GLIOBLASTOMA

This study tested giving chemotherapy and radiation before surgery for people with a newly diagnosed, removable glioblastoma (a fast-growing brain cancer). The goal was to see if this approach could improve tumor control and survival. Only 2 people enrolled before the trial was s…

This study tested a drug called pemigatinib in people whose brain tumors (glioblastoma or similar) had come back after prior treatment and had specific changes in FGFR genes. About 83 participants took the drug daily for two weeks followed by a week off. The goal was to see if tu…

This study tested a new, more precise type of radiation therapy (IMRT with a special MRI-guided boost) against standard radiation, both given with the chemotherapy drug temozolomide, for people with glioblastoma, an aggressive brain cancer. The goal was to see if the newer radiat…

This early-stage trial tested the drug navtemadlin in 32 adults with glioblastoma, an aggressive brain cancer. The goal was to find the safest dose and see how much drug reaches the tumor. The study was stopped early, but results may guide future treatments.

This early-stage study tested a new drug called RMC-5552 in 7 adults whose glioblastoma (a type of brain cancer) had returned after standard treatment. The drug works by blocking a protein that helps cancer cells grow. The main goals were to find the safest dose and see if the dr…

This study tested a new drug called VAL-083 in people with glioblastoma, an aggressive brain cancer, that had come back after standard treatments. The goal was to see if VAL-083 could help patients live longer. However, the trial was stopped early after only 2 people enrolled, so…

This early-stage study tested a new drug called TAS2940 in 29 people with advanced solid tumors (like lung, breast, or brain cancer) that had certain genetic changes (EGFR or HER2). The goal was to find a safe dose and see if it could shrink tumors. The trial was stopped early, s…

This study tested an experimental drug called zotiraciclib (TG02) combined with the standard chemotherapy temozolomide in adults with recurrent anaplastic astrocytoma or glioblastoma. The goal was to find safe doses and see if the combination works better than temozolomide alone.…

This study looked at whether a special MRI using ferumoxytol (an iron-based contrast agent) can tell the difference between true tumor growth and treatment-related inflammation (pseudoprogression) in people with glioblastoma receiving immunotherapy. About 52 adults with newly dia…

This study aimed to see if a high-CBD hemp product could reduce anxiety and improve quality of life in people with glioblastoma, a serious brain tumor. The trial planned to enroll newly diagnosed patients, but it was terminated early with only 2 participants. No results are avail…

This study tested a drug called solriamfetol to see if it could help people with brain tumors (gliomas) feel more awake and improve their memory, mood, and quality of life. Only 2 people enrolled before the study was stopped early. The main goal was to check for side effects.

This study aimed to see how much of the drug infigratinib gets into brain tumors in people with recurrent high-grade glioma (a type of brain cancer). Only 7 participants were enrolled before the study was stopped. The main goal was to measure drug levels in tumor tissue, blood, a…

This early-phase study tested whether the antifungal drug posaconazole can enter brain tumors in high enough amounts to stop cancer cells from dividing. Seven adults with glioblastoma took the drug before surgery so researchers could measure drug levels in their spinal fluid and …

This early-phase study aimed to see if ketoconazole, a drug used for fungal infections, could enter glioblastoma brain tumors in high enough amounts to stop cancer cells from dividing. Only one person was enrolled before the study was terminated. The goal was to gather informatio…

This study looked at a molecule called microRNA-10b in people with gliomas, a type of brain tumor. Researchers wanted to see if higher levels of this molecule could help predict how long patients live or how their tumor behaves. They collected tumor, blood, and spinal fluid sampl…