing brain tumor called glioblastoma. Standard treatment uses radiation and chemo, but the tumor often comes back. Researchers are giving a higher radiation dose along with a drug called bevacizumab, which may protect heal…

This study tests whether adding the immunotherapy drug pembrolizumab to standard treatment (Optune device plus chemotherapy) helps people with newly diagnosed glioblastoma live longer. About 741 adults who have had surgery for glioblastoma will be randomly assigned to receive eit…

This early-phase study tests the safety of an experimental drug called CUE-102 in 18 adults whose glioblastoma (a type of brain cancer) has returned after initial treatment. The drug is designed to help the immune system target cancer cells. The main goal is to find the safest do…

This study follows children who have already taken dabrafenib and/or trametinib for certain brain tumors. Researchers will monitor side effects and track growth over time. The goal is to understand the long-term safety of these medications in young patients.

This early-phase study tests a new approach for people with recurrent high-grade astrocytoma, a serious brain cancer. Participants receive a virus-based gene therapy injected into the tumor cavity during surgery, followed by targeted radiation. The main goal is to find the safest…

This study tests whether giving radiation in a smaller, more targeted area can reduce side effects and improve quality of life for people with glioblastoma, an aggressive brain cancer. About 347 participants will receive standard chemoradiotherapy, but half will get a smaller rad…

This study tests whether adding the drug ruxolitinib to standard treatment (radiation and temozolomide) helps people with newly diagnosed glioblastoma live longer. About 190 adults will be randomly assigned to receive either the standard treatment alone or standard treatment plus…

This early-stage study tests a radioactive drug called 131I-TLX101 given alongside standard treatment for people newly diagnosed with glioblastoma, an aggressive brain cancer. The main goal is to find a safe dose and check for side effects. About 12 adults who have had surgery fo…

This trial tests a device called SonoCloud-9 that uses ultrasound to temporarily open the blood-brain barrier, allowing more chemotherapy (carboplatin) to reach brain tumors. About 560 adults with recurrent glioblastoma will either get this new combination or standard chemotherap…

This early-phase study tests a new two-drug combination for adults whose high-grade glioma (a type of brain cancer) has come back after standard treatment. The drugs are a low, continuous dose of temozolomide (a chemotherapy pill) plus abexinostat (an experimental drug). The main…

This study tests a new drug, VRT106, in 42 adults whose glioblastoma (a serious brain cancer) has come back or worsened. The main goal is to see if the drug is safe and find the best dose. Researchers will also check if it helps shrink tumors or extend life, but this is not a cur…

This early-phase study tests a new drug called WSD0628 combined with radiation therapy for people whose high-grade glioma (a type of brain tumor) has come back after prior treatment. The main goals are to find the safest dose and to see how well the combination works. About 94 ad…

This early-phase study tests whether giving a single dose of targeted radiation inside the brain right after tumor removal can improve outcomes for people with newly diagnosed glioblastoma, an aggressive brain cancer. Fifteen adults aged 40-75 will receive this intraoperative rad…

This study tests if a daily egg powder enriched with a natural protein (antisecretory factor) can help people with newly diagnosed glioblastoma live longer. About 300 adults aged 18-75 who have had surgery and are scheduled for chemo or radiation will take the powder or a placebo…

This study tests a new drug called TLX101-Tx, which delivers targeted radiation directly to brain cancer cells, combined with standard chemotherapy (lomustine) in adults whose glioblastoma has returned after initial treatment. The goal is to see if the combination helps control t…

This early-phase study tests a new treatment called CARv3-TEAM-E T cells for people with glioblastoma, a fast-growing brain cancer. The treatment uses the patient's own immune cells, modified in a lab to better recognize and attack the tumor. The main goal is to find the safest d…

This study tests a new treatment called EBNK-001, which uses donor immune cells (natural killer cells) to fight advanced solid tumors. About 83 adults with cancers like lung, breast, or colorectal cancer that have not responded to standard treatments will receive these cells alon…

This study tests an experimental drug called ONC206 in children and young adults with a type of brain tumor called diffuse midline glioma (DMG) or other recurring brain cancers. The drug works by causing stress in cancer cells, making them die without harming healthy cells. The g…

This study tests a drug called lorlatinib in children (ages 1-21) with a newly diagnosed, aggressive brain tumor that has a specific genetic change (ALK or ROS1 fusion). The goal is to see if the drug can shrink or control the tumor and to check its safety when given alone or wit…

This study tests an experimental drug, BDTX-1535, in people with aggressive brain tumors (high-grade glioma or glioblastoma) that have certain changes in the EGFR gene. The drug aims to block a growth signal that these tumors rely on. The study will check how much drug reaches th…

This early-phase study tests a new treatment for adults with glioblastoma or high-grade glioma that has come back after standard therapy. The treatment uses specially engineered natural killer (NK) cells designed to target two different markers on tumor cells at once, which may h…

This study tests a new treatment for aggressive brain tumors (glioblastoma) that uses a radioactive substance attached to a targeting molecule to deliver radiation directly to cancer cells. It is for 35 adults aged 18-80 who have already had standard treatments like surgery, radi…

This large international study is testing several potential treatments at once for glioblastoma, an aggressive brain cancer. It includes both people newly diagnosed and those whose cancer has returned. The goal is to find which therapies work best by quickly adapting the trial ba…

This study tests a different way of giving the chemotherapy drug temozolomide to people aged 65 and older with a type of brain cancer called glioblastoma that has a marker (unmethylated MGMT) making standard treatment less effective. Instead of the usual schedule, participants ta…

This study tests if a drug called niraparib works better than the standard chemo (temozolomide) for adults with a newly diagnosed, aggressive brain cancer called glioblastoma that has a specific genetic marker (MGMT unmethylated). About 450 people will be randomly assigned to tak…

This study tests a combination of two drugs—Lutathera (a targeted radiation therapy) and olaparib (a PARP inhibitor)—in children and teens aged 3 to 18 with solid tumors that have come back or not responded to standard treatment. The goal is to find the safest dose and see if the…

This study tests if adding a special radiation tile (GammaTile) during brain tumor surgery can help people with a new glioblastoma diagnosis live longer. About 766 adults will be randomly assigned to standard treatment or standard treatment plus the tile. The goal is to see if th…

This study tests whether adding silibinin (a milk thistle extract) to standard chemoradiation and maintenance therapy can delay tumor growth in people with a specific type of newly diagnosed glioblastoma. About 110 participants will receive either silibinin or a placebo alongside…

This study tests a more intense treatment for a fast-growing type of brain cancer called IDH wildtype glioma. It combines higher doses of radiation with the chemotherapy drug temozolomide to try to stop the tumor from growing longer. The trial will enroll 40 adults with this spec…

This program provides ulixertinib, an experimental drug, to adults with advanced solid tumors that have specific genetic changes (MAPK pathway mutations) and who have run out of standard treatments. The goal is to control the cancer, not cure it. Participants may take ulixertinib…

This study tests a treatment using donor immune cells (CAR-NK cells) designed to attack cancer. The specific target on the cancer cells is chosen based on a biopsy of the tumor or a blood test. The goal is to see if this approach is safe and can shrink or control advanced solid t…

This study tests a new drug that delivers radiation directly to cancer cells with a specific marker (GRPR). It is for adults with advanced cancers like prostate, breast, lung, or colon cancer that have come back or spread. The main goal is to find a safe dose and check for side e…

This early-stage study tests whether two experimental drugs, ABBV-637 and ABBV-155, are safe when given alone or with another drug called ERAS-801 for people whose glioblastoma has come back. About 60 adults with a specific type of brain tumor (EGFR gene amplified) will take part…

This study tests a new method called sonobiopsy that uses ultrasound to release DNA from brain tumors into the blood, making it easier to detect without surgery. Researchers will enroll 40 adults with suspected glioblastoma to see if this approach can identify tumor mutations fro…

This study tests a special microscope called CONVIVO that lets surgeons see brain tissue up close during surgery. The goal is to help them tell the difference between normal brain and tumor tissue right away. About 30 adults with different types of brain tumors will take part. If…

This study tests whether the blood thinner apixaban can safely prevent blood clots (venous thromboembolism) in people newly diagnosed with grade 4 glioma, a serious brain cancer. About 40 adults will take apixaban while undergoing standard radiation and chemotherapy. The main goa…

This study tests a 6-week occupational therapy group program for adults with primary brain tumors who are on active treatment. The program covers fatigue management, thinking strategies, relaxation, and peer support. Researchers want to see if it improves quality of life and dail…

This study tests whether giving cancer treatment at home is preferred over going to a clinic. It involves 27 adults with various cancers in the Florida Panhandle. The goal is to see if home care improves patient satisfaction and is safe.

This study tests whether a custom video that shows symptoms specific to a patient's brain tumor can lower anxiety during radiation treatment. About 117 patients with newly diagnosed gliomas and their caregivers will take part. The video is made from the patient's own MRI scan and…

This study tests whether proton beam radiation causes fewer side effects than standard photon radiation in people with glioblastoma, a fast-growing brain tumor. About 326 adults who need radiation after surgery or biopsy will be randomly assigned to one of the two methods. The ma…

This study is testing a small device called a microdialysis catheter that is placed in the brain during surgery to collect fluid samples. The goal is to see if it is safe and can gather useful information (biomarkers) about brain tumors like glioblastoma and metastatic cancer. Ab…

This study is not testing a new treatment. Instead, it collects blood and tumor samples from 80 people with newly diagnosed glioblastoma who are already receiving standard care plus TTFields (a device that uses electric fields to slow cancer growth). Researchers will analyze thes…

This study aims to analyze the genetic makeup of brain tumors in children, teens, and young adults (ages 1 to 39) newly diagnosed with high-grade glioma, including a type called DIPG. By identifying specific genetic changes in each tumor, researchers hope to match patients with m…

This study looks at what factors—like genetics, immune system, and medical history—may influence the risk of getting glioblastoma (a severe brain cancer) and how long people live with it. About 200 adults with this cancer will fill out online surveys and may provide a blood sampl…

This study is looking for biological markers that can predict whether a person with glioblastoma (a type of brain cancer) will survive at least 6 months after treatment with the drug bevacizumab. The study involves 170 adults whose cancer has returned after standard treatment. Re…

This study uses MRI scans to look at brain tumor biology in 50 adults with glioblastoma that can be surgically removed. The goal is to find imaging markers that can predict which patients will benefit from the drug bevacizumab. Participants will have their tumors analyzed for a p…

This study is testing whether an artificial intelligence tool can help match cancer patients to clinical trials they might be eligible for. Researchers will enroll up to 50,000 people with various types of cancer and use the AI to suggest trials. The goal is to see if this approa…

This early-phase trial is testing whether a special egg yolk powder called Salovum® can reduce pressure inside glioblastoma brain tumors. Ten adults with suspected glioblastoma will have pressure and oxygen probes placed during a biopsy, then take Salovum® for a few days. The goa…

This study tests if recording electrical activity in and around high-grade glioma tumors during surgery is safe and feasible. Researchers will take small biopsies at recording sites and follow patients with MRI scans to see if brain activity patterns can predict where the tumor w…

This study tests whether using a special PET scan (FDOPA-PET) to guide radiation therapy can help people with recurrent glioblastoma, an aggressive brain cancer. About 54 adults whose tumor has come back after prior radiation will receive targeted radiation based on the PET scan.…

This study looks at how much of the drug T-DXd gets into brain tumors in people with HER2-positive brain cancer or glioblastoma. About 30 adults will receive the drug before surgery, and researchers will measure drug levels in the tumor during the operation. The goal is to unders…

This early-phase study tests whether a new radioactive tracer can help doctors see tumors on PET/CT scans. About 32 adults with different solid tumors will receive a single injection of the tracer. The goal is to understand where the tracer goes in the body, how it is cleared, an…

This study watches 200 adults having brain tumor surgery to see how often cerebrospinal fluid leaks occur, what makes them more likely, and how doctors treat them. The goal is to find ways to reduce leaks and help patients heal better.

This study collects samples of glioblastoma (a type of brain tumor) and blood from 120 adults during standard surgery. Researchers will examine tissue from different parts of the same tumor to see how they differ. The goal is to learn more about the tumor's structure and behavior…

This study compares two common methods of closing the skin after brain tumor surgery: running stitches (absorbable) and individual stitches (non-absorbable). The goal is to see which method leads to fewer wound problems like infection or fluid leaks. About 382 adults having plann…

This study is testing whether a blood or urine test can detect signals from brain tumors, especially glioblastoma. Researchers will use a special dye (5-ALA) that makes tumor cells glow during surgery to help link what's seen in the blood to the actual tumor. The goal is to devel…

This pilot study will use two types of PET scans and a powerful 7Tesla MRI to create detailed metabolic profiles of glioblastoma, both in newly diagnosed and recurrent tumors. Researchers will compare the scan results with lab tests on tumor tissue to better understand how these …

This study looks at whether having surgery to remove a returning glioblastoma brain tumor helps people live longer and feel better compared to skipping surgery. About 120 adults whose cancer came back after standard treatment will be randomly assigned to either have surgery plus …

This study tests three advanced MRI methods to look at the cells and proteins around glioblastoma brain tumors without needing surgery. Researchers want to understand why some tumors are harder to treat. About 15 adults with suspected glioblastoma will have these special scans be…

This study tests the drug troriluzole in people with recurrent glioblastoma, a type of brain cancer. Participants take the drug before surgery to see how it affects brain activity and glutamate levels in the tumor. The goal is to learn more about the drug's effects, not to treat …