GLIOBLASTOMA

This early-stage study tests a new way to treat a type of aggressive brain cancer (glioblastoma) that has come back after standard treatment. It combines a focused ultrasound device that opens the blood-brain barrier with an immunotherapy drug called pembrolizumab. The main goal …

This study tests a new approach called pharmacoscopy, which uses a lab test on a patient's tumor sample to find which drugs might work best for them. It involves 40 adults with brain tumors like glioblastoma that have not responded to standard treatments. The goal is to see if th…

This phase II trial tests whether vortioxetine, a drug currently used for depression, can help people with newly diagnosed glioblastoma. The study will enroll 78 adults and measure if the drug extends the time before the cancer worsens. Vortioxetine was selected because lab tests…

This early-phase trial tests a personalized vaccine (Bvax) made from each patient's tumor, given alongside standard chemoradiotherapy for newly diagnosed glioblastoma. The goal is to see if the vaccine is safe and can help control the cancer. About 25 adults with glioblastoma wil…

This study tests two experimental drugs, CTX-009 and CTX-471, in people whose glioblastoma (a type of brain cancer) has come back after standard treatments. The drugs work by cutting off the tumor's blood supply and boosting the immune system to attack the cancer. The goal is to …

This study tests whether a special MRI technique (CEST) can help surgeons remove more glioblastoma tissue during surgery. Standard surgery only removes parts of the tumor that show up on regular MRI, but this new method may reveal hidden tumor areas. The trial will compare how lo…

This study tests a personalized vaccine (ZSNeo-DC1.1) made from a patient's own immune cells, combined with standard chemotherapy, for people with newly diagnosed glioblastoma. About 78 participants will be randomly assigned to receive the vaccine plus chemotherapy or chemotherap…

This early safety study tests a special MRI that uses pH (acid levels) to better show where glioblastoma brain tumors have spread into healthy tissue. The goal is to help surgeons remove more of the tumor safely. The study will include 12 VA patients with newly diagnosed or retur…

This study tests whether adding an experimental drug (ADI-PEG 20) to standard radiation and chemotherapy can help children, teens, and young adults with newly diagnosed high-grade glioma. About 97 participants will receive the drug combination to see if it is safe and delays tumo…

This phase 2 trial tests whether placing tiny chemotherapy-releasing seeds (irinotecan-ChemoSeed) directly into the brain after removing a glioblastoma tumor can help keep the cancer from coming back. About 147 adults with newly diagnosed or recurrent glioblastoma will take part.…

This early-stage study tests a fluorescent dye called panitumumab-IRDye800 that attaches to cancer cells and glows under special lights. About 30 adults with brain tumors (like meningioma or glioblastoma) will receive the dye before surgery to help surgeons see tumor tissue more …

This study looks at 50 adults with glioblastoma, an aggressive brain cancer, to see how much of the tumor is removed during surgery and how follow-up chemoradiotherapy affects how long they live. Researchers will track survival from surgery onward. The goal is to better understan…

This study tests a new way to deliver radiation for brain tumors called adaptive radiotherapy, guided by artificial intelligence. About 60 adults with diffuse glioma will get MRI and PET scans during treatment so the radiation dose can be adjusted to target resistant areas and pr…

This early study tests if a tiny device can safely collect fluid from the brain during planned surgery for glioma or epilepsy. Six participants will have the microperfusion catheter placed temporarily during their operation. The goal is to see if the device works and is safe, not…

This study will follow 100 adults with glioblastoma, an aggressive brain tumor, to understand which factors—like genetics, surgery type, and patient health—affect survival and quality of life. Researchers will collect data from multiple hospitals in Europe and the U.S. but will n…

This early-phase study looks at how Acetadote, a drug that affects cell damage, changes metabolism in glioblastoma. Ten newly diagnosed patients will receive Acetadote before surgery, and researchers will measure metabolic changes using MRI scans and tumor tissue analysis. The go…

This study explores whether giving chemotherapy before radiation for high-grade gliomas (aggressive brain tumors) can help doctors better see if new drugs work. After radiation, MRI scans become harder to read, so giving chemo first may make it easier to measure tumor response. T…

This study checks if a special brain scan (PET-MRI) done within 48 hours after glioblastoma surgery is safe and can find leftover tumor better than standard MRI. Fifteen adults who just had their first surgery for suspected glioblastoma will get the scan. The goal is to see if th…

This very early (Phase 0) study will give an oral drug called gallium maltolate to 8 people whose glioblastoma has come back. The main goal is to measure how much gallium gets into the tumor tissue after surgery, compared to untreated tumor samples. This trial does not test if th…

This study aims to understand why glioblastoma, an aggressive brain cancer, returns after treatment. Researchers will analyze blood and tumor samples from 45 patients to uncover the molecular, immune, and metabolic changes that drive recurrence. The goal is to identify new target…

This study looks at 30 people newly diagnosed with glioblastoma, an aggressive brain tumor. Researchers will compare special MRI scans (MRS) with blood tests to find patterns that might help understand the tumor better. The goal is to gather information, not to test a new treatme…

This study tests whether using MRI scans to plan radiotherapy is better than using CT scans alone. Researchers will work with up to 150 cancer patients and 15 healthy volunteers to see if MRI can make treatment more precise and reduce side effects. The goal is to improve how doct…